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Basal ganglia hemorrhage

MedGen UID:
96872
•Concept ID:
C0472377
•
Pathologic Function
Synonyms: Basal Ganglia Hemorrhage; Basal Ganglionic Hemorrhage; Ganglionic Hemorrhage, Basal; Hemorrhage, Basal Ganglia; Hemorrhage, Basal Ganglionic
SNOMED CT: Basal ganglia hemorrhage (195165005)

Definition

Bleeding within the subcortical regions of cerebral hemispheres (BASAL GANGLIA). It is often associated with HYPERTENSION or ARTERIOVENOUS MALFORMATIONS. Clinical manifestations may include HEADACHE; DYSKINESIAS; and HEMIPARESIS. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBasal ganglia hemorrhage

Professional guidelines

PubMed

Bilateral basal ganglia hemorrhage: a systematic review of etiologies, management strategies, and clinical outcomes.
Watanabe G, Conching A, Ogasawara C, Chavda V, Bin-Alamer O, Haider AS, Priola SM, Sharma M, Hoz SS, Chaurasia B, Umana GE, Palmisciano P
Neurosurg Rev 2023 Jun 5;46(1):135. doi: 10.1007/s10143-023-02044-x. PMID: 37273079Free PMC Article
Plasma ADAM-10 levels and functional outcome of acute primary basal ganglia hemorrhage.
Feng MJ, Wang W, Zhang XF, Che FF, Yang J, Ning WB, Gao W, Chen J
Clin Chim Acta 2022 Jan 1;524:18-24. Epub 2021 Nov 28 doi: 10.1016/j.cca.2021.11.026. PMID: 34852263
A Systematic Review and Meta-Analysis on the Treatment of Cerebral Hemorrhage with NaoXueShu Oral Liquid.
Wu L, Li Y, Wang X, Ren X, Zhu H, Sun Y, Xing Y, Zhu L, Gao Y, Shang H
Biomed Res Int 2017;2017:8542576. Epub 2017 May 29 doi: 10.1155/2017/8542576. PMID: 28630871Free PMC Article

Recent clinical studies

Etiology

Trial of Early Minimally Invasive Removal of Intracerebral Hemorrhage.
Pradilla G, Ratcliff JJ, Hall AJ, Saville BR, Allen JW, Paulon G, McGlothlin A, Lewis RJ, Fitzgerald M, Caveney AF, Li XT, Bain M, Gomes J, Jankowitz B, Zenonos G, Molyneaux BJ, Davies J, Siddiqui A, Chicoine MR, Keyrouz SG, Grossberg JA, Shah MV, Singh R, Bohnstedt BN, Frankel M, Wright DW, Barrow DL; ENRICH trial investigators; ENRICH Trial Investigators
N Engl J Med 2024 Apr 11;390(14):1277-1289. doi: 10.1056/NEJMoa2308440. PMID: 38598795
Bilateral basal ganglia hemorrhage: a systematic review of etiologies, management strategies, and clinical outcomes.
Watanabe G, Conching A, Ogasawara C, Chavda V, Bin-Alamer O, Haider AS, Priola SM, Sharma M, Hoz SS, Chaurasia B, Umana GE, Palmisciano P
Neurosurg Rev 2023 Jun 5;46(1):135. doi: 10.1007/s10143-023-02044-x. PMID: 37273079Free PMC Article
Antithrombotic medications and the etiology of intracerebral hemorrhage: MUCH-Italy.
Pezzini A, Grassi M, Paciaroni M, Zini A, Silvestrelli G, Del Zotto E, Caso V, Dell'Acqua ML, Giossi A, Volonghi I, Simone AM, Lanari A, Costa P, Poli L, Morotti A, De Giuli V, Pepe D, Gamba M, Ciccone A, Ritelli M, Colombi M, Agnelli G, Padovani A; Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy) Investigators
Neurology 2014 Feb 11;82(6):529-35. Epub 2014 Jan 15 doi: 10.1212/WNL.0000000000000108. PMID: 24431299
Surgical probings into the basal ganglia: Hemorrhage and hardware-related risks, and costs of microelectrode recording.
Hariz MI
Mov Disord 2011 Jul;26(8):1375-7. Epub 2011 Jun 28 doi: 10.1002/mds.23785. PMID: 21713998
Hypertensive basal ganglia hemorrhage: a prospective study comparing surgical and nonsurgical management.
Tan SH, Ng PY, Yeo TT, Wong SH, Ong PL, Venketasubramanian N
Surg Neurol 2001 Nov;56(5):287-92; discussion 292-3. doi: 10.1016/s0090-3019(01)00561-4. PMID: 11749988

Diagnosis

Good functional outcome following bilateral external capsule hemorrhage mimicking bilateral basal ganglia hemorrhage in a coma patient.
Xu F, Lian L, Liang Q, Deng G, Zhao J, Zhang M, Wang F, Zhu S
Br J Neurosurg 2023 Aug;37(4):682-684. Epub 2019 Jan 29 doi: 10.1080/02688697.2018.1559276. PMID: 30693794
Toluene Poisoning Presenting as Bilateral Basal Ganglia Haemorrhage.
Mahavar S, Chaturvedi A, Singh A, Kumar R, Dariya SS, Sharma R
J Assoc Physicians India 2018 Sep;66(9):93-94. PMID: 31321941
Simultaneous Bilateral Basal Ganglia Hemorrhage.
Yang Z, Chen J, Mu J
Curr Drug Deliv 2017 Sep 6;14(6):807-815. doi: 10.2174/1567201813666160607202811. PMID: 27305920
Antithrombotic medications and the etiology of intracerebral hemorrhage: MUCH-Italy.
Pezzini A, Grassi M, Paciaroni M, Zini A, Silvestrelli G, Del Zotto E, Caso V, Dell'Acqua ML, Giossi A, Volonghi I, Simone AM, Lanari A, Costa P, Poli L, Morotti A, De Giuli V, Pepe D, Gamba M, Ciccone A, Ritelli M, Colombi M, Agnelli G, Padovani A; Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy) Investigators
Neurology 2014 Feb 11;82(6):529-35. Epub 2014 Jan 15 doi: 10.1212/WNL.0000000000000108. PMID: 24431299
Association of interleukin-11 with mortality in patients with spontaneous basal ganglia haemorrhage.
Tu CJ, Liu WG, Dong XQ, Liu JS, Song DG, Yu WH, Zhang ZY, Zhen G, Lou HM
J Int Med Res 2011;39(4):1265-74. doi: 10.1177/147323001103900414. PMID: 21986128

Therapy

Trial of Early Minimally Invasive Removal of Intracerebral Hemorrhage.
Pradilla G, Ratcliff JJ, Hall AJ, Saville BR, Allen JW, Paulon G, McGlothlin A, Lewis RJ, Fitzgerald M, Caveney AF, Li XT, Bain M, Gomes J, Jankowitz B, Zenonos G, Molyneaux BJ, Davies J, Siddiqui A, Chicoine MR, Keyrouz SG, Grossberg JA, Shah MV, Singh R, Bohnstedt BN, Frankel M, Wright DW, Barrow DL; ENRICH trial investigators; ENRICH Trial Investigators
N Engl J Med 2024 Apr 11;390(14):1277-1289. doi: 10.1056/NEJMoa2308440. PMID: 38598795
Real-Time Distal, Multifocal, Repeated Lenticulostriate Bleeding Points during Thrombectomy in a Patient with Acute Variable M1 Occlusion: A Case Report and a Literature Review.
Peschillo S, Diana F, Colonnese C, Mellina V, Marzetti F, La Rosa I, Missori P
J Stroke Cerebrovasc Dis 2017 Oct;26(10):2082-2086. Epub 2017 Jun 1 doi: 10.1016/j.jstrokecerebrovasdis.2017.04.026. PMID: 28579509
Antithrombotic medications and the etiology of intracerebral hemorrhage: MUCH-Italy.
Pezzini A, Grassi M, Paciaroni M, Zini A, Silvestrelli G, Del Zotto E, Caso V, Dell'Acqua ML, Giossi A, Volonghi I, Simone AM, Lanari A, Costa P, Poli L, Morotti A, De Giuli V, Pepe D, Gamba M, Ciccone A, Ritelli M, Colombi M, Agnelli G, Padovani A; Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy) Investigators
Neurology 2014 Feb 11;82(6):529-35. Epub 2014 Jan 15 doi: 10.1212/WNL.0000000000000108. PMID: 24431299
Surgical probings into the basal ganglia: Hemorrhage and hardware-related risks, and costs of microelectrode recording.
Hariz MI
Mov Disord 2011 Jul;26(8):1375-7. Epub 2011 Jun 28 doi: 10.1002/mds.23785. PMID: 21713998
Hypertensive basal ganglia hemorrhage: a prospective study comparing surgical and nonsurgical management.
Tan SH, Ng PY, Yeo TT, Wong SH, Ong PL, Venketasubramanian N
Surg Neurol 2001 Nov;56(5):287-92; discussion 292-3. doi: 10.1016/s0090-3019(01)00561-4. PMID: 11749988

Prognosis

Bilateral basal ganglia hemorrhage: a systematic review of etiologies, management strategies, and clinical outcomes.
Watanabe G, Conching A, Ogasawara C, Chavda V, Bin-Alamer O, Haider AS, Priola SM, Sharma M, Hoz SS, Chaurasia B, Umana GE, Palmisciano P
Neurosurg Rev 2023 Jun 5;46(1):135. doi: 10.1007/s10143-023-02044-x. PMID: 37273079Free PMC Article
Simultaneous Bilateral Basal Ganglia Hemorrhage.
Yang Z, Chen J, Mu J
Curr Drug Deliv 2017 Sep 6;14(6):807-815. doi: 10.2174/1567201813666160607202811. PMID: 27305920
Antithrombotic medications and the etiology of intracerebral hemorrhage: MUCH-Italy.
Pezzini A, Grassi M, Paciaroni M, Zini A, Silvestrelli G, Del Zotto E, Caso V, Dell'Acqua ML, Giossi A, Volonghi I, Simone AM, Lanari A, Costa P, Poli L, Morotti A, De Giuli V, Pepe D, Gamba M, Ciccone A, Ritelli M, Colombi M, Agnelli G, Padovani A; Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy) Investigators
Neurology 2014 Feb 11;82(6):529-35. Epub 2014 Jan 15 doi: 10.1212/WNL.0000000000000108. PMID: 24431299
Hypertensive basal ganglia hemorrhage: a prospective study comparing surgical and nonsurgical management.
Tan SH, Ng PY, Yeo TT, Wong SH, Ong PL, Venketasubramanian N
Surg Neurol 2001 Nov;56(5):287-92; discussion 292-3. doi: 10.1016/s0090-3019(01)00561-4. PMID: 11749988
Striatocapsular haemorrhage.
Chung CS, Caplan LR, Yamamoto Y, Chang HM, Lee SJ, Song HJ, Lee HS, Shin HK, Yoo KM
Brain 2000 Sep;123 ( Pt 9):1850-62. doi: 10.1093/brain/123.9.1850. PMID: 10960049

Clinical prediction guides

Trial of Early Minimally Invasive Removal of Intracerebral Hemorrhage.
Pradilla G, Ratcliff JJ, Hall AJ, Saville BR, Allen JW, Paulon G, McGlothlin A, Lewis RJ, Fitzgerald M, Caveney AF, Li XT, Bain M, Gomes J, Jankowitz B, Zenonos G, Molyneaux BJ, Davies J, Siddiqui A, Chicoine MR, Keyrouz SG, Grossberg JA, Shah MV, Singh R, Bohnstedt BN, Frankel M, Wright DW, Barrow DL; ENRICH trial investigators; ENRICH Trial Investigators
N Engl J Med 2024 Apr 11;390(14):1277-1289. doi: 10.1056/NEJMoa2308440. PMID: 38598795
Bilateral basal ganglia hemorrhage: a systematic review of etiologies, management strategies, and clinical outcomes.
Watanabe G, Conching A, Ogasawara C, Chavda V, Bin-Alamer O, Haider AS, Priola SM, Sharma M, Hoz SS, Chaurasia B, Umana GE, Palmisciano P
Neurosurg Rev 2023 Jun 5;46(1):135. doi: 10.1007/s10143-023-02044-x. PMID: 37273079Free PMC Article
Smartphone navigated endoscopic port surgery of hypertensive basal ganglia hemorrhage.
Li F, Gan Z, Xu X, Zhao Y, Wang Q, Chen C, Liu H, Xiong R, Qi Z, Sun G, Zhang J, Xu B, Chen X
J Clin Neurosci 2022 Jul;101:193-197. Epub 2022 May 21 doi: 10.1016/j.jocn.2022.05.012. PMID: 35609413
Antithrombotic medications and the etiology of intracerebral hemorrhage: MUCH-Italy.
Pezzini A, Grassi M, Paciaroni M, Zini A, Silvestrelli G, Del Zotto E, Caso V, Dell'Acqua ML, Giossi A, Volonghi I, Simone AM, Lanari A, Costa P, Poli L, Morotti A, De Giuli V, Pepe D, Gamba M, Ciccone A, Ritelli M, Colombi M, Agnelli G, Padovani A; Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy) Investigators
Neurology 2014 Feb 11;82(6):529-35. Epub 2014 Jan 15 doi: 10.1212/WNL.0000000000000108. PMID: 24431299
Striatocapsular haemorrhage.
Chung CS, Caplan LR, Yamamoto Y, Chang HM, Lee SJ, Song HJ, Lee HS, Shin HK, Yoo KM
Brain 2000 Sep;123 ( Pt 9):1850-62. doi: 10.1093/brain/123.9.1850. PMID: 10960049

Recent systematic reviews

Neuroendoscopic surgery versus craniotomy for basal ganglia hemorrhage: a systematic review and meta-analysis of randomized controlled trials.
Lobo K, Santos C, Campos P, Oliveira L, da Silva VEB
Neurosurg Rev 2025 Jan 15;48(1):50. doi: 10.1007/s10143-025-03213-w. PMID: 39809946
Bilateral basal ganglia hemorrhage: a systematic review of etiologies, management strategies, and clinical outcomes.
Watanabe G, Conching A, Ogasawara C, Chavda V, Bin-Alamer O, Haider AS, Priola SM, Sharma M, Hoz SS, Chaurasia B, Umana GE, Palmisciano P
Neurosurg Rev 2023 Jun 5;46(1):135. doi: 10.1007/s10143-023-02044-x. PMID: 37273079Free PMC Article
Spontaneous Simultaneous Bilateral Basal Ganglia Hemorrhage (SSBBGH): Systematic Review and Data Analysis on Epidemiology, Clinical Feature, Location of Bleeding, Etiology, Therapeutic Intervention and Outcome.
Alhashim A, Hadhiah K, Al-Dandan H, Aljaman M, Alabdali M, Alshurem M, Aljaafari D, AlQarni M
Vasc Health Risk Manag 2022;18:267-276. Epub 2022 Apr 14 doi: 10.2147/VHRM.S349912. PMID: 35444424Free PMC Article
Hematoma location and morphology of anticoagulation-associated intracerebral hemorrhage.
Seiffge DJ, Curtze S, Dequatre-Ponchelle N, Pezzini A, Tatlisumak T, Cordonnier C, Werring D
Neurology 2019 Feb 19;92(8):e782-e791. Epub 2019 Jan 23 doi: 10.1212/WNL.0000000000006958. PMID: 30674603

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