U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Myopia 6(MYP6)

MedGen UID:
324696
Concept ID:
C1837148
Disease or Syndrome
Synonyms: Myopia, susceptibility to; MYP6
 
Gene (location): SCO2 (22q13.33)
 
Monarch Initiative: MONDO:0012154
OMIM®: 608908

Definition

Myopia, or nearsightedness, is a refractive error of the eye. Light rays from a distant object are focused in front of the retina and those from a near object are focused in the retina; therefore distant objects are blurry and near objects are clear (summary by Kaiser et al., 2004). For a discussion of genetic heterogeneity of susceptibility to myopia, see 160700. [from OMIM]

Clinical features

From HPO
High myopia
MedGen UID:
78759
Concept ID:
C0271183
Disease or Syndrome
A severe form of myopia with greater than -6.00 diopters.

Professional guidelines

PubMed

Tomioka M, Murakami T, Okamoto F, Kinoshita T, Shinomiya K, Nishi T, Jujo T, Obata S, Tsukitome H, Ogura S, Ueda K, Ishii R, Oshika T
Retina 2024 Apr 1;44(4):652-658. doi: 10.1097/IAE.0000000000004016. PMID: 38064668
Moussa G, Samia-Aly E, Ch'ng SW, Lett KS, Mitra A, Tyagi AK, Sharma A, Andreatta W
Eye (Lond) 2022 May;36(5):1080-1085. Epub 2021 May 25 doi: 10.1038/s41433-021-01581-3. PMID: 34035492Free PMC Article
Zheng H, Song L
Eye Sci 2011 Dec;26(4):208-10, 216. doi: 10.3969/j.issn.1000-4432.2011.04.005. PMID: 22187304

Recent clinical studies

Etiology

Shah R, Vlasak N, Evans BJW
Ophthalmic Physiol Opt 2024 Sep;44(6):1248-1260. Epub 2024 Jul 31 doi: 10.1111/opo.13366. PMID: 39082137
Flitcroft I, Ainsworth J, Chia A, Cotter S, Harb E, Jin ZB, Klaver CCW, Moore AT, Nischal KK, Ohno-Matsui K, Paysse EA, Repka MX, Smirnova IY, Snead M, Verhoeven VJM, Verkicharla PK
Invest Ophthalmol Vis Sci 2023 May 1;64(6):3. doi: 10.1167/iovs.64.6.3. PMID: 37126360Free PMC Article
Wu PC, Huang HM, Yu HJ, Fang PC, Chen CT
Asia Pac J Ophthalmol (Phila) 2016 Nov/Dec;5(6):386-393. doi: 10.1097/APO.0000000000000236. PMID: 27898441
Rodríguez Uña I, Pérez Bartolomé F, Urriés Ortiz M, Arriola Villalobos P, Bermúdez Vallecilla M, Fernández-Vega Cueto L, Martín Villaescusa C, Marticorena Álvarez P
Arch Soc Esp Oftalmol 2015 Aug;90(8):365-72. Epub 2015 Mar 24 doi: 10.1016/j.oftal.2015.01.005. PMID: 25817967
Lee JH, Jee D, Kwon JW, Lee WK
Invest Ophthalmol Vis Sci 2013 Aug 13;54(8):5466-71. doi: 10.1167/iovs.13-12478. PMID: 23838769

Diagnosis

Alvarez-Peregrina C, Sanchez-Tena MA, Martinez-Perez C, Villa-Collar C; Clinical Evaluation of MyoCare in Europe –the CEME Study Group, Ohlendorf A
Trials 2023 Oct 17;24(1):674. doi: 10.1186/s13063-023-07696-0. PMID: 37848908Free PMC Article
Flitcroft I, Ainsworth J, Chia A, Cotter S, Harb E, Jin ZB, Klaver CCW, Moore AT, Nischal KK, Ohno-Matsui K, Paysse EA, Repka MX, Smirnova IY, Snead M, Verhoeven VJM, Verkicharla PK
Invest Ophthalmol Vis Sci 2023 May 1;64(6):3. doi: 10.1167/iovs.64.6.3. PMID: 37126360Free PMC Article
Pang Y, Allen M, Robinson J, Frantz KA
Clin Exp Optom 2019 Jan;102(1):57-62. Epub 2018 Jul 28 doi: 10.1111/cxo.12817. PMID: 30054940
Querques G, Corvi F, Querques L, Souied EH, Bandello F
Dev Ophthalmol 2016;56:101-6. Epub 2016 Mar 15 doi: 10.1159/000442800. PMID: 27023343
Wu LJ, You QS, Duan JL, Luo YX, Liu LJ, Li X, Gao Q, Zhu HP, He Y, Xu L, Jonas JB, Wang W, Guo XH
PLoS One 2015;10(3):e0120764. Epub 2015 Mar 24 doi: 10.1371/journal.pone.0120764. PMID: 25803875Free PMC Article

Therapy

Lee SS, Lingham G, Clark A, Read SA, Alonso-Caneiro D, Mackey DA
Invest Ophthalmol Vis Sci 2024 Aug 1;65(10):21. doi: 10.1167/iovs.65.10.21. PMID: 39136629Free PMC Article
Alvarez-Peregrina C, Sanchez-Tena MA, Martinez-Perez C, Villa-Collar C; Clinical Evaluation of MyoCare in Europe –the CEME Study Group, Ohlendorf A
Trials 2023 Oct 17;24(1):674. doi: 10.1186/s13063-023-07696-0. PMID: 37848908Free PMC Article
Tsai TH, Liu YL, Ma IH, Su CC, Lin CW, Lin LL, Hsiao CK, Wang IJ
Ophthalmology 2021 Feb;128(2):290-301. Epub 2020 Jul 15 doi: 10.1016/j.ophtha.2020.07.017. PMID: 32679159
Wu PC, Huang HM, Yu HJ, Fang PC, Chen CT
Asia Pac J Ophthalmol (Phila) 2016 Nov/Dec;5(6):386-393. doi: 10.1097/APO.0000000000000236. PMID: 27898441
Wu LJ, You QS, Duan JL, Luo YX, Liu LJ, Li X, Gao Q, Zhu HP, He Y, Xu L, Jonas JB, Wang W, Guo XH
PLoS One 2015;10(3):e0120764. Epub 2015 Mar 24 doi: 10.1371/journal.pone.0120764. PMID: 25803875Free PMC Article

Prognosis

Lee SS, Lingham G, Clark A, Read SA, Alonso-Caneiro D, Mackey DA
Invest Ophthalmol Vis Sci 2024 Aug 1;65(10):21. doi: 10.1167/iovs.65.10.21. PMID: 39136629Free PMC Article
Shafer BM, Qiu M, Rapuano CJ, Shields CL
Eye Contact Lens 2017 May;43(3):186-191. doi: 10.1097/ICL.0000000000000251. PMID: 26974535
Wu PC, Huang HM, Yu HJ, Fang PC, Chen CT
Asia Pac J Ophthalmol (Phila) 2016 Nov/Dec;5(6):386-393. doi: 10.1097/APO.0000000000000236. PMID: 27898441
Mirshahi A, Ponto KA, Laubert-Reh D, Rahm B, Lackner KJ, Binder H, Pfeiffer N, Unterrainer JM
Invest Ophthalmol Vis Sci 2016 Oct 1;57(13):5230-5236. doi: 10.1167/iovs.16-19507. PMID: 27701634
Younan C, Mitchell P, Cumming RG, Rochtchina E, Wang JJ
Invest Ophthalmol Vis Sci 2002 Dec;43(12):3625-32. PMID: 12454028

Clinical prediction guides

Delgado-Tirado S, López-Miguel A, Báez-Peralta Y, González-Buendía L, Fernández I, Alió JL, Maldonado MJ, Coco-Martín RM
BMC Ophthalmol 2021 May 18;21(1):223. doi: 10.1186/s12886-021-01965-9. PMID: 34006229Free PMC Article
Shafer BM, Qiu M, Rapuano CJ, Shields CL
Eye Contact Lens 2017 May;43(3):186-191. doi: 10.1097/ICL.0000000000000251. PMID: 26974535
Wu PC, Huang HM, Yu HJ, Fang PC, Chen CT
Asia Pac J Ophthalmol (Phila) 2016 Nov/Dec;5(6):386-393. doi: 10.1097/APO.0000000000000236. PMID: 27898441
Rodríguez Uña I, Pérez Bartolomé F, Urriés Ortiz M, Arriola Villalobos P, Bermúdez Vallecilla M, Fernández-Vega Cueto L, Martín Villaescusa C, Marticorena Álvarez P
Arch Soc Esp Oftalmol 2015 Aug;90(8):365-72. Epub 2015 Mar 24 doi: 10.1016/j.oftal.2015.01.005. PMID: 25817967
McBrien NA
Exp Eye Res 2013 Sep;114:128-40. Epub 2013 Feb 8 doi: 10.1016/j.exer.2013.01.014. PMID: 23399866

Recent systematic reviews

Chen CW, Yao JY
Indian J Ophthalmol 2024 Nov 1;72(Suppl 5):S721-S727. Epub 2024 Aug 14 doi: 10.4103/IJO.IJO_1909_23. PMID: 39141497
Pakbin M, Khabazkhoob M, Pakravan M, Fotouhi A, Jafarzadehpour E, Aghamirsalim M, Seyedian MA, Hashemi H
J Cataract Refract Surg 2020 Apr;46(4):622-632. doi: 10.1097/j.jcrs.0000000000000060. PMID: 32271298
Hollands H, Johnson D, Hollands S, Simel DL, Jinapriya D, Sharma S
JAMA 2013 May 15;309(19):2035-42. doi: 10.1001/jama.2013.5099. PMID: 23677315

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...