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Vaginal Germ Cell Tumor

MedGen UID:
925572
•Concept ID:
C4288040
•
Neoplastic Process

Definition

A germ tumor that arises from the vagina. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal Germ Cell Tumor

Professional guidelines

PubMed

The diagnosis and management of pheochromocytoma and paraganglioma during pregnancy.
Clifton-Bligh RJ
Rev Endocr Metab Disord 2023 Feb;24(1):49-56. Epub 2023 Jan 13 doi: 10.1007/s11154-022-09773-2. PMID: 36637675Free PMC Article
Advances in diagnostics and management of gestational trophoblastic disease.
Lukinovic N, Malovrh EP, Takac I, Sobocan M, Knez J
Radiol Oncol 2022 Dec 1;56(4):430-439. Epub 2022 Oct 27 doi: 10.2478/raon-2022-0038. PMID: 36286620Free PMC Article
The diagnosis and treatment of yolk sac tumors in infants and children.
Green DM
Cancer Treat Rev 1983 Dec;10(4):265-88. doi: 10.1016/0305-7372(83)90014-2. PMID: 6362873

Recent clinical studies

Etiology

Advances in diagnostics and management of gestational trophoblastic disease.
Lukinovic N, Malovrh EP, Takac I, Sobocan M, Knez J
Radiol Oncol 2022 Dec 1;56(4):430-439. Epub 2022 Oct 27 doi: 10.2478/raon-2022-0038. PMID: 36286620Free PMC Article
Sacral Dimple.
Khairy S, Azzubi M
World Neurosurg 2017 May;101:811.e7-811.e8. Epub 2017 Feb 27 doi: 10.1016/j.wneu.2017.02.074. PMID: 28245993
First trimester complications.
Martonffy AI, Rindfleisch K, Lozeau AM, Potter B
Prim Care 2012 Mar;39(1):71-82. Epub 2011 Nov 30 doi: 10.1016/j.pop.2011.11.004. PMID: 22309582
Gestational trophoblastic disease.
Loh KY, Sivalingam N, Suryani MY
Med J Malaysia 2004 Dec;59(5):697-702; quiz 703. PMID: 15889580
Overview of common obstetric bleeding disorders.
Carter S
Nurse Pract 1999 Mar;24(3):50-1, 54, 57-8 passim. PMID: 10100241

Diagnosis

Advances in diagnostics and management of gestational trophoblastic disease.
Lukinovic N, Malovrh EP, Takac I, Sobocan M, Knez J
Radiol Oncol 2022 Dec 1;56(4):430-439. Epub 2022 Oct 27 doi: 10.2478/raon-2022-0038. PMID: 36286620Free PMC Article
Melanoma of the lower genital tract: Prognostic factors and treatment modalities.
Gadducci A, Carinelli S, Guerrieri ME, Aletti GD
Gynecol Oncol 2018 Jul;150(1):180-189. Epub 2018 May 1 doi: 10.1016/j.ygyno.2018.04.562. PMID: 29728261
Mucosal melanoma: an update.
Ballester Sánchez R, de Unamuno Bustos B, Navarro Mira M, Botella Estrada R
Actas Dermosifiliogr 2015 Mar;106(2):96-103. Epub 2014 Jul 17 doi: 10.1016/j.ad.2014.04.012. PMID: 25042176
First trimester complications.
Martonffy AI, Rindfleisch K, Lozeau AM, Potter B
Prim Care 2012 Mar;39(1):71-82. Epub 2011 Nov 30 doi: 10.1016/j.pop.2011.11.004. PMID: 22309582
Gestational trophoblastic disease.
Loh KY, Sivalingam N, Suryani MY
Med J Malaysia 2004 Dec;59(5):697-702; quiz 703. PMID: 15889580

Therapy

Pulmonary metastatic gestational choriocarcinoma following an uncomplicated term pregnancy: a case report.
Jafari-Nozad AM, Jahani N
J Med Case Rep 2024 Jun 30;18(1):298. doi: 10.1186/s13256-024-04615-y. PMID: 38944668Free PMC Article
Neuroendocrine carcinoma of vagina with prolonged survival.
Leal-Costa L, Godinho J, Simões P, Casa-Nova M
BMJ Case Rep 2022 Oct 31;15(10) doi: 10.1136/bcr-2022-252031. PMID: 36316052Free PMC Article
Pediatric Vaginal Yolk Sac Tumor: Reappraisal of Treatment Strategy in a Rare Tumor at a Unique Location.
Rajagopal R, Ariffin H, Krishnan S, Abdullah WA, Lin HP
J Pediatr Hematol Oncol 2015 Jul;37(5):391-5. doi: 10.1097/MPH.0000000000000344. PMID: 25929614
Unusual presentations in obstetrics and gynecology.
Lawrence LL
Emerg Med Clin North Am 2003 Aug;21(3):649-65. doi: 10.1016/s0733-8627(03)00040-3. PMID: 12962351
Prenatal oncogenesis and the development of malignant tumors in the infant and adolescent vagina--a review and hypothesis.
Hilgers RD
Gynecol Oncol 1977 Sep;5(3):262-72. doi: 10.1016/0090-8258(77)90035-x. PMID: 332601

Prognosis

GTN Diagnosis and Staging.
Ngu SF, Ngan HYS
Hematol Oncol Clin North Am 2024 Dec;38(6):1161-1171. Epub 2024 Aug 17 doi: 10.1016/j.hoc.2024.07.002. PMID: 39155174
Gynecologic cancer in pregnancy.
Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951Free PMC Article
Mucosal Melanoma: New Insights and Therapeutic Options for a Unique and Aggressive Disease.
Lerner BA, Stewart LA, Horowitz DP, Carvajal RD
Oncology (Williston Park) 2017 Nov 15;31(11):e23-e32. PMID: 29179253
Sacral Dimple.
Khairy S, Azzubi M
World Neurosurg 2017 May;101:811.e7-811.e8. Epub 2017 Feb 27 doi: 10.1016/j.wneu.2017.02.074. PMID: 28245993
Pediatric urologic oncology.
Kramer SA
Urol Clin North Am 1985 Feb;12(1):31-42. PMID: 2983474

Clinical prediction guides

GTN Diagnosis and Staging.
Ngu SF, Ngan HYS
Hematol Oncol Clin North Am 2024 Dec;38(6):1161-1171. Epub 2024 Aug 17 doi: 10.1016/j.hoc.2024.07.002. PMID: 39155174
Case report and literature review: antenatal diagnosis of a fetal anaplastic astrocytoma.
Huang SJ, Liu XL, Huang M, Wang YQ, Lin JR, Zhang XD, Jiang JN, Bai DY, Wang ZX, Su YM
J Matern Fetal Neonatal Med 2022 Dec;35(25):6631-6637. Epub 2021 May 9 doi: 10.1080/14767058.2021.1918668. PMID: 33969782
Stage IV Gestational Choriocarcinoma Diagnosed in the Third Trimester.
Jorgensen K, Roychowdhury M, da Cunha G, Kim YB, Schorge JO
Obstet Gynecol 2019 Jan;133(1):163-166. doi: 10.1097/AOG.0000000000003001. PMID: 30531566
Ten-Year Experience with the Conservative Management of Abnormally Invasive, Residual Trophoblastic Disease. A Retrospective Case Series.
Promberger R, Ott J, Chalubinski KM
Gynecol Obstet Invest 2016;81(4):375-80. Epub 2016 Jan 30 doi: 10.1159/000443395. PMID: 26824748
Acoustic neuroma and pregnancy.
Gaughan RK, Harner SG
Am J Otol 1993 Jan;14(1):88-91. PMID: 8424484

Recent systematic reviews

Clinical features and management of trophoblastic epithelioid tumors: A systematic review.
Gorun F, Tomescu L, Motoc A, Citu C, Sas I, Serban DM, Forga M, Citu IM, Gorun OM
Medicine (Baltimore) 2022 Jul 29;101(30):e29934. doi: 10.1097/MD.0000000000029934. PMID: 35905248Free PMC Article
Delivery management of a complete hydatidiform mole and co-existing viable fetus: A meta-analysis and systematic review.
Wang G, Cao J, Xu X, Han X, Cui H
J Gynecol Obstet Hum Reprod 2022 Jan;51(1):102269. Epub 2021 Nov 9 doi: 10.1016/j.jogoh.2021.102269. PMID: 34767996
Melanoma of the lower genital tract: Prognostic factors and treatment modalities.
Gadducci A, Carinelli S, Guerrieri ME, Aletti GD
Gynecol Oncol 2018 Jul;150(1):180-189. Epub 2018 May 1 doi: 10.1016/j.ygyno.2018.04.562. PMID: 29728261
Clinical challenges of glioma and pregnancy: a systematic review.
van Westrhenen A, Senders JT, Martin E, DiRisio AC, Broekman MLD
J Neurooncol 2018 Aug;139(1):1-11. Epub 2018 Apr 6 doi: 10.1007/s11060-018-2851-3. PMID: 29623596Free PMC Article
Melanoma of the Vagina: Case Report and Systematic Review of the Literature.
Rapi V, Dogan A, Schultheis B, Hartmann F, Rezniczek GA, Tempfer CB
Anticancer Res 2017 Dec;37(12):6911-6920. doi: 10.21873/anticanres.12155. PMID: 29187473

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