U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from OMIM

Scurvy(SCURVY)

MedGen UID:
20684
•Concept ID:
C0036474
•
Disease or Syndrome
Synonyms: Deficiency of vitamin C; Hypoascorbemia; Scorbutus; SCURVY; VITAMIN C, INABILITY TO SYNTHESIZE
SNOMED CT: Scurvy (76169001)
 
Monarch Initiative: MONDO:0009412
OMIM®: 240400

Definition

Abnormally low concentrations of vitamin C in the blood. [from NCI]

Clinical features

From HPO
Abnormality of metabolism/homeostasis
MedGen UID:
867398
•Concept ID:
C4021768
•
Finding
See: Feature record | Search on this feature

Professional guidelines

PubMed

Technical note: The use and misuse of threshold diagnostic criteria in paleopathology.
Vlok M
Am J Biol Anthropol 2023 Jun;181(2):326-335. Epub 2023 Mar 3 doi: 10.1002/ajpa.24721. PMID: 36866523
A review of the effectiveness of hibiscus for treatment of metabolic syndrome.
Jeffery TD, Richardson ML
J Ethnopharmacol 2021 Apr 24;270:113762. Epub 2020 Dec 28 doi: 10.1016/j.jep.2020.113762. PMID: 33383111
The role of vitamin C in the treatment of pain: new insights.
Carr AC, McCall C
J Transl Med 2017 Apr 14;15(1):77. doi: 10.1186/s12967-017-1179-7. PMID: 28410599Free PMC Article

Recent clinical studies

Etiology

Scurvy: old disease, new lessons.
Kinlin LM, Weinstein M
Paediatr Int Child Health 2023 Nov;43(4):83-94. Epub 2023 Dec 29 doi: 10.1080/20469047.2023.2262787. PMID: 37795755
A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection.
Gombart AF, Pierre A, Maggini S
Nutrients 2020 Jan 16;12(1) doi: 10.3390/nu12010236. PMID: 31963293Free PMC Article
Chapter 6: Vitamins and Oral Health.
Gutierrez Gossweiler A, Martinez-Mier EA
Monogr Oral Sci 2020;28:59-67. Epub 2019 Nov 7 doi: 10.1159/000455372. PMID: 31940621
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Pharmacology of vitamin C.
Sauberlich HE
Annu Rev Nutr 1994;14:371-91. doi: 10.1146/annurev.nu.14.070194.002103. PMID: 7946525

Diagnosis

Scurvy: old disease, new lessons.
Kinlin LM, Weinstein M
Paediatr Int Child Health 2023 Nov;43(4):83-94. Epub 2023 Dec 29 doi: 10.1080/20469047.2023.2262787. PMID: 37795755
Scurvy.
Ishizuka K, Ohira Y
QJM 2022 Jul 9;115(7):475. doi: 10.1093/qjmed/hcac122. PMID: 35575388
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Neuropsychiatric scurvy.
Brown TM
Psychosomatics 2015 Jan-Feb;56(1):12-20. Epub 2014 Jun 2 doi: 10.1016/j.psym.2014.05.010. PMID: 25619670

Therapy

Scurvy: old disease, new lessons.
Kinlin LM, Weinstein M
Paediatr Int Child Health 2023 Nov;43(4):83-94. Epub 2023 Dec 29 doi: 10.1080/20469047.2023.2262787. PMID: 37795755
Scurvy.
Ishizuka K, Ohira Y
QJM 2022 Jul 9;115(7):475. doi: 10.1093/qjmed/hcac122. PMID: 35575388
A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection.
Gombart AF, Pierre A, Maggini S
Nutrients 2020 Jan 16;12(1) doi: 10.3390/nu12010236. PMID: 31963293Free PMC Article
Scurvy and embryo culture.
Barnhart KT
Fertil Steril 2018 Jun;109(6):988. doi: 10.1016/j.fertnstert.2018.04.015. PMID: 29935658
Pharmacology of vitamin C.
Sauberlich HE
Annu Rev Nutr 1994;14:371-91. doi: 10.1146/annurev.nu.14.070194.002103. PMID: 7946525

Prognosis

The Troubling Rise of Scurvy: A Review and National Analysis of Incidence, Associated Risk Factors, and Clinical Manifestations.
Reikersdorfer KN, Singh A, Young JD, Batty MB, Steele AE, Yuen LC, Momtaz DA, Weissert JN, Liu DS, Hogue GD
J Am Acad Orthop Surg Glob Res Rev 2024 Jul 1;8(7) Epub 2024 Jul 15 doi: 10.5435/JAAOSGlobal-D-24-00162. PMID: 39018570Free PMC Article
A Case of Scurvy-Uncommon Disease-Presenting as Panniculitis, Purpura, and Oligoarthritis.
Mintsoulis D, Milman N, Fahim S
J Cutan Med Surg 2016 Nov;20(6):592-595. Epub 2016 Jul 14 doi: 10.1177/1203475416660311. PMID: 27416817
Scurvy: a disease almost forgotten.
Olmedo JM, Yiannias JA, Windgassen EB, Gornet MK
Int J Dermatol 2006 Aug;45(8):909-13. doi: 10.1111/j.1365-4632.2006.02844.x. PMID: 16911372
Scurvy and psychiatric symptoms.
DeSantis J
Perspect Psychiatr Care 1993 Jan-Mar;29(1):18-22. doi: 10.1111/j.1744-6163.1993.tb00397.x. PMID: 8451160
The dawn of Darwinian medicine.
Williams GC, Nesse RM
Q Rev Biol 1991 Mar;66(1):1-22. doi: 10.1086/417048. PMID: 2052670

Clinical prediction guides

Clinical therapeutic trials.
Buchanan WW, Kean CA, Rainsford KD, Kean WF
Inflammopharmacology 2024 Feb;32(1):61-71. Epub 2023 Aug 3 doi: 10.1007/s10787-023-01303-z. PMID: 37535211
Scurvy: old disease, new lessons.
Kinlin LM, Weinstein M
Paediatr Int Child Health 2023 Nov;43(4):83-94. Epub 2023 Dec 29 doi: 10.1080/20469047.2023.2262787. PMID: 37795755
Unwinding the potentials of vitamin C in COVID-19 and other diseases: An updated review.
Mehta N, Pokharna P, Shetty SR
Nutr Health 2023 Sep;29(3):415-433. Epub 2022 Nov 29 doi: 10.1177/02601060221139628. PMID: 36445072Free PMC Article
Dietary Vitamin C in Human Health.
Granger M, Eck P
Adv Food Nutr Res 2018;83:281-310. Epub 2018 Feb 16 doi: 10.1016/bs.afnr.2017.11.006. PMID: 29477224
Scurvy: past, present and future.
Magiorkinis E, Beloukas A, Diamantis A
Eur J Intern Med 2011 Apr;22(2):147-52. Epub 2010 Nov 16 doi: 10.1016/j.ejim.2010.10.006. PMID: 21402244

Recent systematic reviews

Vitamin C deficiency can lead to pulmonary hypertension: a systematic review of case reports.
Hemilä H, de Man AME
BMC Pulm Med 2024 Mar 19;24(1):140. doi: 10.1186/s12890-024-02941-x. PMID: 38504249Free PMC Article
Prevalence, risk factors, and clinical outcomes of vitamin C deficiency in adult hospitalized patients in high-income countries: a scoping review.
Golder JE, Bauer JD, Barker LA, Lemoh CN, Gibson SJ, Davidson ZE
Nutr Rev 2024 Nov 1;82(11):1605-1621. doi: 10.1093/nutrit/nuad157. PMID: 38219216Free PMC Article
Bleeding tendency and ascorbic acid requirements: systematic review and meta-analysis of clinical trials.
Hujoel PP, Kato T, Hujoel IA, Hujoel MLA
Nutr Rev 2021 Aug 9;79(9):964-975. doi: 10.1093/nutrit/nuaa115. PMID: 33517432
Nutritional Deficiency Disease Secondary to ARFID Symptoms Associated with Autism and the Broad Autism Phenotype: A Qualitative Systematic Review of Case Reports and Case Series.
Yule S, Wanik J, Holm EM, Bruder MB, Shanley E, Sherman CQ, Fitterman M, Lerner J, Marcello M, Parenchuck N, Roman-White C, Ziff M
J Acad Nutr Diet 2021 Mar;121(3):467-492. Epub 2020 Nov 19 doi: 10.1016/j.jand.2020.10.017. PMID: 33221247
Scurvy as a Sequela of Avoidant-Restrictive Food Intake Disorder in Autism: A Systematic Review.
Sharp WG, Berry RC, Burrell L, Scahill L, McElhanon BO
J Dev Behav Pediatr 2020 Jun/Jul;41(5):397-405. doi: 10.1097/DBP.0000000000000782. PMID: 32044868

Supplemental Content

Filter your results:

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...