Signaling Lymphocytic Activation Molecule Family
Type-I membrane glycoproteins that are expressed primarily on the surface of CD4 or CD8-positive T-CELLS; NATURAL KILLER CELLS; and some populations of B CELLS. They are characterized by an N-terminal, extracellular IMMUNOGLOBULIN-LIKE DOMAIN and a membrane-proximal IMMUNOGLOBULIN C2-SET DOMAIN. SLAMF receptors typically signal through homophilic interactions and are important for mediating the immune response and immune cell differentiation.
Year introduced: 2017
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Subheadings:
Tree Number(s): D09.400.430.890.736, D12.776.395.550.736, D12.776.543.550.746, D12.776.543.750.705.970
MeSH Unique ID: D000071176
Entry Terms:
- Signaling Lymphocytic Activation Molecules
- SLAM Family Receptors
- SLAMF Receptors
- Signaling Lymphocytic Activation Molecule Family Receptors
- Signaling Lymphocytic Activation Molecule Receptors
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