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Logopenic progressive aphasia

MedGen UID:
907332
Concept ID:
C4274665
Mental or Behavioral Dysfunction
Synonyms: Logopenic primary progressive aphasia; logopenic progressive aphasia; Logopenic variant PPA; LPA
SNOMED CT: Logopenic progressive aphasia (716380002)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0016644
Orphanet: ORPHA250831

Definition

A form of primary progressive aphasia with characteristics of impaired single-word retrieval and naming and impaired repetition with spared single-word comprehension and object knowledge. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLogopenic progressive aphasia

Professional guidelines

PubMed

Bisenius S, Neumann J, Schroeter ML
Eur J Neurol 2016 Apr;23(4):704-12. Epub 2016 Feb 22 doi: 10.1111/ene.12902. PMID: 26901360
Sitek EJ, Barczak A, Kluj-Kozłowska K, Kozłowski M, Barcikowska M, Sławek J
Neurol Neurochir Pol 2015;49(4):239-44. Epub 2015 Jun 17 doi: 10.1016/j.pjnns.2015.06.001. PMID: 26188940
Josephs KA, Duffy JR, Fossett TR, Strand EA, Claassen DO, Whitwell JL, Peller PJ
Arch Neurol 2010 May;67(5):596-605. doi: 10.1001/archneurol.2010.78. PMID: 20457960

Recent clinical studies

Etiology

Pham NTT, Graff-Radford J, Machulda MM, Spychalla AJ, Schwarz CG, Senjem ML, Lowe VJ, Vemuri P, Kantarci K, Knopman DS, Petersen RC, Jack CR, Josephs KA, Whitwell JL
Neurobiol Aging 2022 Nov;119:46-55. Epub 2022 Jul 28 doi: 10.1016/j.neurobiolaging.2022.07.008. PMID: 35970009Free PMC Article
Thanprasertsuk S, Likitjaroen Y
BMC Neurol 2021 Jan 13;21(1):22. doi: 10.1186/s12883-020-02039-x. PMID: 33441094Free PMC Article
Buciuc M, Whitwell JL, Kasanuki K, Graff-Radford J, Machulda MM, Duffy JR, Strand EA, Lowe VJ, Graff-Radford NR, Rush BK, Franczak MB, Flanagan ME, Baker MC, Rademakers R, Ross OA, Ghetti BF, Parisi JE, Raghunathan A, Reichard RR, Bigio EH, Dickson DW, Josephs KA
Ann Neurol 2021 Mar;89(3):520-533. Epub 2020 Dec 17 doi: 10.1002/ana.25979. PMID: 33274526Free PMC Article
Teichmann M, Kas A, Boutet C, Ferrieux S, Nogues M, Samri D, Rogan C, Dormont D, Dubois B, Migliaccio R
Brain 2013 Nov;136(Pt 11):3474-88. Epub 2013 Oct 8 doi: 10.1093/brain/awt266. PMID: 24108322
Foxe DG, Irish M, Hodges JR, Piguet O
J Int Neuropsychol Soc 2013 Mar;19(3):247-53. Epub 2013 Jan 8 doi: 10.1017/S1355617712001269. PMID: 23298815

Diagnosis

Thanprasertsuk S, Likitjaroen Y
BMC Neurol 2021 Jan 13;21(1):22. doi: 10.1186/s12883-020-02039-x. PMID: 33441094Free PMC Article
Buciuc M, Whitwell JL, Kasanuki K, Graff-Radford J, Machulda MM, Duffy JR, Strand EA, Lowe VJ, Graff-Radford NR, Rush BK, Franczak MB, Flanagan ME, Baker MC, Rademakers R, Ross OA, Ghetti BF, Parisi JE, Raghunathan A, Reichard RR, Bigio EH, Dickson DW, Josephs KA
Ann Neurol 2021 Mar;89(3):520-533. Epub 2020 Dec 17 doi: 10.1002/ana.25979. PMID: 33274526Free PMC Article
Leyton CE, Hodges JR
Curr Neurol Neurosci Rep 2013 Nov;13(11):396. doi: 10.1007/s11910-013-0396-6. PMID: 24027007
Grossman M
Nat Rev Neurol 2010 Feb;6(2):88-97. doi: 10.1038/nrneurol.2009.216. PMID: 20139998Free PMC Article
Amici S, Gorno-Tempini ML, Ogar JM, Dronkers NF, Miller BL
Behav Neurol 2006;17(2):77-87. doi: 10.1155/2006/260734. PMID: 16873918Free PMC Article

Prognosis

Wong S, Wei G, Husain M, Hodges JR, Piguet O, Irish M, Kumfor F
Cogn Affect Behav Neurosci 2023 Apr;23(2):354-370. Epub 2022 Nov 23 doi: 10.3758/s13415-022-01048-2. PMID: 36417157Free PMC Article
Hardy CJD, Marshall CR, Bond RL, Russell LL, Dick K, Ariti C, Thomas DL, Ross SJ, Agustus JL, Crutch SJ, Rohrer JD, Bamiou DE, Warren JD
Alzheimers Res Ther 2018 Jul 25;10(1):70. doi: 10.1186/s13195-018-0399-2. PMID: 30045755Free PMC Article
Silsby M, Tweedie-Cullen RY, Murray CR, Halliday GM, Hodges JR, Burrell JR
Eur J Neurol 2017 Jul;24(7):956-965. Epub 2017 May 16 doi: 10.1111/ene.13314. PMID: 28510312
Hu WT, McMillan C, Libon D, Leight S, Forman M, Lee VM, Trojanowski JQ, Grossman M
Neurology 2010 Aug 17;75(7):595-602. doi: 10.1212/WNL.0b013e3181ed9c52. PMID: 20713948Free PMC Article
Josephs KA, Duffy JR, Fossett TR, Strand EA, Claassen DO, Whitwell JL, Peller PJ
Arch Neurol 2010 May;67(5):596-605. doi: 10.1001/archneurol.2010.78. PMID: 20457960

Clinical prediction guides

Wong S, Irish M, Husain M, Hodges JR, Piguet O, Kumfor F
J Neurol Sci 2020 Sep 15;416:117007. Epub 2020 Jun 30 doi: 10.1016/j.jns.2020.117007. PMID: 32623141
Clark HM, Utianski RL, Duffy JR, Strand EA, Botha H, Josephs KA, Whitwell JL
Am J Speech Lang Pathol 2020 Feb 21;29(1S):498-510. Epub 2019 Oct 22 doi: 10.1044/2019_AJSLP-CAC48-18-0217. PMID: 31639312Free PMC Article
Watanabe H, Ikeda M, Mori E
BMC Neurol 2019 Nov 25;19(1):299. doi: 10.1186/s12883-019-1524-y. PMID: 31766995Free PMC Article
Leyton CE, Hodges JR, McLean CA, Kril JJ, Piguet O, Ballard KJ
Cortex 2015 Jun;67:122-33. Epub 2015 Apr 1 doi: 10.1016/j.cortex.2015.03.011. PMID: 25955499
Leyton CE, Piguet O, Savage S, Burrell J, Hodges JR
J Alzheimers Dis 2012;32(4):1051-9. doi: 10.3233/JAD-2012-121042. PMID: 22890099

Recent systematic reviews

Mirbod M, Ayubcha C, Redden HWK, Teichner E, Subtirelu RC, Patel R, Raynor W, Werner T, Alavi A, Revheim ME
Ann Nucl Med 2024 Sep;38(9):673-687. Epub 2024 Jul 19 doi: 10.1007/s12149-024-01958-w. PMID: 39028529Free PMC Article

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