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Tuftsin deficiency

MedGen UID:
98311
•Concept ID:
C0398741
•
Disease or Syndrome
Synonym: Tuftsin Deficiency
SNOMED CT: Tuftsin deficiency (234584007)
 
Monarch Initiative: MONDO:0008613
OMIM®: 191150

Clinical features

From HPO
Recurrent infections
MedGen UID:
65998
•Concept ID:
C0239998
•
Finding
Increased susceptibility to infections.
See: Feature record | Search on this feature
Abnormality of the spleen
MedGen UID:
871264
•Concept ID:
C4025749
•
Anatomical Abnormality
An abnormality of the spleen.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Potentiation of the defective monocyte chemotaxis in Hodgkin's disease by in vitro tuftsin treatment.
Lukács K, Berényi E, Kávai M, Szegedi G, Szekerke M
Cancer Immunol Immunother 1983;15(2):162-3. doi: 10.1007/BF00199710. PMID: 6553514Free PMC Article

Recent clinical studies

Etiology

Impaired splenic function and tuftsin deficiency in patients with intestinal failure on long term intravenous nutrition.
Zoli G, Corazza GR, Wood S, Bartoli R, Gasbarrini G, Farthing MJ
Gut 1998 Dec;43(6):759-62. doi: 10.1136/gut.43.6.759. PMID: 9824601Free PMC Article
Splenic autotransplantation after abdominal trauma in childhood. Clinical and experimental data.
Szendrói T, Mikó I, Hajdu Z, Acs G, Kathy S, Furka I, Szabó L
Acta Chir Hung 1997;36(1-4):349-51. PMID: 9408398
Tuftsin deficiency in AIDS.
Corazza GR, Zoli G, Ginaldi L, Cancellieri C, Profeta V, Gasbarrini G, Quaglino D
Lancet 1991 Jan 5;337(8732):12-3. doi: 10.1016/0140-6736(91)93331-3. PMID: 1670648
Congenital tuftsin deficiency.
Constantopoulos A
Ann N Y Acad Sci 1983;419:214-9. doi: 10.1111/j.1749-6632.1983.tb37106.x. PMID: 6201116
Immune function of the spleen.
Trigg ME
South Med J 1979 May;72(5):593-9. doi: 10.1097/00007611-197905000-00025. PMID: 375402

Therapy

Impaired splenic function and tuftsin deficiency in patients with intestinal failure on long term intravenous nutrition.
Zoli G, Corazza GR, Wood S, Bartoli R, Gasbarrini G, Farthing MJ
Gut 1998 Dec;43(6):759-62. doi: 10.1136/gut.43.6.759. PMID: 9824601Free PMC Article
Tuftsin deficiency in AIDS.
Corazza GR, Zoli G, Ginaldi L, Cancellieri C, Profeta V, Gasbarrini G, Quaglino D
Lancet 1991 Jan 5;337(8732):12-3. doi: 10.1016/0140-6736(91)93331-3. PMID: 1670648
Acquired tuftsin deficiency.
Spirer Z, Zakuth V, Orda R, Wiznitzer T, Mondorf W, Stefanescu T, Fridkin M
Ann N Y Acad Sci 1983;419:220-6. doi: 10.1111/j.1749-6632.1983.tb37107.x. PMID: 6424535
Congenital tuftsin deficiency.
Constantopoulos A
Ann N Y Acad Sci 1983;419:214-9. doi: 10.1111/j.1749-6632.1983.tb37106.x. PMID: 6201116
Immune function of the spleen.
Trigg ME
South Med J 1979 May;72(5):593-9. doi: 10.1097/00007611-197905000-00025. PMID: 375402

Prognosis

Impaired tuftsin activity in cirrhosis: relationship with splenic function and clinical outcome.
Trevisani F, Castelli E, Foschi FG, Parazza M, Loggi E, Bertelli M, Melotti C, Domenicali M, Zoli G, Bernardi M
Gut 2002 May;50(5):707-12. doi: 10.1136/gut.50.5.707. PMID: 11950821Free PMC Article
Splenic autotransplantation after abdominal trauma in childhood. Clinical and experimental data.
Szendrói T, Mikó I, Hajdu Z, Acs G, Kathy S, Furka I, Szabó L
Acta Chir Hung 1997;36(1-4):349-51. PMID: 9408398

Clinical prediction guides

Impaired tuftsin activity in cirrhosis: relationship with splenic function and clinical outcome.
Trevisani F, Castelli E, Foschi FG, Parazza M, Loggi E, Bertelli M, Melotti C, Domenicali M, Zoli G, Bernardi M
Gut 2002 May;50(5):707-12. doi: 10.1136/gut.50.5.707. PMID: 11950821Free PMC Article
Biochemical aspects of tuftsin deficiency syndrome.
Najjar VA
Med Biol 1981 Jun;59(3):134-8. PMID: 6895538

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