MedGen

A allergic disease that involves the digestive tract. [from MONDO]

The presence of inflammation of the skin. That is, an abnormality of the skin resulting from the local accumulation of fluid, plasma proteins, and leukocytes. [from HPO]

An inherited susceptibility or predisposition to developing atopic dermatitis that is associated with variation in the region 3p24. [from MONDO]

It is characterized by one or more symptoms including sneezing, itching, nasal congestion, and rhinorrhea. [from HPO]

An inherited susceptibility or predisposition to developing atopic dermatitis that is associated with variation in the region 13q12-q14. [from MONDO]

Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002; Pillai et al., 2006). For a general phenotypic description and a discussion of genetic heterogeneity of asthma, see 600807. [from OMIM]

An inherited susceptibility or predisposition to developing atopic dermatitis that is associated with variation in the region 20p. [from MONDO]

An allergy experienced at a particular time of year when trees or grasses pollinate and elicit an allergic reaction. [from HPO]

Atopic dermatitis (ATOD), also known as eczema, is a common chronic pruritic inflammatory skin disease with a strong genetic component. Onset typically occurs during the first 2 years of life (review by Soderhall et al., 2007). Genetic Heterogeneity of Atopic Dermatitis Many inflammatory diseases, such as atopic eczema, are genetically complex, with multiple alleles at several loci thought to be involved in their pathogenesis. Several susceptibility loci for atopic dermatitis have been identified: ATOD1 on chromosome 3q21, ATOD2 (605803) on chromosome 1q21, ATOD3 (605804) on chromosome 20p, ATOD4 (605805) on chromosome 17q25.3, ATOD5 (603165) on chromosome 13q12-q14, ATOD6 (605845) on chromosome 5q31-q33, ATOD7 (613064) on chromosome 11q13.5, ATOD8 (613518) on chromosome 4q22.1, and ATOD9 (613519) on chromosome 3p24. [from OMIM]

Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs. [from NCI]