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Carcinoma of parotid gland

MedGen UID:
91047
•Concept ID:
C0345602
•
Neoplastic Process
Synonyms: Carcinoma of Parotid; carcinoma of parotid; Carcinoma of Parotid Gland; carcinoma of parotid gland; Carcinoma of the Parotid; carcinoma of the parotid; Carcinoma of the Parotid Gland; carcinoma of the parotid gland; Parotid Carcinoma; parotid carcinoma; Parotid Gland Carcinoma; parotid gland carcinoma
SNOMED CT: Carcinoma of parotid gland (254462001)
 
Monarch Initiative: MONDO:0021331

Definition

A carcinoma that arises from the parotid gland. Representative examples include mucoepidermoid carcinoma, adenoid cystic carcinoma, adenocarcinoma, and carcinoma ex pleomorphic adenoma. [from NCI]

Professional guidelines

PubMed

Clinicopathological features and treatment outcomes of the rare, salivary duct carcinoma of parotid gland.
Al-Qahtani KH, Tunio MA, Bayoumi Y, Gurusamy VM, Bahamdain FA, Fatani H
J Otolaryngol Head Neck Surg 2016 May 16;45(1):32. doi: 10.1186/s40463-016-0146-2. PMID: 27184361Free PMC Article
Management of salivary gland tumors.
Andry G, Hamoir M, Locati LD, Licitra L, Langendijk JA
Expert Rev Anticancer Ther 2012 Sep;12(9):1161-8. doi: 10.1586/era.12.92. PMID: 23098116

Recent clinical studies

Etiology

Clinicopathological features and treatment outcomes of the rare, salivary duct carcinoma of parotid gland.
Al-Qahtani KH, Tunio MA, Bayoumi Y, Gurusamy VM, Bahamdain FA, Fatani H
J Otolaryngol Head Neck Surg 2016 May 16;45(1):32. doi: 10.1186/s40463-016-0146-2. PMID: 27184361Free PMC Article
Adenoid cystic carcinoma of parotid gland treated with surgery and radiotherapy: long-term outcomes, QoL assessment and review of the literature.
Al-Mamgani A, van Rooij P, Sewnaik A, Tans L, Hardillo JA
Oral Oncol 2012 Mar;48(3):278-83. Epub 2011 Nov 16 doi: 10.1016/j.oraloncology.2011.10.014. PMID: 22093375
Oncocytic mucoepidermoid carcinoma of the parotid gland with CRTC1-MAML2 fusion transcript: report of a case with review of literature.
Fujimaki M, Fukumura Y, Saito T, Mitani K, Uchida S, Yokoyama J, Yao T, Ikeda K
Hum Pathol 2011 Dec;42(12):2052-5. Epub 2011 Jun 14 doi: 10.1016/j.humpath.2011.02.021. PMID: 21676434
Widespread metastases from acinic cell carcinoma of parotid gland.
Vidyadhara S, Shetty AP, Rajasekaran S
Singapore Med J 2007 Jan;48(1):e13-5. PMID: 17245497
Oncocytic mucoepidermoid carcinoma of parotid gland origin.
Brannon RB, Willard CC
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003 Dec;96(6):727-33. doi: 10.1016/s1079-2104(03)00377-9. PMID: 14676764

Diagnosis

Mammary analogue secretory carcinoma of parotid gland: Literature review and experience of a dedicated cancer institution in Pakistan.
Shahid H, Dhanani R, Faisal M, Rehman A, Jamshed A, Hussain R
J Pak Med Assoc 2022 May;72(5):950-953. doi: 10.47391/JPMA.2371. PMID: 35713062
Discordance between fine-needle aspiration cytology and histopathology in patients with mucoepidermoid carcinoma of parotid gland.
Iftikhar H, Sohail Awan M, Usman M, Khoja A, Khan W
Ann R Coll Surg Engl 2020 May;102(5):340-342. Epub 2020 Mar 11 doi: 10.1308/rcsann.2020.0022. PMID: 32159383Free PMC Article
Large lipid-rich mammary analogue secretory carcinoma of parotid gland: An unusual case.
Joshi P, Mridha AR, Singh S, Kinra P, Ray R, Thakar A
Indian J Pathol Microbiol 2015 Jul-Sep;58(3):351-3. doi: 10.4103/0377-4929.162897. PMID: 26275262
Synchronous bilateral multifocal acinic cell carcinoma of parotid gland: case report and review of the literature.
Jia YL, Bishwo SP, Nie X, Chen LL
J Oral Maxillofac Surg 2012 Oct;70(10):e574-80. Epub 2012 Aug 3 doi: 10.1016/j.joms.2012.06.006. PMID: 22868030
Oncocytic mucoepidermoid carcinoma of parotid gland origin.
Brannon RB, Willard CC
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003 Dec;96(6):727-33. doi: 10.1016/s1079-2104(03)00377-9. PMID: 14676764

Therapy

Effectiveness and tolerance of electrochemotherapy as palliative therapy for patients with head and neck cancer and malignant melanoma and its relation to early skin reaction.
Caballero-Borrego M, Coll S, Navarrete P
Braz J Otorhinolaryngol 2024 Jan-Feb;90(1):101365. Epub 2023 Nov 22 doi: 10.1016/j.bjorl.2023.101365. PMID: 38006727Free PMC Article
Ado-trastuzumab emtansine (T-DM1) in patients with HER2-amplified tumors excluding breast and gastric/gastroesophageal junction (GEJ) adenocarcinomas: results from the NCI-MATCH trial (EAY131) subprotocol Q.
Jhaveri KL, Wang XV, Makker V, Luoh SW, Mitchell EP, Zwiebel JA, Sharon E, Gray RJ, Li S, McShane LM, Rubinstein LV, Patton D, Williams PM, Hamilton SR, Conley BA, Arteaga CL, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT
Ann Oncol 2019 Nov 1;30(11):1821-1830. doi: 10.1093/annonc/mdz291. PMID: 31504139Free PMC Article
Iris metastasis from adenoid cystic carcinoma of parotid gland.
Montero J, Shields CL, Bianciotto C, Shields JA, Ehya H
Cornea 2011 Mar;30(3):351-3. doi: 10.1097/ICO.0b013e3181e9af33. PMID: 21045673

Prognosis

Mammary analogue secretory carcinoma of parotid gland: Literature review and experience of a dedicated cancer institution in Pakistan.
Shahid H, Dhanani R, Faisal M, Rehman A, Jamshed A, Hussain R
J Pak Med Assoc 2022 May;72(5):950-953. doi: 10.47391/JPMA.2371. PMID: 35713062
Adenoid cystic carcinoma of parotid gland treated with surgery and radiotherapy: long-term outcomes, QoL assessment and review of the literature.
Al-Mamgani A, van Rooij P, Sewnaik A, Tans L, Hardillo JA
Oral Oncol 2012 Mar;48(3):278-83. Epub 2011 Nov 16 doi: 10.1016/j.oraloncology.2011.10.014. PMID: 22093375
Iris metastasis from adenoid cystic carcinoma of parotid gland.
Montero J, Shields CL, Bianciotto C, Shields JA, Ehya H
Cornea 2011 Mar;30(3):351-3. doi: 10.1097/ICO.0b013e3181e9af33. PMID: 21045673
Widespread metastases from acinic cell carcinoma of parotid gland.
Vidyadhara S, Shetty AP, Rajasekaran S
Singapore Med J 2007 Jan;48(1):e13-5. PMID: 17245497
Oncocytic mucoepidermoid carcinoma of parotid gland origin.
Brannon RB, Willard CC
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003 Dec;96(6):727-33. doi: 10.1016/s1079-2104(03)00377-9. PMID: 14676764

Clinical prediction guides

Effectiveness and tolerance of electrochemotherapy as palliative therapy for patients with head and neck cancer and malignant melanoma and its relation to early skin reaction.
Caballero-Borrego M, Coll S, Navarrete P
Braz J Otorhinolaryngol 2024 Jan-Feb;90(1):101365. Epub 2023 Nov 22 doi: 10.1016/j.bjorl.2023.101365. PMID: 38006727Free PMC Article
Ado-trastuzumab emtansine (T-DM1) in patients with HER2-amplified tumors excluding breast and gastric/gastroesophageal junction (GEJ) adenocarcinomas: results from the NCI-MATCH trial (EAY131) subprotocol Q.
Jhaveri KL, Wang XV, Makker V, Luoh SW, Mitchell EP, Zwiebel JA, Sharon E, Gray RJ, Li S, McShane LM, Rubinstein LV, Patton D, Williams PM, Hamilton SR, Conley BA, Arteaga CL, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT
Ann Oncol 2019 Nov 1;30(11):1821-1830. doi: 10.1093/annonc/mdz291. PMID: 31504139Free PMC Article
A mismatch of tumor grade and biologic behaviour in a rare case of Sclerosing Mucoepidermoid Carcinoma of Parotid - with review of literature.
Devi A, Narwal A, Kamboj M, Singh S
J Exp Ther Oncol 2018 Nov;12(4):307-315. PMID: 30476387
Adenoid cystic carcinoma of parotid gland treated with surgery and radiotherapy: long-term outcomes, QoL assessment and review of the literature.
Al-Mamgani A, van Rooij P, Sewnaik A, Tans L, Hardillo JA
Oral Oncol 2012 Mar;48(3):278-83. Epub 2011 Nov 16 doi: 10.1016/j.oraloncology.2011.10.014. PMID: 22093375
Incidence of malignancy in primary Sjogren's syndrome in a Chinese cohort.
Zhang W, Feng S, Yan S, Zhao Y, Li M, Sun J, Zhang FC, Cui Q, Dong Y
Rheumatology (Oxford) 2010 Mar;49(3):571-7. Epub 2009 Dec 29 doi: 10.1093/rheumatology/kep404. PMID: 20040528

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