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Hypervitaminosis A

MedGen UID:: 9378
•Concept ID:: C0020579
•: Disease or Syndrome

Synonyms:	hypervitaminosis A; hypervitaminosis type A
SNOMED CT:	Hypervitaminosis A (64559002)

Monarch Initiative:	MONDO:0006798

Definition

A symptom complex resulting from ingesting excessive amounts of vitamin A. [from MONDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVHypervitaminosis A

Pathological process
- Disease
  - Non-Neoplastic Disorder
    - Non-Neoplastic Disorder by Special Category
      - Metabolic disease
        Nutritional disorder
        Hypervitaminosis A

Professional guidelines

PubMed

Spectrum of Voriconazole-Induced Periostitis With Review of the Differential Diagnosis.

Tan I, Lomasney L, Stacy GS, Lazarus M, Mar WA
AJR Am J Roentgenol 2019 Jan;212(1):157-165. Epub 2018 Nov 7 doi: 10.2214/AJR.18.19991. PMID: 30403528

Isotretinoin (roaccutane) usage--a South African consensus guideline. National Dermatology Working Group.

S Afr Med J 1997 Oct;87(10 Pt 2):1410-3. PMID: 11496385

Assessment of risk factors for carotenodermia and cutaneous signs of hypervitaminosis A in college-aged populations.

Roe DA
Semin Dermatol 1991 Dec;10(4):303-8. PMID: 1764358

See all (9)

Recent clinical studies

Etiology

Vitamin A and Wound Healing.

Zinder R, Cooley R, Vlad LG, Molnar JA
Nutr Clin Pract 2019 Dec;34(6):839-849. doi: 10.1002/ncp.10420. PMID: 31697447

Rubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism.

Mawson AR, Croft AM
Int J Environ Res Public Health 2019 Sep 22;16(19) doi: 10.3390/ijerph16193543. PMID: 31546693 Free PMC Article

Spontaneous fracture: multiple causes.

Wick JY
Consult Pharm 2009 Feb;24(2):100-2, 105-8, 110-2. doi: 10.4140/tcp.n.2009.100. PMID: 19275452

Vitamin A supplementation and risk of skeletal fracture.

Genaro Pde S, Martini LA
Nutr Rev 2004 Feb;62(2):65-7. doi: 10.1111/j.1753-4887.2004.tb00026.x. PMID: 15080368

Vitamin neurotoxicity.

Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

See all (95)

Diagnosis

Rubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism.

Mawson AR, Croft AM
Int J Environ Res Public Health 2019 Sep 22;16(19) doi: 10.3390/ijerph16193543. PMID: 31546693 Free PMC Article

Yellow discolouration.

Boere IA, Hoskam JA
Neth J Med 2006 Feb;64(2):56-7. PMID: 16517992

Vitamins.

Sethuraman U
Pediatr Rev 2006 Feb;27(2):44-55. doi: 10.1542/pir.27-2-44. PMID: 16452274

Noncirrhotic portal hypertension.

Hillaire S, Valla D, Lebrec D
Clin Liver Dis 1997 May;1(1):223-40, xiii. doi: 10.1016/s1089-3261(05)70265-8. PMID: 15562678

Carotenemia.

Leung AK
Adv Pediatr 1987;34:223-48. PMID: 3318296

See all (98)

Therapy

Hypercarotenemia.

Tomás-Velázquez A, Moreno-Artero E, Aguado L
Med Clin (Barc) 2020 Mar 13;154(5):198. Epub 2019 Jul 18 doi: 10.1016/j.medcli.2019.05.018. PMID: 31326097

Vitamin A and Wound Healing.

Zinder R, Cooley R, Vlad LG, Molnar JA
Nutr Clin Pract 2019 Dec;34(6):839-849. doi: 10.1002/ncp.10420. PMID: 31697447

Vitamins.

Sethuraman U
Pediatr Rev 2006 Feb;27(2):44-55. doi: 10.1542/pir.27-2-44. PMID: 16452274

Overnutrition.

Young CM
World Rev Nutr Diet 1973;16:179-202. doi: 10.1159/000393591. PMID: 4584294

Hypervitaminosis A: a review.

Clark L
Aust Vet J 1971 Nov;47(11):568-71. doi: 10.1111/j.1751-0813.1971.tb02061.x. PMID: 4941080

See all (220)

Prognosis

Chronic and acute hypervitaminosis A are associated with suboptimal anthropometric measurements in a cohort of South African preschool children.

Sheftel J, van Stuijvenberg ME, Dhansay MA, Suri DJ, Grahn M, Keuler NS, Binkley NC, Tanumihardjo SA
Am J Clin Nutr 2022 Apr 1;115(4):1059-1068. doi: 10.1093/ajcn/nqab422. PMID: 35030234

Hypertrophic Osteoarthropathy: Clinical and Imaging Features.

Yap FY, Skalski MR, Patel DB, Schein AJ, White EA, Tomasian A, Masih S, Matcuk GR Jr
Radiographics 2017 Jan-Feb;37(1):157-195. Epub 2016 Dec 9 doi: 10.1148/rg.2017160052. PMID: 27935768

Hypervitaminosis A is prevalent in children with CKD and contributes to hypercalcemia.

Manickavasagar B, McArdle AJ, Yadav P, Shaw V, Dixon M, Blomhoff R, Connor GO, Rees L, Ledermann S, Van't Hoff W, Shroff R
Pediatr Nephrol 2015 Feb;30(2):317-25. Epub 2014 Aug 15 doi: 10.1007/s00467-014-2916-2. PMID: 25119682 Free PMC Article

Vitamin neurotoxicity.

Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

Acitretin in the symptomatic therapy for severe recessive x-linked ichthyosis.

Bruckner-Tuderman L, Sigg C, Geiger JM, Gilardi S
Arch Dermatol 1988 Apr;124(4):529-32. PMID: 2965549

See all (27)

Clinical prediction guides

Hypervitaminosis A is prevalent in children with CKD and contributes to hypercalcemia.

Adverse effects of antioxidative vitamins.

Rutkowski M, Grzegorczyk K
Int J Occup Med Environ Health 2012 Jun;25(2):105-21. Epub 2012 Apr 19 doi: 10.2478/S13382-012-0022-x. PMID: 22528540

Carrot man: a case of excessive beta-carotene ingestion.

Sansone RA, Sansone LA
Int J Eat Disord 2012 Sep;45(6):816-8. Epub 2012 Mar 19 doi: 10.1002/eat.22015. PMID: 22431270

Spontaneous fracture: multiple causes.

Wick JY
Consult Pharm 2009 Feb;24(2):100-2, 105-8, 110-2. doi: 10.4140/tcp.n.2009.100. PMID: 19275452

Vitamin neurotoxicity.

Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

See all (50)

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Hypervitaminosis A

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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