U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Multiple fibroadenoma of the breast(MFAB)

MedGen UID:
816248
•Concept ID:
C3809918
•
Neoplastic Process
Synonym: Multiple fibroadenomas of the breast
SNOMED CT: Multiple fibroadenomas of breast (721601007)
 
Gene (location): PRLR (5p13.2)
 
Monarch Initiative: MONDO:0014249
OMIM®: 615554

Definition

Fibroadenoma represents a benign breast disease characterized by lobuloalveolar growth with abnormally high proliferation of the epithelium. Patients with more than 3 fibroadenomas in 1 breast are considered to have multiple fibroadenomas (summary by Bogorad et al., 2008). [from OMIM]

Clinical features

From HPO
Fibroadenoma of the breast
MedGen UID:
64231
•Concept ID:
C0178421
•
Neoplastic Process
A benign biphasic tumor of the breast with epithelial and stromal components.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Fibroepithelial lesions revisited: implications for diagnosis and management.
Tan PH
Mod Pathol 2021 Jan;34(Suppl 1):15-37. Epub 2020 May 27 doi: 10.1038/s41379-020-0583-3. PMID: 32461622
MRI-guided treatment in the breast.
Pediconi F, Marzocca F, Cavallo Marincola B, Napoli A
J Magn Reson Imaging 2018 Dec;48(6):1479-1488. Epub 2018 Oct 14 doi: 10.1002/jmri.26282. PMID: 30318672
Clinical and radiologic data and core needle biopsy findings should dictate management of cellular fibroepithelial tumors of the breast.
Resetkova E, Khazai L, Albarracin CT, Arribas E
Breast J 2010 Nov-Dec;16(6):573-80. doi: 10.1111/j.1524-4741.2010.01013.x. PMID: 21070433

Recent clinical studies

Etiology

Fibroepithelial lesions revisited: implications for diagnosis and management.
Tan PH
Mod Pathol 2021 Jan;34(Suppl 1):15-37. Epub 2020 May 27 doi: 10.1038/s41379-020-0583-3. PMID: 32461622
Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
Histopathology of fibroadenoma of the breast.
Kuijper A, Mommers EC, van der Wall E, van Diest PJ
Am J Clin Pathol 2001 May;115(5):736-42. doi: 10.1309/F523-FMJV-W886-3J38. PMID: 11345838
Karyotypic abnormalities in fibroadenomas of the breast.
Petersson C, Pandis N, Rizou H, Mertens F, Dietrich CU, Adeyinka A, Idvall I, Bondeson L, Georgiou G, Ingvar C, Heim S, Mitelman F
Int J Cancer 1997 Jan 27;70(3):282-6. doi: 10.1002/(sici)1097-0215(19970127)70:3<282::aid-ijc6>3.0.co;2-t. PMID: 9033628

Diagnosis

Refining the classification of breast phyllodes tumours.
Tan PH
Pathology 2023 Jun;55(4):437-448. Epub 2023 Mar 21 doi: 10.1016/j.pathol.2023.02.001. PMID: 37085395
Fibroepithelial lesions revisited: implications for diagnosis and management.
Tan PH
Mod Pathol 2021 Jan;34(Suppl 1):15-37. Epub 2020 May 27 doi: 10.1038/s41379-020-0583-3. PMID: 32461622
MRI-guided treatment in the breast.
Pediconi F, Marzocca F, Cavallo Marincola B, Napoli A
J Magn Reson Imaging 2018 Dec;48(6):1479-1488. Epub 2018 Oct 14 doi: 10.1002/jmri.26282. PMID: 30318672
Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Therapy

Electrical impedance spectroscopy of the breast: clinical imaging results in 26 subjects.
Kerner TE, Paulsen KD, Hartov A, Soho SK, Poplack SP
IEEE Trans Med Imaging 2002 Jun;21(6):638-45. doi: 10.1109/tmi.2002.800606. PMID: 12166860
The nature of tamoxifen action in the control of female breast cancer.
Kodama M, Kodama T
In Vivo 2001 Jul-Aug;15(4):319-25. PMID: 11695224
Cyclosporin A and multiple fibroadenomas of the breast.
Baildam AD, Higgins RM, Hurley E, Furlong A, Walls J, Venning MC, Ackrill P, Mansel RE
Br J Surg 1996 Dec;83(12):1755-7. doi: 10.1002/bjs.1800831229. PMID: 9038560
Fibrocystic disease of the breast.
Greenblatt RB, Samaras C, Vasquez JM, Nezhat C
Clin Obstet Gynecol 1982 Jun;25(2):365-71. doi: 10.1097/00003081-198206000-00019. PMID: 7105513
Fibroadenoma of the female breast. Some epidemiologic surprises.
Nigro DM, Organ CH Jr
Postgrad Med 1976 May;59(5):113-7. doi: 10.1080/00325481.1976.11714358. PMID: 177964

Prognosis

Refining the classification of breast phyllodes tumours.
Tan PH
Pathology 2023 Jun;55(4):437-448. Epub 2023 Mar 21 doi: 10.1016/j.pathol.2023.02.001. PMID: 37085395
Papillary lesions of the breast: A systematic evaluation of cytologic parameters.
Jamidi SK, Li JJX, Aphivatanasiri C, Chow MBCY, Chan RCK, Ng JKM, Tsang JY, Tse GM
Cancer Cytopathol 2021 Aug;129(8):649-661. Epub 2021 Feb 9 doi: 10.1002/cncy.22412. PMID: 33561323
Fibroepithelial lesions revisited: implications for diagnosis and management.
Tan PH
Mod Pathol 2021 Jan;34(Suppl 1):15-37. Epub 2020 May 27 doi: 10.1038/s41379-020-0583-3. PMID: 32461622
Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Clinical prediction guides

Papillary lesions of the breast: A systematic evaluation of cytologic parameters.
Jamidi SK, Li JJX, Aphivatanasiri C, Chow MBCY, Chan RCK, Ng JKM, Tsang JY, Tse GM
Cancer Cytopathol 2021 Aug;129(8):649-661. Epub 2021 Feb 9 doi: 10.1002/cncy.22412. PMID: 33561323
Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Gain-of-function Prolactin Receptor Variants Are Not Associated With Breast Cancer and Multiple Fibroadenoma Risk.
Chakhtoura Z, Laki F, Bernadet M, Cherifi I, Chiche A, Pigat N, Bernichtein S, Courtillot C, Boutillon F, Bièche I, Vacher S, Tanguy ML, Bissery A, Grouthier V, Camparo P, Foretz M, Do Cruzeiro M, Pierre R, Rakotozafy F, Tichet J, Tejedor I, Guidotti JE, Sigal-Zafrani B, Goffin V, Touraine P
J Clin Endocrinol Metab 2016 Nov;101(11):4449-4460. Epub 2016 Aug 30 doi: 10.1210/jc.2016-2372. PMID: 27575941
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
The nature of tamoxifen action in the control of female breast cancer.
Kodama M, Kodama T
In Vivo 2001 Jul-Aug;15(4):319-25. PMID: 11695224

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...