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Increased reactive oxygen species production

MedGen UID:
1390274
•Concept ID:
C4476796
•
Cell or Molecular Dysfunction
Synonyms: Increased ROS production; Oxidative stress
 
HPO: HP:0025464

Definition

An accumulation of free radical groups in the body inadequately neutralized by antioxidants, which creates a potentially unstable and damaging cellular environment linked to tissue damage. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased reactive oxygen species production

Professional guidelines

PubMed

Effects of Stromal Cell Conditioned Medium and Antipurinergic Treatment on Macrophage Phenotype.
Arabiyat AS, Yeisley DJ, Güiza-Argüello VR, Qureshi F, Culibrk RA, Hahn J, Hahn MS
Tissue Eng Part C Methods 2022 Dec;28(12):656-671. doi: 10.1089/ten.TEC.2022.0123. PMID: 36329666Free PMC Article
Oxidative stress and antioxidant treatment in patients with peripheral artery disease.
Koutakis P, Ismaeel A, Farmer P, Purcell S, Smith RS, Eidson JL, Bohannon WT
Physiol Rep 2018 Apr;6(7):e13650. doi: 10.14814/phy2.13650. PMID: 29611350Free PMC Article
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
Huynh K, Bernardo BC, McMullen JR, Ritchie RH
Pharmacol Ther 2014 Jun;142(3):375-415. Epub 2014 Jan 22 doi: 10.1016/j.pharmthera.2014.01.003. PMID: 24462787

Recent clinical studies

Etiology

Endothelial Dysfunction in Youth-Onset Type 2 Diabetes: A Clinical Translational Study.
Abd-Elmoniem KZ, Edwan JH, Dietsche KB, Villalobos-Perez A, Shams N, Matta J, Baumgarten L, Qaddumi WN, Dixon SA, Chowdhury A, Stagliano M, Mabundo L, Wentzel A, Hadigan C, Gharib AM, Chung ST
Circ Res 2024 Aug 30;135(6):639-650. Epub 2024 Jul 29 doi: 10.1161/CIRCRESAHA.124.324272. PMID: 39069898Free PMC Article
Lifestyle factors as determinants of atherosclerotic cardiovascular health.
Schmidt-Trucksäss A, Lichtenstein AH, von Känel R
Atherosclerosis 2024 Aug;395:117577. Epub 2024 May 10 doi: 10.1016/j.atherosclerosis.2024.117577. PMID: 38852021
DHCR24 Insufficiency Promotes Vascular Endothelial Cell Senescence and Endothelial Dysfunction via Inhibition of Caveolin-1/ERK Signaling.
Li H, Yang Z, Liang W, Nie H, Guan Y, Yang N, Ji T, Liu Y, Huang Y, Zhang L, Yan J, Zhang C
J Gerontol A Biol Sci Med Sci 2024 Apr 1;79(4) doi: 10.1093/gerona/glae059. PMID: 38407305Free PMC Article
Protein carbamylation and cardiovascular disease.
Verbrugge FH, Tang WH, Hazen SL
Kidney Int 2015 Sep;88(3):474-8. Epub 2015 Jun 10 doi: 10.1038/ki.2015.166. PMID: 26061545Free PMC Article
Direct contribution of vascular mineralocorticoid receptors to blood pressure regulation.
Barrett KV, McCurley AT, Jaffe IZ
Clin Exp Pharmacol Physiol 2013 Dec;40(12):902-9. doi: 10.1111/1440-1681.12125. PMID: 23710823Free PMC Article

Diagnosis

Endothelial Dysfunction in Youth-Onset Type 2 Diabetes: A Clinical Translational Study.
Abd-Elmoniem KZ, Edwan JH, Dietsche KB, Villalobos-Perez A, Shams N, Matta J, Baumgarten L, Qaddumi WN, Dixon SA, Chowdhury A, Stagliano M, Mabundo L, Wentzel A, Hadigan C, Gharib AM, Chung ST
Circ Res 2024 Aug 30;135(6):639-650. Epub 2024 Jul 29 doi: 10.1161/CIRCRESAHA.124.324272. PMID: 39069898Free PMC Article
Apigenin enhances apoptosis induction by 5-fluorouracil through regulation of thymidylate synthase in colorectal cancer cells.
Yang C, Song J, Hwang S, Choi J, Song G, Lim W
Redox Biol 2021 Nov;47:102144. Epub 2021 Sep 21 doi: 10.1016/j.redox.2021.102144. PMID: 34562873Free PMC Article
The role of sirtuins in mitochondrial function and doxorubicin-induced cardiac dysfunction.
Dolinsky VW
Biol Chem 2017 Aug 28;398(9):955-974. doi: 10.1515/hsz-2016-0316. PMID: 28253192
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC
Nat Med 2016 May;22(5):547-56. Epub 2016 Apr 18 doi: 10.1038/nm.4087. PMID: 27089514Free PMC Article
Traumatic brain injury and mitochondrial dysfunction.
Hiebert JB, Shen Q, Thimmesch AR, Pierce JD
Am J Med Sci 2015 Aug;350(2):132-8. doi: 10.1097/MAJ.0000000000000506. PMID: 26083647

Therapy

Blunted Cardiac Mitophagy in Response to Metabolic Stress Contributes to HFpEF.
Yoshii A, McMillen TS, Wang Y, Zhou B, Chen H, Banerjee D, Herrero M, Wang P, Muraoka N, Wang W, Murry CE, Tian R
Circ Res 2024 Oct 25;135(10):1004-1017. Epub 2024 Sep 27 doi: 10.1161/CIRCRESAHA.123.324103. PMID: 39328167Free PMC Article
Lifestyle factors as determinants of atherosclerotic cardiovascular health.
Schmidt-Trucksäss A, Lichtenstein AH, von Känel R
Atherosclerosis 2024 Aug;395:117577. Epub 2024 May 10 doi: 10.1016/j.atherosclerosis.2024.117577. PMID: 38852021
NRF2 as a Therapeutic Target in Neurodegenerative Diseases.
Brandes MS, Gray NE
ASN Neuro 2020 Jan-Dec;12:1759091419899782. doi: 10.1177/1759091419899782. PMID: 31964153Free PMC Article
Dichloroacetate-induced peripheral neuropathy.
Stacpoole PW, Martyniuk CJ, James MO, Calcutt NA
Int Rev Neurobiol 2019;145:211-238. Epub 2019 Jun 11 doi: 10.1016/bs.irn.2019.05.003. PMID: 31208525
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC
Nat Med 2016 May;22(5):547-56. Epub 2016 Apr 18 doi: 10.1038/nm.4087. PMID: 27089514Free PMC Article

Prognosis

Phenotypic and functional characterisation of synovial fluid-derived neutrophils in knee osteoarthritis and knee infection.
Manukyan G, Gallo J, Mikulkova Z, Trajerova M, Savara J, Slobodova Z, Fidler E, Shrestha B, Kriegova E
Osteoarthritis Cartilage 2023 Jan;31(1):72-82. Epub 2022 Oct 7 doi: 10.1016/j.joca.2022.09.011. PMID: 36216277
Beneficial effect of ursodeoxycholic acid in patients with acyl-CoA oxidase 2 (ACOX2) deficiency-associated hypertransaminasemia.
Alonso-Peña M, Espinosa-Escudero R, Herraez E, Briz O, Cagigal ML, Gonzalez-Santiago JM, Ortega-Alonso A, Fernandez-Rodriguez C, Bujanda L, Calvo Sanchez M, D Avola D, Londoño MC, Diago M, Fernandez-Checa JC, Garcia-Ruiz C, Andrade RJ, Lammert F, Prieto J, Crespo J, Juamperez J, Diaz-Gonzalez A, Monte MJ, Marin JJG
Hepatology 2022 Nov;76(5):1259-1274. Epub 2022 Jul 1 doi: 10.1002/hep.32517. PMID: 35395098Free PMC Article
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC
Nat Med 2016 May;22(5):547-56. Epub 2016 Apr 18 doi: 10.1038/nm.4087. PMID: 27089514Free PMC Article
Protein carbamylation and cardiovascular disease.
Verbrugge FH, Tang WH, Hazen SL
Kidney Int 2015 Sep;88(3):474-8. Epub 2015 Jun 10 doi: 10.1038/ki.2015.166. PMID: 26061545Free PMC Article
Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production.
Tang S, Le PK, Tse S, Wallace DC, Huang T
PLoS One 2009;4(2):e4492. Epub 2009 Feb 16 doi: 10.1371/journal.pone.0004492. PMID: 19221591Free PMC Article

Clinical prediction guides

Blunted Cardiac Mitophagy in Response to Metabolic Stress Contributes to HFpEF.
Yoshii A, McMillen TS, Wang Y, Zhou B, Chen H, Banerjee D, Herrero M, Wang P, Muraoka N, Wang W, Murry CE, Tian R
Circ Res 2024 Oct 25;135(10):1004-1017. Epub 2024 Sep 27 doi: 10.1161/CIRCRESAHA.123.324103. PMID: 39328167Free PMC Article
Mitochondrial dysfunction and increased reactive oxygen species production in MECP2 mutant astrocytes and their impact on neurons.
Tomasello DL, Barrasa MI, Mankus D, Alarcon KI, Lytton-Jean AKR, Liu XS, Jaenisch R
Sci Rep 2024 Sep 4;14(1):20565. doi: 10.1038/s41598-024-71040-y. PMID: 39232000Free PMC Article
Lifestyle factors as determinants of atherosclerotic cardiovascular health.
Schmidt-Trucksäss A, Lichtenstein AH, von Känel R
Atherosclerosis 2024 Aug;395:117577. Epub 2024 May 10 doi: 10.1016/j.atherosclerosis.2024.117577. PMID: 38852021
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC
Nat Med 2016 May;22(5):547-56. Epub 2016 Apr 18 doi: 10.1038/nm.4087. PMID: 27089514Free PMC Article
Protein carbamylation and cardiovascular disease.
Verbrugge FH, Tang WH, Hazen SL
Kidney Int 2015 Sep;88(3):474-8. Epub 2015 Jun 10 doi: 10.1038/ki.2015.166. PMID: 26061545Free PMC Article

Recent systematic reviews

The Effect of Radiation Treatment of Solid Tumors on Neutrophil Infiltration and Function: A Systematic Review.
Raymakers L, Demmers TJ, Meijer GJ, Molenaar IQ, van Santvoort HC, Intven MPW, Leusen JHW, Olofsen PA, Daamen LA
Int J Radiat Oncol Biol Phys 2024 Nov 1;120(3):845-861. Epub 2024 Jul 14 doi: 10.1016/j.ijrobp.2024.07.2141. PMID: 39009323

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