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Benzene toxicity, susceptibility to

MedGen UID:
382673
•Concept ID:
C2675718
•
Finding
Synonym: BENZENE TOXICITY, SUSCEPTIBILITY TO
 
OMIM®: 125860

Professional guidelines

PubMed

Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment.
McHale CM, Zhang L, Smith MT
Carcinogenesis 2012 Feb;33(2):240-52. Epub 2011 Dec 12 doi: 10.1093/carcin/bgr297. PMID: 22166497Free PMC Article
Toxicogenomic profiling of chemically exposed humans in risk assessment.
McHale CM, Zhang L, Hubbard AE, Smith MT
Mutat Res 2010 Dec;705(3):172-83. Epub 2010 Apr 9 doi: 10.1016/j.mrrev.2010.04.001. PMID: 20382258Free PMC Article
The toxicity of benzene and its metabolism and molecular pathology in human risk assessment.
Yardley-Jones A, Anderson D, Parke DV
Br J Ind Med 1991 Jul;48(7):437-44. doi: 10.1136/oem.48.7.437. PMID: 1854646Free PMC Article

Recent clinical studies

Etiology

Benzene exposure is associated with epigenetic changes (Review).
Fenga C, Gangemi S, Costa C
Mol Med Rep 2016 Apr;13(4):3401-5. Epub 2016 Mar 1 doi: 10.3892/mmr.2016.4955. PMID: 26936331
Stem cell and benzene-induced malignancy and hematotoxicity.
Wang L, He X, Bi Y, Ma Q
Chem Res Toxicol 2012 Jul 16;25(7):1303-15. Epub 2012 May 24 doi: 10.1021/tx3001169. PMID: 22540379
Advances in understanding benzene health effects and susceptibility.
Smith MT
Annu Rev Public Health 2010;31:133-48 2 p following 148. doi: 10.1146/annurev.publhealth.012809.103646. PMID: 20070208Free PMC Article
Epigenetics and environmental chemicals.
Baccarelli A, Bollati V
Curr Opin Pediatr 2009 Apr;21(2):243-51. doi: 10.1097/mop.0b013e32832925cc. PMID: 19663042Free PMC Article
The toxicity of benzene and its metabolism and molecular pathology in human risk assessment.
Yardley-Jones A, Anderson D, Parke DV
Br J Ind Med 1991 Jul;48(7):437-44. doi: 10.1136/oem.48.7.437. PMID: 1854646Free PMC Article

Diagnosis

Biomarkers of susceptibility and effect in car painters exposed to organic solvents.
Varona-Uribe M, Ibáñez-Pinilla M, Briceno-Ayala L, Herrera D, Chuaire-Noack L, Martínez-Agüero M, Sánchez Corredor MC, Palma-Parra R, Narvaez D, Groot de Restrepo H
Colomb Med (Cali) 2020 Mar 30;51(1):e3646. doi: 10.25100/cm.v51i1.3646. PMID: 32952228Free PMC Article
Biomarkers of susceptibility following benzene exposure: influence of genetic polymorphisms on benzene metabolism and health effects.
Carbonari D, Chiarella P, Mansi A, Pigini D, Iavicoli S, Tranfo G
Biomark Med 2016;10(2):145-63. Epub 2016 Jan 14 doi: 10.2217/bmm.15.106. PMID: 26764284
Toxic-metabolic, nutritional, and medicinal-induced disorders of cerebellum.
Alekseeva N, McGee J, Kelley RE, Maghzi AH, Gonzalez-Toledo E, Minagar A
Neurol Clin 2014 Nov;32(4):901-11. Epub 2014 Sep 11 doi: 10.1016/j.ncl.2014.07.001. PMID: 25439288
Systems biology of human benzene exposure.
Zhang L, McHale CM, Rothman N, Li G, Ji Z, Vermeulen R, Hubbard AE, Ren X, Shen M, Rappaport SM, North M, Skibola CF, Yin S, Vulpe C, Chanock SJ, Smith MT, Lan Q
Chem Biol Interact 2010 Mar 19;184(1-2):86-93. Epub 2009 Dec 21 doi: 10.1016/j.cbi.2009.12.011. PMID: 20026094Free PMC Article
Pharmacogenetics: detecting sensitive populations.
Shields PG
Environ Health Perspect 1994 Dec;102 Suppl 11(Suppl 11):81-7. doi: 10.1289/ehp.94102s1181. PMID: 7737047Free PMC Article

Therapy

Key Genetic and Epigenetic Mechanisms in Chemical Carcinogenesis.
Ravegnini G, Sammarini G, Hrelia P, Angelini S
Toxicol Sci 2015 Nov;148(1):2-13. doi: 10.1093/toxsci/kfv165. PMID: 26500287
Biomarkers of susceptibility to chemical carcinogens: the example of non-Hodgkin lymphomas.
Kelly RS, Vineis P
Br Med Bull 2014 Sep;111(1):89-100. Epub 2014 Aug 11 doi: 10.1093/bmb/ldu015. PMID: 25114269
Advances in understanding benzene health effects and susceptibility.
Smith MT
Annu Rev Public Health 2010;31:133-48 2 p following 148. doi: 10.1146/annurev.publhealth.012809.103646. PMID: 20070208Free PMC Article
Overview of benzene-induced aplastic anaemia.
Smith MT
Eur J Haematol Suppl 1996;60:107-10. doi: 10.1111/j.1600-0609.1996.tb01655.x. PMID: 8987251
The toxicity of benzene and its metabolism and molecular pathology in human risk assessment.
Yardley-Jones A, Anderson D, Parke DV
Br J Ind Med 1991 Jul;48(7):437-44. doi: 10.1136/oem.48.7.437. PMID: 1854646Free PMC Article

Prognosis

Benzene exposure is associated with epigenetic changes (Review).
Fenga C, Gangemi S, Costa C
Mol Med Rep 2016 Apr;13(4):3401-5. Epub 2016 Mar 1 doi: 10.3892/mmr.2016.4955. PMID: 26936331
Key Genetic and Epigenetic Mechanisms in Chemical Carcinogenesis.
Ravegnini G, Sammarini G, Hrelia P, Angelini S
Toxicol Sci 2015 Nov;148(1):2-13. doi: 10.1093/toxsci/kfv165. PMID: 26500287
Genetic susceptibility to benzene toxicity in humans.
Garte S, Taioli E, Popov T, Bolognesi C, Farmer P, Merlo F
J Toxicol Environ Health A 2008;71(22):1482-9. doi: 10.1080/15287390802349974. PMID: 18836923
Causal models of leukaemia and lymphoma.
Smith MT, Skibola CF, Allan JM, Morgan GJ
IARC Sci Publ 2004;(157):373-92. PMID: 15055307
Pharmacogenetics: detecting sensitive populations.
Shields PG
Environ Health Perspect 1994 Dec;102 Suppl 11(Suppl 11):81-7. doi: 10.1289/ehp.94102s1181. PMID: 7737047Free PMC Article

Clinical prediction guides

Benzene exposure is associated with epigenetic changes (Review).
Fenga C, Gangemi S, Costa C
Mol Med Rep 2016 Apr;13(4):3401-5. Epub 2016 Mar 1 doi: 10.3892/mmr.2016.4955. PMID: 26936331
Key Genetic and Epigenetic Mechanisms in Chemical Carcinogenesis.
Ravegnini G, Sammarini G, Hrelia P, Angelini S
Toxicol Sci 2015 Nov;148(1):2-13. doi: 10.1093/toxsci/kfv165. PMID: 26500287
A review and meta-analysis of outdoor air pollution and risk of childhood leukemia.
Filippini T, Heck JE, Malagoli C, Del Giovane C, Vinceti M
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2015;33(1):36-66. doi: 10.1080/10590501.2015.1002999. PMID: 25803195Free PMC Article
Systems biology of human benzene exposure.
Zhang L, McHale CM, Rothman N, Li G, Ji Z, Vermeulen R, Hubbard AE, Ren X, Shen M, Rappaport SM, North M, Skibola CF, Yin S, Vulpe C, Chanock SJ, Smith MT, Lan Q
Chem Biol Interact 2010 Mar 19;184(1-2):86-93. Epub 2009 Dec 21 doi: 10.1016/j.cbi.2009.12.011. PMID: 20026094Free PMC Article
Causal models of leukaemia and lymphoma.
Smith MT, Skibola CF, Allan JM, Morgan GJ
IARC Sci Publ 2004;(157):373-92. PMID: 15055307

Recent systematic reviews

Biomarkers of occupational benzene exposure: A Systematic Review to estimate the exposure levels and individual susceptibility at low doses.
Zhang Z, Shi W, Ru L, Lv W
Toxicol Ind Health 2024 Oct;40(9-10):539-555. Epub 2024 Jun 12 doi: 10.1177/07482337241259053. PMID: 38864232
The role of genetic polymorphisms for inducing genotoxicity in workers occupationally exposed to benzene: a systematic review.
Guedes Pinto T, Dias TA, Renno ACM, de Barros Viana M, Ribeiro DA
Arch Toxicol 2024 Jul;98(7):1991-2005. Epub 2024 Apr 10 doi: 10.1007/s00204-024-03744-z. PMID: 38600397
Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review.
Chappell G, Pogribny IP, Guyton KZ, Rusyn I
Mutat Res Rev Mutat Res 2016 Apr-Jun;768:27-45. Epub 2016 Mar 31 doi: 10.1016/j.mrrev.2016.03.004. PMID: 27234561Free PMC Article

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