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Alzheimer disease, early-onset, with cerebral amyloid angiopathy

MedGen UID:
400198
Concept ID:
C1863053
Disease or Syndrome
Synonym: Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
 
OMIM®: 104300; 104760

Professional guidelines

PubMed

Cozza M, Amadori L, Boccardi V
J Neurol Sci 2023 Nov 15;454:120866. Epub 2023 Nov 2 doi: 10.1016/j.jns.2023.120866. PMID: 37931443
Charidimou A, Boulouis G, Frosch MP, Baron JC, Pasi M, Albucher JF, Banerjee G, Barbato C, Bonneville F, Brandner S, Calviere L, Caparros F, Casolla B, Cordonnier C, Delisle MB, Deramecourt V, Dichgans M, Gokcal E, Herms J, Hernandez-Guillamon M, Jäger HR, Jaunmuktane Z, Linn J, Martinez-Ramirez S, Martínez-Sáez E, Mawrin C, Montaner J, Moulin S, Olivot JM, Piazza F, Puy L, Raposo N, Rodrigues MA, Roeber S, Romero JR, Samarasekera N, Schneider JA, Schreiber S, Schreiber F, Schwall C, Smith C, Szalardy L, Varlet P, Viguier A, Wardlaw JM, Warren A, Wollenweber FA, Zedde M, van Buchem MA, Gurol ME, Viswanathan A, Al-Shahi Salman R, Smith EE, Werring DJ, Greenberg SM
Lancet Neurol 2022 Aug;21(8):714-725. doi: 10.1016/S1474-4422(22)00208-3. PMID: 35841910Free PMC Article
Auriel E, Charidimou A, Gurol ME, Ni J, Van Etten ES, Martinez-Ramirez S, Boulouis G, Piazza F, DiFrancesco JC, Frosch MP, Pontes-Neto OV, Shoamanesh A, Reijmer Y, Vashkevich A, Ayres AM, Schwab KM, Viswanathan A, Greenberg SM
JAMA Neurol 2016 Feb;73(2):197-202. doi: 10.1001/jamaneurol.2015.4078. PMID: 26720093

Recent clinical studies

Etiology

Cozza M, Amadori L, Boccardi V
J Neurol Sci 2023 Nov 15;454:120866. Epub 2023 Nov 2 doi: 10.1016/j.jns.2023.120866. PMID: 37931443
Inoue Y, Shue F, Bu G, Kanekiyo T
Mol Neurodegener 2023 Jul 11;18(1):46. doi: 10.1186/s13024-023-00640-5. PMID: 37434208Free PMC Article
Hampel H, Elhage A, Cho M, Apostolova LG, Nicoll JAR, Atri A
Brain 2023 Nov 2;146(11):4414-4424. doi: 10.1093/brain/awad188. PMID: 37280110Free PMC Article
Charidimou A, Boulouis G, Frosch MP, Baron JC, Pasi M, Albucher JF, Banerjee G, Barbato C, Bonneville F, Brandner S, Calviere L, Caparros F, Casolla B, Cordonnier C, Delisle MB, Deramecourt V, Dichgans M, Gokcal E, Herms J, Hernandez-Guillamon M, Jäger HR, Jaunmuktane Z, Linn J, Martinez-Ramirez S, Martínez-Sáez E, Mawrin C, Montaner J, Moulin S, Olivot JM, Piazza F, Puy L, Raposo N, Rodrigues MA, Roeber S, Romero JR, Samarasekera N, Schneider JA, Schreiber S, Schreiber F, Schwall C, Smith C, Szalardy L, Varlet P, Viguier A, Wardlaw JM, Warren A, Wollenweber FA, Zedde M, van Buchem MA, Gurol ME, Viswanathan A, Al-Shahi Salman R, Smith EE, Werring DJ, Greenberg SM
Lancet Neurol 2022 Aug;21(8):714-725. doi: 10.1016/S1474-4422(22)00208-3. PMID: 35841910Free PMC Article
Chang Wong E, Chang Chui H
Continuum (Minneap Minn) 2022 Jun 1;28(3):750-780. doi: 10.1212/CON.0000000000001124. PMID: 35678401Free PMC Article

Diagnosis

Inoue Y, Shue F, Bu G, Kanekiyo T
Mol Neurodegener 2023 Jul 11;18(1):46. doi: 10.1186/s13024-023-00640-5. PMID: 37434208Free PMC Article
Charidimou A, Boulouis G, Frosch MP, Baron JC, Pasi M, Albucher JF, Banerjee G, Barbato C, Bonneville F, Brandner S, Calviere L, Caparros F, Casolla B, Cordonnier C, Delisle MB, Deramecourt V, Dichgans M, Gokcal E, Herms J, Hernandez-Guillamon M, Jäger HR, Jaunmuktane Z, Linn J, Martinez-Ramirez S, Martínez-Sáez E, Mawrin C, Montaner J, Moulin S, Olivot JM, Piazza F, Puy L, Raposo N, Rodrigues MA, Roeber S, Romero JR, Samarasekera N, Schneider JA, Schreiber S, Schreiber F, Schwall C, Smith C, Szalardy L, Varlet P, Viguier A, Wardlaw JM, Warren A, Wollenweber FA, Zedde M, van Buchem MA, Gurol ME, Viswanathan A, Al-Shahi Salman R, Smith EE, Werring DJ, Greenberg SM
Lancet Neurol 2022 Aug;21(8):714-725. doi: 10.1016/S1474-4422(22)00208-3. PMID: 35841910Free PMC Article
Chang Wong E, Chang Chui H
Continuum (Minneap Minn) 2022 Jun 1;28(3):750-780. doi: 10.1212/CON.0000000000001124. PMID: 35678401Free PMC Article
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G
Nat Rev Neurol 2013 Feb;9(2):106-18. Epub 2013 Jan 8 doi: 10.1038/nrneurol.2012.263. PMID: 23296339Free PMC Article
Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT
Cold Spring Harb Perspect Med 2011 Sep;1(1):a006189. doi: 10.1101/cshperspect.a006189. PMID: 22229116Free PMC Article

Therapy

Solopova E, Romero-Fernandez W, Harmsen H, Ventura-Antunes L, Wang E, Shostak A, Maldonado J, Donahue MJ, Schultz D, Coyne TM, Charidimou A, Schrag M
Nat Commun 2023 Dec 12;14(1):8220. doi: 10.1038/s41467-023-43933-5. PMID: 38086820Free PMC Article
Hampel H, Elhage A, Cho M, Apostolova LG, Nicoll JAR, Atri A
Brain 2023 Nov 2;146(11):4414-4424. doi: 10.1093/brain/awad188. PMID: 37280110Free PMC Article
Castellani RJ, Shanes ED, McCord M, Reish NJ, Flanagan ME, Mesulam MM, Jamshidi P
J Alzheimers Dis 2023;93(2):803-813. doi: 10.3233/JAD-221305. PMID: 37125554
Markus HS, van Der Flier WM, Smith EE, Bath P, Biessels GJ, Briceno E, Brodtman A, Chabriat H, Chen C, de Leeuw FE, Egle M, Ganesh A, Georgakis MK, Gottesman RF, Kwon S, Launer L, Mok V, O'Brien J, Ottenhoff L, Pendlebury S, Richard E, Sachdev P, Schmidt R, Springer M, Tiedt S, Wardlaw JM, Verdelho A, Webb A, Werring D, Duering M, Levine D, Dichgans M
JAMA Neurol 2022 Nov 1;79(11):1187-1198. doi: 10.1001/jamaneurol.2022.2262. PMID: 35969390Free PMC Article
Jäkel L, De Kort AM, Klijn CJM, Schreuder FHBM, Verbeek MM
Alzheimers Dement 2022 Jan;18(1):10-28. Epub 2021 May 31 doi: 10.1002/alz.12366. PMID: 34057813Free PMC Article

Prognosis

Hampel H, Elhage A, Cho M, Apostolova LG, Nicoll JAR, Atri A
Brain 2023 Nov 2;146(11):4414-4424. doi: 10.1093/brain/awad188. PMID: 37280110Free PMC Article
Stakos DA, Stamatelopoulos K, Bampatsias D, Sachse M, Zormpas E, Vlachogiannis NI, Tual-Chalot S, Stellos K
J Am Coll Cardiol 2020 Mar 3;75(8):952-967. doi: 10.1016/j.jacc.2019.12.033. PMID: 32130931Free PMC Article
Kalaria RN
Neuropharmacology 2018 May 15;134(Pt B):226-239. Epub 2017 Dec 19 doi: 10.1016/j.neuropharm.2017.12.030. PMID: 29273521
Kapasi A, DeCarli C, Schneider JA
Acta Neuropathol 2017 Aug;134(2):171-186. Epub 2017 May 9 doi: 10.1007/s00401-017-1717-7. PMID: 28488154Free PMC Article
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G
Nat Rev Neurol 2013 Feb;9(2):106-18. Epub 2013 Jan 8 doi: 10.1038/nrneurol.2012.263. PMID: 23296339Free PMC Article

Clinical prediction guides

Hampel H, Elhage A, Cho M, Apostolova LG, Nicoll JAR, Atri A
Brain 2023 Nov 2;146(11):4414-4424. doi: 10.1093/brain/awad188. PMID: 37280110Free PMC Article
Ikegawa M, Kakuda N, Miyasaka T, Toyama Y, Nirasawa T, Minta K, Hanrieder J
Brain Connect 2023 Aug;13(6):319-333. Epub 2023 Apr 24 doi: 10.1089/brain.2022.0057. PMID: 36905365Free PMC Article
Markus HS, van Der Flier WM, Smith EE, Bath P, Biessels GJ, Briceno E, Brodtman A, Chabriat H, Chen C, de Leeuw FE, Egle M, Ganesh A, Georgakis MK, Gottesman RF, Kwon S, Launer L, Mok V, O'Brien J, Ottenhoff L, Pendlebury S, Richard E, Sachdev P, Schmidt R, Springer M, Tiedt S, Wardlaw JM, Verdelho A, Webb A, Werring D, Duering M, Levine D, Dichgans M
JAMA Neurol 2022 Nov 1;79(11):1187-1198. doi: 10.1001/jamaneurol.2022.2262. PMID: 35969390Free PMC Article
Kalaria RN
Neuropharmacology 2018 May 15;134(Pt B):226-239. Epub 2017 Dec 19 doi: 10.1016/j.neuropharm.2017.12.030. PMID: 29273521
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G
Nat Rev Neurol 2013 Feb;9(2):106-18. Epub 2013 Jan 8 doi: 10.1038/nrneurol.2012.263. PMID: 23296339Free PMC Article

Recent systematic reviews

Kurz C, Walker L, Rauchmann BS, Perneczky R
Neuropathol Appl Neurobiol 2022 Apr;48(3):e12782. Epub 2022 Feb 2 doi: 10.1111/nan.12782. PMID: 34823269
Jäkel L, De Kort AM, Klijn CJM, Schreuder FHBM, Verbeek MM
Alzheimers Dement 2022 Jan;18(1):10-28. Epub 2021 May 31 doi: 10.1002/alz.12366. PMID: 34057813Free PMC Article
Dupont G, Iwanaga J, Yilmaz E, Tubbs RS
Lymphat Res Biol 2020 Feb;18(1):2-6. Epub 2019 Aug 21 doi: 10.1089/lrb.2018.0079. PMID: 31433264
Dallaire-Théroux C, Callahan BL, Potvin O, Saikali S, Duchesne S
J Alzheimers Dis 2017;57(2):575-601. doi: 10.3233/JAD-161028. PMID: 28282807
Rannikmäe K, Samarasekera N, Martînez-Gonzâlez NA, Al-Shahi Salman R, Sudlow CL
J Neurol Neurosurg Psychiatry 2013 Aug;84(8):901-8. Epub 2013 Mar 2 doi: 10.1136/jnnp-2012-303898. PMID: 23457231

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