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Body mass index quantitative trait locus 18(BMIQ18)

MedGen UID:
811515
Concept ID:
C3714940
Finding
Synonym: BMIQ18
 
Gene (location): MRAP2 (6q14.2)
 
OMIM®: 615457

Recent clinical studies

Etiology

Liu ZY, Huang XB, Yang GM, Zhao S
Eur Rev Med Pharmacol Sci 2023 Sep;27(18):8556-8578. doi: 10.26355/eurrev_202309_33781. PMID: 37782172
Spracklen CN, Horikoshi M, Kim YJ, Lin K, Bragg F, Moon S, Suzuki K, Tam CHT, Tabara Y, Kwak SH, Takeuchi F, Long J, Lim VJY, Chai JF, Chen CH, Nakatochi M, Yao J, Choi HS, Iyengar AK, Perrin HJ, Brotman SM, van de Bunt M, Gloyn AL, Below JE, Boehnke M, Bowden DW, Chambers JC, Mahajan A, McCarthy MI, Ng MCY, Petty LE, Zhang W, Morris AP, Adair LS, Akiyama M, Bian Z, Chan JCN, Chang LC, Chee ML, Chen YI, Chen YT, Chen Z, Chuang LM, Du S, Gordon-Larsen P, Gross M, Guo X, Guo Y, Han S, Howard AG, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Isono M, Jang HM, Jiang G, Jonas JB, Kamatani Y, Katsuya T, Kawaguchi T, Khor CC, Kohara K, Lee MS, Lee NR, Li L, Liu J, Luk AO, Lv J, Okada Y, Pereira MA, Sabanayagam C, Shi J, Shin DM, So WY, Takahashi A, Tomlinson B, Tsai FJ, van Dam RM, Xiang YB, Yamamoto K, Yamauchi T, Yoon K, Yu C, Yuan JM, Zhang L, Zheng W, Igase M, Cho YS, Rotter JI, Wang YX, Sheu WHH, Yokota M, Wu JY, Cheng CY, Wong TY, Shu XO, Kato N, Park KS, Tai ES, Matsuda F, Koh WP, Ma RCW, Maeda S, Millwood IY, Lee J, Kadowaki T, Walters RG, Kim BJ, Mohlke KL, Sim X
Nature 2020 Jun;582(7811):240-245. Epub 2020 May 6 doi: 10.1038/s41586-020-2263-3. PMID: 32499647Free PMC Article
Liu L, Yang XL, Zhang H, Zhang ZJ, Wei XT, Feng GJ, Liu J, Peng HP, Hai R, Shen H, Tian Q, Deng HW, Pei YF, Zhang L
Hum Genet 2020 Aug;139(8):1023-1035. Epub 2020 Apr 1 doi: 10.1007/s00439-020-02155-1. PMID: 32239398Free PMC Article
Kraja AT, Liu C, Fetterman JL, Graff M, Have CT, Gu C, Yanek LR, Feitosa MF, Arking DE, Chasman DI, Young K, Ligthart S, Hill WD, Weiss S, Luan J, Giulianini F, Li-Gao R, Hartwig FP, Lin SJ, Wang L, Richardson TG, Yao J, Fernandez EP, Ghanbari M, Wojczynski MK, Lee WJ, Argos M, Armasu SM, Barve RA, Ryan KA, An P, Baranski TJ, Bielinski SJ, Bowden DW, Broeckel U, Christensen K, Chu AY, Corley J, Cox SR, Uitterlinden AG, Rivadeneira F, Cropp CD, Daw EW, van Heemst D, de las Fuentes L, Gao H, Tzoulaki I, Ahluwalia TS, de Mutsert R, Emery LS, Erzurumluoglu AM, Perry JA, Fu M, Forouhi NG, Gu Z, Hai Y, Harris SE, Hemani G, Hunt SC, Irvin MR, Jonsson AE, Justice AE, Kerrison ND, Larson NB, Lin KH, Love-Gregory LD, Mathias RA, Lee JH, Nauck M, Noordam R, Ong KK, Pankow J, Patki A, Pattie A, Petersmann A, Qi Q, Ribel-Madsen R, Rohde R, Sandow K, Schnurr TM, Sofer T, Starr JM, Taylor AM, Teumer A, Timpson NJ, de Haan HG, Wang Y, Weeke PE, Williams C, Wu H, Yang W, Zeng D, Witte DR, Weir BS, Wareham NJ, Vestergaard H, Turner ST, Torp-Pedersen C, Stergiakouli E, Sheu WH, Rosendaal FR, Ikram MA, Franco OH, Ridker PM, Perls TT, Pedersen O, Nohr EA, Newman AB, Linneberg A, Langenberg C, Kilpeläinen TO, Kardia SLR, Jørgensen ME, Jørgensen T, Sørensen TIA, Homuth G, Hansen T, Goodarzi MO, Deary IJ, Christensen C, Chen YI, Chakravarti A, Brandslund I, Bonnelykke K, Taylor KD, Wilson JG, Rodriguez S, Davies G, Horta BL, Thyagarajan B, Rao DC, Grarup N, Davila-Roman VG, Hudson G, Guo X, Arnett DK, Hayward C, Vaidya D, Mook-Kanamori DO, Tiwari HK, Levy D, Loos RJF, Dehghan A, Elliott P, Malik AN, Scott RA, Becker DM, de Andrade M, Province MA, Meigs JB, Rotter JI, North KE
Am J Hum Genet 2019 Jan 3;104(1):112-138. Epub 2018 Dec 27 doi: 10.1016/j.ajhg.2018.12.001. PMID: 30595373Free PMC Article
Bettella F, Brown AA, Smeland OB, Wang Y, Witoelar A, Buil Demur AA, Thompson WK, Zuber V, Dale AM, Djurovic S, Andreassen OA
PLoS One 2018;13(9):e0202812. Epub 2018 Sep 6 doi: 10.1371/journal.pone.0202812. PMID: 30188921Free PMC Article

Diagnosis

Prasad RB, Kristensen K, Katsarou A, Shaat N
BMC Med Genomics 2021 Nov 20;14(1):274. doi: 10.1186/s12920-021-01123-6. PMID: 34801028Free PMC Article
Johnson MP, Keyho R, Blackburn NB, Laston S, Kumar S, Peralta J, Thapa SS, Towne B, Subedi J, Blangero J, Williams-Blangero S
J Diabetes Res 2019;2019:2310235. Epub 2019 Apr 4 doi: 10.1155/2019/2310235. PMID: 31089471Free PMC Article
Galván-Femenía I, Obón-Santacana M, Piñeyro D, Guindo-Martinez M, Duran X, Carreras A, Pluvinet R, Velasco J, Ramos L, Aussó S, Mercader JM, Puig L, Perucho M, Torrents D, Moreno V, Sumoy L, de Cid R
J Med Genet 2018 Nov;55(11):765-778. Epub 2018 Aug 30 doi: 10.1136/jmedgenet-2018-105437. PMID: 30166351Free PMC Article
Cuellar-Barboza AB, Winham SJ, McElroy SL, Geske JR, Jenkins GD, Colby CL, Prieto ML, Ryu E, Cunningham JM, Frye MA, Biernacka JM
Bipolar Disord 2016 Mar;18(2):124-35. Epub 2016 Mar 2 doi: 10.1111/bdi.12368. PMID: 26934194
Pedersen O
Exp Clin Endocrinol Diabetes 1999;107(2):113-8. doi: 10.1055/s-0029-1212085. PMID: 10320051

Therapy

Iona A, Yao P, Pozarickij A, Kartsonaki C, Said S, Wright N, Lin K, Millwood I, Fry H, Mazidi M, Wang B, Chen Y, Du H, Yang L, Avery D, Schmidt D, Sun D, Pei P, Lv J, Yu C, Hill M, Chen J, Bragg F, Bennett D, Walters R, Li L, Clarke R, Chen Z; China Kadoorie Biobank Collaborative Group
Commun Biol 2024 Oct 15;7(1):1327. doi: 10.1038/s42003-024-06984-y. PMID: 39406990Free PMC Article
Liu ZY, Huang XB, Yang GM, Zhao S
Eur Rev Med Pharmacol Sci 2023 Sep;27(18):8556-8578. doi: 10.26355/eurrev_202309_33781. PMID: 37782172
Liu L, Yang XL, Zhang H, Zhang ZJ, Wei XT, Feng GJ, Liu J, Peng HP, Hai R, Shen H, Tian Q, Deng HW, Pei YF, Zhang L
Hum Genet 2020 Aug;139(8):1023-1035. Epub 2020 Apr 1 doi: 10.1007/s00439-020-02155-1. PMID: 32239398Free PMC Article
Turner ST, Kardia SL, Boerwinkle E, de Andrade M
Genet Epidemiol 2004 Jul;27(1):64-73. doi: 10.1002/gepi.20002. PMID: 15185404
Pedersen O
Exp Clin Endocrinol Diabetes 1999;107(2):113-8. doi: 10.1055/s-0029-1212085. PMID: 10320051

Prognosis

Iona A, Yao P, Pozarickij A, Kartsonaki C, Said S, Wright N, Lin K, Millwood I, Fry H, Mazidi M, Wang B, Chen Y, Du H, Yang L, Avery D, Schmidt D, Sun D, Pei P, Lv J, Yu C, Hill M, Chen J, Bragg F, Bennett D, Walters R, Li L, Clarke R, Chen Z; China Kadoorie Biobank Collaborative Group
Commun Biol 2024 Oct 15;7(1):1327. doi: 10.1038/s42003-024-06984-y. PMID: 39406990Free PMC Article
Prasad RB, Kristensen K, Katsarou A, Shaat N
BMC Med Genomics 2021 Nov 20;14(1):274. doi: 10.1186/s12920-021-01123-6. PMID: 34801028Free PMC Article
Gautvik KM, Günther CC, Prijatelj V, Medina-Gomez C, Shevroja E, Rad LH, Yazdani M, Lindalen E, Valland H, Gautvik VT, Olstad OK, Holden M, Rivadeneira F, Utheim TP, Reppe S
J Bone Miner Res 2020 Jun;35(6):1065-1076. Epub 2020 Mar 2 doi: 10.1002/jbmr.3974. PMID: 32017184
Hsu YH, Estrada K, Evangelou E, Ackert-Bicknell C, Akesson K, Beck T, Brown SJ, Capellini T, Carbone L, Cauley J, Cheung CL, Cummings SR, Czerwinski S, Demissie S, Econs M, Evans D, Farber C, Gautvik K, Harris T, Kammerer C, Kemp J, Koller DL, Kung A, Lawlor D, Lee M, Lorentzon M, McGuigan F, Medina-Gomez C, Mitchell B, Newman A, Nielson C, Ohlsson C, Peacock M, Reppe S, Richards JB, Robbins J, Sigurdsson G, Spector TD, Stefansson K, Streeten E, Styrkarsdottir U, Tobias J, Trajanoska K, Uitterlinden A, Vandenput L, Wilson SG, Yerges-Armstrong L, Young M, Zillikens MC, Rivadeneira F, Kiel DP, Karasik D
J Bone Miner Res 2019 Jul;34(7):1284-1296. Epub 2019 Mar 19 doi: 10.1002/jbmr.3698. PMID: 30888730Free PMC Article
Benyamin B, Pourcain B, Davis OS, Davies G, Hansell NK, Brion MJ, Kirkpatrick RM, Cents RA, Franić S, Miller MB, Haworth CM, Meaburn E, Price TS, Evans DM, Timpson N, Kemp J, Ring S, McArdle W, Medland SE, Yang J, Harris SE, Liewald DC, Scheet P, Xiao X, Hudziak JJ, de Geus EJ; Wellcome Trust Case Control Consortium 2 (WTCCC2), Jaddoe VW, Starr JM, Verhulst FC, Pennell C, Tiemeier H, Iacono WG, Palmer LJ, Montgomery GW, Martin NG, Boomsma DI, Posthuma D, McGue M, Wright MJ, Davey Smith G, Deary IJ, Plomin R, Visscher PM
Mol Psychiatry 2014 Feb;19(2):253-8. Epub 2013 Jan 29 doi: 10.1038/mp.2012.184. PMID: 23358156Free PMC Article

Clinical prediction guides

Hsu YH, Estrada K, Evangelou E, Ackert-Bicknell C, Akesson K, Beck T, Brown SJ, Capellini T, Carbone L, Cauley J, Cheung CL, Cummings SR, Czerwinski S, Demissie S, Econs M, Evans D, Farber C, Gautvik K, Harris T, Kammerer C, Kemp J, Koller DL, Kung A, Lawlor D, Lee M, Lorentzon M, McGuigan F, Medina-Gomez C, Mitchell B, Newman A, Nielson C, Ohlsson C, Peacock M, Reppe S, Richards JB, Robbins J, Sigurdsson G, Spector TD, Stefansson K, Streeten E, Styrkarsdottir U, Tobias J, Trajanoska K, Uitterlinden A, Vandenput L, Wilson SG, Yerges-Armstrong L, Young M, Zillikens MC, Rivadeneira F, Kiel DP, Karasik D
J Bone Miner Res 2019 Jul;34(7):1284-1296. Epub 2019 Mar 19 doi: 10.1002/jbmr.3698. PMID: 30888730Free PMC Article
Bettella F, Brown AA, Smeland OB, Wang Y, Witoelar A, Buil Demur AA, Thompson WK, Zuber V, Dale AM, Djurovic S, Andreassen OA
PLoS One 2018;13(9):e0202812. Epub 2018 Sep 6 doi: 10.1371/journal.pone.0202812. PMID: 30188921Free PMC Article
Cuellar-Barboza AB, Winham SJ, McElroy SL, Geske JR, Jenkins GD, Colby CL, Prieto ML, Ryu E, Cunningham JM, Frye MA, Biernacka JM
Bipolar Disord 2016 Mar;18(2):124-35. Epub 2016 Mar 2 doi: 10.1111/bdi.12368. PMID: 26934194
Ehlers CL, Wilhelmsen KC
Genes Brain Behav 2007 Mar;6(2):184-91. doi: 10.1111/j.1601-183X.2006.00246.x. PMID: 16764678
Pedersen O
Exp Clin Endocrinol Diabetes 1999;107(2):113-8. doi: 10.1055/s-0029-1212085. PMID: 10320051

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