Pleckstrin Homology Domains

Protein domains of approximately 120 amino acids that form two perpendicular anti-parallel beta sheets connected by a loop of variable length and a C-terminal amphipathic helix. PH domains occur in many INTRACELLULAR SIGNALING PROTEINS and CYTOSKELETAL PROTEINS where they bind PHOSPHATIDYLINOSITOLS within the CELL MEMBRANE and INTRACELLULAR MEMBRANES, as well as proteins that include the Betagamma-subunits of HETEROTRIMERIC GTP-BINDING PROTEINS, and PROTEIN KINASE C. These interactions allow the targeting of proteins to different cellular compartments and SIGNAL TRANSDUCTION PATHWAYS.

Year introduced: 2017

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Tree Number(s): G02.111.570.820.709.275.750.469

MeSH Unique ID: D000070539

Entry Terms:

• Domain, Pleckstrin Homology
• Domains, Pleckstrin Homology
• Homology Domain, Pleckstrin
• Homology Domains, Pleckstrin
• Pleckstrin Homology Domain
• PH Domain
• Domain, PH
• Domains, PH
• PH Domains

Previous Indexing:

• Protein Structure, Tertiary (1994-2016)

All MeSH Categories
Phenomena and Processes Category
Chemical Phenomena
Biochemical Phenomena
Molecular Structure
Molecular Conformation
Protein Conformation
Protein Structural Elements
Protein Domains
Pleckstrin Homology Domains