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Sebaceous hyperplasia

MedGen UID:
98352
Concept ID:
C0406484
Disease or Syndrome
Synonyms: Benign seborrheic hyperplasia; Sebaceous gland hyperplasia; Sebaceous Hyperplasia
SNOMED CT: Sebaceous gland hyperplasia (238748009); Sebaceous hyperplasia (238748009); Benign seborrheic hyperplasia (238748009)
 
HPO: HP:0032227

Definition

A common, benign skin condition involving hypertrophy of the sebaceous glands characterized by single or multiple lesions that manifest as yellow, soft, small papules with umbilication. The lesions are located commonly on the central face (specifically, the nose, cheeks and forehead) but may also occur elsewhere, including the chest, mouth, scrotum, foreskin, penile shaft, vulva, and areola. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSebaceous hyperplasia

Conditions with this feature

Sebaceous gland hyperplasia, familial presenile
MedGen UID:
356529
Concept ID:
C1866428
Disease or Syndrome
Sebaceous gland hyperplasia presents as one or more elevated, soft, yellow papules with central umbilication on the face, particularly the forehead. Lesions may spread to the neck and upper part of the thorax. Sebaceous gland hyperplasia occurs frequently in older individuals, particularly in men past middle age (Nomland, 1930). A premature form has its appearance during puberty or just afterwards, male predominance, and excessive sebaceous secretion. Most cases are sporadic (summary by Boonchai and Leenutaphong, 1997).
Birt-Hogg-Dube syndrome 1
MedGen UID:
1051978
Concept ID:
CN375946
Disease or Syndrome
Any Birt-Hogg-Dube (BHD) syndrome in which the cause of the disease is a variation in the FLCN gene.

Professional guidelines

PubMed

Mayur O, Martinez R, McNichol MC, McGee JS
Arch Dermatol Res 2023 Oct;315(8):2427-2429. Epub 2023 Apr 16 doi: 10.1007/s00403-023-02621-6. PMID: 37062777
Zhou YJ, Zheng DL, Hamblin MR, Xu YD, Wen X
Dermatol Ther 2022 Jul;35(7):e15548. Epub 2022 May 12 doi: 10.1111/dth.15548. PMID: 35502558
Chu S, Michelle L, Ekelem C, Sung CT, Rojek N, Mesinkovska NA
Arch Dermatol Res 2021 Aug;313(6):391-430. Epub 2020 Nov 5 doi: 10.1007/s00403-020-02152-4. PMID: 33151346

Recent clinical studies

Etiology

Shen-Wagner J, Amidon J, Carek S
Am Fam Physician 2024 Oct;110(4):353-361. PMID: 39418568
Naldi L, Venturuzzo A, Invernizzi P
Clin Rev Allergy Immunol 2018 Feb;54(1):185-212. doi: 10.1007/s12016-017-8657-9. PMID: 29177692
Flux K
Surg Pathol Clin 2017 Jun;10(2):367-382. doi: 10.1016/j.path.2017.01.009. PMID: 28477886
Richey DF
Dermatol Clin 2007 Jan;25(1):59-65. doi: 10.1016/j.det.2006.09.001. PMID: 17126742
Aloi F, Tomasini C, Soro E, Pippione M
J Am Acad Dermatol 2000 Mar;42(3):468-72. doi: 10.1016/s0190-9622(00)90220-2. PMID: 10688718

Diagnosis

Flux K
Surg Pathol Clin 2017 Jun;10(2):367-382. doi: 10.1016/j.path.2017.01.009. PMID: 28477886
Lipozenčić J, Hadžavdić SL
Clin Dermatol 2014 Jan-Feb;32(1):125-30. doi: 10.1016/j.clindermatol.2013.05.034. PMID: 24314386
Lipozencic J, Ljubojevic S
Clin Dermatol 2011 Mar-Apr;29(2):157-61. doi: 10.1016/j.clindermatol.2010.09.007. PMID: 21396555
Zaballos P, Ara M, Puig S, Malvehy J
Arch Dermatol 2005 Jun;141(6):808. doi: 10.1001/archderm.141.6.808. PMID: 15967945
Mallory SB
Pediatr Clin North Am 1991 Aug;38(4):745-61. doi: 10.1016/s0031-3955(16)38152-4. PMID: 1870904

Therapy

Chu S, Michelle L, Ekelem C, Sung CT, Rojek N, Mesinkovska NA
Arch Dermatol Res 2021 Aug;313(6):391-430. Epub 2020 Nov 5 doi: 10.1007/s00403-020-02152-4. PMID: 33151346
Naldi L, Venturuzzo A, Invernizzi P
Clin Rev Allergy Immunol 2018 Feb;54(1):185-212. doi: 10.1007/s12016-017-8657-9. PMID: 29177692
Liu YS, Cheng YP, Liu CI, Yang CY, Yang CY
J Dermatol 2016 Oct;43(10):1205-1208. doi: 10.1111/1346-8138.13416. PMID: 27130181
Lipozenčić J, Hadžavdić SL
Clin Dermatol 2014 Jan-Feb;32(1):125-30. doi: 10.1016/j.clindermatol.2013.05.034. PMID: 24314386
Lipozencic J, Ljubojevic S
Clin Dermatol 2011 Mar-Apr;29(2):157-61. doi: 10.1016/j.clindermatol.2010.09.007. PMID: 21396555

Prognosis

Cheng AY, Lan J, Lee CH
J Dermatol 2022 Jun;49(6):600-606. Epub 2022 Mar 22 doi: 10.1111/1346-8138.16351. PMID: 35318716
Chapireau D, Bashir SJ, Fan K
Prim Dent J 2020 Mar;9(1):37-42. doi: 10.1177/2050168420911028. PMID: 32519610
Kavoussi H, Rezaei M, Azimi M, Kavoussi R
Acta Dermatovenerol Alp Pannonica Adriat 2019 Mar;28(1):11-14. PMID: 30901063
Ataş H, Gönül M
J Cutan Med Surg 2017 May/Jun;21(3):202-206. Epub 2016 Dec 27 doi: 10.1177/1203475416685076. PMID: 28300439
Schwartz RA, Torre DP
J Am Acad Dermatol 1995 Jul;33(1):90-104. doi: 10.1016/0190-9622(95)90017-9. PMID: 7601953

Clinical prediction guides

Scarampella F, Colombo S, Dehesa A, Godizzi F, Cavicchini S, Fabbri E, Roccabianca P
Vet Dermatol 2023 Dec;34(6):597-607. Epub 2023 Jul 28 doi: 10.1111/vde.13196. PMID: 37503675
Naldi L, Venturuzzo A, Invernizzi P
Clin Rev Allergy Immunol 2018 Feb;54(1):185-212. doi: 10.1007/s12016-017-8657-9. PMID: 29177692
Markowitz O, Schwartz M, Minhas S, Siegel DM
Dermatol Online J 2016 Apr 18;22(4) PMID: 27617454
Liu YS, Cheng YP, Liu CI, Yang CY, Yang CY
J Dermatol 2016 Oct;43(10):1205-1208. doi: 10.1111/1346-8138.13416. PMID: 27130181
Krause W
J Dtsch Dermatol Ges 2011 Dec;9(12):1004-9. Epub 2011 Jun 9 doi: 10.1111/j.1610-0387.2011.07720.x. PMID: 21651722

Recent systematic reviews

Mayur O, Martinez R, McNichol MC, McGee JS
Arch Dermatol Res 2023 Oct;315(8):2427-2429. Epub 2023 Apr 16 doi: 10.1007/s00403-023-02621-6. PMID: 37062777
Chu S, Michelle L, Ekelem C, Sung CT, Rojek N, Mesinkovska NA
Arch Dermatol Res 2021 Aug;313(6):391-430. Epub 2020 Nov 5 doi: 10.1007/s00403-020-02152-4. PMID: 33151346

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