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BLOOD GROUP--LUTHERAN INHIBITOR(INLU)

MedGen UID:
266227
Concept ID:
C1292231
Finding
Synonyms: DOMINANT LU (a-b-) PHENOTYPE; INLU
SNOMED CT: In(Lu) phenotype (115824003); Dominant Lu(a-b-) phenotype (115824003)
 
Gene (location): KLF1 (19p13.13)
 
OMIM®: 111150

Professional guidelines

PubMed

Douketis JD, Spyropoulos AC, Murad MH, Arcelus JI, Dager WE, Dunn AS, Fargo RA, Levy JH, Samama CM, Shah SH, Sherwood MW, Tafur AJ, Tang LV, Moores LK
Chest 2022 Nov;162(5):e207-e243. Epub 2022 Aug 11 doi: 10.1016/j.chest.2022.07.025. PMID: 35964704
Kamada T, Satoh K, Itoh T, Ito M, Iwamoto J, Okimoto T, Kanno T, Sugimoto M, Chiba T, Nomura S, Mieda M, Hiraishi H, Yoshino J, Takagi A, Watanabe S, Koike K
J Gastroenterol 2021 Apr;56(4):303-322. Epub 2021 Feb 23 doi: 10.1007/s00535-021-01769-0. PMID: 33620586Free PMC Article
Kearon C, Akl EA, Comerota AJ, Prandoni P, Bounameaux H, Goldhaber SZ, Nelson ME, Wells PS, Gould MK, Dentali F, Crowther M, Kahn SR
Chest 2012 Feb;141(2 Suppl):e419S-e496S. doi: 10.1378/chest.11-2301. PMID: 22315268Free PMC Article

Recent clinical studies

Etiology

Connolly SJ, Sharma M, Cohen AT, Demchuk AM, Członkowska A, Lindgren AG, Molina CA, Bereczki D, Toni D, Seiffge DJ, Tanne D, Sandset EC, Tsivgoulis G, Christensen H, Beyer-Westendorf J, Coutinho JM, Crowther M, Verhamme P, Amarenco P, Roine RO, Mikulik R, Lemmens R, Veltkamp R, Middeldorp S, Robinson TG, Milling TJ Jr, Tedim-Cruz V, Lang W, Himmelmann A, Ladenvall P, Knutsson M, Ekholm E, Law A, Taylor A, Karyakina T, Xu L, Tsiplova K, Poli S, Kallmünzer B, Gumbinger C, Shoamanesh A; ANNEXA-I Investigators
N Engl J Med 2024 May 16;390(19):1745-1755. doi: 10.1056/NEJMoa2313040. PMID: 38749032
Plow EF, Wang Y, Simon DI
Blood 2018 Apr 26;131(17):1899-1902. Epub 2018 Feb 21 doi: 10.1182/blood-2017-10-784074. PMID: 29467183Free PMC Article
Shatzel JJ, Olson SR, Tao DL, McCarty OJT, Danilov AV, DeLoughery TG
J Thromb Haemost 2017 May;15(5):835-847. Epub 2017 Mar 27 doi: 10.1111/jth.13651. PMID: 28182323Free PMC Article
Rand JH, Wolgast LR
Hematology Am Soc Hematol Educ Program 2012;2012:455-9. doi: 10.1182/asheducation-2012.1.455. PMID: 23233619
Kozek-Langenecker SA
Wien Med Wochenschr 2011 Feb;161(3-4):63-7. doi: 10.1007/s10354-011-0877-7. PMID: 21404141

Diagnosis

Contreras-Pizarro CH, Chumpitaz-Anchiraico G, Ticona Sanjínez R, Peña-Diaz C
Rev Peru Med Exp Salud Publica 2023 Apr-Jun;40(2):242-246. doi: 10.17843/rpmesp.2023.402.12593. PMID: 38232272Free PMC Article
Roh D, Reznik M, Claassen J
Neurosurg Clin N Am 2017 Apr;28(2):211-217. Epub 2017 Feb 1 doi: 10.1016/j.nec.2016.11.003. PMID: 28325455
Martin K, Beyer-Westendorf J, Davidson BL, Huisman MV, Sandset PM, Moll S
J Thromb Haemost 2016 Jun;14(6):1308-13. Epub 2016 Apr 27 doi: 10.1111/jth.13323. PMID: 27299806Free PMC Article
Kulkarni R, Soucie JM
Semin Thromb Hemost 2011 Oct;37(7):737-44. Epub 2011 Dec 20 doi: 10.1055/s-0031-1297164. PMID: 22187396
Br Med J 1974 Mar 9;1(5905):446-8. PMID: 4816858Free PMC Article

Therapy

Connolly SJ, Sharma M, Cohen AT, Demchuk AM, Członkowska A, Lindgren AG, Molina CA, Bereczki D, Toni D, Seiffge DJ, Tanne D, Sandset EC, Tsivgoulis G, Christensen H, Beyer-Westendorf J, Coutinho JM, Crowther M, Verhamme P, Amarenco P, Roine RO, Mikulik R, Lemmens R, Veltkamp R, Middeldorp S, Robinson TG, Milling TJ Jr, Tedim-Cruz V, Lang W, Himmelmann A, Ladenvall P, Knutsson M, Ekholm E, Law A, Taylor A, Karyakina T, Xu L, Tsiplova K, Poli S, Kallmünzer B, Gumbinger C, Shoamanesh A; ANNEXA-I Investigators
N Engl J Med 2024 May 16;390(19):1745-1755. doi: 10.1056/NEJMoa2313040. PMID: 38749032
Li Q, Yakhkind A, Alexandrov AW, Alexandrov AV, Anderson CS, Dowlatshahi D, Frontera JA, Hemphill JC, Ganti L, Kellner C, May C, Morotti A, Parry-Jones A, Sheth KN, Steiner T, Ziai W, Goldstein JN, Mayer SA
Stroke 2024 Feb;55(2):494-505. Epub 2023 Dec 15 doi: 10.1161/STROKEAHA.123.043033. PMID: 38099439
Roh D, Reznik M, Claassen J
Neurosurg Clin N Am 2017 Apr;28(2):211-217. Epub 2017 Feb 1 doi: 10.1016/j.nec.2016.11.003. PMID: 28325455
Kulkarni R, Soucie JM
Semin Thromb Hemost 2011 Oct;37(7):737-44. Epub 2011 Dec 20 doi: 10.1055/s-0031-1297164. PMID: 22187396
Hanley JP
J Clin Pathol 2004 Nov;57(11):1132-9. doi: 10.1136/jcp.2003.008904. PMID: 15509671Free PMC Article

Prognosis

Li Q, Yakhkind A, Alexandrov AW, Alexandrov AV, Anderson CS, Dowlatshahi D, Frontera JA, Hemphill JC, Ganti L, Kellner C, May C, Morotti A, Parry-Jones A, Sheth KN, Steiner T, Ziai W, Goldstein JN, Mayer SA
Stroke 2024 Feb;55(2):494-505. Epub 2023 Dec 15 doi: 10.1161/STROKEAHA.123.043033. PMID: 38099439
Paydas S
Crit Rev Oncol Hematol 2019 Apr;136:56-63. Epub 2019 Feb 10 doi: 10.1016/j.critrevonc.2019.02.001. PMID: 30878129
McNeil JJ, Nelson MR, Woods RL, Lockery JE, Wolfe R, Reid CM, Kirpach B, Shah RC, Ives DG, Storey E, Ryan J, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Radziszewska B, Grimm R, Murray AM; ASPREE Investigator Group
N Engl J Med 2018 Oct 18;379(16):1519-1528. Epub 2018 Sep 16 doi: 10.1056/NEJMoa1803955. PMID: 30221595Free PMC Article
Mehta V, Harward SC, Sankey EW, Nayar G, Codd PJ
J Clin Neurosci 2018 Apr;50:7-15. Epub 2018 Feb 7 doi: 10.1016/j.jocn.2018.01.050. PMID: 29428263
Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA, Tiede A, Kessler CM
Am J Hematol 2017 Jul;92(7):695-705. Epub 2017 Jun 5 doi: 10.1002/ajh.24777. PMID: 28470674

Clinical prediction guides

Connolly SJ, Sharma M, Cohen AT, Demchuk AM, Członkowska A, Lindgren AG, Molina CA, Bereczki D, Toni D, Seiffge DJ, Tanne D, Sandset EC, Tsivgoulis G, Christensen H, Beyer-Westendorf J, Coutinho JM, Crowther M, Verhamme P, Amarenco P, Roine RO, Mikulik R, Lemmens R, Veltkamp R, Middeldorp S, Robinson TG, Milling TJ Jr, Tedim-Cruz V, Lang W, Himmelmann A, Ladenvall P, Knutsson M, Ekholm E, Law A, Taylor A, Karyakina T, Xu L, Tsiplova K, Poli S, Kallmünzer B, Gumbinger C, Shoamanesh A; ANNEXA-I Investigators
N Engl J Med 2024 May 16;390(19):1745-1755. doi: 10.1056/NEJMoa2313040. PMID: 38749032
Li Q, Yakhkind A, Alexandrov AW, Alexandrov AV, Anderson CS, Dowlatshahi D, Frontera JA, Hemphill JC, Ganti L, Kellner C, May C, Morotti A, Parry-Jones A, Sheth KN, Steiner T, Ziai W, Goldstein JN, Mayer SA
Stroke 2024 Feb;55(2):494-505. Epub 2023 Dec 15 doi: 10.1161/STROKEAHA.123.043033. PMID: 38099439
Douxfils J, Adcock DM, Bates SM, Favaloro EJ, Gouin-Thibault I, Guillermo C, Kawai Y, Lindhoff-Last E, Kitchen S, Gosselin RC
Thromb Haemost 2021 Aug;121(8):1008-1020. Epub 2021 May 30 doi: 10.1055/a-1450-8178. [Epub ahead of print] PMID: 33742436
Newland A, Lee EJ, McDonald V, Bussel JB
Immunotherapy 2018 Jan;10(1):9-25. Epub 2017 Oct 2 doi: 10.2217/imt-2017-0097. PMID: 28967793
Flaherty ML
Semin Neurol 2010 Nov;30(5):565-72. Epub 2011 Jan 4 doi: 10.1055/s-0030-1268866. PMID: 21207349

Recent systematic reviews

Key NS, Khorana AA, Kuderer NM, Bohlke K, Lee AYY, Arcelus JI, Wong SL, Balaban EP, Flowers CR, Gates LE, Kakkar AK, Tempero MA, Gupta S, Lyman GH, Falanga A
J Clin Oncol 2023 Jun 1;41(16):3063-3071. Epub 2023 Apr 19 doi: 10.1200/JCO.23.00294. PMID: 37075273
Costa F, Montalto C, Branca M, Hong SJ, Watanabe H, Franzone A, Vranckx P, Hahn JY, Gwon HC, Feres F, Jang Y, De Luca G, Kedhi E, Cao D, Steg PG, Bhatt DL, Stone GW, Micari A, Windecker S, Kimura T, Hong MK, Mehran R, Valgimigli M
Eur Heart J 2023 Mar 14;44(11):954-968. doi: 10.1093/eurheartj/ehac706. PMID: 36477292
Khairani CD, Bejjani A, Piazza G, Jimenez D, Monreal M, Chatterjee S, Pengo V, Woller SC, Cortes-Hernandez J, Connors JM, Kanthi Y, Krumholz HM, Middeldorp S, Falanga A, Cushman M, Goldhaber SZ, Garcia DA, Bikdeli B
J Am Coll Cardiol 2023 Jan 3;81(1):16-30. Epub 2022 Oct 31 doi: 10.1016/j.jacc.2022.10.008. PMID: 36328154Free PMC Article
Wang Y, Ye Z, Ge L, Siemieniuk RAC, Wang X, Wang Y, Hou L, Ma Z, Agoritsas T, Vandvik PO, Perner A, Møller MH, Guyatt GH, Liu L
BMJ 2020 Jan 6;368:l6744. doi: 10.1136/bmj.l6744. PMID: 31907166Free PMC Article
Stanley AJ, Laine L
BMJ 2019 Mar 25;364:l536. doi: 10.1136/bmj.l536. PMID: 30910853

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