Src Homology 2 Domain-Containing, Transforming Protein 1
An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.
Year introduced: 2017
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Subheadings:
Tree Number(s): D12.644.360.024.330.500, D12.776.157.057.162.500, D12.776.476.024.424.500
MeSH Unique ID: D000071425
Entry Terms:
- Src Homology 2 Domain Containing, Transforming Protein 1
- SHC (Src Homology 2 Domain-Containing) Transforming Protein 1
- SHC1 (Src Homology 2 Domain-Containing) Protein
- Src Homology 2 Domain-Containing-Transforming Protein C1
- Src Homology 2 Domain Containing Transforming Protein C1
- ShcA Protein
- SHC-Transforming Protein 1
- SHC Transforming Protein 1
- SHC1 Protein