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Gastroesophageal Junction Small Cell Neuroendocrine Carcinoma

MedGen UID:
925425
•Concept ID:
C4287893
•
Neoplastic Process
Synonym: Gastroesophageal Junction Small Cell Carcinoma

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction. It is characterized by the presence of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastroesophageal Junction Small Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Novel treatment approaches for HER2 positive solid tumors (excluding breast cancer).
Gaye E, Penel N, Lebellec L
Curr Opin Oncol 2022 Sep 1;34(5):570-574. Epub 2022 Aug 5 doi: 10.1097/CCO.0000000000000873. PMID: 35943440
Evolution of ramucirumab in the treatment of cancer - A review of literature.
Vennepureddy A, Singh P, Rastogi R, Atallah JP, Terjanian T
J Oncol Pharm Pract 2017 Oct;23(7):525-539. Epub 2016 Jun 15 doi: 10.1177/1078155216655474. PMID: 27306885
A novel multiple tyrosine-kinase targeted agent to explore the future perspectives of anti-angiogenic therapy for the treatment of multiple solid tumors: cabozantinib.
Roy S, Narang BK, Rastogi SK, Rawal RK
Anticancer Agents Med Chem 2015;15(1):37-47. doi: 10.2174/1871520614666140902153840. PMID: 25181996

Recent clinical studies

Etiology

Assessment of hyperprogression versus the natural course of disease development with nivolumab with or without ipilimumab versus placebo in phase III, randomized, controlled trials.
Kang YK, Reck M, Nghiem P, Feng Y, Plautz G, Kim HR, Owonikoko TK, Boku N, Chen LT, Lei M, Chang H, Lin WH, Roy A, Bello A, Sheng J
J Immunother Cancer 2022 Apr;10(4) doi: 10.1136/jitc-2021-004273. PMID: 35383114Free PMC Article
Lesion-level heterogeneity of radiologic progression in patients treated with pembrolizumab.
Topp BG, Thiagarajan K, De Alwis DP, Snyder A, Hellmann MD
Ann Oncol 2021 Dec;32(12):1618-1625. Epub 2021 Sep 17 doi: 10.1016/j.annonc.2021.09.006. PMID: 34543717
SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction.
Horton RK, Ahadi M, Gill AJ, Said S, Chen ZE, Bakhshwin A, Nichols M, Goldblum JR, Graham RP
Am J Surg Pathol 2021 Mar 1;45(3):414-420. doi: 10.1097/PAS.0000000000001599. PMID: 33027072
Intrathoracic side-to-side esophagogastrostomy with a linear stapler and barbed suture in robot-assisted Ivor Lewis esophagectomy.
Wang F, Zhang H, Zheng Y, Wang Z, Geng Y, Wang Y
J Surg Oncol 2019 Dec;120(7):1142-1147. Epub 2019 Sep 18 doi: 10.1002/jso.25698. PMID: 31535396Free PMC Article
Small-cell carcinoma of the esophagus and gastroesophageal junction: review of the Memorial Sloan-Kettering experience.
Ku GY, Minsky BD, Rusch VW, Bains M, Kelsen DP, Ilson DH
Ann Oncol 2008 Mar;19(3):533-7. Epub 2007 Oct 17 doi: 10.1093/annonc/mdm476. PMID: 17947223

Diagnosis

Intrapatient Tumor Heterogeneity in IHC Interpretation Using PD-L1 IHC 22C3 pharmDx.
Kalpakoff M, Hund S, Musser J, Roach C, Apostolaki A, Vilardo M, Peltz L, Watts B, LaPlaca C, Tabuena-Frolli S, DiMaio MA, Welcher R, Kulangara K
Appl Immunohistochem Mol Morphol 2021 Oct 1;29(9):667-673. doi: 10.1097/PAI.0000000000000941. PMID: 33973887Free PMC Article
SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction.
Horton RK, Ahadi M, Gill AJ, Said S, Chen ZE, Bakhshwin A, Nichols M, Goldblum JR, Graham RP
Am J Surg Pathol 2021 Mar 1;45(3):414-420. doi: 10.1097/PAS.0000000000001599. PMID: 33027072
Platinum-based chemotherapy in combination with PD-1/PD-L1 inhibitors: preclinical and clinical studies and mechanism of action.
Xue Y, Gao S, Gou J, Yin T, He H, Wang Y, Zhang Y, Tang X, Wu R
Expert Opin Drug Deliv 2021 Feb;18(2):187-203. Epub 2020 Oct 5 doi: 10.1080/17425247.2021.1825376. PMID: 32954856
Targeting HER2 expression in cancer: New drugs and new indications.
Vranić S, Bešlija S, Gatalica Z
Bosn J Basic Med Sci 2021 Feb 1;21(1):1-4. doi: 10.17305/bjbms.2020.4908. PMID: 32530388Free PMC Article
From the radiologic pathology archives: esophageal neoplasms: radiologic-pathologic correlation.
Lewis RB, Mehrotra AK, Rodriguez P, Levine MS
Radiographics 2013 Jul-Aug;33(4):1083-108. doi: 10.1148/rg.334135027. PMID: 23842973

Therapy

The Potential of Trastuzumab Deruxtecan as a Tissue Agnostic Drug.
Jørgensen JT
Oncology 2023;101(12):836-842. Epub 2023 Aug 31 doi: 10.1159/000533866. PMID: 37651992
Platinum-based chemotherapy in combination with PD-1/PD-L1 inhibitors: preclinical and clinical studies and mechanism of action.
Xue Y, Gao S, Gou J, Yin T, He H, Wang Y, Zhang Y, Tang X, Wu R
Expert Opin Drug Deliv 2021 Feb;18(2):187-203. Epub 2020 Oct 5 doi: 10.1080/17425247.2021.1825376. PMID: 32954856
Targeting HER2 expression in cancer: New drugs and new indications.
Vranić S, Bešlija S, Gatalica Z
Bosn J Basic Med Sci 2021 Feb 1;21(1):1-4. doi: 10.17305/bjbms.2020.4908. PMID: 32530388Free PMC Article
Camrelizumab: First Global Approval.
Markham A, Keam SJ
Drugs 2019 Aug;79(12):1355-1361. doi: 10.1007/s40265-019-01167-0. PMID: 31313098
Gastroesophageal junction adenocarcinoma.
Swisher SG, Pisters PW, Komaki R, Lahoti S, Ajani JA
Curr Treat Options Oncol 2000 Dec;1(5):387-98. doi: 10.1007/s11864-000-0066-1. PMID: 12057146

Prognosis

Assessment of hyperprogression versus the natural course of disease development with nivolumab with or without ipilimumab versus placebo in phase III, randomized, controlled trials.
Kang YK, Reck M, Nghiem P, Feng Y, Plautz G, Kim HR, Owonikoko TK, Boku N, Chen LT, Lei M, Chang H, Lin WH, Roy A, Bello A, Sheng J
J Immunother Cancer 2022 Apr;10(4) doi: 10.1136/jitc-2021-004273. PMID: 35383114Free PMC Article
SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction.
Horton RK, Ahadi M, Gill AJ, Said S, Chen ZE, Bakhshwin A, Nichols M, Goldblum JR, Graham RP
Am J Surg Pathol 2021 Mar 1;45(3):414-420. doi: 10.1097/PAS.0000000000001599. PMID: 33027072
Targeting HER2 expression in cancer: New drugs and new indications.
Vranić S, Bešlija S, Gatalica Z
Bosn J Basic Med Sci 2021 Feb 1;21(1):1-4. doi: 10.17305/bjbms.2020.4908. PMID: 32530388Free PMC Article
Intrathoracic side-to-side esophagogastrostomy with a linear stapler and barbed suture in robot-assisted Ivor Lewis esophagectomy.
Wang F, Zhang H, Zheng Y, Wang Z, Geng Y, Wang Y
J Surg Oncol 2019 Dec;120(7):1142-1147. Epub 2019 Sep 18 doi: 10.1002/jso.25698. PMID: 31535396Free PMC Article
Unusual case of small cell gastric carcinoma: case report and literature review.
Richards D, Davis D, Yan P, Guha S
Dig Dis Sci 2011 Apr;56(4):951-7. Epub 2010 Sep 18 doi: 10.1007/s10620-010-1404-1. PMID: 20848201

Clinical prediction guides

Indirect Clinical Validation of a Programmed Death-Ligand 1 Laboratory-Developed Test for Gastric/Gastroesophageal Junction Adenocarcinoma with 22C3 Antibody Concentrate.
Kim JM, Kim B, Kim E, Jang M, Cho JH, Lee HS, Kwak Y, Huang L, Krishnan R, Bai SY, Mounawar M, Kim KM
Mol Diagn Ther 2022 Nov;26(6):679-688. Epub 2022 Sep 20 doi: 10.1007/s40291-022-00605-2. PMID: 36125657
Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study.
Lakhani NJ, Chow LQM, Gainor JF, LoRusso P, Lee KW, Chung HC, Lee J, Bang YJ, Hodi FS, Kim WS, Santana-Davila R, Fanning P, Squifflet P, Jin F, Kuo TC, Wan HI, Pons J, Randolph SS, Messersmith WA
Lancet Oncol 2021 Dec;22(12):1740-1751. Epub 2021 Nov 15 doi: 10.1016/S1470-2045(21)00584-2. PMID: 34793719
A Retrospective Study of 52 Patients With Primary Small Cell Carcinoma of the Esophagus Treated With Radical Surgery.
Fan N, Wang Z, Huang Y, Tan Z, Yang H, Lin P
Cancer Control 2021 Jan-Dec;28:10732748211027147. doi: 10.1177/10732748211027147. PMID: 34155924Free PMC Article
Platinum-based chemotherapy in combination with PD-1/PD-L1 inhibitors: preclinical and clinical studies and mechanism of action.
Xue Y, Gao S, Gou J, Yin T, He H, Wang Y, Zhang Y, Tang X, Wu R
Expert Opin Drug Deliv 2021 Feb;18(2):187-203. Epub 2020 Oct 5 doi: 10.1080/17425247.2021.1825376. PMID: 32954856
Targeting HER2 expression in cancer: New drugs and new indications.
Vranić S, Bešlija S, Gatalica Z
Bosn J Basic Med Sci 2021 Feb 1;21(1):1-4. doi: 10.17305/bjbms.2020.4908. PMID: 32530388Free PMC Article

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