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Acute fatty liver of pregnancy(AFLP)

MedGen UID:
264102
•Concept ID:
C1455728
•
Disease or Syndrome
Synonyms: Acute fatty liver, gestational; AFLP
SNOMED CT: Acute fatty liver of pregnancy (716379000); AFLP - acute fatty liver of pregnancy (716379000); Nonalcoholic fatty liver during pregnancy (716379000)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Non-Mendelian inheritance (Orphanet)
 
Monarch Initiative: MONDO:0016573
Orphanet: ORPHA243367

Definition

Acute fatty liver of pregnancy is a rare but severe complication occurring in the third trimester of pregnancy or in early postpartum period bearing a risk for perinatal and maternal mortality with manifestations of jaundice, rise of hepatic injuries and evolving to acute liver failure and encephalopathy. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute fatty liver of pregnancy
Follow this link to review classifications for Acute fatty liver of pregnancy in Orphanet.

Professional guidelines

PubMed

Thrombocytopenia in pregnancy: Diagnosis and approach to management.
Pishko AM, Levine LD, Cines DB
Blood Rev 2020 Mar;40:100638. Epub 2019 Nov 6 doi: 10.1016/j.blre.2019.100638. PMID: 31757523
Acute Fatty Liver of Pregnancy-Differential Diagnosis.
Morton A
Am J Gastroenterol 2017 Aug;112(8):1342. doi: 10.1038/ajg.2017.133. PMID: 28766570
Acute Fatty Liver Disease of Pregnancy: Updates in Pathogenesis, Diagnosis, and Management.
Liu J, Ghaziani TT, Wolf JL
Am J Gastroenterol 2017 Jun;112(6):838-846. Epub 2017 Mar 14 doi: 10.1038/ajg.2017.54. PMID: 28291236

Recent clinical studies

Etiology

Obstetric Disorders and Critical Illness.
Griffin KM, Oxford-Horrey C, Bourjeily G
Clin Chest Med 2022 Sep;43(3):471-488. doi: 10.1016/j.ccm.2022.04.008. PMID: 36116815Free PMC Article
Pregnancy-Associated Liver Diseases.
Terrault NA, Williamson C
Gastroenterology 2022 Jul;163(1):97-117.e1. Epub 2022 Mar 8 doi: 10.1053/j.gastro.2022.01.060. PMID: 35276220
Thrombocytopenia in pregnancy: Diagnosis and approach to management.
Pishko AM, Levine LD, Cines DB
Blood Rev 2020 Mar;40:100638. Epub 2019 Nov 6 doi: 10.1016/j.blre.2019.100638. PMID: 31757523
Acute Fatty Liver Disease of Pregnancy: Updates in Pathogenesis, Diagnosis, and Management.
Liu J, Ghaziani TT, Wolf JL
Am J Gastroenterol 2017 Jun;112(6):838-846. Epub 2017 Mar 14 doi: 10.1038/ajg.2017.54. PMID: 28291236
Coagulation disorders in liver disease.
Amitrano L, Guardascione MA, Brancaccio V, Balzano A
Semin Liver Dis 2002 Feb;22(1):83-96. doi: 10.1055/s-2002-23205. PMID: 11928081

Diagnosis

Pregnancy-Associated Liver Diseases.
Terrault NA, Williamson C
Gastroenterology 2022 Jul;163(1):97-117.e1. Epub 2022 Mar 8 doi: 10.1053/j.gastro.2022.01.060. PMID: 35276220
Acute Fatty Liver of Pregnancy.
Nelson DB, Byrne JJ, Cunningham FG
Obstet Gynecol 2021 Mar 1;137(3):535-546. doi: 10.1097/AOG.0000000000004289. PMID: 33543900
Acute Fatty Liver of Pregnancy.
Nelson DB, Byrne JJ, Cunningham FG
Clin Obstet Gynecol 2020 Mar;63(1):152-164. doi: 10.1097/GRF.0000000000000494. PMID: 31725416
HELLP Syndrome: Pathophysiology and Current Therapies.
Wallace K, Harris S, Addison A, Bean C
Curr Pharm Biotechnol 2018;19(10):816-826. doi: 10.2174/1389201019666180712115215. PMID: 29998801
Acute Fatty Liver Disease of Pregnancy: Updates in Pathogenesis, Diagnosis, and Management.
Liu J, Ghaziani TT, Wolf JL
Am J Gastroenterol 2017 Jun;112(6):838-846. Epub 2017 Mar 14 doi: 10.1038/ajg.2017.54. PMID: 28291236

Therapy

Acute Liver Failure.
Ledgerwood C, Villgran V, Mardirossian N, Dumont T, DiSilvio B
Crit Care Nurs Q 2022 Jul-Sep 01;45(3):248-257. doi: 10.1097/CNQ.0000000000000409. PMID: 35617091
HELLP Syndrome: Pathophysiology and Current Therapies.
Wallace K, Harris S, Addison A, Bean C
Curr Pharm Biotechnol 2018;19(10):816-826. doi: 10.2174/1389201019666180712115215. PMID: 29998801
Postpartum duodenal perforation after acute fatty liver of pregnancy.
Maruyama S, Sato Y, Nakaki A, Satake Y, Emoto I, Kim T
J Obstet Gynaecol 2016;36(1):58-9. Epub 2015 Sep 30 doi: 10.3109/01443615.2015.1036412. PMID: 26421743
Imitators of severe preeclampsia.
Sibai BM
Obstet Gynecol 2007 Apr;109(4):956-66. doi: 10.1097/01.AOG.0000258281.22296.de. PMID: 17400860
Acute fatty liver of pregnancy.
Riely CA
Semin Liver Dis 1987 Feb;7(1):47-54. doi: 10.1055/s-2008-1040563. PMID: 3296215

Prognosis

Acute liver failure in pregnancy.
Alexander V, Benjamin SJ, Subramani K, Sathyendra S, Goel A
Indian J Gastroenterol 2024 Apr;43(2):325-337. Epub 2024 May 1 doi: 10.1007/s12664-024-01571-9. PMID: 38691240
Acute Fatty Liver of Pregnancy.
Nelson DB, Byrne JJ, Cunningham FG
Clin Obstet Gynecol 2020 Mar;63(1):152-164. doi: 10.1097/GRF.0000000000000494. PMID: 31725416
Acute Fatty Liver Disease of Pregnancy: Updates in Pathogenesis, Diagnosis, and Management.
Liu J, Ghaziani TT, Wolf JL
Am J Gastroenterol 2017 Jun;112(6):838-846. Epub 2017 Mar 14 doi: 10.1038/ajg.2017.54. PMID: 28291236
Acute fatty liver of pregnancy.
Vigil-De Gracia P, Lavergne JA
Int J Gynaecol Obstet 2001 Feb;72(2):193-5. doi: 10.1016/s0020-7292(00)00370-2. PMID: 11166756
Acute fatty liver of pregnancy.
Usta IM, Sibai BM
J Med Liban 1995;43(4):186-93. PMID: 8885551

Clinical prediction guides

Comparing acute fatty liver of pregnancy from hemolysis, elevated liver enzymes, and low platelets syndrome.
Byrne JJ, Seasely A, Nelson DB, Mcintire DD, Cunningham FG
J Matern Fetal Neonatal Med 2022 Apr;35(7):1352-1362. Epub 2020 Apr 19 doi: 10.1080/14767058.2020.1754790. PMID: 32308076
Acute Fatty Liver of Pregnancy.
Ademiluyi A, Amakye DO, Jackson N, Betty S
Am J Case Rep 2021 Nov 28;22:e933252. doi: 10.12659/AJCR.933252. PMID: 34839346Free PMC Article
Accurate Prediction of Total PlGF (Placental Growth Factor) From Free PlGF and sFlt-1 (Soluble Fms-Like Tyrosine Kinase-1): Evidence for Markedly Elevated PlGF Levels in Women With Acute Fatty Liver of Pregnancy.
Neuman RI, Saleh L, Verdonk K, van den Meiracker AH, Russcher H, Metselaar HJ, Visser W, Danser AHJ
Hypertension 2021 Aug;78(2):489-498. Epub 2021 Jun 28 doi: 10.1161/HYPERTENSIONAHA.121.17258. PMID: 34176292Free PMC Article
Acute Fatty Liver Disease of Pregnancy: Updates in Pathogenesis, Diagnosis, and Management.
Liu J, Ghaziani TT, Wolf JL
Am J Gastroenterol 2017 Jun;112(6):838-846. Epub 2017 Mar 14 doi: 10.1038/ajg.2017.54. PMID: 28291236
Advances in understanding and treating liver diseases during pregnancy: A review.
Kamimura K, Abe H, Kawai H, Kamimura H, Kobayashi Y, Nomoto M, Aoyagi Y, Terai S
World J Gastroenterol 2015 May 7;21(17):5183-90. doi: 10.3748/wjg.v21.i17.5183. PMID: 25954092Free PMC Article

Recent systematic reviews

Plasma exchange improves survival in acute liver failure - An updated systematic review and meta-analysis focussed on comparing within single etiology.
Sithamparapillai K, Zachariah U, Eapen CE, Goel A
Indian J Gastroenterol 2024 Apr;43(2):397-406. Epub 2024 May 1 doi: 10.1007/s12664-024-01557-7. PMID: 38691239
Leptospirosis in pregnancy: A systematic review.
Selvarajah S, Ran S, Roberts NW, Nair M
PLoS Negl Trop Dis 2021 Sep;15(9):e0009747. Epub 2021 Sep 14 doi: 10.1371/journal.pntd.0009747. PMID: 34520461Free PMC Article
Treating acute fatty liver of pregnancy with artificial liver support therapy: Systematic review.
Wu Z, Huang P, Gong Y, Wan J, Zou W
Medicine (Baltimore) 2018 Sep;97(38):e12473. doi: 10.1097/MD.0000000000012473. PMID: 30235743Free PMC Article
Effect of caesarean section on maternal and foetal outcomes in acute fatty liver of pregnancy: a systematic review and meta-analysis.
Wang HY, Jiang Q, Shi H, Xu YQ, Shi AC, Sun YL, Li J, Ning Q, Shen GX
Sci Rep 2016 Jul 8;6:28826. doi: 10.1038/srep28826. PMID: 27387594Free PMC Article

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