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Trisomy 12

MedGen UID:
98492
Concept ID:
C0432408
Disease or Syndrome
SNOMED CT: Trisomy 12 (205653005)

Definition

A chromosomal abnormality consisting of the presence of a third copy of chromosome 12 in somatic cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrisomy 12

Professional guidelines

PubMed

Jain N, Croner LJ, Allan JN, Siddiqi T, Tedeschi A, Badoux XC, Eckert K, Cheung LWK, Mukherjee A, Dean JP, Szafer-Glusman E, Seymour JF
Clin Cancer Res 2024 Feb 1;30(3):498-505. doi: 10.1158/1078-0432.CCR-22-3934. PMID: 37955424Free PMC Article
Nguyen-Khac F, Balogh Z, Chauzeix J, Veronese L, Chapiro E
Curr Res Transl Med 2023 Oct-Dec;71(4):103410. Epub 2023 Sep 17 doi: 10.1016/j.retram.2023.103410. PMID: 38039634
Gaidano G, Rossi D
Hematology Am Soc Hematol Educ Program 2017 Dec 8;2017(1):329-337. doi: 10.1182/asheducation-2017.1.329. PMID: 29222275Free PMC Article

Recent clinical studies

Etiology

Jain N, Croner LJ, Allan JN, Siddiqi T, Tedeschi A, Badoux XC, Eckert K, Cheung LWK, Mukherjee A, Dean JP, Szafer-Glusman E, Seymour JF
Clin Cancer Res 2024 Feb 1;30(3):498-505. doi: 10.1158/1078-0432.CCR-22-3934. PMID: 37955424Free PMC Article
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Javandoost E, Firoozi-Majd E, Rostamian H, Khakpoor-Koosheh M, Mirzaei HR
Curr Med Chem 2020;27(2):282-297. doi: 10.2174/0929867326666190911114842. PMID: 31544709
Autore F, Strati P, Laurenti L, Ferrajoli A
Haematologica 2018 Jun;103(6):931-938. Epub 2018 May 10 doi: 10.3324/haematol.2017.186684. PMID: 29748447Free PMC Article
Landau DA, Carter SL, Stojanov P, McKenna A, Stevenson K, Lawrence MS, Sougnez C, Stewart C, Sivachenko A, Wang L, Wan Y, Zhang W, Shukla SA, Vartanov A, Fernandes SM, Saksena G, Cibulskis K, Tesar B, Gabriel S, Hacohen N, Meyerson M, Lander ES, Neuberg D, Brown JR, Getz G, Wu CJ
Cell 2013 Feb 14;152(4):714-26. doi: 10.1016/j.cell.2013.01.019. PMID: 23415222Free PMC Article

Diagnosis

Nguyen-Khac F, Balogh Z, Chauzeix J, Veronese L, Chapiro E
Curr Res Transl Med 2023 Oct-Dec;71(4):103410. Epub 2023 Sep 17 doi: 10.1016/j.retram.2023.103410. PMID: 38039634
Javandoost E, Firoozi-Majd E, Rostamian H, Khakpoor-Koosheh M, Mirzaei HR
Curr Med Chem 2020;27(2):282-297. doi: 10.2174/0929867326666190911114842. PMID: 31544709
Autore F, Strati P, Laurenti L, Ferrajoli A
Haematologica 2018 Jun;103(6):931-938. Epub 2018 May 10 doi: 10.3324/haematol.2017.186684. PMID: 29748447Free PMC Article
Dietrich S, Oleś M, Lu J, Sellner L, Anders S, Velten B, Wu B, Hüllein J, da Silva Liberio M, Walther T, Wagner L, Rabe S, Ghidelli-Disse S, Bantscheff M, Oleś AK, Słabicki M, Mock A, Oakes CC, Wang S, Oppermann S, Lukas M, Kim V, Sill M, Benner A, Jauch A, Sutton LA, Young E, Rosenquist R, Liu X, Jethwa A, Lee KS, Lewis J, Putzker K, Lutz C, Rossi D, Mokhir A, Oellerich T, Zirlik K, Herling M, Nguyen-Khac F, Plass C, Andersson E, Mustjoki S, von Kalle C, Ho AD, Hensel M, Dürig J, Ringshausen I, Zapatka M, Huber W, Zenz T
J Clin Invest 2018 Jan 2;128(1):427-445. Epub 2017 Dec 11 doi: 10.1172/JCI93801. PMID: 29227286Free PMC Article
Chen CP, Su YN, Su JW, Chern SR, Chen YT, Chen LF, Wang W
Taiwan J Obstet Gynecol 2013 Mar;52(1):97-105. doi: 10.1016/j.tjog.2013.01.012. PMID: 23548227

Therapy

Jain N, Croner LJ, Allan JN, Siddiqi T, Tedeschi A, Badoux XC, Eckert K, Cheung LWK, Mukherjee A, Dean JP, Szafer-Glusman E, Seymour JF
Clin Cancer Res 2024 Feb 1;30(3):498-505. doi: 10.1158/1078-0432.CCR-22-3934. PMID: 37955424Free PMC Article
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Dietrich S, Oleś M, Lu J, Sellner L, Anders S, Velten B, Wu B, Hüllein J, da Silva Liberio M, Walther T, Wagner L, Rabe S, Ghidelli-Disse S, Bantscheff M, Oleś AK, Słabicki M, Mock A, Oakes CC, Wang S, Oppermann S, Lukas M, Kim V, Sill M, Benner A, Jauch A, Sutton LA, Young E, Rosenquist R, Liu X, Jethwa A, Lee KS, Lewis J, Putzker K, Lutz C, Rossi D, Mokhir A, Oellerich T, Zirlik K, Herling M, Nguyen-Khac F, Plass C, Andersson E, Mustjoki S, von Kalle C, Ho AD, Hensel M, Dürig J, Ringshausen I, Zapatka M, Huber W, Zenz T
J Clin Invest 2018 Jan 2;128(1):427-445. Epub 2017 Dec 11 doi: 10.1172/JCI93801. PMID: 29227286Free PMC Article
Decker S, Zirlik K, Djebatchie L, Hartmann D, Ihorst G, Schmitt-Graeff A, Herchenbach D, Jumaa H, Warmuth M, Veelken H, Dierks C
Blood 2012 Jan 26;119(4):997-1007. Epub 2011 Nov 30 doi: 10.1182/blood-2011-06-359075. PMID: 22130798
Tsimberidou AM, Keating MJ, Wierda WG
Curr Hematol Malig Rep 2007 Oct;2(4):265-71. doi: 10.1007/s11899-007-0036-9. PMID: 20425379

Prognosis

Hobeika C, Rached G, Chebly A, Chouery E, Kourie HR
Pharmacogenomics 2020 Aug;21(13):957-962. Epub 2020 Aug 17 doi: 10.2217/pgs-2020-0022. PMID: 32799640
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Autore F, Strati P, Laurenti L, Ferrajoli A
Haematologica 2018 Jun;103(6):931-938. Epub 2018 May 10 doi: 10.3324/haematol.2017.186684. PMID: 29748447Free PMC Article
Gaidano G, Rossi D
Hematology Am Soc Hematol Educ Program 2017 Dec 8;2017(1):329-337. doi: 10.1182/asheducation-2017.1.329. PMID: 29222275Free PMC Article
Sagatys EM, Zhang L
Cancer Control 2012 Jan;19(1):18-25. doi: 10.1177/107327481201900103. PMID: 22143059

Clinical prediction guides

Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Autore F, Strati P, Laurenti L, Ferrajoli A
Haematologica 2018 Jun;103(6):931-938. Epub 2018 May 10 doi: 10.3324/haematol.2017.186684. PMID: 29748447Free PMC Article
Amaya-Chanaga CI, Rassenti LZ
Best Pract Res Clin Haematol 2016 Mar;29(1):79-89. Epub 2016 Aug 10 doi: 10.1016/j.beha.2016.08.005. PMID: 27742074
Sagatys EM, Zhang L
Cancer Control 2012 Jan;19(1):18-25. doi: 10.1177/107327481201900103. PMID: 22143059
Zenz T, Döhner H, Stilgenbauer S
Best Pract Res Clin Haematol 2007 Sep;20(3):439-53. doi: 10.1016/j.beha.2007.02.006. PMID: 17707832

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