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Diabetic kidney disease

MedGen UID:
8352
•Concept ID:
C0011881
•
Disease or Syndrome
Synonym: Diabetic nephropathy
SNOMED CT: Diabetic nephropathy (127013003); Renal disorder associated with diabetes mellitus (127013003); Diabetic renal disease (127013003); Kidney disorder due to diabetes mellitus (127013003); Disorder of kidney due to diabetes mellitus (127013003)
 
Monarch Initiative: MONDO:0005016

Definition

Progressive kidney disorder caused by vascular damage to the glomerular capillaries, in patients with diabetes mellitus. It is usually manifested with nephritic syndrome and glomerulosclerosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiabetic kidney disease

Professional guidelines

PubMed

Uncovering the mechanism of resveratrol in the treatment of diabetic kidney disease based on network pharmacology, molecular docking, and experimental validation.
Chen S, Li B, Chen L, Jiang H
J Transl Med 2023 Jun 12;21(1):380. doi: 10.1186/s12967-023-04233-0. PMID: 37308949Free PMC Article
American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.
Blonde L, Umpierrez GE, Reddy SS, McGill JB, Berga SL, Bush M, Chandrasekaran S, DeFronzo RA, Einhorn D, Galindo RJ, Gardner TW, Garg R, Garvey WT, Hirsch IB, Hurley DL, Izuora K, Kosiborod M, Olson D, Patel SB, Pop-Busui R, Sadhu AR, Samson SL, Stec C, Tamborlane WV Jr, Tuttle KR, Twining C, Vella A, Vellanki P, Weber SL
Endocr Pract 2022 Oct;28(10):923-1049. Epub 2022 Aug 11 doi: 10.1016/j.eprac.2022.08.002. PMID: 35963508Free PMC Article
Treatment of Diabetic Kidney Disease: Current and Future.
Yamazaki T, Mimura I, Tanaka T, Nangaku M
Diabetes Metab J 2021 Jan;45(1):11-26. Epub 2021 Jan 22 doi: 10.4093/dmj.2020.0217. PMID: 33508907Free PMC Article

Recent clinical studies

Etiology

Molecular mechanisms and therapeutic targets for diabetic kidney disease.
Tuttle KR, Agarwal R, Alpers CE, Bakris GL, Brosius FC, Kolkhof P, Uribarri J
Kidney Int 2022 Aug;102(2):248-260. Epub 2022 Jun 3 doi: 10.1016/j.kint.2022.05.012. PMID: 35661785
Pathophysiologic Mechanisms and Potential Biomarkers in Diabetic Kidney Disease.
Jung CY, Yoo TH
Diabetes Metab J 2022 Mar;46(2):181-197. Epub 2022 Mar 24 doi: 10.4093/dmj.2021.0329. PMID: 35385633Free PMC Article
Diabetic Kidney Disease.
Bonner R, Albajrami O, Hudspeth J, Upadhyay A
Prim Care 2020 Dec;47(4):645-659. Epub 2020 Sep 23 doi: 10.1016/j.pop.2020.08.004. PMID: 33121634
Diabetic Kidney Disease: Challenges, Progress, and Possibilities.
Alicic RZ, Rooney MT, Tuttle KR
Clin J Am Soc Nephrol 2017 Dec 7;12(12):2032-2045. Epub 2017 May 18 doi: 10.2215/CJN.11491116. PMID: 28522654Free PMC Article
Diabetic kidney disease.
Thomas MC, Brownlee M, Susztak K, Sharma K, Jandeleit-Dahm KA, Zoungas S, Rossing P, Groop PH, Cooper ME
Nat Rev Dis Primers 2015 Jul 30;1:15018. doi: 10.1038/nrdp.2015.18. PMID: 27188921Free PMC Article

Diagnosis

Diabetic Kidney Disease: An Update.
Gupta S, Dominguez M, Golestaneh L
Med Clin North Am 2023 Jul;107(4):689-705. Epub 2023 Apr 7 doi: 10.1016/j.mcna.2023.03.004. PMID: 37258007
Systemic immune-inflammation index is associated with diabetic kidney disease in Type 2 diabetes mellitus patients: Evidence from NHANES 2011-2018.
Guo W, Song Y, Sun Y, Du H, Cai Y, You Q, Fu H, Shao L
Front Endocrinol (Lausanne) 2022;13:1071465. Epub 2022 Dec 6 doi: 10.3389/fendo.2022.1071465. PMID: 36561561Free PMC Article
Prevention of Microvascular Complications of Diabetes.
Crasto W, Patel V, Davies MJ, Khunti K
Endocrinol Metab Clin North Am 2021 Sep;50(3):431-455. doi: 10.1016/j.ecl.2021.05.005. PMID: 34399955
Diabetic Kidney Disease.
Bonner R, Albajrami O, Hudspeth J, Upadhyay A
Prim Care 2020 Dec;47(4):645-659. Epub 2020 Sep 23 doi: 10.1016/j.pop.2020.08.004. PMID: 33121634
Diabetic Kidney Disease: Challenges, Progress, and Possibilities.
Alicic RZ, Rooney MT, Tuttle KR
Clin J Am Soc Nephrol 2017 Dec 7;12(12):2032-2045. Epub 2017 May 18 doi: 10.2215/CJN.11491116. PMID: 28522654Free PMC Article

Therapy

Targeting inflammation to treat diabetic kidney disease: the road to 2030.
Rayego-Mateos S, Rodrigues-Diez RR, Fernandez-Fernandez B, Mora-Fernández C, Marchant V, Donate-Correa J, Navarro-González JF, Ortiz A, Ruiz-Ortega M
Kidney Int 2023 Feb;103(2):282-296. Epub 2022 Dec 5 doi: 10.1016/j.kint.2022.10.030. PMID: 36470394
Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors.
DeFronzo RA, Reeves WB, Awad AS
Nat Rev Nephrol 2021 May;17(5):319-334. Epub 2021 Feb 5 doi: 10.1038/s41581-021-00393-8. PMID: 33547417
Treatment of Diabetic Kidney Disease: Current and Future.
Yamazaki T, Mimura I, Tanaka T, Nangaku M
Diabetes Metab J 2021 Jan;45(1):11-26. Epub 2021 Jan 22 doi: 10.4093/dmj.2020.0217. PMID: 33508907Free PMC Article
Diabetic Kidney Disease.
Bonner R, Albajrami O, Hudspeth J, Upadhyay A
Prim Care 2020 Dec;47(4):645-659. Epub 2020 Sep 23 doi: 10.1016/j.pop.2020.08.004. PMID: 33121634
Diabetic Kidney Disease: Challenges, Progress, and Possibilities.
Alicic RZ, Rooney MT, Tuttle KR
Clin J Am Soc Nephrol 2017 Dec 7;12(12):2032-2045. Epub 2017 May 18 doi: 10.2215/CJN.11491116. PMID: 28522654Free PMC Article

Prognosis

Diagnostic challenges of diabetic kidney disease.
Vučić Lovrenčić M, Božičević S, Smirčić Duvnjak L
Biochem Med (Zagreb) 2023 Oct 15;33(3):030501. Epub 2023 Aug 5 doi: 10.11613/BM.2023.030501. PMID: 37545693Free PMC Article
Pathophysiologic Mechanisms and Potential Biomarkers in Diabetic Kidney Disease.
Jung CY, Yoo TH
Diabetes Metab J 2022 Mar;46(2):181-197. Epub 2022 Mar 24 doi: 10.4093/dmj.2021.0329. PMID: 35385633Free PMC Article
Prevention of Microvascular Complications of Diabetes.
Crasto W, Patel V, Davies MJ, Khunti K
Endocrinol Metab Clin North Am 2021 Sep;50(3):431-455. doi: 10.1016/j.ecl.2021.05.005. PMID: 34399955
An updated overview of diabetic nephropathy: Diagnosis, prognosis, treatment goals and latest guidelines.
Selby NM, Taal MW
Diabetes Obes Metab 2020 Apr;22 Suppl 1:3-15. doi: 10.1111/dom.14007. PMID: 32267079
Molecular mechanisms of diabetic kidney disease.
Reidy K, Kang HM, Hostetter T, Susztak K
J Clin Invest 2014 Jun;124(6):2333-40. Epub 2014 Jun 2 doi: 10.1172/JCI72271. PMID: 24892707Free PMC Article

Clinical prediction guides

Diagnostic challenges of diabetic kidney disease.
Vučić Lovrenčić M, Božičević S, Smirčić Duvnjak L
Biochem Med (Zagreb) 2023 Oct 15;33(3):030501. Epub 2023 Aug 5 doi: 10.11613/BM.2023.030501. PMID: 37545693Free PMC Article
Reticulon-1A mediates diabetic kidney disease progression through endoplasmic reticulum-mitochondrial contacts in tubular epithelial cells.
Xie Y, E J, Cai H, Zhong F, Xiao W, Gordon RE, Wang L, Zheng YL, Zhang A, Lee K, He JC
Kidney Int 2022 Aug;102(2):293-306. Epub 2022 Apr 22 doi: 10.1016/j.kint.2022.02.038. PMID: 35469894Free PMC Article
Pathophysiologic Mechanisms and Potential Biomarkers in Diabetic Kidney Disease.
Jung CY, Yoo TH
Diabetes Metab J 2022 Mar;46(2):181-197. Epub 2022 Mar 24 doi: 10.4093/dmj.2021.0329. PMID: 35385633Free PMC Article
Prevention of Microvascular Complications of Diabetes.
Crasto W, Patel V, Davies MJ, Khunti K
Endocrinol Metab Clin North Am 2021 Sep;50(3):431-455. doi: 10.1016/j.ecl.2021.05.005. PMID: 34399955
Molecular mechanisms of diabetic kidney disease.
Reidy K, Kang HM, Hostetter T, Susztak K
J Clin Invest 2014 Jun;124(6):2333-40. Epub 2014 Jun 2 doi: 10.1172/JCI72271. PMID: 24892707Free PMC Article

Recent systematic reviews

Treatment of diabetic kidney disease. A network meta-analysis.
Büttner F, Barbosa CV, Lang H, Tian Z, Melk A, Schmidt BMW
PLoS One 2023;18(11):e0293183. Epub 2023 Nov 2 doi: 10.1371/journal.pone.0293183. PMID: 37917640Free PMC Article
Role and mechanisms of SGLT-2 inhibitors in the treatment of diabetic kidney disease.
Dai ZC, Chen JX, Zou R, Liang XB, Tang JX, Yao CW
Front Immunol 2023;14:1213473. Epub 2023 Sep 21 doi: 10.3389/fimmu.2023.1213473. PMID: 37809091Free PMC Article
Comparative safety of sodium-glucose co-transporter 2 inhibitors in elderly patients with type 2 diabetes mellitus and diabetic kidney disease: a systematic review and meta-analysis.
Liu Y, An C, Liu P, Yang F, Zhao Q
Ren Fail 2023 Dec;45(1):2217287. doi: 10.1080/0886022X.2023.2217287. PMID: 37246403Free PMC Article
Protein restriction for diabetic kidney disease.
Jiang S, Fang J, Li W
Cochrane Database Syst Rev 2023 Jan 3;1(1):CD014906. doi: 10.1002/14651858.CD014906.pub2. PMID: 36594428Free PMC Article
Finerenone in diabetic kidney disease: A systematic review and critical appraisal.
Singh AK, Singh A, Singh R, Misra A
Diabetes Metab Syndr 2022 Oct;16(10):102638. Epub 2022 Oct 4 doi: 10.1016/j.dsx.2022.102638. PMID: 36223666

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