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Infant Acute Biphenotypic Leukemia

MedGen UID:
926425
•Concept ID:
C4288893
•
Neoplastic Process

Definition

An acute biphenotypic leukemia that occurs in infancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfant Acute Biphenotypic Leukemia

Professional guidelines

PubMed

Acute lymphoblastic leukemia-like treatment regimen provides better response in mixed phenotype acute leukemia: a comparative study between adults and pediatric MPAL patients.
Rasekh EO, Osman R, Ibraheem D, Madney Y, Radwan E, Gameel A, Abdelhafiz A, Kamel A, Elfishawi S
Ann Hematol 2021 Mar;100(3):699-707. Epub 2020 Nov 23 doi: 10.1007/s00277-020-04354-2. PMID: 33230570
International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia.
Hrusak O, de Haas V, Stancikova J, Vakrmanova B, Janotova I, Mejstrikova E, Capek V, Trka J, Zaliova M, Luks A, Bleckmann K, Möricke A, Irving J, Konatkowska B, Alexander TB, Inaba H, Schmiegelow K, Stokley S, Zemanova Z, Moorman AV, Rossi JG, Felice MS, Dalla-Pozza L, Morales J, Dworzak M, Buldini B, Basso G, Campbell M, Cabrera ME, Marinov N, Elitzur S, Izraeli S, Luria D, Feuerstein T, Kolenova A, Svec P, Kreminska O, Rabin KR, Polychronopoulou S, da Costa E, Marquart HV, Kattamis A, Ratei R, Reinhardt D, Choi JK, Schrappe M, Stary J
Blood 2018 Jul 19;132(3):264-276. Epub 2018 May 2 doi: 10.1182/blood-2017-12-821363. PMID: 29720486
Diagnosis and management of neonatal leukaemia.
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298

Recent clinical studies

Etiology

Acute lymphoblastic leukemia-like treatment regimen provides better response in mixed phenotype acute leukemia: a comparative study between adults and pediatric MPAL patients.
Rasekh EO, Osman R, Ibraheem D, Madney Y, Radwan E, Gameel A, Abdelhafiz A, Kamel A, Elfishawi S
Ann Hematol 2021 Mar;100(3):699-707. Epub 2020 Nov 23 doi: 10.1007/s00277-020-04354-2. PMID: 33230570
Clinical characteristics and outcome of children with biphenotypic acute leukemia.
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF
Haematologica 2009 Dec;94(12):1682-90. Epub 2009 Aug 27 doi: 10.3324/haematol.2009.009282. PMID: 19713227Free PMC Article
Cytogenetics, molecular and ultrastructural characteristics of biphenotypic acute leukemia identified by the EGIL scoring system.
Owaidah TM, Al Beihany A, Iqbal MA, Elkum N, Roberts GT
Leukemia 2006 Apr;20(4):620-6. doi: 10.1038/sj.leu.2404128. PMID: 16437134
Biphenotypic characteristics, cell size and prognosis in childhood acute myeloblastic leukemia.
Olcay L, Hiçsönmez G, Ertem U, Okur H, Tuncer AM
Turk J Pediatr 1999 Apr-Jun;41(2):219-24. PMID: 10770661
Definition of acute biphenotypic leukemia.
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D
Haematologica 1997 Jan-Feb;82(1):64-6. PMID: 9107085

Diagnosis

Diagnosis and management of neonatal leukaemia.
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Clinical characteristics and outcome of children with biphenotypic acute leukemia.
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF
Haematologica 2009 Dec;94(12):1682-90. Epub 2009 Aug 27 doi: 10.3324/haematol.2009.009282. PMID: 19713227Free PMC Article
Infant acute bilineal leukemia.
Derwich K, Sedek L, Meyer C, Pieczonka A, Dawidowska M, Gaworczyk A, Wachowiak J, Konatkowska B, Witt M, Marschalek R, Szczepański T
Leuk Res 2009 Jul;33(7):1005-8. Epub 2009 Mar 16 doi: 10.1016/j.leukres.2009.02.007. PMID: 19286255
Cytogenetics, molecular and ultrastructural characteristics of biphenotypic acute leukemia identified by the EGIL scoring system.
Owaidah TM, Al Beihany A, Iqbal MA, Elkum N, Roberts GT
Leukemia 2006 Apr;20(4):620-6. doi: 10.1038/sj.leu.2404128. PMID: 16437134
Definition of acute biphenotypic leukemia.
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D
Haematologica 1997 Jan-Feb;82(1):64-6. PMID: 9107085

Therapy

Acute lymphoblastic leukemia-like treatment regimen provides better response in mixed phenotype acute leukemia: a comparative study between adults and pediatric MPAL patients.
Rasekh EO, Osman R, Ibraheem D, Madney Y, Radwan E, Gameel A, Abdelhafiz A, Kamel A, Elfishawi S
Ann Hematol 2021 Mar;100(3):699-707. Epub 2020 Nov 23 doi: 10.1007/s00277-020-04354-2. PMID: 33230570
A systematic description of MLL fusion gene formation.
Wright RL, Vaughan AT
Crit Rev Oncol Hematol 2014 Sep;91(3):283-91. Epub 2014 Apr 8 doi: 10.1016/j.critrevonc.2014.03.004. PMID: 24787275
Diagnosis and management of neonatal leukaemia.
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Clinical characteristics and outcome of children with biphenotypic acute leukemia.
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF
Haematologica 2009 Dec;94(12):1682-90. Epub 2009 Aug 27 doi: 10.3324/haematol.2009.009282. PMID: 19713227Free PMC Article
Controversies of and unique issues in hematopoietic cell transplantation for infant leukemia.
Hunger SP, Loh KM, Baker KS, Schultz KR
Biol Blood Marrow Transplant 2009 Jan;15(1 Suppl):79-83. doi: 10.1016/j.bbmt.2008.10.015. PMID: 19147083

Prognosis

Diagnosis and management of neonatal leukaemia.
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Clinical characteristics and outcome of children with biphenotypic acute leukemia.
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF
Haematologica 2009 Dec;94(12):1682-90. Epub 2009 Aug 27 doi: 10.3324/haematol.2009.009282. PMID: 19713227Free PMC Article
Biphenotypic characteristics, cell size and prognosis in childhood acute myeloblastic leukemia.
Olcay L, Hiçsönmez G, Ertem U, Okur H, Tuncer AM
Turk J Pediatr 1999 Apr-Jun;41(2):219-24. PMID: 10770661
Definition of acute biphenotypic leukemia.
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D
Haematologica 1997 Jan-Feb;82(1):64-6. PMID: 9107085
Leukemia in Down syndrome: a review.
Zipursky A, Poon A, Doyle J
Pediatr Hematol Oncol 1992 Apr-Jun;9(2):139-49. doi: 10.3109/08880019209018329. PMID: 1388043

Clinical prediction guides

Mixed Phenotype Acute Leukemia, B/Myeloid (Bilineal and Biphenotypic), With t(2;22)(q35;q12);EWSR1-FEV.
Montgomery-Goecker C, Koduru P, Botten G, Xu J, Ghisoli M, Goldman SC, Krueger J, Bhushan V, Fuda F, Chen W
J Pediatr Hematol Oncol 2021 Apr 1;43(3):e388-e394. doi: 10.1097/MPH.0000000000001934. PMID: 32925408
Diagnosis and management of neonatal leukaemia.
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Clinical characteristics and outcome of children with biphenotypic acute leukemia.
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF
Haematologica 2009 Dec;94(12):1682-90. Epub 2009 Aug 27 doi: 10.3324/haematol.2009.009282. PMID: 19713227Free PMC Article
Definition of acute biphenotypic leukemia.
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D
Haematologica 1997 Jan-Feb;82(1):64-6. PMID: 9107085
Leukemia in Down syndrome: a review.
Zipursky A, Poon A, Doyle J
Pediatr Hematol Oncol 1992 Apr-Jun;9(2):139-49. doi: 10.3109/08880019209018329. PMID: 1388043

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