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Vulvar Superficial Myofibroblastoma

MedGen UID:
925378
•Concept ID:
C4287846
•
Neoplastic Process

Definition

An uncommon benign polypoid or nodular mesenchymal neoplasm that arises in the vulvar region. It is characterized by the presence of oval or spindle-shaped cells in a collagenous stroma and is separated from the epidermis by a variably thick Grenz zone. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar Superficial Myofibroblastoma

Recent clinical studies

Etiology

Superficial myofibroblastoma of the lower female genital tract: A clinicopathological analysis of 15 cases.
Zhang M, Shi P, Zhou B, Liu J, Li L
Ann Diagn Pathol 2022 Oct;60:152010. Epub 2022 Jul 22 doi: 10.1016/j.anndiagpath.2022.152010. PMID: 35907316
Update on Mesenchymal Lesions of the Lower Female Genital Tract.
Croce S, Perret R, Le Loarer F
Surg Pathol Clin 2022 Jun;15(2):341-367. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.009. PMID: 35715165
A review and update of morphologically bland vulvovaginal mesenchymal lesions.
McCluggage WG
Int J Gynecol Pathol 2005 Jan;24(1):26-38. PMID: 15626915
Superficial cervicovaginal myofibroblastoma: fourteen cases of a distinctive mesenchymal tumor arising from the specialized subepithelial stroma of the lower female genital tract.
Laskin WB, Fetsch JF, Tavassoli FA
Hum Pathol 2001 Jul;32(7):715-25. doi: 10.1053/hupa.2001.25588. PMID: 11486170
Angiomyofibroblastoma of the vulva: case report.
Ustun C, Malazgirt Z, Kandemir B, Kocak I, Bolat I, Gumus S
Pathol Int 1998 Dec;48(12):964-6. doi: 10.1111/j.1440-1827.1998.tb03867.x. PMID: 9952340

Diagnosis

Vulval superficial myofibroblastoma with lymphocytic and eosinophilic infiltrate.
Tan QT, Morgan T, Scurry JP
BMJ Case Rep 2023 Nov 30;16(11) doi: 10.1136/bcr-2022-248800. PMID: 38035683Free PMC Article
Superficial myofibroblastoma of the lower female genital tract: A clinicopathological analysis of 15 cases.
Zhang M, Shi P, Zhou B, Liu J, Li L
Ann Diagn Pathol 2022 Oct;60:152010. Epub 2022 Jul 22 doi: 10.1016/j.anndiagpath.2022.152010. PMID: 35907316
Update on Mesenchymal Lesions of the Lower Female Genital Tract.
Croce S, Perret R, Le Loarer F
Surg Pathol Clin 2022 Jun;15(2):341-367. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.009. PMID: 35715165
Recent developments in vulvovaginal pathology.
McCluggage WG
Histopathology 2009 Jan;54(2):156-73. doi: 10.1111/j.1365-2559.2008.03098.x. PMID: 18637148
Vulvovaginal soft tissue tumours: update and review.
Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053

Therapy

Free latissimus dorsi myocutaneous flap for pelvic floor reconstruction following pelvic exenteration.
Abdou AH, Li L, Khatib-Chahidi K, Troja A, Looft P, Gudewer EM, Raab HR, Antolovic D
Int J Colorectal Dis 2016 Feb;31(2):385-91. Epub 2015 Sep 26 doi: 10.1007/s00384-015-2402-8. PMID: 26410267

Prognosis

Vulval superficial myofibroblastoma with lymphocytic and eosinophilic infiltrate.
Tan QT, Morgan T, Scurry JP
BMJ Case Rep 2023 Nov 30;16(11) doi: 10.1136/bcr-2022-248800. PMID: 38035683Free PMC Article
Recent developments in vulvovaginal pathology.
McCluggage WG
Histopathology 2009 Jan;54(2):156-73. doi: 10.1111/j.1365-2559.2008.03098.x. PMID: 18637148
Superficial cervicovaginal myofibroblastoma: fourteen cases of a distinctive mesenchymal tumor arising from the specialized subepithelial stroma of the lower female genital tract.
Laskin WB, Fetsch JF, Tavassoli FA
Hum Pathol 2001 Jul;32(7):715-25. doi: 10.1053/hupa.2001.25588. PMID: 11486170
Vulvovaginal soft tissue tumours: update and review.
Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053
Superficial angiomyxoma (cutaneous myxoma): a clinicopathologic study of 17 cases arising in the genital region.
Fetsch JF, Laskin WB, Tavassoli FA
Int J Gynecol Pathol 1997 Oct;16(4):325-34. doi: 10.1097/00004347-199710000-00006. PMID: 9421071

Clinical prediction guides

Superficial myofibroblastoma of the lower female genital tract: A clinicopathological analysis of 15 cases.
Zhang M, Shi P, Zhou B, Liu J, Li L
Ann Diagn Pathol 2022 Oct;60:152010. Epub 2022 Jul 22 doi: 10.1016/j.anndiagpath.2022.152010. PMID: 35907316
HMGA2 Is a Useful Marker of Vulvovaginal Aggressive Angiomyxoma But May Be Positive in Other Mesenchymal Lesions at This Site.
Harkness R, McCluggage WG
Int J Gynecol Pathol 2021 Mar 1;40(2):185-189. doi: 10.1097/PGP.0000000000000689. PMID: 32897956
Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma.
Flucke U, van Krieken JH, Mentzel T
Mod Pathol 2011 Jan;24(1):82-9. Epub 2010 Sep 17 doi: 10.1038/modpathol.2010.170. PMID: 20852591
Recent developments in vulvovaginal pathology.
McCluggage WG
Histopathology 2009 Jan;54(2):156-73. doi: 10.1111/j.1365-2559.2008.03098.x. PMID: 18637148
Vulvovaginal soft tissue tumours: update and review.
Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053

Recent systematic reviews

Superficial myofibroblastoma of the lower female genital tract: A clinicopathological analysis of 15 cases.
Zhang M, Shi P, Zhou B, Liu J, Li L
Ann Diagn Pathol 2022 Oct;60:152010. Epub 2022 Jul 22 doi: 10.1016/j.anndiagpath.2022.152010. PMID: 35907316

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