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Cartilage development disorder

MedGen UID:
935
•Concept ID:
C0008449
•
Disease or Syndrome
Synonym: Chondrodystrophy
SNOMED CT: Congenital anomaly of cartilage (67988000); Chondrodystrophy (67988000); Abnormal development of cartilage (67988000)
 
Monarch Initiative: MONDO:0020779

Definition

Any dysfunction in the growth of cartilage. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCartilage development disorder

Professional guidelines

PubMed

Management of chronic pain associated with temporomandibular disorders: a clinical practice guideline.
Busse JW, Casassus R, Carrasco-Labra A, Durham J, Mock D, Zakrzewska JM, Palmer C, Samer CF, Coen M, Guevremont B, Hoppe T, Guyatt GH, Crandon HN, Yao L, Sadeghirad B, Vandvik PO, Siemieniuk RAC, Lytvyn L, Hunskaar BS, Agoritsas T
BMJ 2023 Dec 15;383:e076227. doi: 10.1136/bmj-2023-076227. PMID: 38101929
Surgical treatment of complex meniscus tear and disease: state of the art.
Ozeki N, Seil R, Krych AJ, Koga H
J ISAKOS 2021 Jan;6(1):35-45. Epub 2020 Sep 17 doi: 10.1136/jisakos-2019-000380. PMID: 33833044
Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis.
Lin YJ, Anzaghe M, Schülke S
Cells 2020 Apr 3;9(4) doi: 10.3390/cells9040880. PMID: 32260219Free PMC Article

Recent clinical studies

Etiology

Management of chronic pain associated with temporomandibular disorders: a clinical practice guideline.
Busse JW, Casassus R, Carrasco-Labra A, Durham J, Mock D, Zakrzewska JM, Palmer C, Samer CF, Coen M, Guevremont B, Hoppe T, Guyatt GH, Crandon HN, Yao L, Sadeghirad B, Vandvik PO, Siemieniuk RAC, Lytvyn L, Hunskaar BS, Agoritsas T
BMJ 2023 Dec 15;383:e076227. doi: 10.1136/bmj-2023-076227. PMID: 38101929
Osteoarthritis: pathogenic signaling pathways and therapeutic targets.
Yao Q, Wu X, Tao C, Gong W, Chen M, Qu M, Zhong Y, He T, Chen S, Xiao G
Signal Transduct Target Ther 2023 Feb 3;8(1):56. doi: 10.1038/s41392-023-01330-w. PMID: 36737426Free PMC Article
NF-κB Signaling Pathways in Osteoarthritic Cartilage Destruction.
Choi MC, Jo J, Park J, Kang HK, Park Y
Cells 2019 Jul 17;8(7) doi: 10.3390/cells8070734. PMID: 31319599Free PMC Article
Apophysitis and Osteochondrosis: Common Causes of Pain in Growing Bones.
Achar S, Yamanaka J
Am Fam Physician 2019 May 15;99(10):610-618. PMID: 31083875
Rheumatoid arthritis.
Scott DL, Wolfe F, Huizinga TW
Lancet 2010 Sep 25;376(9746):1094-108. doi: 10.1016/S0140-6736(10)60826-4. PMID: 20870100

Diagnosis

Mucopolysaccharidosis IVA: Diagnosis, Treatment, and Management.
Sawamoto K, Álvarez González JV, Piechnik M, Otero FJ, Couce ML, Suzuki Y, Tomatsu S
Int J Mol Sci 2020 Feb 23;21(4) doi: 10.3390/ijms21041517. PMID: 32102177Free PMC Article
Single-cell RNA-seq analysis reveals the progression of human osteoarthritis.
Ji Q, Zheng Y, Zhang G, Hu Y, Fan X, Hou Y, Wen L, Li L, Xu Y, Wang Y, Tang F
Ann Rheum Dis 2019 Jan;78(1):100-110. Epub 2018 Jul 19 doi: 10.1136/annrheumdis-2017-212863. PMID: 30026257Free PMC Article
Subglottic Stenosis.
Marston AP, White DR
Clin Perinatol 2018 Dec;45(4):787-804. Epub 2018 Aug 27 doi: 10.1016/j.clp.2018.07.013. PMID: 30396418
Cartilage diseases.
Krishnan Y, Grodzinsky AJ
Matrix Biol 2018 Oct;71-72:51-69. Epub 2018 May 24 doi: 10.1016/j.matbio.2018.05.005. PMID: 29803938Free PMC Article
Rheumatoid arthritis.
Scott DL, Wolfe F, Huizinga TW
Lancet 2010 Sep 25;376(9746):1094-108. doi: 10.1016/S0140-6736(10)60826-4. PMID: 20870100

Therapy

Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis.
Hu Q, Ecker M
Int J Mol Sci 2021 Feb 9;22(4) doi: 10.3390/ijms22041742. PMID: 33572320Free PMC Article
Mechanisms and therapeutic implications of cellular senescence in osteoarthritis.
Coryell PR, Diekman BO, Loeser RF
Nat Rev Rheumatol 2021 Jan;17(1):47-57. Epub 2020 Nov 18 doi: 10.1038/s41584-020-00533-7. PMID: 33208917Free PMC Article
Emerging pharmaceutical therapies for osteoarthritis.
Latourte A, Kloppenburg M, Richette P
Nat Rev Rheumatol 2020 Dec;16(12):673-688. Epub 2020 Oct 29 doi: 10.1038/s41584-020-00518-6. PMID: 33122845
A stem cell-based approach to cartilage repair.
Johnson K, Zhu S, Tremblay MS, Payette JN, Wang J, Bouchez LC, Meeusen S, Althage A, Cho CY, Wu X, Schultz PG
Science 2012 May 11;336(6082):717-21. Epub 2012 Apr 5 doi: 10.1126/science.1215157. PMID: 22491093
Rheumatoid arthritis.
Scott DL, Wolfe F, Huizinga TW
Lancet 2010 Sep 25;376(9746):1094-108. doi: 10.1016/S0140-6736(10)60826-4. PMID: 20870100

Prognosis

Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes.
Nygaard G, Firestein GS
Nat Rev Rheumatol 2020 Jun;16(6):316-333. Epub 2020 May 11 doi: 10.1038/s41584-020-0413-5. PMID: 32393826Free PMC Article
Single-cell RNA-seq analysis reveals the progression of human osteoarthritis.
Ji Q, Zheng Y, Zhang G, Hu Y, Fan X, Hou Y, Wen L, Li L, Xu Y, Wang Y, Tang F
Ann Rheum Dis 2019 Jan;78(1):100-110. Epub 2018 Jul 19 doi: 10.1136/annrheumdis-2017-212863. PMID: 30026257Free PMC Article
Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis.
Robinson WH, Lepus CM, Wang Q, Raghu H, Mao R, Lindstrom TM, Sokolove J
Nat Rev Rheumatol 2016 Oct;12(10):580-92. Epub 2016 Aug 19 doi: 10.1038/nrrheum.2016.136. PMID: 27539668Free PMC Article
The role of synovitis in osteoarthritis pathogenesis.
Scanzello CR, Goldring SR
Bone 2012 Aug;51(2):249-57. Epub 2012 Feb 22 doi: 10.1016/j.bone.2012.02.012. PMID: 22387238Free PMC Article
Rheumatoid arthritis.
Scott DL, Wolfe F, Huizinga TW
Lancet 2010 Sep 25;376(9746):1094-108. doi: 10.1016/S0140-6736(10)60826-4. PMID: 20870100

Clinical prediction guides

Metformin limits osteoarthritis development and progression through activation of AMPK signalling.
Li J, Zhang B, Liu WX, Lu K, Pan H, Wang T, Oh CD, Yi D, Huang J, Zhao L, Ning G, Xing C, Xiao G, Liu-Bryan R, Feng S, Chen D
Ann Rheum Dis 2020 May;79(5):635-645. Epub 2020 Mar 10 doi: 10.1136/annrheumdis-2019-216713. PMID: 32156705Free PMC Article
Single-cell RNA-seq analysis reveals the progression of human osteoarthritis.
Ji Q, Zheng Y, Zhang G, Hu Y, Fan X, Hou Y, Wen L, Li L, Xu Y, Wang Y, Tang F
Ann Rheum Dis 2019 Jan;78(1):100-110. Epub 2018 Jul 19 doi: 10.1136/annrheumdis-2017-212863. PMID: 30026257Free PMC Article
Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management.
Marshall M, Watt FE, Vincent TL, Dziedzic K
Nat Rev Rheumatol 2018 Nov;14(11):641-656. doi: 10.1038/s41584-018-0095-4. PMID: 30305701
Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use.
Kraus VB, Blanco FJ, Englund M, Karsdal MA, Lohmander LS
Osteoarthritis Cartilage 2015 Aug;23(8):1233-41. Epub 2015 Apr 9 doi: 10.1016/j.joca.2015.03.036. PMID: 25865392Free PMC Article
The role of synovitis in osteoarthritis pathogenesis.
Scanzello CR, Goldring SR
Bone 2012 Aug;51(2):249-57. Epub 2012 Feb 22 doi: 10.1016/j.bone.2012.02.012. PMID: 22387238Free PMC Article

Recent systematic reviews

The Effects of Chronological Age on the Chondrogenic Potential of Mesenchymal Stromal Cells: A Systematic Review.
Vogt A, Kapetanos K, Christodoulou N, Asimakopoulos D, Birch MA, McCaskie AW, Khan W
Int J Mol Sci 2023 Oct 23;24(20) doi: 10.3390/ijms242015494. PMID: 37895174Free PMC Article
Nanodevices for deep cartilage penetration.
Xu XL, Xue Y, Ding JY, Zhu ZH, Wu XC, Song YJ, Cao YL, Tang LG, Ding DF, Xu JG
Acta Biomater 2022 Dec;154:23-48. Epub 2022 Oct 12 doi: 10.1016/j.actbio.2022.10.007. PMID: 36243371
Phenotypic alteration of macrophages during osteoarthritis: a systematic review.
Zhu X, Lee CW, Xu H, Wang YF, Yung PSH, Jiang Y, Lee OK
Arthritis Res Ther 2021 Apr 10;23(1):110. doi: 10.1186/s13075-021-02457-3. PMID: 33838669Free PMC Article
A systematic review on the role of eicosanoid pathways in rheumatoid arthritis.
Hoxha M
Adv Med Sci 2018 Mar;63(1):22-29. Epub 2017 Aug 14 doi: 10.1016/j.advms.2017.06.004. PMID: 28818745
Synovium and cartilage biomarkers in hemophilic arthropathy.
Rodriguez-Merchan EC
Expert Rev Hematol 2016;9(4):409-14. Epub 2016 Feb 3 doi: 10.1586/17474086.2016.1141674. PMID: 26761216

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