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Ceftazidime response

MedGen UID:
979174
Concept ID:
CN297723
Sign or Symptom
Drug:
ceftazidime
MedGen UID:
3289
Concept ID:
C0007559
Antibiotic
A beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftazidime binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftazidime is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftazidine also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS). [from NCI]

Professional guidelines

PubMed

Pintado V, Ruiz-Garbajosa P, Aguilera-Alonso D, Baquero-Artigao F, Bou G, Cantón R, Grau S, Gutiérrez-Gutiérrez B, Larrosa N, Machuca I, Martínez Martínez L, Montero MM, Morte-Romea E, Oliver A, Paño-Pardo JR, Sorlí L
Enferm Infecc Microbiol Clin (Engl Ed) 2023 Jun-Jul;41(6):360-370. Epub 2022 Dec 13 doi: 10.1016/j.eimce.2022.06.014. PMID: 36522272
Shirley M
Drugs 2018 Apr;78(6):675-692. doi: 10.1007/s40265-018-0902-x. PMID: 29671219
Perry CM, Markham A
Drugs 1999 May;57(5):805-43. doi: 10.2165/00003495-199957050-00017. PMID: 10353303

Curated

DailyMed Drug Label, ceftazidime, 2020

Recent clinical studies

Etiology

Gatti M, Pea F
Expert Rev Clin Pharmacol 2021 May;14(5):583-599. Epub 2021 Apr 29 doi: 10.1080/17512433.2021.1901574. PMID: 33687300
Zhanel GG, Golden AR, Zelenitsky S, Wiebe K, Lawrence CK, Adam HJ, Idowu T, Domalaon R, Schweizer F, Zhanel MA, Lagacé-Wiens PRS, Walkty AJ, Noreddin A, Lynch Iii JP, Karlowsky JA
Drugs 2019 Feb;79(3):271-289. doi: 10.1007/s40265-019-1055-2. PMID: 30712199
Wiersinga WJ, Virk HS, Torres AG, Currie BJ, Peacock SJ, Dance DAB, Limmathurotsakul D
Nat Rev Dis Primers 2018 Feb 1;4:17107. doi: 10.1038/nrdp.2017.107. PMID: 29388572Free PMC Article
Carmeli Y, Armstrong J, Laud PJ, Newell P, Stone G, Wardman A, Gasink LB
Lancet Infect Dis 2016 Jun;16(6):661-673. Epub 2016 Apr 20 doi: 10.1016/S1473-3099(16)30004-4. PMID: 27107460
Perry CM, Markham A
Drugs 1999 May;57(5):805-43. doi: 10.2165/00003495-199957050-00017. PMID: 10353303

Diagnosis

Pintado V, Ruiz-Garbajosa P, Aguilera-Alonso D, Baquero-Artigao F, Bou G, Cantón R, Grau S, Gutiérrez-Gutiérrez B, Larrosa N, Machuca I, Martínez Martínez L, Montero MM, Morte-Romea E, Oliver A, Paño-Pardo JR, Sorlí L
Enferm Infecc Microbiol Clin (Engl Ed) 2023 Jun-Jul;41(6):360-370. Epub 2022 Dec 13 doi: 10.1016/j.eimce.2022.06.014. PMID: 36522272
Castón JJ, Cano A, Pérez-Camacho I, Aguado JM, Carratalá J, Ramasco F, Soriano A, Pintado V, Castelo-Corral L, Sousa A, Fariñas MC, Muñoz P, Abril López De Medrano V, Sanz-Peláez Ó, Los-Arcos I, Gracia-Ahufinger I, Pérez-Nadales E, Vidal E, Doblas A, Natera C, Martínez-Martínez L, Torre-Cisneros J
J Antimicrob Chemother 2022 Apr 27;77(5):1452-1460. doi: 10.1093/jac/dkac049. PMID: 35187577
Wiersinga WJ, Virk HS, Torres AG, Currie BJ, Peacock SJ, Dance DAB, Limmathurotsakul D
Nat Rev Dis Primers 2018 Feb 1;4:17107. doi: 10.1038/nrdp.2017.107. PMID: 29388572Free PMC Article
Puthucheary SD
Med J Malaysia 2009 Dec;64(4):266-74. PMID: 20954549
White NJ
Lancet 2003 May 17;361(9370):1715-22. doi: 10.1016/s0140-6736(03)13374-0. PMID: 12767750

Therapy

Pintado V, Ruiz-Garbajosa P, Aguilera-Alonso D, Baquero-Artigao F, Bou G, Cantón R, Grau S, Gutiérrez-Gutiérrez B, Larrosa N, Machuca I, Martínez Martínez L, Montero MM, Morte-Romea E, Oliver A, Paño-Pardo JR, Sorlí L
Enferm Infecc Microbiol Clin (Engl Ed) 2023 Jun-Jul;41(6):360-370. Epub 2022 Dec 13 doi: 10.1016/j.eimce.2022.06.014. PMID: 36522272
Zhanel GG, Golden AR, Zelenitsky S, Wiebe K, Lawrence CK, Adam HJ, Idowu T, Domalaon R, Schweizer F, Zhanel MA, Lagacé-Wiens PRS, Walkty AJ, Noreddin A, Lynch Iii JP, Karlowsky JA
Drugs 2019 Feb;79(3):271-289. doi: 10.1007/s40265-019-1055-2. PMID: 30712199
Shirley M
Drugs 2018 Apr;78(6):675-692. doi: 10.1007/s40265-018-0902-x. PMID: 29671219
Wiersinga WJ, Virk HS, Torres AG, Currie BJ, Peacock SJ, Dance DAB, Limmathurotsakul D
Nat Rev Dis Primers 2018 Feb 1;4:17107. doi: 10.1038/nrdp.2017.107. PMID: 29388572Free PMC Article
Carmeli Y, Armstrong J, Laud PJ, Newell P, Stone G, Wardman A, Gasink LB
Lancet Infect Dis 2016 Jun;16(6):661-673. Epub 2016 Apr 20 doi: 10.1016/S1473-3099(16)30004-4. PMID: 27107460

Prognosis

Castón JJ, Cano A, Pérez-Camacho I, Aguado JM, Carratalá J, Ramasco F, Soriano A, Pintado V, Castelo-Corral L, Sousa A, Fariñas MC, Muñoz P, Abril López De Medrano V, Sanz-Peláez Ó, Los-Arcos I, Gracia-Ahufinger I, Pérez-Nadales E, Vidal E, Doblas A, Natera C, Martínez-Martínez L, Torre-Cisneros J
J Antimicrob Chemother 2022 Apr 27;77(5):1452-1460. doi: 10.1093/jac/dkac049. PMID: 35187577
Cornely OA, Cisneros JM, Torre-Cisneros J, Rodríguez-Hernández MJ, Tallón-Aguilar L, Calbo E, Horcajada JP, Queckenberg C, Zettelmeyer U, Arenz D, Rosso-Fernández CM, Jiménez-Jorge S, Turner G, Raber S, O'Brien S, Luckey A; COMBACTE-CARE consortium/REJUVENATE Study Group
J Antimicrob Chemother 2020 Mar 1;75(3):618-627. doi: 10.1093/jac/dkz497. PMID: 31828337Free PMC Article
Zhanel GG, Golden AR, Zelenitsky S, Wiebe K, Lawrence CK, Adam HJ, Idowu T, Domalaon R, Schweizer F, Zhanel MA, Lagacé-Wiens PRS, Walkty AJ, Noreddin A, Lynch Iii JP, Karlowsky JA
Drugs 2019 Feb;79(3):271-289. doi: 10.1007/s40265-019-1055-2. PMID: 30712199
Wiersinga WJ, Virk HS, Torres AG, Currie BJ, Peacock SJ, Dance DAB, Limmathurotsakul D
Nat Rev Dis Primers 2018 Feb 1;4:17107. doi: 10.1038/nrdp.2017.107. PMID: 29388572Free PMC Article
Cunha BA, Gill MV
Med Clin North Am 1995 Jul;79(4):721-32. doi: 10.1016/s0025-7125(16)30035-9. PMID: 7791419

Clinical prediction guides

Torres A, Wible M, Tawadrous M, Irani P, Stone GG, Quintana A, Debabov D, Burroughs M, Bradford PA, Kollef M
J Antimicrob Chemother 2023 Nov 6;78(11):2672-2682. doi: 10.1093/jac/dkad280. PMID: 37700689Free PMC Article
Nichols WW, Bradford PA, Stone GG
J Antimicrob Chemother 2023 Apr 3;78(4):871-892. doi: 10.1093/jac/dkad049. PMID: 36883356
Castón JJ, Cano A, Pérez-Camacho I, Aguado JM, Carratalá J, Ramasco F, Soriano A, Pintado V, Castelo-Corral L, Sousa A, Fariñas MC, Muñoz P, Abril López De Medrano V, Sanz-Peláez Ó, Los-Arcos I, Gracia-Ahufinger I, Pérez-Nadales E, Vidal E, Doblas A, Natera C, Martínez-Martínez L, Torre-Cisneros J
J Antimicrob Chemother 2022 Apr 27;77(5):1452-1460. doi: 10.1093/jac/dkac049. PMID: 35187577
Cornely OA, Cisneros JM, Torre-Cisneros J, Rodríguez-Hernández MJ, Tallón-Aguilar L, Calbo E, Horcajada JP, Queckenberg C, Zettelmeyer U, Arenz D, Rosso-Fernández CM, Jiménez-Jorge S, Turner G, Raber S, O'Brien S, Luckey A; COMBACTE-CARE consortium/REJUVENATE Study Group
J Antimicrob Chemother 2020 Mar 1;75(3):618-627. doi: 10.1093/jac/dkz497. PMID: 31828337Free PMC Article
Zhanel GG, Golden AR, Zelenitsky S, Wiebe K, Lawrence CK, Adam HJ, Idowu T, Domalaon R, Schweizer F, Zhanel MA, Lagacé-Wiens PRS, Walkty AJ, Noreddin A, Lynch Iii JP, Karlowsky JA
Drugs 2019 Feb;79(3):271-289. doi: 10.1007/s40265-019-1055-2. PMID: 30712199

Recent systematic reviews

Bucataru A, Turcu-Stiolica A, Calina D, Balasoiu AT, Zlatian OM, Osman A, Balasoiu M, Ghenea AE
Int J Mol Sci 2024 Sep 4;25(17) doi: 10.3390/ijms25179574. PMID: 39273526Free PMC Article
Beig M, Aghamohammad S, Majidzadeh N, Asforooshani MK, Rezaie N, Abed S, Khiavi EHG, Sholeh M
J Glob Antimicrob Resist 2024 Sep;38:376-388. Epub 2024 Jul 26 doi: 10.1016/j.jgar.2024.06.018. PMID: 39069234
Huang M, Cai F, Liu C, Zheng H, Lin X, Li Y, Wang L, Ruan J
Am J Infect Control 2024 Jul;52(7):774-784. Epub 2024 Feb 28 doi: 10.1016/j.ajic.2024.02.016. PMID: 38428591
Chen TY, Hsu CK, Shih SC, Weng TS, Tang HJ, Lai CC
Int J Antimicrob Agents 2023 Aug;62(2):106844. Epub 2023 May 7 doi: 10.1016/j.ijantimicag.2023.106844. PMID: 37160243
Sternbach N, Leibovici Weissman Y, Avni T, Yahav D
J Antimicrob Chemother 2018 Aug 1;73(8):2021-2029. doi: 10.1093/jac/dky124. PMID: 29659836

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