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respiratory syncytial virus infection

MedGen UID:: 48424
•Concept ID:: C0035235
•: Disease or Syndrome

Synonyms:	Infection, RSV; Infections, Respiratory Syncytial Virus; Respiratory Syncytial Virus Infection; Respiratory Syncytial Virus Infections; RSV Infection; RSV Infections
SNOMED CT:	RSV - Respiratory syncytial virus infection (55735004); Respiratory syncytial virus infection (55735004)

Monarch Initiative:	MONDO:0001577

Definition

Infection with the respiratory syncytial virus, an RNA virus of the genus Pneumovirus, in the family Paramyxoviridae, which is characterized by the formation of syncytia in tissue culture. It causes minor respiratory infection with rhinitis and cough in adults, but is capable of causing severe bronchitis and bronchopneumonia in young children. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVrespiratory syncytial virus infection

Infection
- viral disease
  - RNA Virus Infections
    - Mononegavirales infectious disease
      - Disease caused by Paramyxoviridae
        Disease caused by Pneumovirus
        respiratory syncytial virus infection
        Pneumonia caused by respiratory syncytial virus

Professional guidelines

PubMed

Ribavirin treatment for respiratory syncytial virus infection in patients with haematologic malignancy and haematopoietic stem cell transplant recipients: a systematic review and meta-analysis.

Manothummetha K, Mongkolkaew T, Tovichayathamrong P, Boonyawairote R, Meejun T, Srisurapanont K, Phongkhun K, Sanguankeo A, Torvorapanit P, Moonla C, Plongla R, Kates OS, Avery RK, Nematollahi S, Permpalung N
Clin Microbiol Infect 2023 Oct;29(10):1272-1279. Epub 2023 Apr 26 doi: 10.1016/j.cmi.2023.04.021. PMID: 37116860

Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment.

Griffiths C, Drews SJ, Marchant DJ
Clin Microbiol Rev 2017 Jan;30(1):277-319. doi: 10.1128/CMR.00010-16. PMID: 27903593 Free PMC Article

Diagnosis and management of bronchiolitis.

American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis
Pediatrics 2006 Oct;118(4):1774-93. doi: 10.1542/peds.2006-2223. PMID: 17015575

See all (68)

Recent clinical studies

Etiology

Epidemiology of Respiratory Infections during the COVID-19 Pandemic.

Principi N, Autore G, Ramundo G, Esposito S
Viruses 2023 May 13;15(5) doi: 10.3390/v15051160. PMID: 37243246 Free PMC Article

Economic burden of respiratory syncytial virus infection in adults: a systematic literature review.

Grace M, Colosia A, Wolowacz S, Panozzo C, Ghaswalla P
J Med Econ 2023 Jan-Dec;26(1):742-759. doi: 10.1080/13696998.2023.2213125. PMID: 37167068

Respiratory syncytial virus infection in the modern era.

Ludlow M
Curr Opin Infect Dis 2023 Jun 1;36(3):155-163. Epub 2023 Mar 20 doi: 10.1097/QCO.0000000000000917. PMID: 36939556

Respiratory Syncytial Virus is the Most Common Causative Agent of Viral Bronchiolitis in Young Children: An Updated Review.

Hon KL, Leung AKC, Wong AHC, Dudi A, Leung KKY
Curr Pediatr Rev 2023;19(2):139-149. doi: 10.2174/1573396318666220810161945. PMID: 35950255

Incidence of Respiratory Syncytial Virus Infection Among Hospitalized Adults, 2017-2020.

Branche AR, Saiman L, Walsh EE, Falsey AR, Sieling WD, Greendyke W, Peterson DR, Vargas CY, Phillips M, Finelli L
Clin Infect Dis 2022 Mar 23;74(6):1004-1011. doi: 10.1093/cid/ciab595. PMID: 34244735

See all (779)

Diagnosis

Respiratory Syncytial Virus is the Most Common Causative Agent of Viral Bronchiolitis in Young Children: An Updated Review.

Hon KL, Leung AKC, Wong AHC, Dudi A, Leung KKY
Curr Pediatr Rev 2023;19(2):139-149. doi: 10.2174/1573396318666220810161945. PMID: 35950255

Burden of respiratory syncytial virus infection in older and high-risk adults: a systematic review and meta-analysis of the evidence from developed countries.

Nguyen-Van-Tam JS, O'Leary M, Martin ET, Heijnen E, Callendret B, Fleischhackl R, Comeaux C, Tran TMP, Weber K
Eur Respir Rev 2022 Dec 31;31(166) Epub 2022 Nov 15 doi: 10.1183/16000617.0105-2022. PMID: 36384703 Free PMC Article

Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment.

Griffiths C, Drews SJ, Marchant DJ
Clin Microbiol Rev 2017 Jan;30(1):277-319. doi: 10.1128/CMR.00010-16. PMID: 27903593 Free PMC Article

Respiratory syncytial virus infection and bronchiolitis.

Piedimonte G, Perez MK
Pediatr Rev 2014 Dec;35(12):519-30. doi: 10.1542/pir.35-12-519. PMID: 25452661 Free PMC Article

Respiratory syncytial virus infection in elderly and high-risk adults.

Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE
N Engl J Med 2005 Apr 28;352(17):1749-59. doi: 10.1056/NEJMoa043951. PMID: 15858184

See all (463)

Therapy

Respiratory syncytial virus infection and novel interventions.

Langedijk AC, Bont LJ
Nat Rev Microbiol 2023 Nov;21(11):734-749. Epub 2023 Jul 12 doi: 10.1038/s41579-023-00919-w. PMID: 37438492

Respiratory Syncytial Virus is the Most Common Causative Agent of Viral Bronchiolitis in Young Children: An Updated Review.

Hon KL, Leung AKC, Wong AHC, Dudi A, Leung KKY
Curr Pediatr Rev 2023;19(2):139-149. doi: 10.2174/1573396318666220810161945. PMID: 35950255

Burden of respiratory syncytial virus infection in older and high-risk adults: a systematic review and meta-analysis of the evidence from developed countries.

Respiratory syncytial virus infection in adults.

Nam HH, Ison MG
BMJ 2019 Sep 10;366:l5021. doi: 10.1136/bmj.l5021. PMID: 31506273

Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment.

Griffiths C, Drews SJ, Marchant DJ
Clin Microbiol Rev 2017 Jan;30(1):277-319. doi: 10.1128/CMR.00010-16. PMID: 27903593 Free PMC Article

See all (465)

Prognosis

Change in functional status associated with respiratory syncytial virus infection in hospitalized older adults.

Branche AR, Saiman L, Walsh EE, Falsey AR, Jia H, Barrett A, Alba L, Phillips M, Finelli L
Influenza Other Respir Viruses 2022 Nov;16(6):1151-1160. Epub 2022 Sep 7 doi: 10.1111/irv.13043. PMID: 36069297 Free PMC Article

Incidence of Respiratory Syncytial Virus Infection Among Hospitalized Adults, 2017-2020.

Branche AR, Saiman L, Walsh EE, Falsey AR, Sieling WD, Greendyke W, Peterson DR, Vargas CY, Phillips M, Finelli L
Clin Infect Dis 2022 Mar 23;74(6):1004-1011. doi: 10.1093/cid/ciab595. PMID: 34244735

Burden of respiratory syncytial virus infection in community-dwelling older adults in Europe (RESCEU): an international prospective cohort study.

Korsten K, Adriaenssens N, Coenen S, Butler C, Ravanfar B, Rutter H, Allen J, Falsey A, Pirçon JY, Gruselle O, Pavot V, Vernhes C, Balla-Jhagjhoorsingh S, Öner D, Ispas G, Aerssens J, Shinde V, Verheij T, Bont L, Wildenbeest J; RESCEU investigators
Eur Respir J 2021 Apr;57(4) Epub 2021 Apr 1 doi: 10.1183/13993003.02688-2020. PMID: 33060153

Severe Morbidity and Short- and Mid- to Long-term Mortality in Older Adults Hospitalized with Respiratory Syncytial Virus Infection.

Tseng HF, Sy LS, Ackerson B, Solano Z, Slezak J, Luo Y, Fischetti CA, Shinde V
J Infect Dis 2020 Sep 14;222(8):1298-1310. doi: 10.1093/infdis/jiaa361. PMID: 32591787

A Real-World Analysis of Patient Characteristics and Predictors of Hospitalization Among US Medicare Beneficiaries with Respiratory Syncytial Virus Infection.

Wyffels V, Kariburyo F, Gavart S, Fleischhackl R, Yuce H
Adv Ther 2020 Mar;37(3):1203-1217. Epub 2020 Feb 5 doi: 10.1007/s12325-020-01230-3. PMID: 32026380 Free PMC Article

See all (309)

Clinical prediction guides

Ziresovir in Hospitalized Infants with Respiratory Syncytial Virus Infection.

Zhao S, Shang Y, Yin Y, Zou Y, Xu Y, Zhong L, Zhang H, Zhang H, Zhao D, Shen T, Huang D, Chen Q, Yang Q, Yang Y, Dong X, Li L, Chen Z, Liu E, Deng L, Jiang W, Cheng H, Nong G, Wang X, Chen Y, Ding R, Zhou W, Zheng Y, Shen Z, Lu X, Hao C, Zhu X, Jia T, Wu Y, Zou G, Rito K, Wu JZ, Liu H, Ni X; AIRFLO Study Group
N Engl J Med 2024 Sep 26;391(12):1096-1107. doi: 10.1056/NEJMoa2313551. PMID: 39321361

Host Responses to Respiratory Syncytial Virus Infection.

Agac A, Kolbe SM, Ludlow M, Osterhaus ADME, Meineke R, Rimmelzwaan GF
Viruses 2023 Sep 26;15(10) doi: 10.3390/v15101999. PMID: 37896776 Free PMC Article

Ribavirin treatment for respiratory syncytial virus infection in patients with haematologic malignancy and haematopoietic stem cell transplant recipients: a systematic review and meta-analysis.

Underascertainment of Respiratory Syncytial Virus Infection in Adults Due to Diagnostic Testing Limitations: A Systematic Literature Review and Meta-analysis.

Onwuchekwa C, Moreo LM, Menon S, Machado B, Curcio D, Kalina W, Atwell JE, Gessner BD, Siapka M, Agarwal N, Rubbrecht M, Nair H, Rozenbaum M, Aponte-Torres Z, Vroling H, Begier E
J Infect Dis 2023 Jul 14;228(2):173-184. doi: 10.1093/infdis/jiad012. PMID: 36661222 Free PMC Article

Respiratory Syncytial Virus is the Most Common Causative Agent of Viral Bronchiolitis in Young Children: An Updated Review.

Hon KL, Leung AKC, Wong AHC, Dudi A, Leung KKY
Curr Pediatr Rev 2023;19(2):139-149. doi: 10.2174/1573396318666220810161945. PMID: 35950255

See all (408)