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Somatropin recombinant response

MedGen UID:
980340
•Concept ID:
CN297855
•
Sign or Symptom
Drug:
somatropin recombinant
MedGen UID:
60967
•Concept ID:
C0169964
•
Pharmacologic Substance
A recombinant form of endogenous human growth hormone (GH), a polypeptide produced by the anterior lobe of the human pituitary gland. GH exhibits growth-promoting effects and metabolic effects on carbohydrate, fat, protein and bone metabolism. GH stimulates protein synthesis and the uptake of amino acids into cells, and induces lipolysis in adipose tissues. The secretion of GH increases with sexual maturation and then declines steadily. [from NCI]
somatropin recombinant

Professional guidelines

PubMed

Mammalian cell-derived somatropin : a review of its use in the management of HIV-associated wasting.
Goldsmith DR, Wagstaff AJ
Drugs 2006;66(3):387-401. doi: 10.2165/00003495-200666030-00014. PMID: 16526830
Recombinant DNA produced somatropin in the treatment of prepubertal growth hormone deficient children.
Chang TC, Kuo HF, Liu PC, Shih KC, Zeisel HJ, Ho LT
Zhonghua Yi Xue Za Zhi (Taipei) 1991 Jan;47(1):7-12. PMID: 1848467
Recombinant somatropin in treatment of growth hormone deficient children in Sweden and Finland.
Albertsson-Wikland K, Aronson S, Nilsson KO, Ritzén M, Tuvemo T, Westgren U, Westphal O, Perheentupa J, Sipilä I, Wilton P
Acta Paediatr Scand Suppl 1988;347:176-9. PMID: 3254032

Curated

DailyMed Drug Label, somatropin recombinant, 2020

Recent clinical studies

Etiology

Children With Idiopathic Short Stature: An Expanding Role for Genetic Investigation in Their Medical Evaluation.
Cohen LE, Rogol AD
Endocr Pract 2024 Jul;30(7):679-686. Epub 2024 Apr 26 doi: 10.1016/j.eprac.2024.04.009. PMID: 38679385
Safety of long-term use of daily and long-acting growth hormone in growth hormone-deficient adults on cancer risk.
Boguszewski CL
Best Pract Res Clin Endocrinol Metab 2023 Dec;37(6):101817. Epub 2023 Aug 24 doi: 10.1016/j.beem.2023.101817. PMID: 37643936
Clinical Characteristics of Short-Stature Patients With Collagen Gene Mutation and the Therapeutic Response to rhGH.
Chen M, Miao H, Liang H, Ke X, Yang H, Gong F, Wang L, Duan L, Chen S, Pan H, Zhu H
Front Endocrinol (Lausanne) 2022;13:820001. Epub 2022 Feb 16 doi: 10.3389/fendo.2022.820001. PMID: 35250876Free PMC Article
Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective.
Collett-Solberg PF, Ambler G, Backeljauw PF, Bidlingmaier M, Biller BMK, Boguszewski MCS, Cheung PT, Choong CSY, Cohen LE, Cohen P, Dauber A, Deal CL, Gong C, Hasegawa Y, Hoffman AR, Hofman PL, Horikawa R, Jorge AAL, Juul A, Kamenický P, Khadilkar V, Kopchick JJ, Kriström B, Lopes MLA, Luo X, Miller BS, Misra M, Netchine I, Radovick S, Ranke MB, Rogol AD, Rosenfeld RG, Saenger P, Wit JM, Woelfle J
Horm Res Paediatr 2019;92(1):1-14. Epub 2019 Sep 12 doi: 10.1159/000502231. PMID: 31514194Free PMC Article
Altering metabolism.
Pereira CT, Murphy KD, Herndon DN
J Burn Care Rehabil 2005 May-Jun;26(3):194-9. PMID: 15879740

Diagnosis

Children With Idiopathic Short Stature: An Expanding Role for Genetic Investigation in Their Medical Evaluation.
Cohen LE, Rogol AD
Endocr Pract 2024 Jul;30(7):679-686. Epub 2024 Apr 26 doi: 10.1016/j.eprac.2024.04.009. PMID: 38679385
Short stature related to Growth Hormone Insensitivity (GHI) in childhood.
Mastromauro C, Giannini C, Chiarelli F
Front Endocrinol (Lausanne) 2023;14:1141039. Epub 2023 Mar 15 doi: 10.3389/fendo.2023.1141039. PMID: 37008935Free PMC Article
Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective.
Collett-Solberg PF, Ambler G, Backeljauw PF, Bidlingmaier M, Biller BMK, Boguszewski MCS, Cheung PT, Choong CSY, Cohen LE, Cohen P, Dauber A, Deal CL, Gong C, Hasegawa Y, Hoffman AR, Hofman PL, Horikawa R, Jorge AAL, Juul A, Kamenický P, Khadilkar V, Kopchick JJ, Kriström B, Lopes MLA, Luo X, Miller BS, Misra M, Netchine I, Radovick S, Ranke MB, Rogol AD, Rosenfeld RG, Saenger P, Wit JM, Woelfle J
Horm Res Paediatr 2019;92(1):1-14. Epub 2019 Sep 12 doi: 10.1159/000502231. PMID: 31514194Free PMC Article
Alternatives in the Treatment of Short Stature.
Lanes R, González Briceño LG
Adv Pediatr 2017 Aug;64(1):111-131. doi: 10.1016/j.yapd.2017.03.004. PMID: 28688585
Diagnosis and management of growth hormone deficiency in childhood and adolescence--part 2: growth hormone treatment in growth hormone deficient children.
Tanaka T, Cohen P, Clayton PE, Laron Z, Hintz RL, Sizonenko PC
Growth Horm IGF Res 2002 Oct;12(5):323-41. doi: 10.1016/s1096-6374(02)00045-x. PMID: 12213187

Therapy

Safety of long-term use of daily and long-acting growth hormone in growth hormone-deficient adults on cancer risk.
Boguszewski CL
Best Pract Res Clin Endocrinol Metab 2023 Dec;37(6):101817. Epub 2023 Aug 24 doi: 10.1016/j.beem.2023.101817. PMID: 37643936
Association between pituitary height and growth response to recombinant human growth hormone in prepubertal children with growth hormone deficiency.
Zhang Z, Zhang X, Niu W, Yuan Y
Endocrine 2023 Feb;79(2):287-291. Epub 2022 Oct 20 doi: 10.1007/s12020-022-03217-2. PMID: 36264534
Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective.
Collett-Solberg PF, Ambler G, Backeljauw PF, Bidlingmaier M, Biller BMK, Boguszewski MCS, Cheung PT, Choong CSY, Cohen LE, Cohen P, Dauber A, Deal CL, Gong C, Hasegawa Y, Hoffman AR, Hofman PL, Horikawa R, Jorge AAL, Juul A, Kamenický P, Khadilkar V, Kopchick JJ, Kriström B, Lopes MLA, Luo X, Miller BS, Misra M, Netchine I, Radovick S, Ranke MB, Rogol AD, Rosenfeld RG, Saenger P, Wit JM, Woelfle J
Horm Res Paediatr 2019;92(1):1-14. Epub 2019 Sep 12 doi: 10.1159/000502231. PMID: 31514194Free PMC Article
Alternatives in the Treatment of Short Stature.
Lanes R, González Briceño LG
Adv Pediatr 2017 Aug;64(1):111-131. doi: 10.1016/j.yapd.2017.03.004. PMID: 28688585
Altering metabolism.
Pereira CT, Murphy KD, Herndon DN
J Burn Care Rehabil 2005 May-Jun;26(3):194-9. PMID: 15879740

Prognosis

Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature.
Stevens A, Perchard R, Garner T, Clayton P, Murray P
Rev Endocr Metab Disord 2021 Mar;22(1):135-143. Epub 2021 Mar 12 doi: 10.1007/s11154-021-09637-1. PMID: 33712998Free PMC Article
Once-weekly Somapacitan is Effective and Well Tolerated in Adults with GH Deficiency: A Randomized Phase 3 Trial.
Johannsson G, Gordon MB, Højby Rasmussen M, Håkonsson IH, Karges W, Sværke C, Tahara S, Takano K, Biller BMK
J Clin Endocrinol Metab 2020 Apr 1;105(4):e1358-76. doi: 10.1210/clinem/dgaa049. PMID: 32022863Free PMC Article
Alternatives in the Treatment of Short Stature.
Lanes R, González Briceño LG
Adv Pediatr 2017 Aug;64(1):111-131. doi: 10.1016/j.yapd.2017.03.004. PMID: 28688585
Optimizing growth hormone dosing in children with idiopathic short stature.
Keni J, Cohen P
Horm Res 2009 Jan;71 Suppl 1:70-4. Epub 2009 Jan 21 doi: 10.1159/000178043. PMID: 19153511
Growth and growth hormone in children born small for gestational age.
Rapaport R, Tuvemo T
Acta Paediatr 2005 Oct;94(10):1348-55. doi: 10.1111/j.1651-2227.2005.tb01801.x. PMID: 16263627

Clinical prediction guides

Long-acting PEGylated growth hormone in children with idiopathic short stature.
Luo X, Zhao S, Yang Y, Dong G, Chen L, Li P, Luo F, Gong C, Xu Z, Xu X, Gong H, Du H, Hou L, Zhong Y, Shi Q, Chen X, Chen X, Xu L, Cheng R, Su C, Ma Y, Xu L, Zhang L, Lu H
Eur J Endocrinol 2022 Nov 1;187(5):709-718. Epub 2022 Oct 13 doi: 10.1530/EJE-22-0449. PMID: 36130048
Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature.
Stevens A, Perchard R, Garner T, Clayton P, Murray P
Rev Endocr Metab Disord 2021 Mar;22(1):135-143. Epub 2021 Mar 12 doi: 10.1007/s11154-021-09637-1. PMID: 33712998Free PMC Article
Once-weekly Somapacitan is Effective and Well Tolerated in Adults with GH Deficiency: A Randomized Phase 3 Trial.
Johannsson G, Gordon MB, Højby Rasmussen M, Håkonsson IH, Karges W, Sværke C, Tahara S, Takano K, Biller BMK
J Clin Endocrinol Metab 2020 Apr 1;105(4):e1358-76. doi: 10.1210/clinem/dgaa049. PMID: 32022863Free PMC Article
The P2 promoter of the IGF1 gene is a major epigenetic locus for GH responsiveness.
Ouni M, Belot MP, Castell AL, Fradin D, Bougnères P
Pharmacogenomics J 2016 Feb;16(1):102-6. Epub 2015 Apr 14 doi: 10.1038/tpj.2015.26. PMID: 25869012Free PMC Article
Metabolic benefits of growth hormone therapy in idiopathic short stature.
Dahlgren J
Horm Res Paediatr 2011;76 Suppl 3:56-8. Epub 2011 Sep 7 doi: 10.1159/000330165. PMID: 21912170

Recent systematic reviews

The influence of growth hormone on pediatric body composition: A systematic review.
Ferruzzi A, Vrech M, Pietrobelli A, Cavarzere P, Zerman N, Guzzo A, Flodmark CE, Piacentini G, Antoniazzi F
Front Endocrinol (Lausanne) 2023;14:1093691. Epub 2023 Feb 9 doi: 10.3389/fendo.2023.1093691. PMID: 36843617Free PMC Article
Evaluating human epidermal growth factor receptor 2 roles in the efficacy of Tamoxifen treatment in breast cancer, a systematic review.
Mansouri S, Mokhtari-Hesari P, Naghavi-Al-Hosseini F, Seyednejad SA, Majidzadeh-A K, Moradi-Kalbolandi S, Ghahremanlou M, Farahmand L
Pharmacol Rep 2021 Apr;73(2):435-442. Epub 2021 Mar 7 doi: 10.1007/s43440-021-00237-z. PMID: 33682068
The impact of growth hormone therapy on adult height in noonan syndrome: a systematic review.
Giacomozzi C, Deodati A, Shaikh MG, Ahmed SF, Cianfarani S
Horm Res Paediatr 2015;83(3):167-76. Epub 2015 Feb 21 doi: 10.1159/000371635. PMID: 25721697
Metabolic benefits of growth hormone therapy in idiopathic short stature.
Dahlgren J
Horm Res Paediatr 2011;76 Suppl 3:56-8. Epub 2011 Sep 7 doi: 10.1159/000330165. PMID: 21912170
Impact of the exon 3-deleted growth hormone (GH) receptor polymorphism on baseline height and the growth response to recombinant human GH therapy in GH-deficient (GHD) and non-GHD children with short stature: a systematic review and meta-analysis.
Wassenaar MJ, Dekkers OM, Pereira AM, Wit JM, Smit JW, Biermasz NR, Romijn JA
J Clin Endocrinol Metab 2009 Oct;94(10):3721-30. Epub 2009 Jul 7 doi: 10.1210/jc.2009-0425. PMID: 19584188

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