U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from PMC

Sperm-specific antigen 1(SSFA1)

MedGen UID:
244171
•Concept ID:
C1420425
•
Finding
Synonyms: FERTILIZATION ANTIGEN 1; SSFA1
 
Monarch Initiative: MONDO:0011161
OMIM®: 601876

Professional guidelines

PubMed

Differential diagnosis of immature germ cells in semen utilizing monoclonal antibody MHS-10 to the intra-acrosomal antigen SP-10.
Homyk M, Anderson DJ, Wolff H, Herr JC
Fertil Steril 1990 Feb;53(2):323-30. doi: 10.1016/s0015-0282(16)53289-0. PMID: 2298314

Recent clinical studies

Etiology

Antigen unmasking does not improve the visualization of phospholipase C zeta in human spermatozoa.
Meng X, Jones C, Melo P, Ross C, Mounce G, Child T, Coward K
Asian J Androl 2022 Jul-Aug;24(4):345-352. doi: 10.4103/aja202168. PMID: 34893574Free PMC Article
Fluorescence- and magnetic-activated cell sorting strategies to separate spermatozoa involving plural contributors from biological mixtures for human identification.
Xu Y, Xie J, Chen R, Cao Y, Ping Y, Xu Q, Hu W, Wu D, Gu L, Zhou H, Chen X, Zhao Z, Zhong J, Li R
Sci Rep 2016 Nov 18;6:36515. doi: 10.1038/srep36515. PMID: 27857155Free PMC Article
Assessment of sperm antigen specific T regulatory cells in women with recurrent miscarriage.
Liu C, Wang XZ, Sun XB
Early Hum Dev 2013 Feb;89(2):95-100. Epub 2012 Aug 25 doi: 10.1016/j.earlhumdev.2012.08.003. PMID: 22925355
Gene expression alterations in cryptorchid males using spermatozoal microarray analysis.
Nguyen MT, Delaney DP, Kolon TF
Fertil Steril 2009 Jul;92(1):182-7. Epub 2008 Aug 8 doi: 10.1016/j.fertnstert.2008.05.043. PMID: 18687424
Unregulated production of virus and/or sperm specific anti-idiotypic antibodies as a cause of AIDS.
Hsia S, Doran DM, Shockley RK, Galle PC, Lutcher CL, Hodge LD
Lancet 1984 Jun 2;1(8388):1212-4. doi: 10.1016/s0140-6736(84)91695-7. PMID: 6144926

Diagnosis

Sperm-specific proteins: new implications for diagnostic development and cancer immunotherapy.
O'Donnell L, Smith LB, Rebourcet D
Curr Opin Cell Biol 2022 Aug;77:102104. Epub 2022 Jun 4 doi: 10.1016/j.ceb.2022.102104. PMID: 35671587
Antigen unmasking does not improve the visualization of phospholipase C zeta in human spermatozoa.
Meng X, Jones C, Melo P, Ross C, Mounce G, Child T, Coward K
Asian J Androl 2022 Jul-Aug;24(4):345-352. doi: 10.4103/aja202168. PMID: 34893574Free PMC Article
Opisthorchis viverrini: analysis of the sperm-specific rhophilin associated tail protein 1-like.
Rattanachan S, Grams R, Tesana S, Smooker PM, Grams SV
Acta Trop 2014 Dec;140:34-40. Epub 2014 Aug 11 doi: 10.1016/j.actatropica.2014.08.002. PMID: 25124046
Assessment of sperm antigen specific T regulatory cells in women with recurrent miscarriage.
Liu C, Wang XZ, Sun XB
Early Hum Dev 2013 Feb;89(2):95-100. Epub 2012 Aug 25 doi: 10.1016/j.earlhumdev.2012.08.003. PMID: 22925355
The fertilization antigen (FA-1): applications in immunocontraception and infertility in humans.
Naz RK
Am J Reprod Immunol Microbiol 1988 Jan;16(1):21-7. doi: 10.1111/j.1600-0897.1988.tb00172.x. PMID: 3285707

Therapy

Discovery of human posterior head 20 (hPH20) and homo sapiens sperm acrosome associated 1 (hSPACA1) immunocontraceptive epitopes and their effects on fertility in male and female mice.
Chen X, Liu X, Ren X, Li X, Wang L, Zang W
Reprod Fertil Dev 2016 Mar;28(4):416-27. doi: 10.1071/RD14134. PMID: 25209425
Development of antifertility vaccine using sperm specific proteins.
Bandivdekar AH
Indian J Med Res 2014 Nov;140 Suppl(Suppl 1):S73-7. PMID: 25673547Free PMC Article
Antisperm contraceptive vaccines: where we are and where we are going?
Naz RK
Am J Reprod Immunol 2011 Jul;66(1):5-12. Epub 2011 Apr 11 doi: 10.1111/j.1600-0897.2011.01000.x. PMID: 21481057Free PMC Article
Vaccine for contraception targeting sperm.
Naz RK
Immunol Rev 1999 Oct;171:193-202. doi: 10.1111/j.1600-065x.1999.tb01349.x. PMID: 10582172
Immunocontraception in rodents: a review of the development of a sperm-based immunocontraceptive vaccine for the grey squirrel (Sciurus carolinensis).
Moore HD, Jenkins NM, Wong C
Reprod Fertil Dev 1997;9(1):125-9. doi: 10.1071/r96053. PMID: 9109202

Prognosis

Glycolipids as potential binding sites for HIV: topology in the sperm plasma membrane in relation to the regulation of membrane fusion.
Gadella BM, Hammache D, Piéroni G, Colenbrander B, van Golde LM, Fantini J
J Reprod Immunol 1998 Dec;41(1-2):233-53. doi: 10.1016/s0165-0378(98)00061-8. PMID: 10213313
Sperm antigens and their use in the development of an immunocontraceptive.
Diekman AB, Herr JC
Am J Reprod Immunol 1997 Jan;37(1):111-7. doi: 10.1111/j.1600-0897.1997.tb00199.x. PMID: 9138444

Clinical prediction guides

Antigen unmasking enhances visualization efficacy of the oocyte activation factor, phospholipase C zeta, in mammalian sperm.
Kashir J, Buntwal L, Nomikos M, Calver BL, Stamatiadis P, Ashley P, Vassilakopoulou V, Sanders D, Knaggs P, Livaniou E, Bunkheila A, Swann K, Lai FA
Mol Hum Reprod 2017 Jan;23(1):54-67. Epub 2016 Dec 8 doi: 10.1093/molehr/gaw073. PMID: 27932551
Mixed testicular atrophy related to atherosclerosis: first lessons from the ApoE(-/-)/ LDL receptor(-/-) double knockout mouse model.
Langheinrich AC, Paradowska A, Kilinski R, Kampschulte M, Steinfeld K, Altinkilic B, Steger K, Stieger P, Bergmann M, Weidner W
Int J Androl 2012 Aug;35(4):562-71. Epub 2011 Dec 13 doi: 10.1111/j.1365-2605.2011.01228.x. PMID: 22150227
Gene expression alterations in cryptorchid males using spermatozoal microarray analysis.
Nguyen MT, Delaney DP, Kolon TF
Fertil Steril 2009 Jul;92(1):182-7. Epub 2008 Aug 8 doi: 10.1016/j.fertnstert.2008.05.043. PMID: 18687424
Antifertility effect of passive administration of antibodies to 80 kDa human sperm antigen and its synthetic peptides in male and female rats.
Bandivdekar AH, Vernekar VJ, Kamada M, Raghavan VP
Am J Reprod Immunol 2005 Dec;54(6):332-41. doi: 10.1111/j.1600-0897.2005.00309.x. PMID: 16305658
Sperm antigens and their use in the development of an immunocontraceptive.
Diekman AB, Herr JC
Am J Reprod Immunol 1997 Jan;37(1):111-7. doi: 10.1111/j.1600-0897.1997.tb00199.x. PMID: 9138444

Supplemental Content

Filter your results:

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...