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Larva migrans, visceral

MedGen UID:
9681
•Concept ID:
C0023049
•
Disease or Syndrome
Synonyms: Larva Migran, Visceral; Larva Migrans, Visceral; Migran, Visceral Larva; Migrans, Visceral Larva; Visceral Larva Migran; Visceral Larva Migrans; Visceral Larva Migrans Syndrome
SNOMED CT: Visceral larva migrans syndrome (87121004); Toxocaral visceral larva migrans (87121004)
 
Monarch Initiative: MONDO:0024954

Definition

A parasitic infection caused by worms found in domestic animals. In humans nematode larvae enter the portal system from the small intestine and disseminate in visceral organs causing inflammatory reactions. Signs and symptoms include eosinophilia, hepatomegaly, splenomegaly, and lung infections. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLarva migrans, visceral

Professional guidelines

PubMed

Eosinophilic pneumonias in children: A review of the epidemiology, diagnosis, and treatment.
Giovannini-Chami L, Blanc S, Hadchouel A, Baruchel A, Boukari R, Dubus JC, Fayon M, Le Bourgeois M, Nathan N, Albertini M, Clément A, de Blic J
Pediatr Pulmonol 2016 Feb;51(2):203-16. Epub 2015 Dec 30 doi: 10.1002/ppul.23368. PMID: 26716396
Visceral larva migrans: a risk assessment in Baton Rouge, Louisiana.
Smith RE, Hagstad HV, Beard GB
Int J Zoonoses 1984 Dec;11(2):189-94. PMID: 6534905
Thiabendazole treatment of presumptive visceral larva migrans (VLM).
Perrin J, Boxerbaum B, Doershuk CF
Clin Pediatr (Phila) 1975 Feb;14(2):147-50. doi: 10.1177/000992287501400206. PMID: 1112077

Recent clinical studies

Etiology

Visceral larva migrans in immigrants from latin america.
Turrientes MC, Perez de Ayala A, Norman F, Navarro M, Perez-Molina JA, Rodriquez-Ferrer M, Garate T, Lopez-Velez R
Emerg Infect Dis 2011 Jul;17(7):1263-5. doi: 10.3201/eid1707.101204. PMID: 21762582Free PMC Article
Parasitic pneumonia.
Berk SL, Verghese A
Semin Respir Infect 1988 Jun;3(2):172-8. PMID: 3041517
Zoonotic visceral and ocular larva migrans.
Glickman LT, Shofer FS
Vet Clin North Am Small Anim Pract 1987 Jan;17(1):39-53. doi: 10.1016/s0195-5616(87)50604-0. PMID: 3551310
Ocular toxocariasis: a review of the literature.
Molk R
Ann Ophthalmol 1983 Mar;15(3):216-9, 222-7, 230-1. PMID: 6342500
Children, pets, and disease.
Altamura RF
J Am Osteopath Assoc 1982 Jan;81(5):334-40. PMID: 7035416

Diagnosis

Hepatic Visceral Larva Migrans Causing Hepatic Artery Pseudo-Aneurysm.
Ritu, Madhusudhan KS, Malik R
Indian Pediatr 2021 Feb 15;58(2):184-186. doi: 10.1007/s13312-021-2141-6. PMID: 33632956Free PMC Article
Imaging of toxocariasis.
Dietrich CF, Cretu C, Dong Y
Adv Parasitol 2020;109:165-187. Epub 2020 Apr 25 doi: 10.1016/bs.apar.2020.03.001. PMID: 32381196
Toxocariasis in Japan.
Akao N, Ohta N
Parasitol Int 2007 Jun;56(2):87-93. Epub 2007 Jan 26 doi: 10.1016/j.parint.2007.01.009. PMID: 17317275
Visceral and ocular larva migrans.
Hotez PJ
Semin Neurol 1993 Jun;13(2):175-9. doi: 10.1055/s-2008-1041123. PMID: 8356352
Visceral larva migrans.
Cypress RH
Cornell Vet 1978 Jul;68(3):283-96. PMID: 352615

Therapy

The visceral larva migrans caused by Toxocara canis: a case report.
Gakosso LGC, Baadi F, Abakka FZ, Basraoui D, Jalal H
Pan Afr Med J 2020;36:150. Epub 2020 Jul 3 doi: 10.11604/pamj.2020.36.150.24176. PMID: 32874414Free PMC Article
Visceral larva migrans presenting as multiple liver abscesses.
Ramachandran J, Chandramohan A, Gangadharan SK, Unnikrishnan LS, Priyambada L, Simon A
Trop Doct 2013 Oct;43(4):154-7. Epub 2013 Oct 7 doi: 10.1177/0049475513507254. PMID: 24100348
Parasitic pulmonary eosinophilia.
Chitkara RK, Krishna G
Semin Respir Crit Care Med 2006 Apr;27(2):171-84. doi: 10.1055/s-2006-939520. PMID: 16612768
Human toxocariasis.
Gillespie SH
J Appl Bacteriol 1987 Dec;63(6):473-9. doi: 10.1111/j.1365-2672.1987.tb02716.x. PMID: 3326868
Thiabendazole in visceral larva migrans.
Aur RJ, Pratt CB, Johnson WW
Am J Dis Child 1971 Mar;121(3):226-9. doi: 10.1001/archpedi.1971.02100140092008. PMID: 5551874

Prognosis

Visceral larva Migrans in a Young Italian Patient: A Diagnostic Dilemma.
Francalanci E, Manciulli T, Bandini G, Blanc P, Bonelli SI, Brunetti E, Gotuzzo E, Cretu CM, Gobbi F, Bartoloni A, Zammarchi L
Acta Parasitol 2023 Dec;68(4):937-941. Epub 2023 Oct 23 doi: 10.1007/s11686-023-00723-9. PMID: 37872438Free PMC Article
Visceral larva migrans presenting as multiple liver abscesses.
Ramachandran J, Chandramohan A, Gangadharan SK, Unnikrishnan LS, Priyambada L, Simon A
Trop Doct 2013 Oct;43(4):154-7. Epub 2013 Oct 7 doi: 10.1177/0049475513507254. PMID: 24100348
Image of the month. Hepatic visceral larva migrans due to Toxocara Canis.
Chandrashekhara SH, Sharma R, Bagh S, Garg P
Gastroenterol Clin Biol 2010 Nov;34(11):573-4. Epub 2010 Oct 30 doi: 10.1016/j.gcb.2010.07.012. PMID: 21036500
Visceral larva migrans and tropical pyomyositis: a case report.
Lambertucci JR, Rayes A, Serufo JC, Teixeira DM, Gerspacher-Lara R, Nascimento E, Brasileiro Filho G, Silva AC
Rev Inst Med Trop Sao Paulo 1998 Nov-Dec;40(6):383-5. doi: 10.1590/s0036-46651998000600008. PMID: 10436659
Thiabendazole treatment of presumptive visceral larva migrans (VLM).
Perrin J, Boxerbaum B, Doershuk CF
Clin Pediatr (Phila) 1975 Feb;14(2):147-50. doi: 10.1177/000992287501400206. PMID: 1112077

Clinical prediction guides

Visceral larva Migrans in a Young Italian Patient: A Diagnostic Dilemma.
Francalanci E, Manciulli T, Bandini G, Blanc P, Bonelli SI, Brunetti E, Gotuzzo E, Cretu CM, Gobbi F, Bartoloni A, Zammarchi L
Acta Parasitol 2023 Dec;68(4):937-941. Epub 2023 Oct 23 doi: 10.1007/s11686-023-00723-9. PMID: 37872438Free PMC Article
The visceral larva migrans caused by Toxocara canis: a case report.
Gakosso LGC, Baadi F, Abakka FZ, Basraoui D, Jalal H
Pan Afr Med J 2020;36:150. Epub 2020 Jul 3 doi: 10.11604/pamj.2020.36.150.24176. PMID: 32874414Free PMC Article
Helminth Infections and Cardiovascular Diseases: Toxocara Species is Contributing to the Disease.
Zibaei M
Curr Cardiol Rev 2017;13(1):56-62. doi: 10.2174/1573403x12666160803100436. PMID: 27492228Free PMC Article
Image of the month. Hepatic visceral larva migrans due to Toxocara Canis.
Chandrashekhara SH, Sharma R, Bagh S, Garg P
Gastroenterol Clin Biol 2010 Nov;34(11):573-4. Epub 2010 Oct 30 doi: 10.1016/j.gcb.2010.07.012. PMID: 21036500
Visceral larva migrans: a seroepidemiological survey in five municipalities of São Paulo state, Brazil.
Chieffi PP, Ueda M, Camargo ED, de Souza AM, Guedes ML, Gerbi LJ, Spir M, Moreira AS
Rev Inst Med Trop Sao Paulo 1990 May-Jun;32(3):204-10. doi: 10.1590/s0036-46651990000300010. PMID: 2135374

Recent systematic reviews

Status of human toxocariasis, a neglected parasitic zoonosis in Iran: a systematic review from past to current.
Shafiei R, Rahimi MT, Emameh RZ, Mirzaei M, Perez-Cordon G, Ahmadpour E
Trop Doct 2020 Oct;50(4):285-291. Epub 2020 Jun 17 doi: 10.1177/0049475520931545. PMID: 32998656
Epidemiological situation of toxocariasis in Iran: meta-analysis and systematic review.
Abdi J, Darabi M, Sayehmiri K
Pak J Biol Sci 2012 Nov 15;15(22):1052-5. doi: 10.3923/pjbs.2012.1052.1055. PMID: 24261119

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