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Polyploidy

MedGen UID:
18567
Concept ID:
C0032578
Cell or Molecular Dysfunction
Synonyms: Polyploid; Polyploidies; Polyploids
SNOMED CT: Polyploidy syndrome (72991005); Polyploidy (72991005); Polyploidy (48099008)
 
Monarch Initiative: MONDO:0019934
Orphanet: ORPHA96321

Definition

A numerical chromosomal abnormality characterized by the presence of more than two sets of chromosomes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolyploidy
Follow this link to review classifications for Polyploidy in Orphanet.

Professional guidelines

PubMed

Hagege A, Ambrosetti D, Boyer J, Bozec A, Doyen J, Chamorey E, He X, Bourget I, Rousset J, Saada E, Rastoin O, Parola J, Luciano F, Cao Y, Pagès G, Dufies M
Theranostics 2021;11(19):9571-9586. Epub 2021 Sep 21 doi: 10.7150/thno.61711. PMID: 34646387Free PMC Article
Wang L, Xu J, Niu W, Hu L, Zhang Y, Sun Y
J Assist Reprod Genet 2020 Aug;37(8):1853-1860. Epub 2020 Jun 9 doi: 10.1007/s10815-020-01849-9. PMID: 32519011Free PMC Article
Milunsky A, Atkins L, Littlefield JW
J Pediatr 1971 Aug;79(2):303-5. doi: 10.1016/s0022-3476(71)80120-8. PMID: 5560056

Recent clinical studies

Etiology

You B, Xia T, Gu M, Zhang Z, Zhang Q, Shen J, Fan Y, Yao H, Pan S, Lu Y, Cheng T, Yang Z, He X, Zhang H, Shi M, Liu D, You Y
Cancer Res 2022 Mar 1;82(5):846-858. doi: 10.1158/0008-5472.CAN-21-2342. PMID: 34965934Free PMC Article
Spoelhof JP, Soltis DE, Soltis PS
Evolution 2021 Sep;75(9):2299-2308. Epub 2021 Jul 19 doi: 10.1111/evo.14307. PMID: 34251678
Hayashi A, Hong J, Iacobuzio-Donahue CA
Nat Rev Gastroenterol Hepatol 2021 Jul;18(7):469-481. Epub 2021 Jun 4 doi: 10.1038/s41575-021-00463-z. PMID: 34089011
Duensing A, Duensing S
Adv Exp Med Biol 2010;676:93-103. doi: 10.1007/978-1-4419-6199-0_6. PMID: 20687471
Merlo LM, Wang LS, Pepper JW, Rabinovitch PS, Maley CC
Adv Exp Med Biol 2010;676:1-13. doi: 10.1007/978-1-4419-6199-0_1. PMID: 20687466

Diagnosis

Matsuura T, Ueda Y, Harada Y, Hayashi K, Horisaka K, Yano Y, So S, Kido M, Fukumoto T, Kodama Y, Hara E, Matsumoto T
Br J Cancer 2023 Oct;129(8):1251-1260. Epub 2023 Sep 15 doi: 10.1038/s41416-023-02408-6. PMID: 37715023Free PMC Article
Hayashi A, Hong J, Iacobuzio-Donahue CA
Nat Rev Gastroenterol Hepatol 2021 Jul;18(7):469-481. Epub 2021 Jun 4 doi: 10.1038/s41575-021-00463-z. PMID: 34089011
Miles DM, Desdouets C, Géli V
Curr Genet 2019 Oct;65(5):1081-1088. Epub 2019 Apr 11 doi: 10.1007/s00294-019-00967-x. PMID: 30976832
Chan NC, Chan NP
Methods Mol Biol 2017;1541:295-302. doi: 10.1007/978-1-4939-6703-2_23. PMID: 27910031
Bird RJ, Hurren BJ
Clin Anat 2016 Jul;29(5):606-19. Epub 2016 Feb 21 doi: 10.1002/ca.22695. PMID: 26823086

Therapy

Zhang X, Yao J, Li X, Niu N, Liu Y, Hajek RA, Peng G, Westin S, Sood AK, Liu J
Sci Adv 2023 Jul 21;9(29):eadf7195. doi: 10.1126/sciadv.adf7195. PMID: 37478190Free PMC Article
Lau CH, Seow KM, Chen KH
Int J Mol Sci 2022 Jul 23;23(15) doi: 10.3390/ijms23158125. PMID: 35897700Free PMC Article
Choi IY, Kwon EC, Kim NS
Genes Genomics 2020 Jul;42(7):699-714. Epub 2020 May 22 doi: 10.1007/s13258-020-00941-9. PMID: 32445179
Vilgelm AE, Cobb P, Malikayil K, Flaherty D, Andrew Johnson C, Raman D, Saleh N, Higgins B, Vara BA, Johnston JN, Johnson DB, Kelley MC, Chen SC, Ayers GD, Richmond A
EBioMedicine 2017 Oct;24:43-55. Epub 2017 Sep 19 doi: 10.1016/j.ebiom.2017.09.016. PMID: 29030058Free PMC Article
Duncan AW
Semin Cell Dev Biol 2013 Apr;24(4):347-56. Epub 2013 Jan 16 doi: 10.1016/j.semcdb.2013.01.003. PMID: 23333793

Prognosis

Qiao K, Han J, Zhang H, Li Y, Hou X, Jia Y, Sun Y, Wang H, Xu Z, Liu H, Zhang H, Liu H, Zhang W, Sun T
Cell Rep 2023 Dec 26;42(12):113563. Epub 2023 Dec 12 doi: 10.1016/j.celrep.2023.113563. PMID: 38088929
D'Amato Figueiredo MV, Alexiou GA, Vartholomatos G, Rehder R
Int J Mol Sci 2022 Nov 3;23(21) doi: 10.3390/ijms232113430. PMID: 36362215Free PMC Article
De Chiara L, Conte C, Semeraro R, Diaz-Bulnes P, Angelotti ML, Mazzinghi B, Molli A, Antonelli G, Landini S, Melica ME, Peired AJ, Maggi L, Donati M, La Regina G, Allinovi M, Ravaglia F, Guasti D, Bani D, Cirillo L, Becherucci F, Guzzi F, Magi A, Annunziato F, Lasagni L, Anders HJ, Lazzeri E, Romagnani P
Nat Commun 2022 Oct 4;13(1):5805. doi: 10.1038/s41467-022-33110-5. PMID: 36195583Free PMC Article
Sladky VC, Eichin F, Reiberger T, Villunger A
J Hepatol 2021 Nov;75(5):1177-1191. Epub 2021 Jul 3 doi: 10.1016/j.jhep.2021.06.030. PMID: 34228992
Crow JF
J Genet 2008 Dec;87(4):349-53. doi: 10.1007/s12041-008-0057-8. PMID: 19147924

Clinical prediction guides

Qiao K, Han J, Zhang H, Li Y, Hou X, Jia Y, Sun Y, Wang H, Xu Z, Liu H, Zhang H, Liu H, Zhang W, Sun T
Cell Rep 2023 Dec 26;42(12):113563. Epub 2023 Dec 12 doi: 10.1016/j.celrep.2023.113563. PMID: 38088929
Zhang S, Lin YH, Tarlow B, Zhu H
Cell Cycle 2019 Jun;18(12):1302-1315. Epub 2019 May 26 doi: 10.1080/15384101.2019.1618123. PMID: 31096847Free PMC Article
Van de Peer Y, Mizrachi E, Marchal K
Nat Rev Genet 2017 Jul;18(7):411-424. Epub 2017 May 15 doi: 10.1038/nrg.2017.26. PMID: 28502977
Gentric G, Desdouets C
Am J Pathol 2014 Feb;184(2):322-31. Epub 2013 Oct 17 doi: 10.1016/j.ajpath.2013.06.035. PMID: 24140012
Gentric G, Celton-Morizur S, Desdouets C
Clin Res Hepatol Gastroenterol 2012 Feb;36(1):29-34. Epub 2011 Jul 21 doi: 10.1016/j.clinre.2011.05.011. PMID: 21778131

Recent systematic reviews

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