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Cervical Adenocarcinoma Admixed with Neuroendocrine Carcinoma

MedGen UID:
927353
•Concept ID:
C4289821
•
Neoplastic Process

Definition

A carcinoma that arises from the cervix and is characterized by the presence of a cervical adenocarcinoma variant and a neuroendocrine carcinoma component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Adenocarcinoma Admixed with Neuroendocrine Carcinoma

Professional guidelines

PubMed

The impact of neo/adjuvant treatment choices on prognosis for surgically treated small-cell neuroendocrine carcinoma of the cervix.
Zhao D, Sun S, Yang Z, Wang P, Qiu H
Neoplasma 2024 Feb;71(1):70-76. Epub 2024 Jan 12 doi: 10.4149/neo_2023_230802N404. PMID: 38215035
Endocervical adenocarcinoma and its variants: their morphology and differential diagnosis.
Young RH, Clement PB
Histopathology 2002 Sep;41(3):185-207. doi: 10.1046/j.1365-2559.2002.01462.x. PMID: 12207781

Recent clinical studies

Etiology

A case of metastatic HPV-related cervical small cell neuroendocrine carcinoma with varying cytomorphology found in cytological specimens of a solid organ transplant recipient.
Fasanya-Maku H, Petty D, Knapik J, Leon M, Gonsalves C
Diagn Cytopathol 2024 Sep;52(9):E202-E207. Epub 2024 May 31 doi: 10.1002/dc.25361. PMID: 38819099
The impact of neo/adjuvant treatment choices on prognosis for surgically treated small-cell neuroendocrine carcinoma of the cervix.
Zhao D, Sun S, Yang Z, Wang P, Qiu H
Neoplasma 2024 Feb;71(1):70-76. Epub 2024 Jan 12 doi: 10.4149/neo_2023_230802N404. PMID: 38215035

Diagnosis

A case of metastatic HPV-related cervical small cell neuroendocrine carcinoma with varying cytomorphology found in cytological specimens of a solid organ transplant recipient.
Fasanya-Maku H, Petty D, Knapik J, Leon M, Gonsalves C
Diagn Cytopathol 2024 Sep;52(9):E202-E207. Epub 2024 May 31 doi: 10.1002/dc.25361. PMID: 38819099
Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix.
Bellone S, Jeong K, Halle MK, Krakstad C, McNamara B, Greenman M, Mutlu L, Demirkiran C, Hartwich TMP, Yang-Hartwich Y, Zipponi M, Buza N, Hui P, Raspagliesi F, Lopez S, Paolini B, Milione M, Perrone E, Scambia G, Altwerger G, Ravaggi A, Bignotti E, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz PE, Quick CM, Angioli R, Terranova C, Zaidi S, Nandi S, Alexandrov LB, Siegel ER, Choi J, Schlessinger J, Santin AD
Proc Natl Acad Sci U S A 2024 Apr 23;121(17):e2321898121. Epub 2024 Apr 16 doi: 10.1073/pnas.2321898121. PMID: 38625939Free PMC Article
Mixed endocervical adenocarcinoma and high-grade neuroendocrine carcinoma of the cervix: A case report.
Teoman G, Ersoz S
Indian J Pathol Microbiol 2021 Jan-Mar;64(1):174-176. doi: 10.4103/IJPM.IJPM_1006_19. PMID: 33433435
Adenocarcinoma in situ admixed with small cell neuroendocrine carcinoma of the cervix: A case report with cytological features.
Nishiumi Y, Nishimura T, Kashu I, Aoki T, Itoh R, Tsuta K, Ishida M
Diagn Cytopathol 2018 Sep;46(9):752-755. Epub 2018 Apr 15 doi: 10.1002/dc.23940. PMID: 29656585
Endocervical adenocarcinoma and its variants: their morphology and differential diagnosis.
Young RH, Clement PB
Histopathology 2002 Sep;41(3):185-207. doi: 10.1046/j.1365-2559.2002.01462.x. PMID: 12207781

Therapy

A case of metastatic HPV-related cervical small cell neuroendocrine carcinoma with varying cytomorphology found in cytological specimens of a solid organ transplant recipient.
Fasanya-Maku H, Petty D, Knapik J, Leon M, Gonsalves C
Diagn Cytopathol 2024 Sep;52(9):E202-E207. Epub 2024 May 31 doi: 10.1002/dc.25361. PMID: 38819099

Prognosis

The impact of neo/adjuvant treatment choices on prognosis for surgically treated small-cell neuroendocrine carcinoma of the cervix.
Zhao D, Sun S, Yang Z, Wang P, Qiu H
Neoplasma 2024 Feb;71(1):70-76. Epub 2024 Jan 12 doi: 10.4149/neo_2023_230802N404. PMID: 38215035
Morphologic and Molecular Heterogeneity of Cervical Neuroendocrine Neoplasia: A Report of 14 Cases.
Ordulu Z, Mino-Kenudson M, Young RH, Van de Vijver K, Zannoni GF, Félix A, Burandt E, Wong A, Nardi V, Oliva E
Am J Surg Pathol 2022 Dec 1;46(12):1670-1681. Epub 2022 Sep 5 doi: 10.1097/PAS.0000000000001943. PMID: 36069807
Mixed endocervical adenocarcinoma and high-grade neuroendocrine carcinoma of the cervix: A case report.
Teoman G, Ersoz S
Indian J Pathol Microbiol 2021 Jan-Mar;64(1):174-176. doi: 10.4103/IJPM.IJPM_1006_19. PMID: 33433435

Clinical prediction guides

The impact of neo/adjuvant treatment choices on prognosis for surgically treated small-cell neuroendocrine carcinoma of the cervix.
Zhao D, Sun S, Yang Z, Wang P, Qiu H
Neoplasma 2024 Feb;71(1):70-76. Epub 2024 Jan 12 doi: 10.4149/neo_2023_230802N404. PMID: 38215035
Adenocarcinoma in situ admixed with small cell neuroendocrine carcinoma of the cervix: A case report with cytological features.
Nishiumi Y, Nishimura T, Kashu I, Aoki T, Itoh R, Tsuta K, Ishida M
Diagn Cytopathol 2018 Sep;46(9):752-755. Epub 2018 Apr 15 doi: 10.1002/dc.23940. PMID: 29656585

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