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Mupirocin response

MedGen UID:
982278
•Concept ID:
CN298694
•
Sign or Symptom
Drug:
mupirocin
MedGen UID:
88368
•Concept ID:
C0085259
•
Antibiotic
A natural crotonic acid derivative extracted from Pseudomonas fluorescens. Mupirocin inhibits bacterial protein synthesis by specific reversible binding to bacterial isoleucyl tRNA synthase. With excellent activity against gram-positive staphylococci and streptococci, it is primarily used for treatment of primary and secondary skin disorders, nasal infections, and wound healing. (NCI04) [from NCI]
mupirocin

Professional guidelines

PubMed

Distinct Skin Microbiota Imbalance and Responses to Clinical Treatment in Children With Atopic Dermatitis.
Liu Y, Wang S, Dai W, Liang Y, Shen C, Li Y, Jiao L, Bian Y, Gao Z, Li Y, Li D, Li S, Blaser MJ, Tang YW, Ma L
Front Cell Infect Microbiol 2020;10:336. Epub 2020 Jul 3 doi: 10.3389/fcimb.2020.00336. PMID: 32719752Free PMC Article
Characterization and management of exfoliative cheilitis: a single-center experience.
Almazrooa SA, Woo SB, Mawardi H, Treister N
Oral Surg Oral Med Oral Pathol Oral Radiol 2013 Dec;116(6):e485-9. doi: 10.1016/j.oooo.2013.08.016. PMID: 24237731
Topical mupirocin in the treatment of bacterial skin infections.
Rumsfield J, West DP, Aronson IK
Drug Intell Clin Pharm 1986 Dec;20(12):943-8. doi: 10.1177/106002808602001204. PMID: 3102197

Curated

DailyMed Drug Label, mupirocin, 2007

Recent clinical studies

Etiology

The Role of Staphylococcus aureus in Secondary Infections in Patients with Atopic Dermatitis (AD).
Buda A, Międzobrodzki J
Pol J Microbiol 2016 Aug 26;65(3):253-259. doi: 10.5604/17331331.1215600. PMID: 29334062
Bacterial diseases of the skin.
Edlich RF, Winters KL, Britt LD, Long WB 3rd
J Long Term Eff Med Implants 2005;15(5):499-510. doi: 10.1615/jlongtermeffmedimplants.v15.i5.40. PMID: 16218899
Is tea tree oil effective at eradicating MRSA colonization? A review.
Flaxman D, Griffiths P
Br J Community Nurs 2005 Mar;10(3):123-6. doi: 10.12968/bjcn.2005.10.3.17615. PMID: 15824699
A comparison of the efficacy and safety of mupirocin cream and cephalexin in the treatment of secondarily infected eczema.
Rist T, Parish LC, Capin LR, Sulica V, Bushnell WD, Cupo MA
Clin Exp Dermatol 2002 Jan;27(1):14-20. doi: 10.1046/j.0307-6938.2001.00960.x. PMID: 11952661
Peritoneal infections.
Piraino B
Adv Ren Replace Ther 2000 Oct;7(4):280-8. doi: 10.1053/jarr.2000.18035. PMID: 11073560

Diagnosis

Attitudes and Awareness of Cornea Specialists and Oculoplastic Surgeons toward Methicillin-Resistant Staphylococcus aureus Decolonization.
Law JJ, Hatcher JB, Mawn LA, LaRue RW, Makadia F, Chen Q, Liu Y, Shieh C
Surg Infect (Larchmt) 2022 Aug;23(6):590-596. Epub 2022 Jul 22 doi: 10.1089/sur.2021.378. PMID: 35867008
Global analysis of the Staphylococcus aureus response to mupirocin.
Reiss S, Pané-Farré J, Fuchs S, François P, Liebeke M, Schrenzel J, Lindequist U, Lalk M, Wolz C, Hecker M, Engelmann S
Antimicrob Agents Chemother 2012 Feb;56(2):787-804. Epub 2011 Nov 21 doi: 10.1128/AAC.05363-11. PMID: 22106209Free PMC Article
Bacterial diseases of the skin.
Edlich RF, Winters KL, Britt LD, Long WB 3rd
J Long Term Eff Med Implants 2005;15(5):499-510. doi: 10.1615/jlongtermeffmedimplants.v15.i5.40. PMID: 16218899
Peritoneal infections.
Piraino B
Adv Ren Replace Ther 2000 Oct;7(4):280-8. doi: 10.1053/jarr.2000.18035. PMID: 11073560
Perianal candidosis--a comparative study with mupirocin and nystatin.
de Wet PM, Rode H, van Dyk A, Millar AJ
Int J Dermatol 1999 Aug;38(8):618-22. doi: 10.1046/j.1365-4362.1999.00757.x. PMID: 10487455

Therapy

Bacterial colonization, overgrowth, and superinfection in atopic dermatitis.
Rangel SM, Paller AS
Clin Dermatol 2018 Sep-Oct;36(5):641-647. Epub 2018 Jun 1 doi: 10.1016/j.clindermatol.2018.05.005. PMID: 30217276
Bacterial diseases of the skin.
Edlich RF, Winters KL, Britt LD, Long WB 3rd
J Long Term Eff Med Implants 2005;15(5):499-510. doi: 10.1615/jlongtermeffmedimplants.v15.i5.40. PMID: 16218899
A comparison of the efficacy and safety of mupirocin cream and cephalexin in the treatment of secondarily infected eczema.
Rist T, Parish LC, Capin LR, Sulica V, Bushnell WD, Cupo MA
Clin Exp Dermatol 2002 Jan;27(1):14-20. doi: 10.1046/j.0307-6938.2001.00960.x. PMID: 11952661
Topical mupirocin in the treatment of bacterial skin infections.
Rumsfield J, West DP, Aronson IK
Drug Intell Clin Pharm 1986 Dec;20(12):943-8. doi: 10.1177/106002808602001204. PMID: 3102197
Mupirocin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.
Ward A, Campoli-Richards DM
Drugs 1986 Nov;32(5):425-44. doi: 10.2165/00003495-198632050-00002. PMID: 3098541

Prognosis

The Role of Staphylococcus aureus in Secondary Infections in Patients with Atopic Dermatitis (AD).
Buda A, Międzobrodzki J
Pol J Microbiol 2016 Aug 26;65(3):253-259. doi: 10.5604/17331331.1215600. PMID: 29334062
Has decolonization played a central role in the decline in UK methicillin-resistant Staphylococcus aureus transmission? A focus on evidence from intensive care.
Edgeworth JD
J Antimicrob Chemother 2011 Apr;66 Suppl 2:ii41-7. Epub 2010 Sep 18 doi: 10.1093/jac/dkq325. PMID: 20852273
Effect of once-a-week vs thrice-a-week application of mupirocin on methicillin and mupirocin resistance in peritoneal dialysis patients: three years of experience.
Cavdar C, Saglam F, Sifil A, Celik A, Atay T, Gungor O, Ozder A, Gulay Z, Camsari T
Ren Fail 2008;30(4):417-22. doi: 10.1080/08860220801964228. PMID: 18569916
Bacterial diseases of the skin.
Edlich RF, Winters KL, Britt LD, Long WB 3rd
J Long Term Eff Med Implants 2005;15(5):499-510. doi: 10.1615/jlongtermeffmedimplants.v15.i5.40. PMID: 16218899
Perianal candidosis--a comparative study with mupirocin and nystatin.
de Wet PM, Rode H, van Dyk A, Millar AJ
Int J Dermatol 1999 Aug;38(8):618-22. doi: 10.1046/j.1365-4362.1999.00757.x. PMID: 10487455

Clinical prediction guides

Subinhibitory Concentrations of Antibiotics Alter the Response of Klebsiella pneumoniae to Components of Innate Host Defense.
Opoku-Temeng C, Freedman B, Porter AR, Kobayashi SD, Chen L, Kreiswirth BN, DeLeo FR
Microbiol Spectr 2022 Dec 21;10(6):e0151722. Epub 2022 Oct 20 doi: 10.1128/spectrum.01517-22. PMID: 36264264Free PMC Article
Has decolonization played a central role in the decline in UK methicillin-resistant Staphylococcus aureus transmission? A focus on evidence from intensive care.
Edgeworth JD
J Antimicrob Chemother 2011 Apr;66 Suppl 2:ii41-7. Epub 2010 Sep 18 doi: 10.1093/jac/dkq325. PMID: 20852273
Effect of once-a-week vs thrice-a-week application of mupirocin on methicillin and mupirocin resistance in peritoneal dialysis patients: three years of experience.
Cavdar C, Saglam F, Sifil A, Celik A, Atay T, Gungor O, Ozder A, Gulay Z, Camsari T
Ren Fail 2008;30(4):417-22. doi: 10.1080/08860220801964228. PMID: 18569916
A comparison of the efficacy and safety of mupirocin cream and cephalexin in the treatment of secondarily infected eczema.
Rist T, Parish LC, Capin LR, Sulica V, Bushnell WD, Cupo MA
Clin Exp Dermatol 2002 Jan;27(1):14-20. doi: 10.1046/j.0307-6938.2001.00960.x. PMID: 11952661
Mupirocin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.
Ward A, Campoli-Richards DM
Drugs 1986 Nov;32(5):425-44. doi: 10.2165/00003495-198632050-00002. PMID: 3098541

Recent systematic reviews

Antibiotics and antiseptics for venous leg ulcers.
O'Meara S, Al-Kurdi D, Ologun Y, Ovington LG, Martyn-St James M, Richardson R
Cochrane Database Syst Rev 2014 Jan 10;2014(1):CD003557. doi: 10.1002/14651858.CD003557.pub5. PMID: 24408354Free PMC Article
Antibiotics and antiseptics for venous leg ulcers.
O'Meara S, Al-Kurdi D, Ologun Y, Ovington LG, Martyn-St James M, Richardson R
Cochrane Database Syst Rev 2013 Dec 23;(12):CD003557. doi: 10.1002/14651858.CD003557.pub4. PMID: 24363048

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