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Susceptibility to HIV infection

MedGen UID:
332156
Concept ID:
C1836230
Finding
Synonyms: HIV-1, SUSCEPTIBILITY TO; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, RESISTANCE TO; Human immunodeficiency virus type 1, susceptibility to
 
Genes (locations): CCL11 (17q12); CCL2 (17q12); CCL3 (17q12); CCL3L1; CCL5 (17q12); CCR2 (3p21.31); CCR5 (3p21.31); CD209 (19p13.2); CX3CR1 (3p22.2); CXCL12 (10q11.21); CXCR1 (2q35); HLA-C (6p21.33); IFNG (12q15); IL10 (1q32.1); KIR3DL1 (19q13.42); TLR3 (4q35.1)
 
Monarch Initiative: MONDO:0004951
OMIM®: 609423

Definition

The pathogenesis of HIV infection and the progression from infection to AIDS vary significantly between exposed individuals. Infection occurs after the virus, which has macrophage (M)- and T lymphocyte (T)-tropic strains and more than 12 subtypes, survives an array of nonspecific, nongenetic environmental and host factors. [from OMIM]

Professional guidelines

PubMed

Alsulami K, Bolastig N, Dupuy FP, Mabanga T, Gilbert L, Kiani Z, Routy JP, Bruneau J, Thomas R, Tremblay C, Tsoukas CM, Szabo J, Côté P, Trottier B, LeBlanc R, Rouleau D, Bernard NF; investigators in the Montreal Primary HIV Infection cohort
J Virol 2021 Jul 26;95(16):e0041721. doi: 10.1128/JVI.00417-21. PMID: 34076484Free PMC Article
Nkenfou CN, Tchakounté C, Nkenfou-Tchinda CN, Ngoufack MN, Yatchou LG, Elong E, Kamgaing R, Tiga A, Ambada G, Kuiate JR, Ndjolo A
Curr HIV Res 2021;19(4):342-351. doi: 10.2174/1570162X19666210412121143. PMID: 33845725
Marmor M, Sheppard HW, Donnell D, Bozeman S, Celum C, Buchbinder S, Koblin B, Seage GR 3rd; HIV Network for Prevention Trials Vaccine Preparedness Protocol Team
J Acquir Immune Defic Syndr 2001 Aug 15;27(5):472-81. doi: 10.1097/00126334-200108150-00009. PMID: 11511825

Recent clinical studies

Etiology

Bayigga L, Kateete DP, Anderson DJ, Sekikubo M, Nakanjako D
Am J Obstet Gynecol 2019 Feb;220(2):155-166. Epub 2018 Oct 12 doi: 10.1016/j.ajog.2018.10.014. PMID: 30321529Free PMC Article
Azim T, Bontell I, Strathdee SA
Int J Drug Policy 2015 Feb;26 Suppl 1(0 1):S16-21. Epub 2014 Sep 17 doi: 10.1016/j.drugpo.2014.09.003. PMID: 25277726Free PMC Article
Seeley J, Watts CH, Kippax S, Russell S, Heise L, Whiteside A
J Int AIDS Soc 2012;15 Suppl 1(Suppl 1):1-4. doi: 10.7448/IAS.15.3.17397. PMID: 22905346Free PMC Article
Restrepo C, Rallón NI, Carrillo J, Soriano V, Blanco J, Benito JM
AIDS Rev 2011 Jan-Mar;13(1):30-40. PMID: 21412387
Lama J, Planelles V
Retrovirology 2007 Jul 25;4:52. doi: 10.1186/1742-4690-4-52. PMID: 17651505Free PMC Article

Diagnosis

Kelly S, Jacobs ES, Stone M, Keating SM, Lee TH, Chafets D, Heitman J, Dimapasoc M, Operskalski E, Hagar W, Vichinsky E, Busch MP, Norris PJ, Custer B; Recipient Epidemiology and Donor Evaluation Study (REDS-III)
PLoS One 2020;15(4):e0218880. Epub 2020 Apr 8 doi: 10.1371/journal.pone.0218880. PMID: 32267841Free PMC Article
Adebayo OW, Salerno JP
Res Theory Nurs Pract 2019 Aug 1;33(3):275-291. doi: 10.1891/1541-6577.33.3.275. PMID: 31615946
Devadas K, Biswas S, Haleyurgirisetty M, Wood O, Ragupathy V, Lee S, Hewlett I
PLoS One 2016;11(1):e0147421. Epub 2016 Jan 28 doi: 10.1371/journal.pone.0147421. PMID: 26821323Free PMC Article
Seeley J, Watts CH, Kippax S, Russell S, Heise L, Whiteside A
J Int AIDS Soc 2012;15 Suppl 1(Suppl 1):1-4. doi: 10.7448/IAS.15.3.17397. PMID: 22905346Free PMC Article
Raghavan S, Alagarasu K, Selvaraj P
Tuberculosis (Edinb) 2012 Jan;92(1):18-30. Epub 2011 Sep 22 doi: 10.1016/j.tube.2011.08.004. PMID: 21943869

Therapy

Haddad LB, Tang JH, Davis NL, Kourtis AP, Chinula L, Msika A, Tegha G, Hosseinipour MC, Nelson JAE, Hobbs MM, Gajer P, Ravel J, De Paris K
mSphere 2023 Feb 21;8(1):e0058522. Epub 2023 Jan 9 doi: 10.1128/msphere.00585-22. PMID: 36622252Free PMC Article
Kelly S, Jacobs ES, Stone M, Keating SM, Lee TH, Chafets D, Heitman J, Dimapasoc M, Operskalski E, Hagar W, Vichinsky E, Busch MP, Norris PJ, Custer B; Recipient Epidemiology and Donor Evaluation Study (REDS-III)
PLoS One 2020;15(4):e0218880. Epub 2020 Apr 8 doi: 10.1371/journal.pone.0218880. PMID: 32267841Free PMC Article
Biasin M, De Luca M, Gnudi F, Clerici M
Expert Rev Clin Immunol 2013 Apr;9(4):319-34. doi: 10.1586/eci.13.16. PMID: 23557268
Raghavan S, Alagarasu K, Selvaraj P
Tuberculosis (Edinb) 2012 Jan;92(1):18-30. Epub 2011 Sep 22 doi: 10.1016/j.tube.2011.08.004. PMID: 21943869
Hilber AM, Francis SC, Chersich M, Scott P, Redmond S, Bender N, Miotti P, Temmerman M, Low N
PLoS One 2010 Feb 9;5(2):e9119. doi: 10.1371/journal.pone.0009119. PMID: 20161749Free PMC Article

Prognosis

Alsulami K, Bolastig N, Dupuy FP, Mabanga T, Gilbert L, Kiani Z, Routy JP, Bruneau J, Thomas R, Tremblay C, Tsoukas CM, Szabo J, Côté P, Trottier B, LeBlanc R, Rouleau D, Bernard NF; investigators in the Montreal Primary HIV Infection cohort
J Virol 2021 Jul 26;95(16):e0041721. doi: 10.1128/JVI.00417-21. PMID: 34076484Free PMC Article
Angulo JMC, Cuesta TAC, Menezes EP, Pedroso C, Brites C
Braz J Infect Dis 2019 Mar-Apr;23(2):71-78. Epub 2019 May 18 doi: 10.1016/j.bjid.2019.04.009. PMID: 31112676Free PMC Article
Kaur G, Mehra N
Tissue Antigens 2009 Apr;73(4):289-301. doi: 10.1111/j.1399-0039.2009.01220.x. PMID: 19317737Free PMC Article
Coggins C, Segal S
J Reprod Immunol 1998 Dec;41(1-2):3-15. doi: 10.1016/s0165-0378(98)00045-x. PMID: 10213297
McManus TJ, Weatherburn P
Br Med Bull 1994 Jan;50(1):115-23. doi: 10.1093/oxfordjournals.bmb.a072870. PMID: 8149188

Clinical prediction guides

Haddad LB, Tang JH, Davis NL, Kourtis AP, Chinula L, Msika A, Tegha G, Hosseinipour MC, Nelson JAE, Hobbs MM, Gajer P, Ravel J, De Paris K
mSphere 2023 Feb 21;8(1):e0058522. Epub 2023 Jan 9 doi: 10.1128/msphere.00585-22. PMID: 36622252Free PMC Article
Gumbs SBH, Kübler R, Gharu L, Schipper PJ, Borst AL, Snijders GJLJ, Ormel PR, van Berlekom AB, Wensing AMJ, de Witte LD, Nijhuis M
J Neurovirol 2022 Feb;28(1):64-91. Epub 2022 Feb 9 doi: 10.1007/s13365-021-01049-w. PMID: 35138593Free PMC Article
Alsulami K, Bolastig N, Dupuy FP, Mabanga T, Gilbert L, Kiani Z, Routy JP, Bruneau J, Thomas R, Tremblay C, Tsoukas CM, Szabo J, Côté P, Trottier B, LeBlanc R, Rouleau D, Bernard NF; investigators in the Montreal Primary HIV Infection cohort
J Virol 2021 Jul 26;95(16):e0041721. doi: 10.1128/JVI.00417-21. PMID: 34076484Free PMC Article
Venkatesh KK, Cu-Uvin S
Am J Reprod Immunol 2013 Feb;69 Suppl 1:68-73. Epub 2012 Oct 11 doi: 10.1111/aji.12029. PMID: 23057756
Kaur G, Mehra N
Tissue Antigens 2009 Apr;73(4):289-301. doi: 10.1111/j.1399-0039.2009.01220.x. PMID: 19317737Free PMC Article

Recent systematic reviews

Newman PA, Logie C
AIDS 2010 Jul 17;24(11):1749-56. doi: 10.1097/qad.0b013e32833adbe8. PMID: 20597165
Hilber AM, Francis SC, Chersich M, Scott P, Redmond S, Bender N, Miotti P, Temmerman M, Low N
PLoS One 2010 Feb 9;5(2):e9119. doi: 10.1371/journal.pone.0009119. PMID: 20161749Free PMC Article

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