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Major affective disorder 2(MAFD2)

MedGen UID:
326975
Concept ID:
C1839839
Mental or Behavioral Dysfunction
Synonyms: MAFD2; MANIC-DEPRESSIVE ILLNESS; MANIC-DEPRESSIVE PSYCHOSIS, X-LINKED
 
Monarch Initiative: MONDO:0010648
OMIM®: 309200

Clinical features

From HPO
Bipolar affective disorder
MedGen UID:
2649
Concept ID:
C0005586
Mental or Behavioral Dysfunction
Bipolar disorder is an illness of mood characterized by alternating episodes of elevated and depressed moods, which are interspersed with euthymic periods.

Professional guidelines

PubMed

Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279

Curated

UK NICE Clinical Guideline CG185, Bipolar disorder: assessment and management, 2023

Recent clinical studies

Etiology

Cuesta MJ, Sánchez-Torres AM, García de Jalón E, Moreno-Izco L, Gil-Berrozpe GJ, Zarzuela A, Papiol S, Fañanás L, Peralta V; SEGPEPs Group
Schizophr Res 2024 Jan;263:237-245. Epub 2023 Jan 20 doi: 10.1016/j.schres.2022.12.022. PMID: 36682995
Kendler KS, Klee A
Am J Med Genet B Neuropsychiatr Genet 2021 Mar;186(2):90-100. Epub 2021 Jan 22 doi: 10.1002/ajmg.b.32831. PMID: 33484094

Diagnosis

Kendler KS
J Affect Disord 2021 Mar 1;282:979-990. Epub 2021 Jan 6 doi: 10.1016/j.jad.2020.12.200. PMID: 33601743
Kendler KS, Engstrom EJ
J Affect Disord 2020 Jun 1;270:42-50. Epub 2020 Mar 29 doi: 10.1016/j.jad.2020.03.094. PMID: 32275219
Kendler KS
Mol Psychiatry 2017 Nov;22(11):1539-1553. Epub 2017 Aug 8 doi: 10.1038/mp.2017.148. PMID: 28785109
Demontis F, Serra F, Serra G
Curr Neuropharmacol 2017 Apr;15(3):417-423. doi: 10.2174/1570159X14666160715165648. PMID: 28503114Free PMC Article
Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279

Therapy

Demontis F, Serra F, Serra G
Curr Neuropharmacol 2017 Apr;15(3):417-423. doi: 10.2174/1570159X14666160715165648. PMID: 28503114Free PMC Article
Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279
Xiang YT, Hu C, Wang G, Zheng QW, Fang YR, Ungvari GS, Kilbourne AM, Lai KY, Si TM, Chen DF, Lu Z, Yang HC, Hu J, Chen ZY, Huang Y, Sun J, Wang XP, Li HC, Zhang JB, Chiu HF
Hum Psychopharmacol 2012 Nov;27(6):626-31. Epub 2012 Oct 2 doi: 10.1002/hup.2262. PMID: 23027671

Prognosis

Cuesta MJ, Sánchez-Torres AM, García de Jalón E, Moreno-Izco L, Gil-Berrozpe GJ, Zarzuela A, Papiol S, Fañanás L, Peralta V; SEGPEPs Group
Schizophr Res 2024 Jan;263:237-245. Epub 2023 Jan 20 doi: 10.1016/j.schres.2022.12.022. PMID: 36682995
Kendler KS, Engstrom EJ
J Affect Disord 2020 Jun 1;270:42-50. Epub 2020 Mar 29 doi: 10.1016/j.jad.2020.03.094. PMID: 32275219
Kendler KS
Mol Psychiatry 2017 Nov;22(11):1539-1553. Epub 2017 Aug 8 doi: 10.1038/mp.2017.148. PMID: 28785109

Clinical prediction guides

Cuesta MJ, Sánchez-Torres AM, García de Jalón E, Moreno-Izco L, Gil-Berrozpe GJ, Zarzuela A, Papiol S, Fañanás L, Peralta V; SEGPEPs Group
Schizophr Res 2024 Jan;263:237-245. Epub 2023 Jan 20 doi: 10.1016/j.schres.2022.12.022. PMID: 36682995
Kendler KS, Klee A
Am J Med Genet B Neuropsychiatr Genet 2021 Mar;186(2):90-100. Epub 2021 Jan 22 doi: 10.1002/ajmg.b.32831. PMID: 33484094
Demontis F, Serra F, Serra G
Curr Neuropharmacol 2017 Apr;15(3):417-423. doi: 10.2174/1570159X14666160715165648. PMID: 28503114Free PMC Article
Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279

Recent systematic reviews

Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Clinical Guideline CG185, Bipolar disorder: assessment and management, 2023

    Consumer resources

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