U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cataract 41(CTRCT41)

MedGen UID:
811742
•Concept ID:
C3805412
•
Disease or Syndrome
Synonyms: CATARACT 41, CONGENITAL NUCLEAR TYPE; CTRCT41
 
Gene (location): WFS1 (4p16.1)
 
Monarch Initiative: MONDO:0007287
OMIM®: 116400

Definition

Cataract is an opacification of the lens or lens capsule in the eye and is the most common cause of childhood blindness in the world, with an incidence of 1 to 3 per 10,000 live births. If untreated in infancy or childhood, it frequently causes visual impairment and can result in irreversible amblyopia. Nuclear cataract refers to opacification within the embryonal and/or fetal nuclei of the lens (summary by Berry et al., 2013). [from OMIM]

Clinical features

From HPO
Nuclear cataract
MedGen UID:
140274
•Concept ID:
C0392557
•
Finding
A nuclear cataract is an opacity or clouding that develops in the lens nucleus. That is, a nuclear cataract is one that is located in the center of the lens. The nucleus tends to darken changing from clear to yellow and sometimes brown.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Neonatal classic galactosemia-diagnosis, clinical profile and molecular characteristics in unscreened Turkish population.
Çelik M, Akdeniz O, Ozbek MN, Kirbiyik O
J Trop Pediatr 2022 Oct 6;68(6) doi: 10.1093/tropej/fmac098. PMID: 36375035

Recent clinical studies

Etiology

Visual Impairment, Eye Conditions, and Diagnoses of Neurodegeneration and Dementia.
Ferguson EL, Thoma M, Buto PT, Wang J, Glymour MM, Hoffmann TJ, Choquet H, Andrews SJ, Yaffe K, Casaletto K, Brenowitz WD
JAMA Netw Open 2024 Jul 1;7(7):e2424539. doi: 10.1001/jamanetworkopen.2024.24539. PMID: 39078629Free PMC Article
Association Between Cataract Extraction and Development of Dementia.
Lee CS, Gibbons LE, Lee AY, Yanagihara RT, Blazes MS, Lee ML, McCurry SM, Bowen JD, McCormick WC, Crane PK, Larson EB
JAMA Intern Med 2022 Feb 1;182(2):134-141. doi: 10.1001/jamainternmed.2021.6990. PMID: 34870676Free PMC Article
Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis.
Hashemi H, Pakzad R, Yekta A, Aghamirsalim M, Pakbin M, Ramin S, Khabazkhoob M
Eye (Lond) 2020 Aug;34(8):1357-1370. Epub 2020 Feb 13 doi: 10.1038/s41433-020-0806-3. PMID: 32055021Free PMC Article
Long-term follow-up of epikeratophakia.
Kang J, Cabot F, Yoo SH
J Cataract Refract Surg 2015 Mar;41(3):670-3. Epub 2014 Dec 20 doi: 10.1016/j.jcrs.2014.11.035. PMID: 25535108
Combined cataract and glaucoma surgery.
Storr-Paulsen A, Bernth-Petersen P
Curr Opin Ophthalmol 2001 Feb;12(1):41-46. doi: 10.1097/00055735-200102000-00008. PMID: 11150080

Diagnosis

Visual Impairment, Eye Conditions, and Diagnoses of Neurodegeneration and Dementia.
Ferguson EL, Thoma M, Buto PT, Wang J, Glymour MM, Hoffmann TJ, Choquet H, Andrews SJ, Yaffe K, Casaletto K, Brenowitz WD
JAMA Netw Open 2024 Jul 1;7(7):e2424539. doi: 10.1001/jamanetworkopen.2024.24539. PMID: 39078629Free PMC Article
Association Between Cataract Extraction and Development of Dementia.
Lee CS, Gibbons LE, Lee AY, Yanagihara RT, Blazes MS, Lee ML, McCurry SM, Bowen JD, McCormick WC, Crane PK, Larson EB
JAMA Intern Med 2022 Feb 1;182(2):134-141. doi: 10.1001/jamainternmed.2021.6990. PMID: 34870676Free PMC Article
Axenfeld-Rieger syndrome.
Bengarai W, Chokrani H, Berraho A
J Fr Ophtalmol 2018 May;41(5):470-471. Epub 2018 May 21 doi: 10.1016/j.jfo.2017.10.010. PMID: 29793789
Unilateral pyramidal cataract.
El Moize Z, Lezrek O, Htiti N, El Harrak Y, Tachfouti S, Laghmari M, Cherkaoui O
J Fr Ophtalmol 2018 May;41(5):483-484. doi: 10.1016/j.jfo.2017.09.018. PMID: 29759651
Hallermann-Streiff syndrome: a review.
Cohen MM Jr
Am J Med Genet 1991 Dec 15;41(4):488-99. doi: 10.1002/ajmg.1320410423. PMID: 1776643

Therapy

Association Between Cataract Extraction and Development of Dementia.
Lee CS, Gibbons LE, Lee AY, Yanagihara RT, Blazes MS, Lee ML, McCurry SM, Bowen JD, McCormick WC, Crane PK, Larson EB
JAMA Intern Med 2022 Feb 1;182(2):134-141. doi: 10.1001/jamainternmed.2021.6990. PMID: 34870676Free PMC Article
Interventions for preventing falls in older people living in the community.
Gillespie LD, Robertson MC, Gillespie WJ, Sherrington C, Gates S, Clemson LM, Lamb SE
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD007146. doi: 10.1002/14651858.CD007146.pub3. PMID: 22972103Free PMC Article
Drug-induced cataracts.
Prescrire Int 2011 Feb;20(113):41-3. PMID: 21488590
Posterior capsule opacification.
Schmidbauer JM, Vargas LG, Peng Q, Escobar-Gomez M, Werner L, Arthur SN, Apple DJ
Int Ophthalmol Clin 2001 Summer;41(3):109-31. doi: 10.1097/00004397-200107000-00010. PMID: 11481543
Anterior capsule opacification.
Macky TA, Pandey SK, Werner L, Trivedi RH, Izak AM, Apple DJ
Int Ophthalmol Clin 2001 Summer;41(3):17-31. doi: 10.1097/00004397-200107000-00004. PMID: 11481537

Prognosis

Dual Sensory Impairment as a Predictor of Loneliness and Isolation in Older Adults: National Cohort Study.
Wang Q, Zhang S, Wang Y, Zhao D, Zhou C
JMIR Public Health Surveill 2022 Nov 14;8(11):e39314. doi: 10.2196/39314. PMID: 36374533Free PMC Article
The Risks and Benefits of Myopia Control.
Bullimore MA, Ritchey ER, Shah S, Leveziel N, Bourne RRA, Flitcroft DI
Ophthalmology 2021 Nov;128(11):1561-1579. Epub 2021 May 4 doi: 10.1016/j.ophtha.2021.04.032. PMID: 33961969
Demographic and Clinical Features of Pediatric Uveitis in Israel.
Habot-Wilner Z, Tiosano L, Sanchez JM, Shulman S, Barequet D, Rahat O, Amarilyo G, Amer R
Ocul Immunol Inflamm 2020;28(1):43-53. Epub 2018 Oct 17 doi: 10.1080/09273948.2018.1535079. PMID: 30332547
Long-term follow-up of epikeratophakia.
Kang J, Cabot F, Yoo SH
J Cataract Refract Surg 2015 Mar;41(3):670-3. Epub 2014 Dec 20 doi: 10.1016/j.jcrs.2014.11.035. PMID: 25535108
Hallerman-Streiff syndrome.
Nicholson AD, Menon S
J Postgrad Med 1995 Jan-Mar;41(1):22-3. PMID: 10740699

Clinical prediction guides

Phenotypic expansion of EGP5-related Vici syndrome: 15 Dutch patients carrying a founder variant.
Vansenne F, Fock JM, Stolte-Dijkstra I, Meiners LC, van den Boogaard MH, Jaeger B, Boven L, Vos YJ, Sinke RJ, Verbeek DS
Eur J Paediatr Neurol 2022 Nov;41:91-98. Epub 2022 Nov 12 doi: 10.1016/j.ejpn.2022.11.003. PMID: 36410285
Dual Sensory Impairment as a Predictor of Loneliness and Isolation in Older Adults: National Cohort Study.
Wang Q, Zhang S, Wang Y, Zhao D, Zhou C
JMIR Public Health Surveill 2022 Nov 14;8(11):e39314. doi: 10.2196/39314. PMID: 36374533Free PMC Article
Associations in corticocapsular adhesions.
Mansour AM, Ahmed IIK, Charbaji AR, Mansour HA, El Jawhari KM
Eye (Lond) 2022 Jan;36(1):193-197. Epub 2021 Mar 5 doi: 10.1038/s41433-021-01482-5. PMID: 33674725Free PMC Article
Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis.
Hashemi H, Pakzad R, Yekta A, Aghamirsalim M, Pakbin M, Ramin S, Khabazkhoob M
Eye (Lond) 2020 Aug;34(8):1357-1370. Epub 2020 Feb 13 doi: 10.1038/s41433-020-0806-3. PMID: 32055021Free PMC Article
Radiation cataract.
Kleiman NJ
Ann ICRP 2012 Oct-Dec;41(3-4):80-97. Epub 2012 Aug 22 doi: 10.1016/j.icrp.2012.06.018. PMID: 23089007

Recent systematic reviews

Comparison of refractive surgeries (SMILE, LASIK, and PRK) with and without corneal crosslinking: systematic review and meta-analysis.
Hira S, Klein Heffel K, Mehmood F, Sehgal K, Felix De Farias Santos AC, Steuernagel Del Valle G
J Cataract Refract Surg 2024 May 1;50(5):523-533. doi: 10.1097/j.jcrs.0000000000001405. PMID: 38288954
Vancomycin-Associated Hemorrhagic Occlusive Retinal Vasculitis: A Case Series and Systematic Review.
Matović K, Mekjavić PJ, Groznik AL, Fakin A, Petrovič MG, Pfeifer V, Valentinčič NV
Ophthalmic Surg Lasers Imaging Retina 2022 Dec;53(12):702-712. Epub 2022 Dec 1 doi: 10.3928/23258160-20221026-03. PMID: 36547956
Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis.
Hashemi H, Pakzad R, Yekta A, Aghamirsalim M, Pakbin M, Ramin S, Khabazkhoob M
Eye (Lond) 2020 Aug;34(8):1357-1370. Epub 2020 Feb 13 doi: 10.1038/s41433-020-0806-3. PMID: 32055021Free PMC Article
Safety of deferring review after uneventful cataract surgery until 2 weeks postoperatively.
Kessel L, Andresen J, Erngaard D, Flesner P, Tendal B, Hjortdal J
J Cataract Refract Surg 2015 Dec;41(12):2755-64. doi: 10.1016/j.jcrs.2015.11.010. PMID: 26796457
Interventions for preventing falls in older people living in the community.
Gillespie LD, Robertson MC, Gillespie WJ, Sherrington C, Gates S, Clemson LM, Lamb SE
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD007146. doi: 10.1002/14651858.CD007146.pub3. PMID: 22972103Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...