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Vaginal Endometriosis

MedGen UID:
924096
•Concept ID:
C4281749
•
Disease or Syndrome

Definition

Endometriosis that affects the vagina. It is characterized by the presence of endometrial stroma with or without endometrial-type glands in the vagina. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal Endometriosis

Professional guidelines

PubMed

Post-traumatic amenorrhea: the role of diagnostic and operative hysteroscopy in the prevention, diagnosis, differential diagnosis and treatment.
Pulcinella R, Giannone L, Candelori E, Giannone E, Patacchiola F
Minerva Ginecol 2014 Feb;66(1):69-76. PMID: 24569405
The diagnosis and management of infiltrating nodular recto-vaginal endometriosis.
Wright JT
Curr Opin Obstet Gynecol 2000 Aug;12(4):283-7. doi: 10.1097/00001703-200008000-00003. PMID: 10954147
Endometriosis; vaginal smear findings as an aid in diagnosis and in the evaluation of treatment.
NEWMAN GT
J Med Soc N J 1950 Jun;47(6):279-81. PMID: 15422305

Recent clinical studies

Etiology

Feasibility and safety of transvaginal specimen extraction in deep endometriosis colorectal resectional surgery and analysis of risk factors for postoperative complications.
Spagnolo E, Marí-Alexandre J, Di Saverio S, Gilabert-Estellés J, Agababyan C, Garcia-Casarrubios P, López A, González-Cantó E, Pascual I, Hernández A
Tech Coloproctol 2022 Apr;26(4):261-270. Epub 2022 Jan 29 doi: 10.1007/s10151-021-02565-x. PMID: 35091790
Atypical vaginal location of endometriosis following repeated urogynaecological surgery.
Christensen AE, Kjer JJ, Hartwell D, Perlman S
BMJ Case Rep 2021 Aug 26;14(8) doi: 10.1136/bcr-2021-244186. PMID: 34446516Free PMC Article
Systematic evaluation of endometriosis by transvaginal ultrasound can accurately replace diagnostic laparoscopy, mainly for deep and ovarian endometriosis.
Goncalves MO, Siufi Neto J, Andres MP, Siufi D, de Mattos LA, Abrao MS
Hum Reprod 2021 May 17;36(6):1492-1500. doi: 10.1093/humrep/deab085. PMID: 33864088
Feasibility and safety of two different surgical routes for the eradication of recto-vaginal endometriosis with vaginal mucosa infiltration (Endo-Vag-r study).
Raimondo D, Turco LC, Cosentino F, Mabrouk M, Mastronardi M, Borghese G, Giaquinto I, Vargiu V, Fagotti A, Meriggiola MC, Chiantera V, Scambia G, Seracchioli R
Acta Obstet Gynecol Scand 2020 Aug;99(8):1050-1056. Epub 2020 Feb 27 doi: 10.1111/aogs.13824. PMID: 32049366
Endometriosis and pelvic pain: relation to disease stage and localization.
Vercellini P, Trespidi L, De Giorgi O, Cortesi I, Parazzini F, Crosignani PG
Fertil Steril 1996 Feb;65(2):299-304. PMID: 8566252

Diagnosis

Accuracy of transvaginal ultrasound for diagnosis of deep endometriosis in uterosacral ligaments, rectovaginal septum, vagina and bladder: systematic review and meta-analysis.
Guerriero S, Ajossa S, Minguez JA, Jurado M, Mais V, Melis GB, Alcazar JL
Ultrasound Obstet Gynecol 2015 Nov;46(5):534-45. doi: 10.1002/uog.15667. PMID: 26250349
The pathology of endometriosis: a survey of the many faces of a common disease emphasizing diagnostic pitfalls and unusual and newly appreciated aspects.
Clement PB
Adv Anat Pathol 2007 Jul;14(4):241-60. doi: 10.1097/PAP.0b013e3180ca7d7b. PMID: 17592255
The diagnosis and management of infiltrating nodular recto-vaginal endometriosis.
Wright JT
Curr Opin Obstet Gynecol 2000 Aug;12(4):283-7. doi: 10.1097/00001703-200008000-00003. PMID: 10954147
Vaginal endometriosis. Two case reports and review of the literature on rare urogenital sites.
Azzena A, Ferrara A, Castellan L, Quintieri F, Salmaso R
Clin Exp Obstet Gynecol 1996;23(2):94-8. PMID: 8737621
Endometriosis and pelvic pain: relation to disease stage and localization.
Vercellini P, Trespidi L, De Giorgi O, Cortesi I, Parazzini F, Crosignani PG
Fertil Steril 1996 Feb;65(2):299-304. PMID: 8566252

Therapy

Systematic evaluation of endometriosis by transvaginal ultrasound can accurately replace diagnostic laparoscopy, mainly for deep and ovarian endometriosis.
Goncalves MO, Siufi Neto J, Andres MP, Siufi D, de Mattos LA, Abrao MS
Hum Reprod 2021 May 17;36(6):1492-1500. doi: 10.1093/humrep/deab085. PMID: 33864088
Carbon dioxide (CO(2)) laser ablation of symptomatic vaginal endometriosis: a pilot study.
Buggio L, Monti E, Liverani C, Frattaruolo MP, Dridi D, Somigliana E
Lasers Med Sci 2021 Aug;36(6):1227-1233. Epub 2020 Oct 16 doi: 10.1007/s10103-020-03162-4. PMID: 33067704
The diagnosis and management of infiltrating nodular recto-vaginal endometriosis.
Wright JT
Curr Opin Obstet Gynecol 2000 Aug;12(4):283-7. doi: 10.1097/00001703-200008000-00003. PMID: 10954147
Treatment of vaginal endometriosis with danazol.
Koskimies AI, Meyer B, Widholm O
Acta Obstet Gynecol Scand Suppl 1984;123:67-8. doi: 10.3109/00016348409156985. PMID: 6594017
Malignant transformation of vaginal endometriosis.
Granai CO, Walters MD, Safaii H, Jelen I, Madoc-Jones H, Moukhtar M
Obstet Gynecol 1984 Oct;64(4):592-5. PMID: 6483304

Prognosis

Systematic evaluation of endometriosis by transvaginal ultrasound can accurately replace diagnostic laparoscopy, mainly for deep and ovarian endometriosis.
Goncalves MO, Siufi Neto J, Andres MP, Siufi D, de Mattos LA, Abrao MS
Hum Reprod 2021 May 17;36(6):1492-1500. doi: 10.1093/humrep/deab085. PMID: 33864088
Accuracy of transvaginal ultrasound for diagnosis of deep endometriosis in uterosacral ligaments, rectovaginal septum, vagina and bladder: systematic review and meta-analysis.
Guerriero S, Ajossa S, Minguez JA, Jurado M, Mais V, Melis GB, Alcazar JL
Ultrasound Obstet Gynecol 2015 Nov;46(5):534-45. doi: 10.1002/uog.15667. PMID: 26250349
Ultrasound mapping system for the surgical management of deep infiltrating endometriosis.
Exacoustos C, Malzoni M, Di Giovanni A, Lazzeri L, Tosti C, Petraglia F, Zupi E
Fertil Steril 2014 Jul;102(1):143-150.e2. Epub 2014 Apr 29 doi: 10.1016/j.fertnstert.2014.03.043. PMID: 24794315
Transvaginal sonography vs. clinical examination in the preoperative diagnosis of deep infiltrating endometriosis.
Hudelist G, Ballard K, English J, Wright J, Banerjee S, Mastoroudes H, Thomas A, Singer CF, Keckstein J
Ultrasound Obstet Gynecol 2011 Apr;37(4):480-7. doi: 10.1002/uog.8935. PMID: 21433168
Vaginal endometriosis. Two case reports and review of the literature on rare urogenital sites.
Azzena A, Ferrara A, Castellan L, Quintieri F, Salmaso R
Clin Exp Obstet Gynecol 1996;23(2):94-8. PMID: 8737621

Clinical prediction guides

Feasibility and safety of transvaginal specimen extraction in deep endometriosis colorectal resectional surgery and analysis of risk factors for postoperative complications.
Spagnolo E, Marí-Alexandre J, Di Saverio S, Gilabert-Estellés J, Agababyan C, Garcia-Casarrubios P, López A, González-Cantó E, Pascual I, Hernández A
Tech Coloproctol 2022 Apr;26(4):261-270. Epub 2022 Jan 29 doi: 10.1007/s10151-021-02565-x. PMID: 35091790
Systematic evaluation of endometriosis by transvaginal ultrasound can accurately replace diagnostic laparoscopy, mainly for deep and ovarian endometriosis.
Goncalves MO, Siufi Neto J, Andres MP, Siufi D, de Mattos LA, Abrao MS
Hum Reprod 2021 May 17;36(6):1492-1500. doi: 10.1093/humrep/deab085. PMID: 33864088
Malignant Transformation of Vaginal Endometriosis - A Review of Literature.
Cozzolino M, Nasioudis D, Sisti G, Coccia ME
Gynecol Obstet Invest 2017;82(2):105-112. Epub 2016 Sep 13 doi: 10.1159/000449198. PMID: 27618565
Accuracy of transvaginal ultrasound for diagnosis of deep endometriosis in uterosacral ligaments, rectovaginal septum, vagina and bladder: systematic review and meta-analysis.
Guerriero S, Ajossa S, Minguez JA, Jurado M, Mais V, Melis GB, Alcazar JL
Ultrasound Obstet Gynecol 2015 Nov;46(5):534-45. doi: 10.1002/uog.15667. PMID: 26250349
Endometriosis and pelvic pain: relation to disease stage and localization.
Vercellini P, Trespidi L, De Giorgi O, Cortesi I, Parazzini F, Crosignani PG
Fertil Steril 1996 Feb;65(2):299-304. PMID: 8566252

Recent systematic reviews

Accuracy of transvaginal ultrasound for diagnosis of deep endometriosis in uterosacral ligaments, rectovaginal septum, vagina and bladder: systematic review and meta-analysis.
Guerriero S, Ajossa S, Minguez JA, Jurado M, Mais V, Melis GB, Alcazar JL
Ultrasound Obstet Gynecol 2015 Nov;46(5):534-45. doi: 10.1002/uog.15667. PMID: 26250349

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