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Impairment of fructose metabolism

MedGen UID:: 869161
•Concept ID:: C4023581
•: Finding

HPO:	HP:0011033

Definition

An impairment of a fructose metabolic process. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVImpairment of fructose metabolism

Phenotypic abnormality
- Abnormality of metabolism/homeostasis
  - Abnormal metabolism
    - Impairment of fructose metabolism
      - Hereditary fructosuria

Conditions with this feature

Essential fructosuria

MedGen UID:: 78645
•Concept ID:: C0268160
•: Disease or Syndrome

Essential fructosuria is a benign, asymptomatic defect of intermediary metabolism characterized by the intermittent appearance of fructose in the urine (summary by Bonthron et al., 1994).

See: Condition Record

Essential fructosuria

Professional guidelines

PubMed

Targeting BCAA metabolism to potentiate metformin's therapeutic efficacy in the treatment of diabetes in mice.

Zhao X, Zhang X, Pei J, Liu Y, Niu W, Sun H
Diabetologia 2023 Nov;66(11):2139-2153. Epub 2023 Aug 15 doi: 10.1007/s00125-023-05985-6. PMID: 37581618

Long-Term Efficacy and Safety of Anti-Obesity Treatment: Where Do We Stand?

Tak YJ, Lee SY
Curr Obes Rep 2021 Mar;10(1):14-30. Epub 2021 Jan 6 doi: 10.1007/s13679-020-00422-w. PMID: 33410104 Free PMC Article

Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome.

Rom O, Liu Y, Liu Z, Zhao Y, Wu J, Ghrayeb A, Villacorta L, Fan Y, Chang L, Wang L, Liu C, Yang D, Song J, Rech JC, Guo Y, Wang H, Zhao G, Liang W, Koike Y, Lu H, Koike T, Hayek T, Pennathur S, Xi C, Wen B, Sun D, Garcia-Barrio MT, Aviram M, Gottlieb E, Mor I, Liu W, Zhang J, Chen YE
Sci Transl Med 2020 Dec 2;12(572) doi: 10.1126/scitranslmed.aaz2841. PMID: 33268508 Free PMC Article

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Recent clinical studies

Etiology

The Impact of Free and Added Sugars on Cognitive Function: A Systematic Review and Meta-Analysis.

Gillespie KM, White MJ, Kemps E, Moore H, Dymond A, Bartlett SE
Nutrients 2023 Dec 25;16(1) doi: 10.3390/nu16010075. PMID: 38201905 Free PMC Article

Long-Term Efficacy and Safety of Anti-Obesity Treatment: Where Do We Stand?

Tak YJ, Lee SY
Curr Obes Rep 2021 Mar;10(1):14-30. Epub 2021 Jan 6 doi: 10.1007/s13679-020-00422-w. PMID: 33410104 Free PMC Article

Fructose and hepatic insulin resistance.

Softic S, Stanhope KL, Boucher J, Divanovic S, Lanaspa MA, Johnson RJ, Kahn CR
Crit Rev Clin Lab Sci 2020 Aug;57(5):308-322. Epub 2020 Jan 14 doi: 10.1080/10408363.2019.1711360. PMID: 31935149 Free PMC Article

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease.

Jensen T, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C, Nakagawa T, Kuwabara M, Sato Y, Kang DH, Tolan DR, Sanchez-Lozada LG, Rosen HR, Lanaspa MA, Diehl AM, Johnson RJ
J Hepatol 2018 May;68(5):1063-1075. Epub 2018 Feb 2 doi: 10.1016/j.jhep.2018.01.019. PMID: 29408694 Free PMC Article

The Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease.

DiNicolantonio JJ, Lucan SC, O'Keefe JH
Prog Cardiovasc Dis 2016 Mar-Apr;58(5):464-72. Epub 2015 Nov 14 doi: 10.1016/j.pcad.2015.11.006. PMID: 26586275 Free PMC Article

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Diagnosis

Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma.

Zhang X, Yu K, Ma L, Qian Z, Tian X, Miao Y, Niu Y, Xu X, Guo S, Yang Y, Wang Z, Xue X, Gu C, Fang W, Sun J, Yu Y, Wang J
Theranostics 2021;11(12):5650-5674. Epub 2021 Mar 24 doi: 10.7150/thno.55482. PMID: 33897873 Free PMC Article

Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis.

Hansen HH, Ægidius HM, Oró D, Evers SS, Heebøll S, Eriksen PL, Thomsen KL, Bengtsson A, Veidal SS, Feigh M, Suppli MP, Knop FK, Grønbæk H, Miranda D, Trevaskis JL, Vrang N, Jelsing J, Rigbolt KTG
BMC Gastroenterol 2020 Jul 6;20(1):210. doi: 10.1186/s12876-020-01356-2. PMID: 32631250 Free PMC Article

Fructose and hepatic insulin resistance.

The Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease.

DiNicolantonio JJ, Lucan SC, O'Keefe JH
Prog Cardiovasc Dis 2016 Mar-Apr;58(5):464-72. Epub 2015 Nov 14 doi: 10.1016/j.pcad.2015.11.006. PMID: 26586275 Free PMC Article

Metabolic effects of fructose and the worldwide increase in obesity.

Tappy L, Lê KA
Physiol Rev 2010 Jan;90(1):23-46. doi: 10.1152/physrev.00019.2009. PMID: 20086073

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Therapy

The Impact of Free and Added Sugars on Cognitive Function: A Systematic Review and Meta-Analysis.

Gillespie KM, White MJ, Kemps E, Moore H, Dymond A, Bartlett SE
Nutrients 2023 Dec 25;16(1) doi: 10.3390/nu16010075. PMID: 38201905 Free PMC Article

Long-Term Efficacy and Safety of Anti-Obesity Treatment: Where Do We Stand?

Tak YJ, Lee SY
Curr Obes Rep 2021 Mar;10(1):14-30. Epub 2021 Jan 6 doi: 10.1007/s13679-020-00422-w. PMID: 33410104 Free PMC Article

Fructose and hepatic insulin resistance.

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease.

The Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease.

DiNicolantonio JJ, Lucan SC, O'Keefe JH
Prog Cardiovasc Dis 2016 Mar-Apr;58(5):464-72. Epub 2015 Nov 14 doi: 10.1016/j.pcad.2015.11.006. PMID: 26586275 Free PMC Article

See all (218)

Prognosis

Discovery and validation of plasma, saliva and multi-fluid plasma-saliva metabolomic scores predicting insulin resistance and diabetes progression or regression among Puerto Rican adults.

Haslam DE, Liang L, Guo K, Martínez-Lozano M, Pérez CM, Lee CH, Morou-Bermudez E, Clish C, Wong DTW, Manson JE, Hu FB, Stampfer MJ, Joshipura K, Bhupathiraju SN
Diabetologia 2024 Sep;67(9):1838-1852. Epub 2024 May 21 doi: 10.1007/s00125-024-06169-6. PMID: 38772919

O-GlcNAcylation of MORC2 at threonine 556 by OGT couples TGF-β signaling to breast cancer progression.

Liu YY, Liu HY, Yu TJ, Lu Q, Zhang FL, Liu GY, Shao ZM, Li DQ
Cell Death Differ 2022 Apr;29(4):861-873. Epub 2022 Jan 1 doi: 10.1038/s41418-021-00901-0. PMID: 34974534 Free PMC Article

Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming.

Liu J, Liu ZX, Wu QN, Lu YX, Wong CW, Miao L, Wang Y, Wang Z, Jin Y, He MM, Ren C, Wang DS, Chen DL, Pu HY, Feng L, Li B, Xie D, Zeng MS, Huang P, Lin A, Lin D, Xu RH, Ju HQ
Nat Commun 2020 Mar 20;11(1):1507. doi: 10.1038/s41467-020-15112-3. PMID: 32198345 Free PMC Article

Uric Acid as a Cause of the Metabolic Syndrome.

King C, Lanaspa MA, Jensen T, Tolan DR, Sánchez-Lozada LG, Johnson RJ
Contrib Nephrol 2018;192:88-102. Epub 2018 Jan 23 doi: 10.1159/000484283. PMID: 29393133

The Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease.

DiNicolantonio JJ, Lucan SC, O'Keefe JH
Prog Cardiovasc Dis 2016 Mar-Apr;58(5):464-72. Epub 2015 Nov 14 doi: 10.1016/j.pcad.2015.11.006. PMID: 26586275 Free PMC Article

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Clinical prediction guides

ALDOB/KAT2A interactions epigenetically modulate TGF-β expression and T cell functions in hepatocellular carcinogenesis.

Yin C, Zhang C, Wang Y, Liu G, Wang N, Liang N, Zhang L, Tu Q, Lv J, Jiang H, Ma H, Du C, Li M, He X, Chen S, Guo J, Li S, Qin J, Li N, Tao Y, Yin H
Hepatology 2025 Jan 1;81(1):77-93. Epub 2023 Dec 5 doi: 10.1097/HEP.0000000000000704. PMID: 38051951

Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability: Insights from McArdle disease.

Valenzuela PL, Santalla A, Alejo LB, Merlo A, Bustos A, Castellote-Bellés L, Ferrer-Costa R, Maffiuletti NA, Barranco-Gil D, Pinós T, Lucia A
J Sport Health Sci 2024 May;13(3):398-408. Epub 2023 Nov 27 doi: 10.1016/j.jshs.2023.11.006. PMID: 38030066 Free PMC Article

Colonic L-cell impairment in aged subjects with type 2 diabetes leads to diminished GLP-1 production.

Wang QY, Zhang W, Zhao Y, Chen HL, Liu Q, Wang ZH, Zeng LT, Li J, Chen SJ, Wei L, Iwakuma T, Cai JP
Diabetes Metab Syndr 2023 Dec;17(12):102907. Epub 2023 Nov 11 doi: 10.1016/j.dsx.2023.102907. PMID: 37980723

O-GlcNAcylation of MORC2 at threonine 556 by OGT couples TGF-β signaling to breast cancer progression.

Liu YY, Liu HY, Yu TJ, Lu Q, Zhang FL, Liu GY, Shao ZM, Li DQ
Cell Death Differ 2022 Apr;29(4):861-873. Epub 2022 Jan 1 doi: 10.1038/s41418-021-00901-0. PMID: 34974534 Free PMC Article

The Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease.

DiNicolantonio JJ, Lucan SC, O'Keefe JH
Prog Cardiovasc Dis 2016 Mar-Apr;58(5):464-72. Epub 2015 Nov 14 doi: 10.1016/j.pcad.2015.11.006. PMID: 26586275 Free PMC Article

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Recent systematic reviews

Dietary glycation compounds - implications for human health.

Hellwig M, Diel P, Eisenbrand G, Grune T, Guth S, Henle T, Humpf HU, Joost HG, Marko D, Raupbach J, Roth A, Vieths S, Mally A
Crit Rev Toxicol 2024 Sep;54(8):485-617. Epub 2024 Aug 16 doi: 10.1080/10408444.2024.2362985. PMID: 39150724

The Impact of Free and Added Sugars on Cognitive Function: A Systematic Review and Meta-Analysis.

Gillespie KM, White MJ, Kemps E, Moore H, Dymond A, Bartlett SE
Nutrients 2023 Dec 25;16(1) doi: 10.3390/nu16010075. PMID: 38201905 Free PMC Article

Chronic fructose substitution for glucose or sucrose in food or beverages has little effect on fasting blood glucose, insulin, or triglycerides: a systematic review and meta-analysis.

Evans RA, Frese M, Romero J, Cunningham JH, Mills KE
Am J Clin Nutr 2017 Aug;106(2):519-529. Epub 2017 Jun 7 doi: 10.3945/ajcn.116.145169. PMID: 28592603

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Links from PMC

Impairment of fructose metabolism

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

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