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Aneurysmal bone cyst

MedGen UID:
57758
•Concept ID:
C0152244
•
Disease or Syndrome; Finding
Synonyms: Aneurysmal bone cyst (disease); Aneurysmal bone cysts
SNOMED CT: Aneurysmal bone cyst (76000001); ABC - Aneurysmal bone cyst (203468000); Aneurysmal bone cyst (203468000)
 
HPO: HP:0012063
Monarch Initiative: MONDO:0018815
OMIM®: 606179
Orphanet: ORPHA480553

Definition

Aneurysmal bone cysts are benign primary or secondary lesions that are rapidly expansive and locally destructive. They are located in the posterior elements of the vertebral column or the flat or long bones of patients under 30 years of age. The cysts are blood-filled and separated by septa containing spindle cells, trabeculae of bone, and osteoclastic giant cells (Biesecker et al., 1970). Histopathologically and radiographically, aneurysmal bone cysts are similar to telangiectatic osteosarcoma from which they must be differentiated. [from OMIM]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAneurysmal bone cyst

Professional guidelines

PubMed

Management of RANKL-mediated Disorders With Denosumab in Children and Adolescents: A Global Expert Guidance Document.
Vanderniet JA, Szymczuk V, Högler W, Beck-Nielsen SS, Uday S, Merchant N, Crane JL, Ward LM, Boyce AM, Munns CF
J Clin Endocrinol Metab 2024 Apr 19;109(5):1371-1382. doi: 10.1210/clinem/dgad657. PMID: 38041865Free PMC Article
Update on aneurysmal bone cyst: pathophysiology, histology, imaging and treatment.
Restrepo R, Zahrah D, Pelaez L, Temple HT, Murakami JW
Pediatr Radiol 2022 Aug;52(9):1601-1614. Epub 2022 Aug 9 doi: 10.1007/s00247-022-05396-6. PMID: 35941207Free PMC Article
Aneurysmal Bone Cyst: A Review of Management.
Muratori F, Mondanelli N, Rizzo AR, Beltrami G, Giannotti S, Capanna R, Campanacci DA
Surg Technol Int 2019 Nov 10;35:325-335. PMID: 31476792

Recent clinical studies

Etiology

Management of RANKL-mediated Disorders With Denosumab in Children and Adolescents: A Global Expert Guidance Document.
Vanderniet JA, Szymczuk V, Högler W, Beck-Nielsen SS, Uday S, Merchant N, Crane JL, Ward LM, Boyce AM, Munns CF
J Clin Endocrinol Metab 2024 Apr 19;109(5):1371-1382. doi: 10.1210/clinem/dgad657. PMID: 38041865Free PMC Article
Allograft Versus Bioactive Glass (BG-S53P4) in Pediatric Benign Bone Lesions: A Randomized Clinical Trial.
Syvänen J, Serlo W, Jalkanen J, Kohonen I, Raitio A, Nietosvaara Y, Helenius I
J Bone Joint Surg Am 2023 May 3;105(9):659-666. Epub 2023 Jan 19 doi: 10.2106/JBJS.22.00716. PMID: 36727973Free PMC Article
Giant Cell-Rich Tumors of Bone.
Hartmann W, Harder D, Baumhoer D
Surg Pathol Clin 2021 Dec;14(4):695-706. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.010. PMID: 34742488
Bone cysts: unicameral and aneurysmal bone cyst.
Mascard E, Gomez-Brouchet A, Lambot K
Orthop Traumatol Surg Res 2015 Feb;101(1 Suppl):S119-27. Epub 2015 Jan 8 doi: 10.1016/j.otsr.2014.06.031. PMID: 25579825
Vertebral chondroblastoma.
Ilaslan H, Sundaram M, Unni KK
Skeletal Radiol 2003 Feb;32(2):66-71. Epub 2002 Nov 21 doi: 10.1007/s00256-002-0599-4. PMID: 12589483

Diagnosis

Update on aneurysmal bone cyst: pathophysiology, histology, imaging and treatment.
Restrepo R, Zahrah D, Pelaez L, Temple HT, Murakami JW
Pediatr Radiol 2022 Aug;52(9):1601-1614. Epub 2022 Aug 9 doi: 10.1007/s00247-022-05396-6. PMID: 35941207Free PMC Article
Understanding Unicameral and Aneurysmal Bone Cysts.
Rosenblatt J, Koder A
Pediatr Rev 2019 Feb;40(2):51-59. doi: 10.1542/pir.2015-0128. PMID: 30709971
Aneurysmal bone cyst of C2 treated with novel anterior reconstruction and stabilization.
Rajasekaran S, Aiyer SN, Shetty AP, Kanna R, Maheswaran A
Eur Spine J 2019 Feb;28(2):270-278. Epub 2016 Mar 23 doi: 10.1007/s00586-016-4518-0. PMID: 27007865
Chondroblastoma: An Update.
Chen W, DiFrancesco LM
Arch Pathol Lab Med 2017 Jun;141(6):867-871. doi: 10.5858/arpa.2016-0281-RS. PMID: 28557595
Bone cysts: unicameral and aneurysmal bone cyst.
Mascard E, Gomez-Brouchet A, Lambot K
Orthop Traumatol Surg Res 2015 Feb;101(1 Suppl):S119-27. Epub 2015 Jan 8 doi: 10.1016/j.otsr.2014.06.031. PMID: 25579825

Therapy

Management of RANKL-mediated Disorders With Denosumab in Children and Adolescents: A Global Expert Guidance Document.
Vanderniet JA, Szymczuk V, Högler W, Beck-Nielsen SS, Uday S, Merchant N, Crane JL, Ward LM, Boyce AM, Munns CF
J Clin Endocrinol Metab 2024 Apr 19;109(5):1371-1382. doi: 10.1210/clinem/dgad657. PMID: 38041865Free PMC Article
Allograft Versus Bioactive Glass (BG-S53P4) in Pediatric Benign Bone Lesions: A Randomized Clinical Trial.
Syvänen J, Serlo W, Jalkanen J, Kohonen I, Raitio A, Nietosvaara Y, Helenius I
J Bone Joint Surg Am 2023 May 3;105(9):659-666. Epub 2023 Jan 19 doi: 10.2106/JBJS.22.00716. PMID: 36727973Free PMC Article
Aneurysmal bone cyst and osteoblastoma after neoadjuvant denosumab: histologic spectrum and potential diagnostic pitfalls.
Hung YP, Bredella MA, Lobmaier IVK, Lozano-Calderón SA, Rosenberg AE, Nielsen GP
APMIS 2022 Apr;130(4):206-214. Epub 2022 Feb 18 doi: 10.1111/apm.13211. PMID: 35114728
Denosumab in the management of Aneurysmal bone cyst.
Maximen J, Robin F, Tronchot A, Rossetti A, Ropars M, Guggenbuhl P
Joint Bone Spine 2022 Jan;89(1):105260. Epub 2021 Sep 2 doi: 10.1016/j.jbspin.2021.105260. PMID: 34481945
Aneurysmal bone cyst (ABC) : treatment options and proposal of a follow-up regime.
Hauschild O, Lüdemann M, Engelhardt M, Baumhoer D, Baumann T, Elger T, Südkamp NP, Herget GW
Acta Orthop Belg 2016 Aug;82(3):474-483. PMID: 29119887

Prognosis

Rare aneurysmal bone cysts: multifocal, extraosseous, and surface variants.
Angelini A, Mavrogenis AF, Pagliarini E, Igoumenou VG, Gulia A, Kelekis A, Righi A, Errani C, Rossi G, Ruggieri P
Eur J Orthop Surg Traumatol 2020 Aug;30(6):969-978. Epub 2020 Feb 27 doi: 10.1007/s00590-020-02640-3. PMID: 32107639
Bone cysts: unicameral and aneurysmal bone cyst.
Mascard E, Gomez-Brouchet A, Lambot K
Orthop Traumatol Surg Res 2015 Feb;101(1 Suppl):S119-27. Epub 2015 Jan 8 doi: 10.1016/j.otsr.2014.06.031. PMID: 25579825
Telangiectatic osteosarcoma.
Sangle NA, Layfield LJ
Arch Pathol Lab Med 2012 May;136(5):572-6. doi: 10.5858/arpa.2011-0204-RS. PMID: 22540307
Aneurysmal bone cyst.
Mendenhall WM, Zlotecki RA, Gibbs CP, Reith JD, Scarborough MT, Mendenhall NP
Am J Clin Oncol 2006 Jun;29(3):311-5. doi: 10.1097/01.coc.0000204403.13451.52. PMID: 16755186
Vertebral chondroblastoma.
Ilaslan H, Sundaram M, Unni KK
Skeletal Radiol 2003 Feb;32(2):66-71. Epub 2002 Nov 21 doi: 10.1007/s00256-002-0599-4. PMID: 12589483

Clinical prediction guides

Aneurysmal bone cyst: Is selective arterial embolization effective as curettage and bone grafting?
Cevolani L, Staals E, Campanacci L, Dozza B, Martella C, Spinnato P, Di Carlo M, Peta G, Donati DM, Miceli M, Facchini G
J Surg Oncol 2023 Dec;128(8):1428-1436. Epub 2023 Aug 28 doi: 10.1002/jso.27422. PMID: 37638388
Primary aneurysmal bone cyst of hands and feet: A series of 14 cases.
Pena-Burgos EM, Serra-Del Carpio G, Tapia-Viñe M, Iglesias Urraca C, Cordero García JM, Ortiz-Cruz EJ, Pozo-Kreilinger JJ
Ann Diagn Pathol 2023 Oct;66:152169. Epub 2023 Jun 1 doi: 10.1016/j.anndiagpath.2023.152169. PMID: 37295038
Allograft Versus Bioactive Glass (BG-S53P4) in Pediatric Benign Bone Lesions: A Randomized Clinical Trial.
Syvänen J, Serlo W, Jalkanen J, Kohonen I, Raitio A, Nietosvaara Y, Helenius I
J Bone Joint Surg Am 2023 May 3;105(9):659-666. Epub 2023 Jan 19 doi: 10.2106/JBJS.22.00716. PMID: 36727973Free PMC Article
Aneurysmal bone cyst--clinical and morphological aspects.
Rădulescu R, Bădilă A, Manolescu R, Sajin M, Japie I
Rom J Morphol Embryol 2014;55(3):977-81. PMID: 25329131
Craniofacial fibrous dysplasia.
Hanifi B, Samil KS, Yasar C, Cengiz C, Ercan A, Ramazan D
Clin Imaging 2013 Nov-Dec;37(6):1109-15. Epub 2013 Aug 29 doi: 10.1016/j.clinimag.2013.01.010. PMID: 23993753

Recent systematic reviews

Rare Aneurysmal Bone Cyst Presentation in the Orbit: A Systematic Review of the Literature with an Illustrative Case Report.
O'Leary S, Hayat F, Amasa S, Ammar Haider M, Akram Asbeutah S, AlDallal U, Barrie U, Ismail M
World Neurosurg 2024 Nov;191:1-9. Epub 2024 Aug 2 doi: 10.1016/j.wneu.2024.07.185. PMID: 39097084
Aneurysmal bone cyst of the spine in adult patients: A systematic review and comparison of primary vs secondary lesions.
Palmisciano P, Hunter M, Lokesh N, Bin Alamer O, Scalia G, Giammalva GR, Maugeri R, Iacopino DG, Umana GE, Haider AS
J Clin Neurosci 2022 Jun;100:15-22. Epub 2022 Apr 1 doi: 10.1016/j.jocn.2022.03.040. PMID: 35367732
Minimally invasive treatment of aneurysmal bone cysts: Systematic literature review.
Cottalorda J, Louahem Sabah D, Joly Monrigal P, Jeandel C, Delpont M
Orthop Traumatol Surg Res 2022 Jun;108(4):103272. Epub 2022 Mar 21 doi: 10.1016/j.otsr.2022.103272. PMID: 35331923
Benign Tumors of the Spine: Has New Chemotherapy and Interventional Radiology Changed the Treatment Paradigm?
Charest-Morin R, Boriani S, Fisher CG, Patel SR, Kawahara N, Mendel E, Bettegowda C, Rhines LD
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20:S178-S185. doi: 10.1097/BRS.0000000000001818. PMID: 27488295
Aggressive "benign" primary spine neoplasms: osteoblastoma, aneurysmal bone cyst, and giant cell tumor.
Harrop JS, Schmidt MH, Boriani S, Shaffrey CI
Spine (Phila Pa 1976) 2009 Oct 15;34(22 Suppl):S39-47. doi: 10.1097/BRS.0b013e3181ba0024. PMID: 19829276

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