MedGen

Increased susceptibility to protozoan infections, as manifested by recurrent episodes of protozoan infection. [from HPO]

An abnormally decreased potassium concentration in the blood occurring periodically with a return to normal between the episodes. [from HPO]

Infection with protozoa of the genus trypanosoma. [from MONDO]

A rare vector-borne parasitic disease caused by a protozoa of the <i>Trypanosoma</i> genus transmitted by the bite of a tsetse fly (genus <i>Glossina</i>), that is found under its chronic form (average duration of 3 years) in western and central Africa (in case of the <i>T. brucei gambiense</i> sub-species), and under its acute form (lasting from few weeks to 6 months) in eastern and southern Africa (in case of the <i>T. brucei rhodesiense</i> sub-species). HAT comprises an initial hemo-lymphatic stage characterized by fever, weakness, musculoskeletal pain, anemia, and lymphadenopathy, along with dermatologic, cardiac and endocrine complications or hepatosplenomegaly, followed by a meningo-encephalitic stage characterized by neurologic involvement (sleep disturbances, psychiatric disorders, seizures) that progresses, in the absence of treatment, towards a fatal meningoencephalitis. [from ORDO]