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Syringocystadenoma papilliferum

MedGen UID:
98362
Concept ID:
C0406803
Neoplastic Process
Synonyms: Papillary Syringocystadenoma; Papillary Syringocystadenomas; Papilliferum, Syringocystadenoma; Syringocystadenoma Papilliferum; Syringocystadenoma Papilliferums; Syringocystadenoma, Papillary
SNOMED CT: Papillary syringadenoma (8934006); Papillary syringocystadenoma (8934006); Syringocystadenoma papilliferum (8934006); Nevus syringocystadenomatosus papilliferus (239121009); Syringocystadenoma papilliferum (239121009)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
Concept ID:
CN307042
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
 
Monarch Initiative: MONDO:0019392
Orphanet: ORPHA840

Definition

A rare non-malignant adnexal neoplasm that originates from the apocrine or eccrine sweat glands and is characterized histologically by cystic, papillary, and ductal invaginations into the dermis lined by double-layered outer cuboidal and luminal high columnar epithelium and connected to the epidermis. Dilated capillaries and a dense infiltrate of plasma cells are characteristic. Clinically, lesions are asymptomatic with a heterogeneous, non-distinctive appearance ranging from skin-colored to pink papules or plaques, occurring most commonly in the head and neck area. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSyringocystadenoma papilliferum
Follow this link to review classifications for Syringocystadenoma papilliferum in Orphanet.

Professional guidelines

Recent clinical studies

Etiology

Aggarwal D, Chatterjee D, Keshavamurthy V, Chhikara K, Saikia UN, Radotra BD, De D, Singh MP
Indian J Dermatol Venereol Leprol 2023 Jan-Mar;89(2):266-273. doi: 10.25259/IJDVL_845_20. PMID: 34623039
McBride JD, Billings SD, Komforti MK
J Cutan Pathol 2021 Nov;48(11):1387-1391. Epub 2021 Jun 16 doi: 10.1111/cup.14080. PMID: 34089523
Jiao L, Han X, Xu J, Sun J, Ma L
Dermatol Ther 2020 Nov;33(6):e13762. Epub 2020 Jul 8 doi: 10.1111/dth.13762. PMID: 32495466
Narang T, De D, Dogra S, Saikia UN, Handa S
Arch Dermatol 2008 Nov;144(11):1509-14. doi: 10.1001/archderm.144.11.1509-b. PMID: 19015430
Karg E, Korom I, Varga E, Ban G, Turi S
Pediatr Dermatol 2008 Jan-Feb;25(1):132-3. doi: 10.1111/j.1525-1470.2007.00607.x. PMID: 18304179

Diagnosis

Hsieh MS, Bishop JA, Yu Fong Chang J
Surg Pathol Clin 2021 Mar;14(1):43-51. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.006. PMID: 33526222
Guerra-Jiménez G, González Aguado R, Arenas Rodríguez A, Ramos Macías Á
Acta Otorrinolaringol Esp (Engl Ed) 2017 Jul-Aug;68(4):235-237. Epub 2016 Sep 19 doi: 10.1016/j.otorri.2016.06.005. PMID: 27658577
Mundi JP, Rose AE, Boyd KP, Patel RR, Lipkin G
Dermatol Online J 2013 Dec 16;19(12):20722. PMID: 24365013
Ferringer T
Cutis 2011 Dec;88(6):268, 273-4. PMID: 22372162
Karg E, Korom I, Varga E, Ban G, Turi S
Pediatr Dermatol 2008 Jan-Feb;25(1):132-3. doi: 10.1111/j.1525-1470.2007.00607.x. PMID: 18304179

Therapy

Pang S, Cevik J, Sreedharan S, Wilks DJ
Ann Plast Surg 2024 Jun 1;92(6):711-719. Epub 2024 May 9 doi: 10.1097/SAP.0000000000003879. PMID: 38725109
Alegría-Landa V, Jo-Velasco M, Santonja C, Eraña I, Vergara-Sanchez A, Kutzner H, Requena L
J Cutan Pathol 2020 Jan;47(1):12-16. Epub 2019 Sep 4 doi: 10.1111/cup.13572. PMID: 31449665
Cassarino DS, Su A, Robbins BA, Altree-Tacha D, Ra S
J Cutan Pathol 2017 Jun;44(6):544-547. Epub 2017 Apr 20 doi: 10.1111/cup.12939. PMID: 28343365
Watanabe Y, Shido K, Niihori T, Niizuma H, Katata Y, Iizuka C, Oba D, Moriya K, Saito-Nanjo Y, Onuma M, Rikiishi T, Sasahara Y, Watanabe M, Aiba S, Saito R, Sonoda Y, Tominaga T, Aoki Y, Kure S
Am J Med Genet A 2016 Jan;170A(1):189-94. Epub 2015 Sep 11 doi: 10.1002/ajmg.a.37376. PMID: 26360803

Prognosis

Hsieh MS, Bishop JA, Yu Fong Chang J
Surg Pathol Clin 2021 Mar;14(1):43-51. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.006. PMID: 33526222
Satter E, Grady D, Schlocker CT
Dermatol Online J 2014 Apr 16;20(4):22335. PMID: 24746298
Idriss MH, Elston DM
J Am Acad Dermatol 2014 Feb;70(2):332-7. Epub 2013 Nov 20 doi: 10.1016/j.jaad.2013.10.004. PMID: 24268309
Narang T, De D, Dogra S, Saikia UN, Handa S
Arch Dermatol 2008 Nov;144(11):1509-14. doi: 10.1001/archderm.144.11.1509-b. PMID: 19015430
Karg E, Korom I, Varga E, Ban G, Turi S
Pediatr Dermatol 2008 Jan-Feb;25(1):132-3. doi: 10.1111/j.1525-1470.2007.00607.x. PMID: 18304179

Clinical prediction guides

Zwierz A, Masna K, Burduk P
J Int Adv Otol 2022 Nov;18(6):544-547. doi: 10.5152/iao.2022.21594. PMID: 36349679Free PMC Article
Jakobiec FA, Rai R, Lefebvre DR
Surv Ophthalmol 2014 Sep-Oct;59(5):540-7. Epub 2014 Jan 28 doi: 10.1016/j.survophthal.2014.01.002. PMID: 24661803
Minami Y, Uede K, Sagawa K, Kimura A, Tsuji T, Furukawa F
Br J Dermatol 2004 Jul;151(1):165-9. doi: 10.1111/j.1365-2133.2004.06079.x. PMID: 15270886
Aiba S, Tagami H
J Cutan Pathol 1989 Aug;16(4):207-10. doi: 10.1111/j.1600-0560.1989.tb00042.x. PMID: 2677069
Umbert P, Winkelmann RK
J Cutan Pathol 1976;3(2):75-87. doi: 10.1111/j.1600-0560.1976.tb00850.x. PMID: 993400

Recent systematic reviews

Wan L, Park A, Khachemoune A
Arch Dermatol Res 2024 Jun 21;316(7):421. doi: 10.1007/s00403-024-03176-w. PMID: 38904691
Pang S, Cevik J, Sreedharan S, Wilks DJ
Ann Plast Surg 2024 Jun 1;92(6):711-719. Epub 2024 May 9 doi: 10.1097/SAP.0000000000003879. PMID: 38725109

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