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FIGO Stage IVB Ovarian Cancer

MedGen UID:
926842
•Concept ID:
C4289310
•
Neoplastic Process
Synonym: FIGO Stage IVB Ovarian Carcinoma

Definition

Ovarian cancer with hepatic and/or splenic parenchymal metastasis, metastasis to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside of the abdominal cavity). (FIGO, 2014) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFIGO Stage IVB Ovarian Cancer

Professional guidelines

PubMed

Does maximal effort cytoreductive surgery after 6-cycles of chemotherapy play a role in the management of advanced ovarian cancer?
Cassar V, Rundle S, Rongali VBS, Korompelis P, Ang C
Arch Gynecol Obstet 2024 Dec;310(6):3057-3065. Epub 2024 Oct 17 doi: 10.1007/s00404-024-07778-7. PMID: 39417877
Treatment outcomes and complications in FIGO stage IIIC and IVB endometrioid endometrial cancer patients presenting as nodal spreads following systematic lymphadenectomy and adjuvant therapy.
Kong TW, Jo E, Son JH, Paek J, Chang SJ, Ryu HS
J Obstet Gynaecol Res 2021 Sep;47(9):3322-3330. Epub 2021 Jun 30 doi: 10.1111/jog.14915. PMID: 34196087

Recent clinical studies

Etiology

FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813Free PMC Article
FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
Int J Gynaecol Obstet 2023 Aug;162(2):383-394. Epub 2023 Jun 20 doi: 10.1002/ijgo.14923. PMID: 37337978
Surgical staging of apparent early-stage ovarian mucinous carcinoma.
Yuan Z, Zhang Y, Cao D, Shen K
World J Surg Oncol 2022 Sep 24;20(1):307. doi: 10.1186/s12957-022-02758-0. PMID: 36153622Free PMC Article
TRUST: Trial of Radical Upfront Surgical Therapy in advanced ovarian cancer (ENGOT ov33/AGO-OVAR OP7).
Reuss A, du Bois A, Harter P, Fotopoulou C, Sehouli J, Aletti G, Guyon F, Greggi S, Mosgaard BJ, Reinthaller A, Hilpert F, Schade-Brittinger C, Chi DS, Mahner S
Int J Gynecol Cancer 2019 Oct;29(8):1327-1331. Epub 2019 Aug 15 doi: 10.1136/ijgc-2019-000682. PMID: 31420412
Outcomes of patients with advanced stage ovarian cancer with intestinal metastasis.
Kebapcı E, Gülseren V, Tuğmen C, Gökçü M, Solmaz U, Sert İ, Kocaer M, Özer M, Ölmez M, Sancı M
Ginekol Pol 2017;88(10):537-542. doi: 10.5603/GP.a2017.0098. PMID: 29192414

Diagnosis

Differentiation of survival outcomes by anatomic involvement and histology with the revised 2023 International Federation of Gynecology and Obstetrics staging system for endometrial cancer.
Gravbrot N, Weil CR, DeCesaris CM, Gaffney DK, Suneja G, Burt LM
Eur J Cancer 2024 Apr;201:113913. Epub 2024 Feb 10 doi: 10.1016/j.ejca.2024.113913. PMID: 38377777
JGOG2046: a feasibility study of neoadjuvant chemotherapy followed by debulking surgery for clinically diagnosed FIGO stage IVb endometrial cancer.
Nakanishi T, Saito T, Aoki D, Watanabe Y, Ushijima K, Takano M, Sugiyama T, Yaegashi N, Takehara K
Int J Clin Oncol 2023 Mar;28(3):436-444. Epub 2023 Feb 2 doi: 10.1007/s10147-022-02284-9. PMID: 36729215
Quality Indicators and Survival Outcome in Stage IIIB-IVB Epithelial Ovarian Cancer Treated at a Single Institution.
Steinberga I, Jansson K, Sorbe B
In Vivo 2019 Sep-Oct;33(5):1521-1530. doi: 10.21873/invivo.11632. PMID: 31471400Free PMC Article
TRUST: Trial of Radical Upfront Surgical Therapy in advanced ovarian cancer (ENGOT ov33/AGO-OVAR OP7).
Reuss A, du Bois A, Harter P, Fotopoulou C, Sehouli J, Aletti G, Guyon F, Greggi S, Mosgaard BJ, Reinthaller A, Hilpert F, Schade-Brittinger C, Chi DS, Mahner S
Int J Gynecol Cancer 2019 Oct;29(8):1327-1331. Epub 2019 Aug 15 doi: 10.1136/ijgc-2019-000682. PMID: 31420412
The FIGO Stage IVA Versus IVB of Ovarian Cancer: Prognostic Value and Predictive Value for Neoadjuvant Chemotherapy.
Tajik P, van de Vrie R, Zafarmand MH, Coens C, Buist MR, Vergote I, Bossuyt PMM, Kenter GG
Int J Gynecol Cancer 2018 Mar;28(3):453-458. doi: 10.1097/IGC.0000000000001186. PMID: 29324537

Therapy

The impact of Paclitaxel-based hyperthermic intraperitoneal chemotherapy in advanced high-grade serous ovarian cancer patients - interim analysis of safety and immediate efficacy of a randomized control trial (C-HOC trial).
Wang Q, Liu H, Shen Y, Shen L, Li J, Feng W
J Ovarian Res 2024 Jul 12;17(1):145. doi: 10.1186/s13048-024-01468-3. PMID: 38997720Free PMC Article
Treatment outcomes and complications in FIGO stage IIIC and IVB endometrioid endometrial cancer patients presenting as nodal spreads following systematic lymphadenectomy and adjuvant therapy.
Kong TW, Jo E, Son JH, Paek J, Chang SJ, Ryu HS
J Obstet Gynaecol Res 2021 Sep;47(9):3322-3330. Epub 2021 Jun 30 doi: 10.1111/jog.14915. PMID: 34196087
TRUST: Trial of Radical Upfront Surgical Therapy in advanced ovarian cancer (ENGOT ov33/AGO-OVAR OP7).
Reuss A, du Bois A, Harter P, Fotopoulou C, Sehouli J, Aletti G, Guyon F, Greggi S, Mosgaard BJ, Reinthaller A, Hilpert F, Schade-Brittinger C, Chi DS, Mahner S
Int J Gynecol Cancer 2019 Oct;29(8):1327-1331. Epub 2019 Aug 15 doi: 10.1136/ijgc-2019-000682. PMID: 31420412
The FIGO Stage IVA Versus IVB of Ovarian Cancer: Prognostic Value and Predictive Value for Neoadjuvant Chemotherapy.
Tajik P, van de Vrie R, Zafarmand MH, Coens C, Buist MR, Vergote I, Bossuyt PMM, Kenter GG
Int J Gynecol Cancer 2018 Mar;28(3):453-458. doi: 10.1097/IGC.0000000000001186. PMID: 29324537
Long-lasting complete remission of a patient with cervical cancer FIGO IVB treated by concomitant chemobrachyradiotherapy with ifosfamide and cisplatin and consolidation chemotherapy--a case report.
Vrdoljak E, Hamm W, Omrcen T, Prskalo T
Eur J Gynaecol Oncol 2004;25(2):247-9. PMID: 15032295

Prognosis

Differentiation of survival outcomes by anatomic involvement and histology with the revised 2023 International Federation of Gynecology and Obstetrics staging system for endometrial cancer.
Gravbrot N, Weil CR, DeCesaris CM, Gaffney DK, Suneja G, Burt LM
Eur J Cancer 2024 Apr;201:113913. Epub 2024 Feb 10 doi: 10.1016/j.ejca.2024.113913. PMID: 38377777
FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813Free PMC Article
FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
Int J Gynaecol Obstet 2023 Aug;162(2):383-394. Epub 2023 Jun 20 doi: 10.1002/ijgo.14923. PMID: 37337978
Residual tumor and primary debulking surgery vs interval debulking surgery in stage IV epithelial ovarian cancer.
Sørensen SM, Høgdall C, Mosgaard BJ, Dalgaard MIR, Jensen MP, Fuglsang K, Schnack TH
Acta Obstet Gynecol Scand 2022 Mar;101(3):334-343. Epub 2022 Feb 21 doi: 10.1111/aogs.14319. PMID: 35187660Free PMC Article
The FIGO Stage IVA Versus IVB of Ovarian Cancer: Prognostic Value and Predictive Value for Neoadjuvant Chemotherapy.
Tajik P, van de Vrie R, Zafarmand MH, Coens C, Buist MR, Vergote I, Bossuyt PMM, Kenter GG
Int J Gynecol Cancer 2018 Mar;28(3):453-458. doi: 10.1097/IGC.0000000000001186. PMID: 29324537

Clinical prediction guides

The impact of Paclitaxel-based hyperthermic intraperitoneal chemotherapy in advanced high-grade serous ovarian cancer patients - interim analysis of safety and immediate efficacy of a randomized control trial (C-HOC trial).
Wang Q, Liu H, Shen Y, Shen L, Li J, Feng W
J Ovarian Res 2024 Jul 12;17(1):145. doi: 10.1186/s13048-024-01468-3. PMID: 38997720Free PMC Article
Differentiation of survival outcomes by anatomic involvement and histology with the revised 2023 International Federation of Gynecology and Obstetrics staging system for endometrial cancer.
Gravbrot N, Weil CR, DeCesaris CM, Gaffney DK, Suneja G, Burt LM
Eur J Cancer 2024 Apr;201:113913. Epub 2024 Feb 10 doi: 10.1016/j.ejca.2024.113913. PMID: 38377777
Treatment outcomes and complications in FIGO stage IIIC and IVB endometrioid endometrial cancer patients presenting as nodal spreads following systematic lymphadenectomy and adjuvant therapy.
Kong TW, Jo E, Son JH, Paek J, Chang SJ, Ryu HS
J Obstet Gynaecol Res 2021 Sep;47(9):3322-3330. Epub 2021 Jun 30 doi: 10.1111/jog.14915. PMID: 34196087
Quality Indicators and Survival Outcome in Stage IIIB-IVB Epithelial Ovarian Cancer Treated at a Single Institution.
Steinberga I, Jansson K, Sorbe B
In Vivo 2019 Sep-Oct;33(5):1521-1530. doi: 10.21873/invivo.11632. PMID: 31471400Free PMC Article
The FIGO Stage IVA Versus IVB of Ovarian Cancer: Prognostic Value and Predictive Value for Neoadjuvant Chemotherapy.
Tajik P, van de Vrie R, Zafarmand MH, Coens C, Buist MR, Vergote I, Bossuyt PMM, Kenter GG
Int J Gynecol Cancer 2018 Mar;28(3):453-458. doi: 10.1097/IGC.0000000000001186. PMID: 29324537

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