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Triple-negative breast cancer

MedGen UID:
761659
Concept ID:
C3539878
Neoplastic Process
Synonyms: Breast Cancer, Triple-Negative; Breast Cancers, Triple-Negative; Breast Neoplasm, Triple-Negative; Breast Neoplasms, Triple-Negative; ER Negative PR Negative HER2 Negative Breast Cancer; ER Negative PR Negative HER2 Negative Breast Neoplasms; ER-Negative PR-Negative HER2-Negative Breast Cancer; ER-Negative PR-Negative HER2-Negative Breast Neoplasms; Triple Negative Breast Cancer; Triple Negative Breast Neoplasm; Triple Negative Breast Neoplasms; Triple-Negative Breast Cancer; Triple-Negative Breast Cancers; Triple-Negative Breast Neoplasm; Triple-Negative Breast Neoplasms
SNOMED CT: Triple negative malignant neoplasm of breast (706970001); TNBC - Triple-negative breast cancer (706970001); Triple-negative breast cancer (706970001)

Definition

The absence of staining for estrogen receptor, progesterone receptor, and hormone epidermal growth factor receptor 2 (HER2/neu). [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Triple-negative breast cancer

Professional guidelines

PubMed

Bianchini G, De Angelis C, Licata L, Gianni L
Nat Rev Clin Oncol 2022 Feb;19(2):91-113. Epub 2021 Nov 9 doi: 10.1038/s41571-021-00565-2. PMID: 34754128
Yin L, Duan JJ, Bian XW, Yu SC
Breast Cancer Res 2020 Jun 9;22(1):61. doi: 10.1186/s13058-020-01296-5. PMID: 32517735Free PMC Article
Waks AG, Winer EP
JAMA 2019 Jan 22;321(3):288-300. doi: 10.1001/jama.2018.19323. PMID: 30667505

Recent clinical studies

Etiology

Karim AM, Eun Kwon J, Ali T, Jang J, Ullah I, Lee YG, Park DW, Park J, Jeang JW, Kang SC
Biochem Pharmacol 2023 Jun;212:115545. Epub 2023 Apr 11 doi: 10.1016/j.bcp.2023.115545. PMID: 37044296
Corti C, Venetis K, Sajjadi E, Zattoni L, Curigliano G, Fusco N
Expert Opin Investig Drugs 2022 Jun;31(6):593-605. Epub 2022 Mar 24 doi: 10.1080/13543784.2022.2054326. PMID: 35311430
Bianchini G, De Angelis C, Licata L, Gianni L
Nat Rev Clin Oncol 2022 Feb;19(2):91-113. Epub 2021 Nov 9 doi: 10.1038/s41571-021-00565-2. PMID: 34754128
Howard FM, Olopade OI
Cancer J 2021 Jan-Feb 01;27(1):8-16. doi: 10.1097/PPO.0000000000000500. PMID: 33475288
Dent R, Trudeau M, Pritchard KI, Hanna WM, Kahn HK, Sawka CA, Lickley LA, Rawlinson E, Sun P, Narod SA
Clin Cancer Res 2007 Aug 1;13(15 Pt 1):4429-34. doi: 10.1158/1078-0432.CCR-06-3045. PMID: 17671126

Diagnosis

Zou Y, Xie J, Zheng S, Liu W, Tang Y, Tian W, Deng X, Wu L, Zhang Y, Wong CW, Tan D, Liu Q, Xie X
Int J Surg 2022 Nov;107:106936. Epub 2022 Sep 20 doi: 10.1016/j.ijsu.2022.106936. PMID: 36341760
Li Y, Zhang H, Merkher Y, Chen L, Liu N, Leonov S, Chen Y
J Hematol Oncol 2022 Aug 29;15(1):121. doi: 10.1186/s13045-022-01341-0. PMID: 36038913Free PMC Article
Howard FM, Olopade OI
Cancer J 2021 Jan-Feb 01;27(1):8-16. doi: 10.1097/PPO.0000000000000500. PMID: 33475288
Yin L, Duan JJ, Bian XW, Yu SC
Breast Cancer Res 2020 Jun 9;22(1):61. doi: 10.1186/s13058-020-01296-5. PMID: 32517735Free PMC Article
Keenan TE, Tolaney SM
J Natl Compr Canc Netw 2020 Apr;18(4):479-489. doi: 10.6004/jnccn.2020.7554. PMID: 32259782

Therapy

Schmid P, Cortes J, Dent R, Pusztai L, McArthur H, Kümmel S, Bergh J, Denkert C, Park YH, Hui R, Harbeck N, Takahashi M, Untch M, Fasching PA, Cardoso F, Andersen J, Patt D, Danso M, Ferreira M, Mouret-Reynier MA, Im SA, Ahn JH, Gion M, Baron-Hay S, Boileau JF, Ding Y, Tryfonidis K, Aktan G, Karantza V, O'Shaughnessy J; KEYNOTE-522 Investigators
N Engl J Med 2022 Feb 10;386(6):556-567. doi: 10.1056/NEJMoa2112651. PMID: 35139274
Cortes J, Cescon DW, Rugo HS, Nowecki Z, Im SA, Yusof MM, Gallardo C, Lipatov O, Barrios CH, Holgado E, Iwata H, Masuda N, Otero MT, Gokmen E, Loi S, Guo Z, Zhao J, Aktan G, Karantza V, Schmid P; KEYNOTE-355 Investigators
Lancet 2020 Dec 5;396(10265):1817-1828. doi: 10.1016/S0140-6736(20)32531-9. PMID: 33278935
Schmid P, Cortes J, Pusztai L, McArthur H, Kümmel S, Bergh J, Denkert C, Park YH, Hui R, Harbeck N, Takahashi M, Foukakis T, Fasching PA, Cardoso F, Untch M, Jia L, Karantza V, Zhao J, Aktan G, Dent R, O'Shaughnessy J; KEYNOTE-522 Investigators
N Engl J Med 2020 Feb 27;382(9):810-821. doi: 10.1056/NEJMoa1910549. PMID: 32101663
Schmid P, Adams S, Rugo HS, Schneeweiss A, Barrios CH, Iwata H, Diéras V, Hegg R, Im SA, Shaw Wright G, Henschel V, Molinero L, Chui SY, Funke R, Husain A, Winer EP, Loi S, Emens LA; IMpassion130 Trial Investigators
N Engl J Med 2018 Nov 29;379(22):2108-2121. Epub 2018 Oct 20 doi: 10.1056/NEJMoa1809615. PMID: 30345906
Cortazar P, Zhang L, Untch M, Mehta K, Costantino JP, Wolmark N, Bonnefoi H, Cameron D, Gianni L, Valagussa P, Swain SM, Prowell T, Loibl S, Wickerham DL, Bogaerts J, Baselga J, Perou C, Blumenthal G, Blohmer J, Mamounas EP, Bergh J, Semiglazov V, Justice R, Eidtmann H, Paik S, Piccart M, Sridhara R, Fasching PA, Slaets L, Tang S, Gerber B, Geyer CE Jr, Pazdur R, Ditsch N, Rastogi P, Eiermann W, von Minckwitz G
Lancet 2014 Jul 12;384(9938):164-72. Epub 2014 Feb 14 doi: 10.1016/S0140-6736(13)62422-8. PMID: 24529560

Prognosis

Wang X, Wang SS, Huang H, Cai L, Zhao L, Peng RJ, Lin Y, Tang J, Zeng J, Zhang LH, Ke YL, Wang XM, Liu XM, Chen QJ, Zhang AQ, Xu F, Bi XW, Huang JJ, Li JB, Pang DM, Xue C, Shi YX, He ZY, Lin HX, An X, Xia W, Cao Y, Guo Y, Su YH, Hua X, Wang XY, Hong RX, Jiang KK, Song CG, Huang ZZ, Shi W, Zhong YY, Yuan ZY; South China Breast Cancer Group (SCBCG)
JAMA 2021 Jan 5;325(1):50-58. doi: 10.1001/jama.2020.23370. PMID: 33300950Free PMC Article
Sukumar J, Gast K, Quiroga D, Lustberg M, Williams N
Expert Rev Anticancer Ther 2021 Feb;21(2):135-148. doi: 10.1080/14737140.2021.1840984. PMID: 33198517Free PMC Article
Cortes J, Cescon DW, Rugo HS, Nowecki Z, Im SA, Yusof MM, Gallardo C, Lipatov O, Barrios CH, Holgado E, Iwata H, Masuda N, Otero MT, Gokmen E, Loi S, Guo Z, Zhao J, Aktan G, Karantza V, Schmid P; KEYNOTE-355 Investigators
Lancet 2020 Dec 5;396(10265):1817-1828. doi: 10.1016/S0140-6736(20)32531-9. PMID: 33278935
Waks AG, Winer EP
JAMA 2019 Jan 22;321(3):288-300. doi: 10.1001/jama.2018.19323. PMID: 30667505
Foulkes WD, Smith IE, Reis-Filho JS
N Engl J Med 2010 Nov 11;363(20):1938-48. doi: 10.1056/NEJMra1001389. PMID: 21067385

Clinical prediction guides

Ding S, Qiao N, Zhu Q, Tong Y, Wang S, Chen X, Tian Q, Xiao Y, Shen K
Cancer Commun (Lond) 2023 Jun;43(6):661-684. Epub 2023 May 9 doi: 10.1002/cac2.12429. PMID: 37158690Free PMC Article
Yang F, Xiao Y, Ding JH, Jin X, Ma D, Li DQ, Shi JX, Huang W, Wang YP, Jiang YZ, Shao ZM
Cell Metab 2023 Jan 3;35(1):84-100.e8. Epub 2022 Oct 17 doi: 10.1016/j.cmet.2022.09.021. PMID: 36257316
Agostinetto E, Losurdo A, Nader-Marta G, Santoro A, Punie K, Barroso R, Popovic L, Solinas C, Kok M, de Azambuja E, Lambertini M
Expert Opin Investig Drugs 2022 Jun;31(6):567-591. Epub 2022 Mar 9 doi: 10.1080/13543784.2022.2049232. PMID: 35240902
Howard FM, Olopade OI
Cancer J 2021 Jan-Feb 01;27(1):8-16. doi: 10.1097/PPO.0000000000000500. PMID: 33475288
Ai D, Yao J, Yang F, Huo L, Chen H, Lu W, Soto LMS, Jiang M, Raso MG, Wang S, Bell D, Liu J, Wang H, Tan D, Torres-Cabala C, Gan Q, Wu Y, Albarracin C, Hung MC, Meric-Bernstam F, Wistuba II, Prieto VG, Sahin AA, Ding Q
Mod Pathol 2021 Apr;34(4):710-719. Epub 2020 Oct 3 doi: 10.1038/s41379-020-00692-8. PMID: 33011748

Recent systematic reviews

Mason SR, Willson ML, Egger SJ, Beith J, Dear RF, Goodwin A
Cochrane Database Syst Rev 2023 Sep 8;9(9):CD014805. doi: 10.1002/14651858.CD014805.pub2. PMID: 37681577Free PMC Article
van den Ende NS, Nguyen AH, Jager A, Kok M, Debets R, van Deurzen CHM
Int J Mol Sci 2023 Feb 3;24(3) doi: 10.3390/ijms24032969. PMID: 36769287Free PMC Article
Schettini F, Venturini S, Giuliano M, Lambertini M, Pinato DJ, Onesti CE, De Placido P, Harbeck N, Lüftner D, Denys H, Van Dam P, Arpino G, Zaman K, Mustacchi G, Gligorov J, Awada A, Campone M, Wildiers H, Gennari A, Tjan-Heijnen V, Bartsch R, Cortes J, Paris I, Martín M, De Placido S, Del Mastro L, Jerusalem G, Curigliano G, Prat A, Generali D
Cancer Treat Rev 2022 Dec;111:102468. Epub 2022 Sep 28 doi: 10.1016/j.ctrv.2022.102468. PMID: 36202026
Poggio F, Bruzzone M, Ceppi M, Pondé NF, La Valle G, Del Mastro L, de Azambuja E, Lambertini M
Ann Oncol 2018 Jul 1;29(7):1497-1508. doi: 10.1093/annonc/mdy127. PMID: 29873695
Baretta Z, Mocellin S, Goldin E, Olopade OI, Huo D
Medicine (Baltimore) 2016 Oct;95(40):e4975. doi: 10.1097/MD.0000000000004975. PMID: 27749552Free PMC Article

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