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Amelanotic skin melanoma

MedGen UID:
91149
•Concept ID:
C0349515
•
Neoplastic Process
Synonyms: amelanotic cutaneous (skin) melanoma; Amelanotic Cutaneous Melanoma; Amelanotic Malignant Melanoma (of Skin); amelanotic malignant melanoma (of skin); Amelanotic malignant melanoma of skin; Amelanotic Malignant Melanoma of Skin; amelanotic malignant melanoma of skin; Amelanotic Malignant Melanoma of the Skin; amelanotic malignant melanoma of the skin; Amelanotic Malignant Skin Melanoma; amelanotic malignant skin melanoma; Amelanotic melanoma; Amelanotic Melanoma of Skin; amelanotic melanoma of skin; Amelanotic Melanoma of the Skin; amelanotic melanoma of the skin; amelanotic melanoma of zone of skin; Amelanotic Skin Melanoma; amelanotic skin melanoma; skin amelanotic malignant melanoma; skin amelanotic melanoma; zone of skin amelanotic melanoma
SNOMED CT: Amelanotic melanoma (276751004); Amelanotic malignant melanoma of skin (276751004)
 
Monarch Initiative: MONDO:0005208

Definition

A rare cutaneous melanoma where most of the melanoma tumor cells are devoid of melanin pigment. Amelanotic melanomas are more likely to present at a more advanced stage of disease, compared with pigmented melanomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmelanotic skin melanoma

Professional guidelines

PubMed

Clinical characteristics and treatment outcomes of primary malignant melanoma of esophagus: a single center experience.
Kim TS, Min BH, Min YW, Lee H, Rhee PL, Kim JJ, Lee JH
BMC Gastroenterol 2022 Mar 29;22(1):157. doi: 10.1186/s12876-022-02235-8. PMID: 35351022Free PMC Article
Genital melanoma: prognosis factors and treatment modality.
Ferraioli D, Lamblin G, Mathevet P, Hetu J, Berakdar I, Beurrier F, Chopin N
Arch Gynecol Obstet 2016 Nov;294(5):1037-1045. Epub 2016 Jun 30 doi: 10.1007/s00404-016-4144-4. PMID: 27365105
Management of lentigo maligna and lentigo maligna melanoma: seminars in surgical oncology.
Arlette JP, Trotter MJ, Trotter T, Temple CL
J Surg Oncol 2004 Jul 1;86(4):179-86. doi: 10.1002/jso.20081. PMID: 15221924

Recent clinical studies

Etiology

Melanoma clinicopathological groups characterized and compared with dermoscopy and reflectance confocal microscopy.
Faldetta C, Kaleci S, Chester J, Ruini C, Ciardo S, Manfredini M, Guida S, Chello C, Cantisani C, Young JN, Cabral P, Gulati N, Guttman-Yassky E, Pellacani G, Farnetani F
J Am Acad Dermatol 2024 Feb;90(2):309-318. Epub 2023 Nov 19 doi: 10.1016/j.jaad.2023.09.084. PMID: 37988042
Trends in pediatric skin cancer.
Moustafa D, Neale H, Hawryluk EB
Curr Opin Pediatr 2020 Aug;32(4):516-523. doi: 10.1097/MOP.0000000000000917. PMID: 32618791
Phenotypic and genotypic analysis of amelanotic and hypomelanotic melanoma patients.
Rayner JE, McMeniman EK, Duffy DL, De'Ambrosis B, Smithers BM, Jagirdar K, Lee KJ, Soyer HP, Sturm RA
J Eur Acad Dermatol Venereol 2019 Jun;33(6):1076-1083. Epub 2019 Mar 15 doi: 10.1111/jdv.15446. PMID: 30680790
Paediatric melanoma.
Stefanaki C, Chardalias L, Soura E, Katsarou A, Stratigos A
J Eur Acad Dermatol Venereol 2017 Oct;31(10):1604-1615. Epub 2017 May 22 doi: 10.1111/jdv.14299. PMID: 28449284
Desmoplastic melanoma: a review.
Chen LL, Jaimes N, Barker CA, Busam KJ, Marghoob AA
J Am Acad Dermatol 2013 May;68(5):825-33. Epub 2012 Dec 23 doi: 10.1016/j.jaad.2012.10.041. PMID: 23267722Free PMC Article

Diagnosis

Cutaneous melanoma.
Long GV, Swetter SM, Menzies AM, Gershenwald JE, Scolyer RA
Lancet 2023 Aug 5;402(10400):485-502. Epub 2023 Jul 24 doi: 10.1016/S0140-6736(23)00821-8. PMID: 37499671
Amelanotic melanoma.
Gong HZ, Zheng HY, Li J
Melanoma Res 2019 Jun;29(3):221-230. doi: 10.1097/CMR.0000000000000571. PMID: 30672881
Unusual Clinical Presentations of Malignant Melanoma: A Review of Clinical and Histologic Features with Special Emphasis on Dermatoscopic Findings.
Cabrera R, Recule F
Am J Clin Dermatol 2018 Nov;19(Suppl 1):15-23. doi: 10.1007/s40257-018-0373-6. PMID: 30374898Free PMC Article
Amelanotic melanoma.
Muinonen-Martin AJ, O'Shea SJ, Newton-Bishop J
BMJ 2018 Mar 15;360:k826. doi: 10.1136/bmj.k826. PMID: 29545447
Pink lesions.
Giacomel J, Zalaudek I
Dermatol Clin 2013 Oct;31(4):649-78, ix. doi: 10.1016/j.det.2013.06.005. PMID: 24075552

Therapy

Cyclin-Dependent Kinase Inhibitors in the Rare Subtypes of Melanoma Therapy.
Kaszubski J, Gagat M, Grzanka A, Wawrzyniak A, Niklińska W, Łapot M, Żuryń A
Molecules 2024 Nov 6;29(22) doi: 10.3390/molecules29225239. PMID: 39598629Free PMC Article
Pterostilbene-Mediated Inhibition of Cell Proliferation and Cell Death Induction in Amelanotic and Melanotic Melanoma.
Wawszczyk J, Jesse K, Kapral M
Int J Mol Sci 2023 Jan 6;24(2) doi: 10.3390/ijms24021115. PMID: 36674631Free PMC Article
Amelanotic Melanoma Concealed by Psoriasis.
Curman P, Lapins J, Radros N, Krynitz B, Wikström JD
Acta Derm Venereol 2020 Mar 12;100(6):adv00082. doi: 10.2340/00015555-3397. PMID: 31930427Free PMC Article
The diagnostic accuracy of dermoscopy and reflectance confocal microscopy for amelanotic/hypomelanotic melanoma: a systematic review and meta-analysis.
Lan J, Wen J, Cao S, Yin T, Jiang B, Lou Y, Zhu J, An X, Suo H, Li D, Zhang Y, Tao J
Br J Dermatol 2020 Aug;183(2):210-219. Epub 2019 Dec 22 doi: 10.1111/bjd.18722. PMID: 31747045
Childhood melanoma: an increasingly important health problem in the USA.
Slade AD, Austin MT
Curr Opin Pediatr 2014 Jun;26(3):356-61. doi: 10.1097/MOP.0000000000000082. PMID: 24786371

Prognosis

Amelanotic Melanoma-Biochemical and Molecular Induction Pathways.
Misiąg P, Molik K, Kisielewska M, Typek P, Skowron I, Karwowska A, Kuźnicki J, Wojno A, Ekiert M, Choromańska A
Int J Mol Sci 2024 Oct 26;25(21) doi: 10.3390/ijms252111502. PMID: 39519055Free PMC Article
Amelanotic melanoma.
Gong HZ, Zheng HY, Li J
Melanoma Res 2019 Jun;29(3):221-230. doi: 10.1097/CMR.0000000000000571. PMID: 30672881
Unusual Clinical Presentations of Malignant Melanoma: A Review of Clinical and Histologic Features with Special Emphasis on Dermatoscopic Findings.
Cabrera R, Recule F
Am J Clin Dermatol 2018 Nov;19(Suppl 1):15-23. doi: 10.1007/s40257-018-0373-6. PMID: 30374898Free PMC Article
Desmoplastic melanoma: a review.
Chen LL, Jaimes N, Barker CA, Busam KJ, Marghoob AA
J Am Acad Dermatol 2013 May;68(5):825-33. Epub 2012 Dec 23 doi: 10.1016/j.jaad.2012.10.041. PMID: 23267722Free PMC Article
Amelanotic malignant melanoma.
Adler MJ, White CR Jr
Semin Cutan Med Surg 1997 Jun;16(2):122-30. doi: 10.1016/s1085-5629(97)80006-5. PMID: 9220551

Clinical prediction guides

Melanoma clinicopathological groups characterized and compared with dermoscopy and reflectance confocal microscopy.
Faldetta C, Kaleci S, Chester J, Ruini C, Ciardo S, Manfredini M, Guida S, Chello C, Cantisani C, Young JN, Cabral P, Gulati N, Guttman-Yassky E, Pellacani G, Farnetani F
J Am Acad Dermatol 2024 Feb;90(2):309-318. Epub 2023 Nov 19 doi: 10.1016/j.jaad.2023.09.084. PMID: 37988042
Cutaneous melanoma metastases: Clinical and dermoscopic findings.
Kostaki M, Plaka M, Moustaki M, Befon A, Champsas G, Kypreou K, Chardalia V, Chasapi V, Polydorou D, Stratigos A
J Eur Acad Dermatol Venereol 2023 May;37(5):941-944. Epub 2022 Nov 5 doi: 10.1111/jdv.18701. PMID: 36310344
Phenotypic and genotypic analysis of amelanotic and hypomelanotic melanoma patients.
Rayner JE, McMeniman EK, Duffy DL, De'Ambrosis B, Smithers BM, Jagirdar K, Lee KJ, Soyer HP, Sturm RA
J Eur Acad Dermatol Venereol 2019 Jun;33(6):1076-1083. Epub 2019 Mar 15 doi: 10.1111/jdv.15446. PMID: 30680790
Desmoplastic melanoma: a review.
Chen LL, Jaimes N, Barker CA, Busam KJ, Marghoob AA
J Am Acad Dermatol 2013 May;68(5):825-33. Epub 2012 Dec 23 doi: 10.1016/j.jaad.2012.10.041. PMID: 23267722Free PMC Article
Key points in the dermoscopic diagnosis of hypomelanotic melanoma and nodular melanoma.
Moloney FJ, Menzies SW
J Dermatol 2011 Jan;38(1):10-5. doi: 10.1111/j.1346-8138.2010.01140.x. PMID: 21175750

Recent systematic reviews

Bone marrow metastases: a systematic review of a neglected involvement in malignant melanoma.
Paolino G, Carugno A, Rongioletti F, Ponzoni M, Russo V, Sena P, Ardigò M, Costanzo A, Mercuri SR, Valenti M
Melanoma Res 2024 Feb 1;34(1):31-37. Epub 2023 Nov 8 doi: 10.1097/CMR.0000000000000942. PMID: 37939076
Oral Amelanotic Melanoma: A Systematic Review of Case Reports and Case Series.
Bansal SP, Dhanawade SS, Arvandekar AS, Mehta V, Desai RS
Head Neck Pathol 2022 Jun;16(2):513-524. Epub 2021 Jul 26 doi: 10.1007/s12105-021-01366-w. PMID: 34309791Free PMC Article
Clinical and Dermoscopic Features Associated With Difficult-to-Recognize Variants of Cutaneous Melanoma: A Systematic Review.
Pampena R, Lai M, Lombardi M, Mirra M, Raucci M, Lallas A, Apalla Z, Argenziano G, Pellacani G, Longo C
JAMA Dermatol 2020 Apr 1;156(4):430-439. doi: 10.1001/jamadermatol.2019.4912. PMID: 32101255
The diagnostic accuracy of dermoscopy and reflectance confocal microscopy for amelanotic/hypomelanotic melanoma: a systematic review and meta-analysis.
Lan J, Wen J, Cao S, Yin T, Jiang B, Lou Y, Zhu J, An X, Suo H, Li D, Zhang Y, Tao J
Br J Dermatol 2020 Aug;183(2):210-219. Epub 2019 Dec 22 doi: 10.1111/bjd.18722. PMID: 31747045

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