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Aneurysmal bone cyst

MedGen UID:
57758
•Concept ID:
C0152244
•
Disease or Syndrome; Finding
Synonyms: Aneurysmal bone cyst (disease); Aneurysmal bone cysts
SNOMED CT: Aneurysmal bone cyst (76000001); ABC - Aneurysmal bone cyst (203468000); Aneurysmal bone cyst (203468000)
 
HPO: HP:0012063
Monarch Initiative: MONDO:0018815
OMIM®: 606179
Orphanet: ORPHA480553

Definition

Aneurysmal bone cysts are benign primary or secondary lesions that are rapidly expansive and locally destructive. They are located in the posterior elements of the vertebral column or the flat or long bones of patients under 30 years of age. The cysts are blood-filled and separated by septa containing spindle cells, trabeculae of bone, and osteoclastic giant cells (Biesecker et al., 1970). Histopathologically and radiographically, aneurysmal bone cysts are similar to telangiectatic osteosarcoma from which they must be differentiated. [from OMIM]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAneurysmal bone cyst

Professional guidelines

PubMed

Management of RANKL-mediated Disorders With Denosumab in Children and Adolescents: A Global Expert Guidance Document.
Vanderniet JA, Szymczuk V, Högler W, Beck-Nielsen SS, Uday S, Merchant N, Crane JL, Ward LM, Boyce AM, Munns CF
J Clin Endocrinol Metab 2024 Apr 19;109(5):1371-1382. doi: 10.1210/clinem/dgad657. PMID: 38041865Free PMC Article
Minimally Invasive Treatment of a Cervical Aneurysmal Bone Cyst Through Percutaneous Doxycycline-Albumin Foam Injection.
Bueno Neves F, Jansen O, Trentmann J, Mostafa K, Madjidyar J
Cardiovasc Intervent Radiol 2023 Mar;46(3):408-410. Epub 2022 Nov 1 doi: 10.1007/s00270-022-03292-y. PMID: 36319714Free PMC Article
Update on aneurysmal bone cyst: pathophysiology, histology, imaging and treatment.
Restrepo R, Zahrah D, Pelaez L, Temple HT, Murakami JW
Pediatr Radiol 2022 Aug;52(9):1601-1614. Epub 2022 Aug 9 doi: 10.1007/s00247-022-05396-6. PMID: 35941207Free PMC Article

Recent clinical studies

Etiology

Management of RANKL-mediated Disorders With Denosumab in Children and Adolescents: A Global Expert Guidance Document.
Vanderniet JA, Szymczuk V, Högler W, Beck-Nielsen SS, Uday S, Merchant N, Crane JL, Ward LM, Boyce AM, Munns CF
J Clin Endocrinol Metab 2024 Apr 19;109(5):1371-1382. doi: 10.1210/clinem/dgad657. PMID: 38041865Free PMC Article
Allograft Versus Bioactive Glass (BG-S53P4) in Pediatric Benign Bone Lesions: A Randomized Clinical Trial.
Syvänen J, Serlo W, Jalkanen J, Kohonen I, Raitio A, Nietosvaara Y, Helenius I
J Bone Joint Surg Am 2023 May 3;105(9):659-666. Epub 2023 Jan 19 doi: 10.2106/JBJS.22.00716. PMID: 36727973Free PMC Article
The role of neoadjuvant denosumab in the treatment of aneurysmal bone cysts: a case series and review of the literature.
Giantini-Larsen AM, Chakravarthy VB, Barzilai O, Newman WC, Wexler L, Bilsky MH
J Neurosurg Pediatr 2022 Dec 1;30(6):547-554. Epub 2022 Sep 30 doi: 10.3171/2022.8.PEDS22314. PMID: 36282899
Bone cysts: unicameral and aneurysmal bone cyst.
Mascard E, Gomez-Brouchet A, Lambot K
Orthop Traumatol Surg Res 2015 Feb;101(1 Suppl):S119-27. Epub 2015 Jan 8 doi: 10.1016/j.otsr.2014.06.031. PMID: 25579825
Vertebral chondroblastoma.
Ilaslan H, Sundaram M, Unni KK
Skeletal Radiol 2003 Feb;32(2):66-71. Epub 2002 Nov 21 doi: 10.1007/s00256-002-0599-4. PMID: 12589483

Diagnosis

Update on aneurysmal bone cyst: pathophysiology, histology, imaging and treatment.
Restrepo R, Zahrah D, Pelaez L, Temple HT, Murakami JW
Pediatr Radiol 2022 Aug;52(9):1601-1614. Epub 2022 Aug 9 doi: 10.1007/s00247-022-05396-6. PMID: 35941207Free PMC Article
Orbital Aneurysmal Bone Cyst in a Patient With McCune-Albright Syndrome.
Sweeney AR, Allen RC
Ophthalmic Plast Reconstr Surg 2021 Jan-Feb 01;37(1):e37. doi: 10.1097/IOP.0000000000001650. PMID: 32251179
Bone-Related Lesions of the Jaws.
Baumhoer D
Surg Pathol Clin 2017 Sep;10(3):693-704. Epub 2017 Jun 2 doi: 10.1016/j.path.2017.04.007. PMID: 28797509
Chondroblastoma: An Update.
Chen W, DiFrancesco LM
Arch Pathol Lab Med 2017 Jun;141(6):867-871. doi: 10.5858/arpa.2016-0281-RS. PMID: 28557595
Bone cysts: unicameral and aneurysmal bone cyst.
Mascard E, Gomez-Brouchet A, Lambot K
Orthop Traumatol Surg Res 2015 Feb;101(1 Suppl):S119-27. Epub 2015 Jan 8 doi: 10.1016/j.otsr.2014.06.031. PMID: 25579825

Therapy

Management of RANKL-mediated Disorders With Denosumab in Children and Adolescents: A Global Expert Guidance Document.
Vanderniet JA, Szymczuk V, Högler W, Beck-Nielsen SS, Uday S, Merchant N, Crane JL, Ward LM, Boyce AM, Munns CF
J Clin Endocrinol Metab 2024 Apr 19;109(5):1371-1382. doi: 10.1210/clinem/dgad657. PMID: 38041865Free PMC Article
Allograft Versus Bioactive Glass (BG-S53P4) in Pediatric Benign Bone Lesions: A Randomized Clinical Trial.
Syvänen J, Serlo W, Jalkanen J, Kohonen I, Raitio A, Nietosvaara Y, Helenius I
J Bone Joint Surg Am 2023 May 3;105(9):659-666. Epub 2023 Jan 19 doi: 10.2106/JBJS.22.00716. PMID: 36727973Free PMC Article
Local Recurrence of Metatarsal Aneurysmal Bone Cyst after Percutaneous Sclerotherapy.
Günay B, Ustabaşıoğlu FE, Çiftdemir M, Uslu B, Usta U
Balkan Med J 2022 Nov 7;39(6):448-449. Epub 2022 Oct 27 doi: 10.4274/balkanmedj.galenos.2022.2022-9-104. PMID: 36300539Free PMC Article
Aneurysmal bone cyst treated with percutaneous doxycycline: is a single treatment sufficient?
Woon JTK, Hoon D, Graydon A, Flint M, Doyle AJ
Skeletal Radiol 2019 May;48(5):765-771. Epub 2019 Feb 26 doi: 10.1007/s00256-019-03188-y. PMID: 30809704
Denosumab: Current Use in the Treatment of Primary Bone Tumors.
Savvidou OD, Bolia IK, Chloros GD, Papanastasiou J, Koutsouradis P, Papagelopoulos PJ
Orthopedics 2017 Jul 1;40(4):204-210. doi: 10.3928/01477447-20170627-04. PMID: 28732103

Prognosis

Bone cysts: unicameral and aneurysmal bone cyst.
Mascard E, Gomez-Brouchet A, Lambot K
Orthop Traumatol Surg Res 2015 Feb;101(1 Suppl):S119-27. Epub 2015 Jan 8 doi: 10.1016/j.otsr.2014.06.031. PMID: 25579825
Telangiectatic osteosarcoma.
Sangle NA, Layfield LJ
Arch Pathol Lab Med 2012 May;136(5):572-6. doi: 10.5858/arpa.2011-0204-RS. PMID: 22540307
Aneurysmal bone cyst.
Mendenhall WM, Zlotecki RA, Gibbs CP, Reith JD, Scarborough MT, Mendenhall NP
Am J Clin Oncol 2006 Jun;29(3):311-5. doi: 10.1097/01.coc.0000204403.13451.52. PMID: 16755186
Vertebral chondroblastoma.
Ilaslan H, Sundaram M, Unni KK
Skeletal Radiol 2003 Feb;32(2):66-71. Epub 2002 Nov 21 doi: 10.1007/s00256-002-0599-4. PMID: 12589483
Aneurysmal bone cyst. Pathology, clinical course and radiologic appearances.
Dabska M, Buraczewski J
Cancer 1969 Feb;23(2):371-89. doi: 10.1002/1097-0142(196902)23:2<371::aid-cncr2820230213>3.0.co;2-2. PMID: 5764977

Clinical prediction guides

Primary aneurysmal bone cyst of hands and feet: A series of 14 cases.
Pena-Burgos EM, Serra-Del Carpio G, Tapia-Viñe M, Iglesias Urraca C, Cordero García JM, Ortiz-Cruz EJ, Pozo-Kreilinger JJ
Ann Diagn Pathol 2023 Oct;66:152169. Epub 2023 Jun 1 doi: 10.1016/j.anndiagpath.2023.152169. PMID: 37295038
Allograft Versus Bioactive Glass (BG-S53P4) in Pediatric Benign Bone Lesions: A Randomized Clinical Trial.
Syvänen J, Serlo W, Jalkanen J, Kohonen I, Raitio A, Nietosvaara Y, Helenius I
J Bone Joint Surg Am 2023 May 3;105(9):659-666. Epub 2023 Jan 19 doi: 10.2106/JBJS.22.00716. PMID: 36727973Free PMC Article
Craniofacial fibrous dysplasia.
Hanifi B, Samil KS, Yasar C, Cengiz C, Ercan A, Ramazan D
Clin Imaging 2013 Nov-Dec;37(6):1109-15. Epub 2013 Aug 29 doi: 10.1016/j.clinimag.2013.01.010. PMID: 23993753
Aneurysmal bone cyst; observations on fifty cases.
LICHTENSTEIN L
J Bone Joint Surg Am 1957 Jul;39-A(4):873-82. PMID: 13438943
Aneurysmal bone cyst; further observations.
LICHTENSTEIN L
Cancer 1953 Nov;6(6):1228-37. doi: 10.1002/1097-0142(195311)6:6<1228::aid-cncr2820060617>3.0.co;2-a. PMID: 13106840

Recent systematic reviews

Rare Aneurysmal Bone Cyst Presentation in the Orbit: A Systematic Review of the Literature with an Illustrative Case Report.
O'Leary S, Hayat F, Amasa S, Ammar Haider M, Akram Asbeutah S, AlDallal U, Barrie U, Ismail M
World Neurosurg 2024 Nov;191:1-9. Epub 2024 Aug 2 doi: 10.1016/j.wneu.2024.07.185. PMID: 39097084
Aneurysmal bone cyst of the spine in adult patients: A systematic review and comparison of primary vs secondary lesions.
Palmisciano P, Hunter M, Lokesh N, Bin Alamer O, Scalia G, Giammalva GR, Maugeri R, Iacopino DG, Umana GE, Haider AS
J Clin Neurosci 2022 Jun;100:15-22. Epub 2022 Apr 1 doi: 10.1016/j.jocn.2022.03.040. PMID: 35367732
Minimally invasive treatment of aneurysmal bone cysts: Systematic literature review.
Cottalorda J, Louahem Sabah D, Joly Monrigal P, Jeandel C, Delpont M
Orthop Traumatol Surg Res 2022 Jun;108(4):103272. Epub 2022 Mar 21 doi: 10.1016/j.otsr.2022.103272. PMID: 35331923
Benign Tumors of the Spine: Has New Chemotherapy and Interventional Radiology Changed the Treatment Paradigm?
Charest-Morin R, Boriani S, Fisher CG, Patel SR, Kawahara N, Mendel E, Bettegowda C, Rhines LD
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20:S178-S185. doi: 10.1097/BRS.0000000000001818. PMID: 27488295
Aggressive "benign" primary spine neoplasms: osteoblastoma, aneurysmal bone cyst, and giant cell tumor.
Harrop JS, Schmidt MH, Boriani S, Shaffrey CI
Spine (Phila Pa 1976) 2009 Oct 15;34(22 Suppl):S39-47. doi: 10.1097/BRS.0b013e3181ba0024. PMID: 19829276

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