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Atypical Meningioma

MedGen UID:
96558
•Concept ID:
C0431122
•
Neoplastic Process
Synonym: Atypical meningioma
SNOMED CT: Atypical meningioma (128914005)

Definition

A WHO grade II meningioma characterized by the presence of brain invasion and an increased mitotic activity, or at least three of the following morphologic features: small cells, high cellularity, prominent nucleoli, lack of architectural pattern, and necrosis. [from NCI]

Professional guidelines

PubMed

Management of Atypical and Anaplastic Meningiomas.
Higgins D, Shah AH, Komotar RJ, Ivan ME
Neurosurg Clin N Am 2023 Jul;34(3):437-446. Epub 2023 Apr 18 doi: 10.1016/j.nec.2023.02.011. PMID: 37210132
Management of Atypical and Anaplastic Meningiomas.
Buttrick S, Shah AH, Komotar RJ, Ivan ME
Neurosurg Clin N Am 2016 Apr;27(2):239-47. Epub 2016 Feb 20 doi: 10.1016/j.nec.2015.11.003. PMID: 27012388
An evidence-based treatment algorithm for the management of WHO Grade II and III meningiomas.
Sun SQ, Hawasli AH, Huang J, Chicoine MR, Kim AH
Neurosurg Focus 2015 Mar;38(3):E3. doi: 10.3171/2015.1.FOCUS14757. PMID: 25727225

Recent clinical studies

Etiology

Advances in the systemic therapy for recurrent meningiomas and the challenges ahead.
Li Y, Drappatz J
Expert Rev Neurother 2023 Jul-Dec;23(11):995-1004. Epub 2023 Sep 11 doi: 10.1080/14737175.2023.2254498. PMID: 37695700
Pathology of meningiomas.
Solomon DA, Pekmezci M
Handb Clin Neurol 2020;169:87-99. doi: 10.1016/B978-0-12-804280-9.00005-6. PMID: 32553300
Prognostic factors for progression in atypical meningioma.
Shakir SI, Souhami L, Petrecca K, Mansure JJ, Singh K, Panet-Raymond V, Shenouda G, Al-Odaini AA, Abdulkarim B, Guiot MC
J Neurosurg 2018 Nov 1;129(5):1240-1248. Epub 2018 Jan 19 doi: 10.3171/2017.6.JNS17120. PMID: 29350599
The role of radiotherapy in the management of high-grade meningiomas.
Hwang KL, Hwang WL, Bussière MR, Shih HA
Chin Clin Oncol 2017 Jul;6(Suppl 1):S5. doi: 10.21037/cco.2017.06.09. PMID: 28758409
Recent advances in the management of atypical meningiomas.
Messerer M, Richoz B, Cossu G, Dhermain F, Hottinger AF, Parker F, Levivier M, Daniel RT
Neurochirurgie 2016 Aug;62(4):213-22. Epub 2016 Jun 28 doi: 10.1016/j.neuchi.2016.02.003. PMID: 27370103

Diagnosis

Intraparenchymal atypical meningioma in the posterior fossa: a case report and literature review.
Cai Q, Wang S, Zheng M, Qin H, Feng D
Br J Neurosurg 2023 Oct;37(5):1167-1170. Epub 2021 Feb 17 doi: 10.1080/02688697.2021.1884651. PMID: 33595378
Atypical meningiomas.
Chen R, Aghi MK
Handb Clin Neurol 2020;170:233-244. doi: 10.1016/B978-0-12-822198-3.00043-4. PMID: 32586495
Recent advances in the management of atypical meningiomas.
Messerer M, Richoz B, Cossu G, Dhermain F, Hottinger AF, Parker F, Levivier M, Daniel RT
Neurochirurgie 2016 Aug;62(4):213-22. Epub 2016 Jun 28 doi: 10.1016/j.neuchi.2016.02.003. PMID: 27370103
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.
Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW
Acta Neuropathol 2016 Jun;131(6):803-20. Epub 2016 May 9 doi: 10.1007/s00401-016-1545-1. PMID: 27157931
An atypical meningioma.
Lin W, Kevorkian CG
Am J Phys Med Rehabil 2008 Sep;87(9):693. doi: 10.1097/PHM.0b013e3181837cc7. PMID: 18716480

Therapy

Radiation therapy for atypical and anaplastic meningiomas: an overview of current results and controversial issues.
Vagnoni L, Aburas S, Giraffa M, Russo I, Chiarella V, Paolini S, Tini P, Minniti G
Neurosurg Rev 2022 Oct;45(5):3019-3033. Epub 2022 Jun 4 doi: 10.1007/s10143-022-01806-3. PMID: 35665867Free PMC Article
Rapid development of an atypical meningioma during Nivolumab therapy for metastatic renal cell carcinoma.
Abele N, Luchtmann M, Donitza A, Janitzky A, Sandalcioglu IE, Skalej M, Schostak M, Reifenberger G, Mawrin C
Clin Neurol Neurosurg 2020 Aug;195:105938. Epub 2020 May 20 doi: 10.1016/j.clineuro.2020.105938. PMID: 32502948
Bevacizumab in refractory higher-grade and atypical meningioma: the current state of affairs.
Dasanu CA, Alvarez-Argote J, Limonadi FM, Codreanu I
Expert Opin Biol Ther 2019 Feb;19(2):99-104. Epub 2018 Dec 17 doi: 10.1080/14712598.2019.1559292. PMID: 30556741
Salvage therapy outcomes for atypical meningioma.
Chen WC, Hara J, Magill ST, Wu A, Aghi MK, Theodosopoulos PV, Perry A, McDermott MW, Sneed PK, Raleigh DR, Braunstein SE
J Neurooncol 2018 Jun;138(2):425-433. Epub 2018 Feb 26 doi: 10.1007/s11060-018-2813-9. PMID: 29480505
Metachronous secondary atypical meningioma and anaplastic astrocytoma after postoperative craniospinal irradiation for medulloblastoma.
Hope AJ, Mansur DB, Tu PH, Simpson JR
Childs Nerv Syst 2006 Sep;22(9):1201-7. Epub 2006 Mar 29 doi: 10.1007/s00381-006-0062-2. PMID: 16570196

Prognosis

Management of Atypical and Anaplastic Meningiomas.
Higgins D, Shah AH, Komotar RJ, Ivan ME
Neurosurg Clin N Am 2023 Jul;34(3):437-446. Epub 2023 Apr 18 doi: 10.1016/j.nec.2023.02.011. PMID: 37210132
Prognostic factors for progression in atypical meningioma.
Shakir SI, Souhami L, Petrecca K, Mansure JJ, Singh K, Panet-Raymond V, Shenouda G, Al-Odaini AA, Abdulkarim B, Guiot MC
J Neurosurg 2018 Nov 1;129(5):1240-1248. Epub 2018 Jan 19 doi: 10.3171/2017.6.JNS17120. PMID: 29350599
Recent advances in the management of atypical meningiomas.
Messerer M, Richoz B, Cossu G, Dhermain F, Hottinger AF, Parker F, Levivier M, Daniel RT
Neurochirurgie 2016 Aug;62(4):213-22. Epub 2016 Jun 28 doi: 10.1016/j.neuchi.2016.02.003. PMID: 27370103
Management of Atypical and Anaplastic Meningiomas.
Buttrick S, Shah AH, Komotar RJ, Ivan ME
Neurosurg Clin N Am 2016 Apr;27(2):239-47. Epub 2016 Feb 20 doi: 10.1016/j.nec.2015.11.003. PMID: 27012388
Metachronous secondary atypical meningioma and anaplastic astrocytoma after postoperative craniospinal irradiation for medulloblastoma.
Hope AJ, Mansur DB, Tu PH, Simpson JR
Childs Nerv Syst 2006 Sep;22(9):1201-7. Epub 2006 Mar 29 doi: 10.1007/s00381-006-0062-2. PMID: 16570196

Clinical prediction guides

Atypical meningioma: Histopathological, genetic, and epigenetic features to predict recurrence risk.
Marastoni E, Barresi V
Histol Histopathol 2024 Mar;39(3):293-302. Epub 2023 Oct 20 doi: 10.14670/HH-18-670. PMID: 37921468
A machine learning-based integrated clinical model for predicting prognosis in atypical meningioma patients.
Song D, Zhang M, Duan C, Wei M, Xu D, An Y, Zhang L, Wang F, Feng M, Qian Z, Gao Q, Guo F
Acta Neurochir (Wien) 2023 Dec;165(12):4191-4201. Epub 2023 Oct 11 doi: 10.1007/s00701-023-05831-z. PMID: 37819396
Discrimination between microcystic meningioma and atypical meningioma using whole-lesion apparent diffusion coefficient histogram analysis.
Liu X, Huang X, Han T, Li S, Xue C, Deng J, Zhou Q, Sun Q, Zhou J
Clin Radiol 2022 Nov;77(11):864-869. Epub 2022 Aug 25 doi: 10.1016/j.crad.2022.07.004. PMID: 36030110
Radiation therapy for atypical and anaplastic meningiomas: an overview of current results and controversial issues.
Vagnoni L, Aburas S, Giraffa M, Russo I, Chiarella V, Paolini S, Tini P, Minniti G
Neurosurg Rev 2022 Oct;45(5):3019-3033. Epub 2022 Jun 4 doi: 10.1007/s10143-022-01806-3. PMID: 35665867Free PMC Article
Mitotic Index and Progression-Free Survival in Atypical Meningiomas.
Domingo RA, Tripathi S, Vivas-Buitrago T, Lu VM, Chaichana KL, Quiñones-Hinojosa A
World Neurosurg 2020 Oct;142:191-196. Epub 2020 Jun 29 doi: 10.1016/j.wneu.2020.06.189. PMID: 32615290

Recent systematic reviews

Should adjuvant radiotherapy be used in atypical meningioma (WHO grade 2) following gross total resection? A systematic review and Meta-analysis.
Wujanto C, Chan TY, Soon YY, Vellayappan B
Acta Oncol 2022 Sep;61(9):1075-1083. Epub 2022 Sep 2 doi: 10.1080/0284186X.2022.2116994. PMID: 36052871
Adjuvant radiotherapy versus observation following gross total resection for atypical meningioma: a systematic review and meta-analysis.
Chun SW, Kim KM, Kim MS, Kang H, Dho YS, Seo Y, Kim JW, Kim YH, Park CK
Radiat Oncol 2021 Feb 17;16(1):34. doi: 10.1186/s13014-021-01759-9. PMID: 33596974Free PMC Article
Association of Race with Survival in Intracranial World Health Organization Grade II and III Meningioma in the United States: Systematic Literature Review.
Elder T, Ejikeme T, Felton P, Raghavan A, Wright J, Wright CH, Zhou X, Duncan K, Sajatovic M, Hodges T
World Neurosurg 2020 Jun;138:e361-e369. Epub 2020 Mar 3 doi: 10.1016/j.wneu.2020.02.120. PMID: 32142947
A Systematic Review of Ion Radiotherapy in Maintaining Local Control Regarding Atypical and Anaplastic Meningiomas.
Coggins WS, Pham NK, Nguyen AV, Branch DW, Guillet JY, Korst G, Lall RR
World Neurosurg 2019 Dec;132:282-291. Epub 2019 Aug 30 doi: 10.1016/j.wneu.2019.08.149. PMID: 31476452
Adjuvant radiotherapy for atypical and malignant meningiomas: a systematic review.
Kaur G, Sayegh ET, Larson A, Bloch O, Madden M, Sun MZ, Barani IJ, James CD, Parsa AT
Neuro Oncol 2014 May;16(5):628-36. Epub 2014 Apr 2 doi: 10.1093/neuonc/nou025. PMID: 24696499Free PMC Article

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