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Cervical Yolk Sac Tumor

MedGen UID:
927339
•Concept ID:
C4289807
•
Neoplastic Process
Synonym: Cervical Endodermal Sinus Tumor

Definition

A yolk sac tumor that arises from the cervix. Patients present with abnormal vaginal bleeding and a polypoid, friable mass, protruding into the vagina. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Yolk Sac Tumor

Professional guidelines

PubMed

The presentation and management of mandibular tumors in the pediatric population.
Benoit MM, Vargas SO, Bhattacharyya N, McGill TA, Robson CD, Ferraro N, Didas AE, Labow BI, Upton J, Taghinia A, Meara JG, Marcus KJ, Mack J, Rodriguez-Galindo C, Rahbar R
Laryngoscope 2013 Aug;123(8):2035-42. Epub 2013 May 13 doi: 10.1002/lary.24020. PMID: 23670306
Ex-utero intrapartum treatment procedure for giant neck masses--fetal and maternal outcomes.
Lazar DA, Olutoye OO, Moise KJ Jr, Ivey RT, Johnson A, Ayres N, Olutoye OA, Rodriguez MA, Cass DL
J Pediatr Surg 2011 May;46(5):817-22. doi: 10.1016/j.jpedsurg.2011.02.006. PMID: 21616233
Conservative treatment for lower gynecological tract malignancies in children and adolescents: the Institut Gustave-Roussy experience.
Gerbaulet AP, Esche BA, Haie CM, Castaigne D, Flamant F, Chassagne D
Int J Radiat Oncol Biol Phys 1989 Sep;17(3):655-8. doi: 10.1016/0360-3016(89)90119-3. PMID: 2777654

Recent clinical studies

Etiology

SMARCB1 (INI-1)-Deficient Adenocarcinoma of the Sinonasal Tract: A Potentially Under-Recognized form of Sinonasal Adenocarcinoma with Occasional Yolk Sac Tumor-Like Features.
Shah AA, Jain D, Ababneh E, Agaimy A, Hoschar AP, Griffith CC, Magliocca KR, Wenig BM, Rooper LM, Bishop JA
Head Neck Pathol 2020 Jun;14(2):465-472. Epub 2019 Aug 29 doi: 10.1007/s12105-019-01065-7. PMID: 31468350Free PMC Article
Pathology and molecular biology of teratomas in childhood and adolescence.
Harms D, Zahn S, Göbel U, Schneider DT
Klin Padiatr 2006 Nov-Dec;218(6):296-302. doi: 10.1055/s-2006-942271. PMID: 17080330
Nonmidline yolk sac tumour of the head and neck region in an infant with Dandy Walker syndrome--case report and review of literature.
Upadhyaya M, Oak SN, Kulkarni BK, Kalgutkar A
Indian J Cancer 1997 Dec;34(4):159-63. PMID: 9715538
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor.
Golbang P, Khan A, Scurry J, MacIsaac I, Planner R
Gynecol Oncol 1997 Oct;67(1):102-6. doi: 10.1006/gyno.1997.4807. PMID: 9345364
Immunodiagnosis in gynaecologic oncology: possibilities and limitations.
Bolis PF, Franchi M
Eur J Gynaecol Oncol 1984;5(1):45-52. PMID: 6698054

Diagnosis

The diverse morphology and immunophenotype of ovarian endometrioid carcinomas.
Talia KL, McCluggage WG
Pathology 2023 Apr;55(3):269-286. Epub 2023 Jan 21 doi: 10.1016/j.pathol.2023.01.003. PMID: 36759286
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
Ex-utero intrapartum treatment procedure for giant neck masses--fetal and maternal outcomes.
Lazar DA, Olutoye OO, Moise KJ Jr, Ivey RT, Johnson A, Ayres N, Olutoye OA, Rodriguez MA, Cass DL
J Pediatr Surg 2011 May;46(5):817-22. doi: 10.1016/j.jpedsurg.2011.02.006. PMID: 21616233
Primary yolk sac tumor arising in the pancreas with hepatic metastasis: a case report.
Zhang B, Gao S, Chen Y, Wu Y
Korean J Radiol 2010 Jul-Aug;11(4):472-5. Epub 2010 Jun 21 doi: 10.3348/kjr.2010.11.4.472. PMID: 20592932Free PMC Article
Endodermal sinus tumor (yolk sac tumor) of the temporal bone: an exotic disease for otorhinolaryngologists and head and neck surgeons.
Devaney KO, Ferlito A, Rinaldo A
Acta Otolaryngol 2003 Aug;123(6):747-8. doi: 10.1080/00016480310000692. PMID: 12953777

Therapy

A primary mediastinal germ cell tumor of yolk sac type: case report.
Darif K, Benbrahim Z, Acharfi N, Khacha A, Maaroufi M, Amaadour L, Oualla K, Arifi S, Mellas N
Pan Afr Med J 2021;38:330. Epub 2021 Apr 6 doi: 10.11604/pamj.2021.38.330.23730. PMID: 34285753Free PMC Article
Yolk Sac Tumors of the Head and Neck in Aicardi Syndrome.
Epperson MV, Born HL, Wang D, Myer CM 4th
Ann Otol Rhinol Laryngol 2020 Mar;129(3):301-305. Epub 2019 Oct 22 doi: 10.1177/0003489419883660. PMID: 31640397
Nasopharyngeal yolk sac tumors: a rare pediatric occurrence.
Mantle B, Osborne RF
Ear Nose Throat J 2013 Aug;92(8):336-8. doi: 10.1177/014556131309200806. PMID: 23975485
Endodermal sinus tumor of the maxillary sinus.
Westerveld GJ, Quak JJ, Bresters D, Zwaan CM, van der Valk P, Leemans CR
Otolaryngol Head Neck Surg 2001 Jun;124(6):691-2. doi: 10.1177/019459980112400620. PMID: 11391265
Nonmidline yolk sac tumour of the head and neck region in an infant with Dandy Walker syndrome--case report and review of literature.
Upadhyaya M, Oak SN, Kulkarni BK, Kalgutkar A
Indian J Cancer 1997 Dec;34(4):159-63. PMID: 9715538

Prognosis

Yolk Sac Tumor in the Anterior Mediastinum Presenting as Acute Pericarditis.
Aroshidze B, Boyapati L, Pokhrel A, Gotlieb V, Khan A, Erdinc B, Cheema MA
Am J Case Rep 2022 Jan 25;23:e932616. doi: 10.12659/AJCR.932616. PMID: 35077441Free PMC Article
Cystathionine Gamma-Lyase Is Increased in Testicular Seminomas, Embryonal, and Yolk Sac Tumors.
Ozluk E, Patel S, Coppola D, Ghali G, Cotelingam JD, Kevil CG, Shackelford RE
Anticancer Res 2021 Sep;41(9):4211-4214. Epub 2021 Sep 1 doi: 10.21873/anticanres.15225. PMID: 34475040Free PMC Article
Mixed adenoneuroendocrine carcinoma of the tongue arising within a congenital enteric cyst.
Ligthelm LJ, Bunn BK, Raubenheimer EJ, van Heerden WFP
Head Neck 2018 May;40(5):E53-E57. Epub 2018 Feb 23 doi: 10.1002/hed.25117. PMID: 29473257
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
Endodermal sinus tumor of the maxillary sinus.
Westerveld GJ, Quak JJ, Bresters D, Zwaan CM, van der Valk P, Leemans CR
Otolaryngol Head Neck Surg 2001 Jun;124(6):691-2. doi: 10.1177/019459980112400620. PMID: 11391265

Clinical prediction guides

Revertant mosaicism for family mutations is not observed in BRCA1/2 phenocopies.
Azzollini J, Pesenti C, Ferrari L, Fontana L, Calvello M, Peissel B, Portera G, Tabano S, Carcangiu ML, Riva P, Miozzo M, Manoukian S
PLoS One 2017;12(2):e0171663. Epub 2017 Feb 15 doi: 10.1371/journal.pone.0171663. PMID: 28199346Free PMC Article
"Somatic-type" malignancies arising from testicular germ cell tumors: a clinicopathologic study of 124 cases with emphasis on glandular tumors supporting frequent yolk sac tumor origin.
Magers MJ, Kao CS, Cole CD, Rice KR, Foster RS, Einhorn LH, Ulbright TM
Am J Surg Pathol 2014 Oct;38(10):1396-409. doi: 10.1097/PAS.0000000000000262. PMID: 24921638
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
Report on malignancies in the German juvenile idiopathic arthritis registry.
Horneff G, Foeldvari I, Minden K, Moebius D, Hospach T
Rheumatology (Oxford) 2011 Jan;50(1):230-6. doi: 10.1093/rheumatology/keq361. PMID: 21148157
Nonmidline yolk sac tumour of the head and neck region in an infant with Dandy Walker syndrome--case report and review of literature.
Upadhyaya M, Oak SN, Kulkarni BK, Kalgutkar A
Indian J Cancer 1997 Dec;34(4):159-63. PMID: 9715538

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