Substrate Cycling
A set of opposing, nonequilibrium reactions catalyzed by different enzymes which act simultaneously, with at least one of the reactions driven by ATP hydrolysis. The results of the cycle are that ATP energy is depleted, heat is produced and no net substrate-to-product conversion is achieved. Examples of substrate cycling are cycling of gluconeogenesis and glycolysis pathways and cycling of the triglycerides and fatty acid pathways. Rates of substrate cycling may be increased many-fold in association with hypermetabolic states resulting from severe burns, cold exposure, hyperthyroidism, or acute exercise.
Year introduced: 1989
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Subheadings:
Tree Number(s): G02.111.833, G03.295.835
MeSH Unique ID: D015219
Entry Terms:
- Cyclings, Substrate
- Cycling, Substrate
- Substrate Cyclings
- Futile Cycles
- Cycle, Futile
- Cycles, Futile
- Futile Cycle
- Futile Cycling
- Cycling, Futile
- Cyclings, Futile
- Futile Cyclings
- Futile Substrate Cycles
- Cycle, Futile Substrate
- Cycles, Futile Substrate
- Futile Substrate Cycle
- Substrate Cycle, Futile
- Substrate Cycles, Futile
- Futile Substrate Cycling
- Cycling, Futile Substrate
- Cyclings, Futile Substrate
- Futile Substrate Cyclings
- Substrate Cycling, Futile
- Substrate Cyclings, Futile
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