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Cervical Neuroendocrine Tumor G2

MedGen UID:
927347
•Concept ID:
C4289815
•
Neoplastic Process
Synonym: Cervical Low Grade Neuroendocrine Tumor, Grade 2

Definition

A well-differentiated, intermediate grade neuroendocrine neoplasm arising from the cervix. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Neuroendocrine Tumor G2

Professional guidelines

PubMed

Radio hyperthermia for re-treatment of superficial tumours.
Gabriele P, Ferrara T, Baiotto B, Garibaldi E, Marini PG, Penduzzu G, Giovannini V, Bardati F, Guiot C
Int J Hyperthermia 2009 May;25(3):189-98. doi: 10.1080/02656730802669593. PMID: 19212860

Recent clinical studies

Etiology

Molecular profiling and target actionability for precision medicine in neuroendocrine neoplasms: real-world data.
Boilève A, Faron M, Fodil-Cherif S, Bayle A, Lamartina L, Planchard D, Tselikas L, Kanaan C, Scoazec JY, Ducreux M, Italiano A, Baudin E, Hadoux J
Eur J Cancer 2023 Jun;186:122-132. Epub 2023 Mar 24 doi: 10.1016/j.ejca.2023.03.024. PMID: 37062210
Neuroendocrine Neoplasms of the Larynx: A Clinicopathologic Analysis of 27 Neuroendocrine Tumors and Neuroendocrine Carcinomas.
Bal M, Sharma A, Rane SU, Mittal N, Chaukar D, Prabhash K, Patil A
Head Neck Pathol 2022 Jun;16(2):375-387. Epub 2021 Aug 16 doi: 10.1007/s12105-021-01367-9. PMID: 34401980Free PMC Article
Phase 1/2 Trial of Pembrolizumab and Concurrent Chemoradiation Therapy for Limited-Stage SCLC.
Welsh JW, Heymach JV, Guo C, Menon H, Klein K, Cushman TR, Verma V, Hess KR, Shroff G, Tang C, Skoulidis F, Jeter M, Comeaux N, Patel RR, Chen D, Ozgen T, Nguyen QN, Chang JY, Altan M, Zhang J, Papadimitrakopoulou VA, Simon GR, Byers LA, Glisson B
J Thorac Oncol 2020 Dec;15(12):1919-1927. Epub 2020 Sep 8 doi: 10.1016/j.jtho.2020.08.022. PMID: 32916308Free PMC Article
Laryngeal Neuroendocrine Tumor With Elevated Serum Calcitonin: A Diagnostic and Therapeutic Challenge. Case Report and Review of Literature.
Feola T, Puliani G, Sesti F, Modica R, Biffoni M, Di Gioia C, Carletti R, Anastasi E, Di Vito V, Centello R, Lenzi A, Isidori AM, Faggiano A, Giannetta E
Front Endocrinol (Lausanne) 2020;11:397. Epub 2020 Jul 16 doi: 10.3389/fendo.2020.00397. PMID: 32765421Free PMC Article
Mutagen sensitivity in common cutaneous malignant melanoma and dysplastic naevus syndrome.
Cloos J, Willems EM, van Warmerdam JM, Braakhuis BJ, Snow GB, Meijer S
Melanoma Res 1999 Jun;9(3):292-6. doi: 10.1097/00008390-199906000-00011. PMID: 10465585

Diagnosis

World premiere: transoral robot-assisted excision for nasopharyngeal ectopic pituitary adenoma.
Louerat S, Hans S, Laroche S, Hyvrard C, Baudouin R
Eur Arch Otorhinolaryngol 2024 Dec;281(12):6705-6709. Epub 2024 Jul 31 doi: 10.1007/s00405-024-08850-3. PMID: 39083058
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Overview of the 2022 WHO Classification of Head and Neck Neuroendocrine Neoplasms.
Mete O, Wenig BM
Head Neck Pathol 2022 Mar;16(1):123-142. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01435-8. PMID: 35312985Free PMC Article
Neuroendocrine Neoplasms of the Larynx: A Clinicopathologic Analysis of 27 Neuroendocrine Tumors and Neuroendocrine Carcinomas.
Bal M, Sharma A, Rane SU, Mittal N, Chaukar D, Prabhash K, Patil A
Head Neck Pathol 2022 Jun;16(2):375-387. Epub 2021 Aug 16 doi: 10.1007/s12105-021-01367-9. PMID: 34401980Free PMC Article
Laryngeal Neuroendocrine Tumor With Elevated Serum Calcitonin: A Diagnostic and Therapeutic Challenge. Case Report and Review of Literature.
Feola T, Puliani G, Sesti F, Modica R, Biffoni M, Di Gioia C, Carletti R, Anastasi E, Di Vito V, Centello R, Lenzi A, Isidori AM, Faggiano A, Giannetta E
Front Endocrinol (Lausanne) 2020;11:397. Epub 2020 Jul 16 doi: 10.3389/fendo.2020.00397. PMID: 32765421Free PMC Article
Mutagen sensitivity in common cutaneous malignant melanoma and dysplastic naevus syndrome.
Cloos J, Willems EM, van Warmerdam JM, Braakhuis BJ, Snow GB, Meijer S
Melanoma Res 1999 Jun;9(3):292-6. doi: 10.1097/00008390-199906000-00011. PMID: 10465585

Therapy

Phase 1/2 Trial of Pembrolizumab and Concurrent Chemoradiation Therapy for Limited-Stage SCLC.
Welsh JW, Heymach JV, Guo C, Menon H, Klein K, Cushman TR, Verma V, Hess KR, Shroff G, Tang C, Skoulidis F, Jeter M, Comeaux N, Patel RR, Chen D, Ozgen T, Nguyen QN, Chang JY, Altan M, Zhang J, Papadimitrakopoulou VA, Simon GR, Byers LA, Glisson B
J Thorac Oncol 2020 Dec;15(12):1919-1927. Epub 2020 Sep 8 doi: 10.1016/j.jtho.2020.08.022. PMID: 32916308Free PMC Article
Concurrent irradiation with the anti-programmed cell death ligand-1 immune checkpoint blocker durvalumab: Single centre subset analysis from a phase 1/2 trial.
Levy A, Massard C, Soria JC, Deutsch E
Eur J Cancer 2016 Nov;68:156-162. Epub 2016 Oct 17 doi: 10.1016/j.ejca.2016.09.013. PMID: 27764686
Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin.
Chan LP, Chou TH, Ding HY, Chen PR, Chiang FY, Kuo PL, Liang CH
Biochim Biophys Acta 2012 Jul;1820(7):1081-91. Epub 2012 Apr 24 doi: 10.1016/j.bbagen.2012.04.013. PMID: 22554915
AR42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas.
Bush ML, Oblinger J, Brendel V, Santarelli G, Huang J, Akhmametyeva EM, Burns SS, Wheeler J, Davis J, Yates CW, Chaudhury AR, Kulp S, Chen CS, Chang LS, Welling DB, Jacob A
Neuro Oncol 2011 Sep;13(9):983-99. Epub 2011 Jul 21 doi: 10.1093/neuonc/nor072. PMID: 21778190Free PMC Article
Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis.
Zhang Y, Wu LJ, Tashiro S, Onodera S, Ikejima T
Acta Pharmacol Sin 2004 Jan;25(1):83-9. PMID: 14704127

Prognosis

Molecular profiling and target actionability for precision medicine in neuroendocrine neoplasms: real-world data.
Boilève A, Faron M, Fodil-Cherif S, Bayle A, Lamartina L, Planchard D, Tselikas L, Kanaan C, Scoazec JY, Ducreux M, Italiano A, Baudin E, Hadoux J
Eur J Cancer 2023 Jun;186:122-132. Epub 2023 Mar 24 doi: 10.1016/j.ejca.2023.03.024. PMID: 37062210
"Neuroendocrine Tumor Grade 3 (NET G3)" of the Uterine Cervix: A Report of 2 Cases.
Katafuchi T, Kawakami F, Iwagoi Y, Saito F, Mikami Y
Int J Gynecol Pathol 2022 Sep 1;41(5):470-475. Epub 2021 Sep 27 doi: 10.1097/PGP.0000000000000828. PMID: 34570015
Neuroendocrine Neoplasms of the Larynx: A Clinicopathologic Analysis of 27 Neuroendocrine Tumors and Neuroendocrine Carcinomas.
Bal M, Sharma A, Rane SU, Mittal N, Chaukar D, Prabhash K, Patil A
Head Neck Pathol 2022 Jun;16(2):375-387. Epub 2021 Aug 16 doi: 10.1007/s12105-021-01367-9. PMID: 34401980Free PMC Article
Differences and Similarities in the Clinicopathological Features of Pancreatic Neuroendocrine Tumors in China and the United States: A Multicenter Study.
Zhu LM, Tang L, Qiao XW, Wolin E, Nissen NN, Dhall D, Chen J, Shen L, Chi Y, Yuan YZ, Ben QW, Lv B, Zhou YR, Bai CM, Chen J, Song YL, Song TT, Lu CM, Yu R, Chen YJ
Medicine (Baltimore) 2016 Feb;95(7):e2836. doi: 10.1097/MD.0000000000002836. PMID: 26886644Free PMC Article
G2M arrest, blocked apoptosis, and low growth fraction may explain indolent behavior of head and neck paragangliomas.
Dekker PB, Kuipers-Dijkshoorn N, Hogendoorn PC, van der Mey AG, Cornelisse CJ
Hum Pathol 2003 Jul;34(7):690-8. doi: 10.1016/s0046-8177(03)00237-5. PMID: 12874765

Clinical prediction guides

Neuroendocrine Neoplasms of the Larynx: A Clinicopathologic Analysis of 27 Neuroendocrine Tumors and Neuroendocrine Carcinomas.
Bal M, Sharma A, Rane SU, Mittal N, Chaukar D, Prabhash K, Patil A
Head Neck Pathol 2022 Jun;16(2):375-387. Epub 2021 Aug 16 doi: 10.1007/s12105-021-01367-9. PMID: 34401980Free PMC Article
Phase 1/2 Trial of Pembrolizumab and Concurrent Chemoradiation Therapy for Limited-Stage SCLC.
Welsh JW, Heymach JV, Guo C, Menon H, Klein K, Cushman TR, Verma V, Hess KR, Shroff G, Tang C, Skoulidis F, Jeter M, Comeaux N, Patel RR, Chen D, Ozgen T, Nguyen QN, Chang JY, Altan M, Zhang J, Papadimitrakopoulou VA, Simon GR, Byers LA, Glisson B
J Thorac Oncol 2020 Dec;15(12):1919-1927. Epub 2020 Sep 8 doi: 10.1016/j.jtho.2020.08.022. PMID: 32916308Free PMC Article
Radio hyperthermia for re-treatment of superficial tumours.
Gabriele P, Ferrara T, Baiotto B, Garibaldi E, Marini PG, Penduzzu G, Giovannini V, Bardati F, Guiot C
Int J Hyperthermia 2009 May;25(3):189-98. doi: 10.1080/02656730802669593. PMID: 19212860
Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis.
Zhang Y, Wu LJ, Tashiro S, Onodera S, Ikejima T
Acta Pharmacol Sin 2004 Jan;25(1):83-9. PMID: 14704127
Use of 1,2:5,6-dianhydrogalactitol in studies on cell kinetics-directed chemotherapy schedules in human tumors in vivo.
Barranco SC, Townsend CM, Costanzi JJ, May JT, Baltz R, O'Quinn AG, Leipzig B, Hokanson KM, Guseman LF, Boerwinkle WR
Cancer Res 1982 Jul;42(7):2899-2905. PMID: 7083178

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